{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:22:13Z","timestamp":1786980133460,"version":"build-2736575974"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1007\/s00415-010-5589-1","type":"journal-article","created":{"date-parts":[[2010,5,11]],"date-time":"2010-05-11T14:57:09Z","timestamp":1273589829000},"page":"1654-1660","source":"Crossref","is-referenced-by-count":42,"title":["Retinal nerve fiber layer thickness in subgroups of multiple sclerosis, measured by optical coherence tomography and scanning laser polarimetry"],"prefix":"10.1007","volume":"257","author":[{"given":"Theodora A. M.","family":"Siepman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marijke","family":"Wefers Bettink-Remeijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogier Q.","family":"Hintzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,5,12]]},"reference":[{"key":"5589_CR1","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/S0140-6736(08)61620-7","volume":"372","author":"A Compston","year":"2008","unstructured":"Compston A, Coles A (2008) Multiple sclerosis. Lancet 372:1502\u20131517","journal-title":"Lancet"},{"key":"5589_CR2","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1007\/s00415-002-0790-5","volume":"249","author":"N Stefano De","year":"2002","unstructured":"De Stefano N, Iannucci G, Sormani MP et al (2002) MR correlates of cerebral atrophy in patients with multiple sclerosis. J Neurol 249:1072\u20131077","journal-title":"J Neurol"},{"key":"5589_CR3","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/ana.20832","volume":"59","author":"DS Goodin","year":"2006","unstructured":"Goodin DS (2006) Magnetic resonance imaging as a surrogate outcome measure of disability in multiple sclerosis: have we been overly harsh in our assessment? Ann Neurol 59:597\u2013605","journal-title":"Ann Neurol"},{"key":"5589_CR4","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1167\/iovs.03-0646","volume":"45","author":"NJ Reus","year":"2004","unstructured":"Reus NJ, Lemij HG (2004) The relationship between standard automated perimetry and GDx VCC measurements. Invest Ophthalmol Vis Sci 45:840\u2013845","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"5589_CR5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/sj.eye.6702942","volume":"23","author":"EZ Blumenthal","year":"2009","unstructured":"Blumenthal EZ, Parikh RS, Pe\u2019er J et al (2009) Retinal nerve fibre layer imaging compared with histological measurements in a human eye. Eye 23:171\u2013175","journal-title":"Eye"},{"key":"5589_CR6","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1001\/archopht.1990.01070060105058","volume":"108","author":"RN Weinreb","year":"1990","unstructured":"Weinreb RN, Dreher AW, Coleman A, Quigley H, Shaw B, Reiter K (1990) Histopathologic validation of Fourier-ellipsometry measurements of retinal nerve fiber layer thickness. Arch Ophthalmol 108:557\u2013560","journal-title":"Arch Ophthalmol"},{"key":"5589_CR7","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1136\/bjo.2005.086447","volume":"90","author":"M Sehi","year":"2006","unstructured":"Sehi M, Guaqueta DC, Greenfield DS (2006) An enhancement module to improve the atypical birefringence pattern using scanning laser polarimetry with variable corneal compensation. Br J Ophthalmol 90:749\u2013753","journal-title":"Br J Ophthalmol"},{"key":"5589_CR8","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1167\/iovs.05-0067","volume":"47","author":"NJ Reus","year":"2006","unstructured":"Reus NJ, Zhou Q, Lemij HG (2006) Enhanced imaging algorithm for scanning laser polarimetry with variable corneal compensation. Invest Ophthalmol Vis Sci 47:3870\u20133877","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"5589_CR9","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/ICU.0b013e3282f4b1c2","volume":"19","author":"HG Lemij","year":"2008","unstructured":"Lemij HG, Reus NJ (2008) New developments in scanning laser polarimetry for glaucoma. Curr Opin Ophthalmol 19:136\u2013140","journal-title":"Curr Opin Ophthalmol"},{"key":"5589_CR10","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1002\/ana.20851","volume":"59","author":"F Costello","year":"2006","unstructured":"Costello F, Coupland S, Hodge W et al (2006) Quantifying axonal loss after optic neuritis with optical coherence tomography. Ann Neurol 59:963\u2013969","journal-title":"Ann Neurol"},{"key":"5589_CR11","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1177\/1352458508091367","volume":"14","author":"F Costello","year":"2008","unstructured":"Costello F, Hodge W, Pan YI, Eggenberger E, Coupland S, Kardon RH (2008) Tracking retinal nerve fiber layer loss after optic neuritis: a prospective study using optical coherence tomography. Mult Scler 14:893\u2013905","journal-title":"Mult Scler"},{"key":"5589_CR12","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ana.20575","volume":"58","author":"SA Trip","year":"2005","unstructured":"Trip SA, Schlottmann PG, Jones SJ et al (2005) Retinal nerve fiber layer axonal loss and visual dysfunction in optic neuritis. Ann Neurol 58:383\u2013391","journal-title":"Ann Neurol"},{"key":"5589_CR13","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s00415-007-0538-3","volume":"254","author":"P Albrecht","year":"2007","unstructured":"Albrecht P, Frohlich R, Hartung HP, Kieseier BC, Methner A (2007) Optical coherence tomography measures axonal loss in multiple sclerosis independently of optic neuritis. J Neurol 254:1595\u20131596","journal-title":"J Neurol"},{"key":"5589_CR14","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ophtha.2005.10.040","volume":"113","author":"JB Fisher","year":"2006","unstructured":"Fisher JB, Jacobs DA, Markowitz CE et al (2006) Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis. Ophthalmology 113:324\u2013332","journal-title":"Ophthalmology"},{"key":"5589_CR15","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/ncpneuro0950","volume":"4","author":"EM Frohman","year":"2008","unstructured":"Frohman EM, Fujimoto JG, Frohman TC, Calabresi PA, Cutter G, Balcer LJ (2008) Optical coherence tomography: a window into the mechanisms of multiple sclerosis. Nat Clin Pract Neurol 4:664\u2013675","journal-title":"Nat Clin Pract Neurol"},{"key":"5589_CR16","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1212\/01.wnl.0000295995.46586.ae","volume":"69","author":"E Gordon-Lipkin","year":"2007","unstructured":"Gordon-Lipkin E, Chodkowski B, Reich DS et al (2007) Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis. Neurology 69:1603\u20131609","journal-title":"Neurology"},{"key":"5589_CR17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jns.2007.10.020","volume":"268","author":"E Grazioli","year":"2008","unstructured":"Grazioli E, Zivadinov R, Weinstock-Guttman B et al (2008) Retinal nerve fiber layer thickness is associated with brain MRI outcomes in multiple sclerosis. J Neurol Sci 268:12\u201317","journal-title":"J Neurol Sci"},{"key":"5589_CR18","first-page":"277","volume":"131","author":"AP Henderson","year":"2008","unstructured":"Henderson AP, Trip SA, Schlottmann PG et al (2008) An investigation of the retinal nerve fibre layer in progressive multiple sclerosis using optical coherence tomography. Brain 131:277\u2013287","journal-title":"Brain"},{"key":"5589_CR19","first-page":"2520","volume":"40","author":"V Parisi","year":"1999","unstructured":"Parisi V, Manni G, Spadaro M et al (1999) Correlation between morphological and functional retinal impairment in multiple sclerosis patients. Invest Ophthalmol Vis Sci 40:2520\u20132527","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"5589_CR20","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1212\/01.wnl.0000294876.49861.dc","volume":"69","author":"M Pulicken","year":"2007","unstructured":"Pulicken M, Gordon-Lipkin E, Balcer LJ, Frohman E, Cutter G, Calabresi PA (2007) Optical coherence tomography and disease subtype in multiple sclerosis. Neurology 69:2085\u20132092","journal-title":"Neurology"},{"key":"5589_CR21","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1212\/01.wnl.0000260612.51849.ed","volume":"68","author":"J Sepulcre","year":"2007","unstructured":"Sepulcre J, Murie-Fernandez M, Salinas-Alaman A, Garcia-Layana A, Bejarano B, Villoslada P (2007) Diagnostic accuracy of retinal abnormalities in predicting disease activity in MS. Neurology 68:1488\u20131494","journal-title":"Neurology"},{"key":"5589_CR22","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00415-008-0985-5","volume":"255","author":"M Siger","year":"2008","unstructured":"Siger M, Dziegielewski K, Jasek L et al (2008) Optical coherence tomography in multiple sclerosis: thickness of the retinal nerve fiber layer as a potential measure of axonal loss and brain atrophy. J Neurol 255:1555\u20131560","journal-title":"J Neurol"},{"key":"5589_CR23","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1159\/000099299","volume":"221","author":"G Della Mea","year":"2007","unstructured":"Della Mea G, Bacchetti S, Zeppieri M, Brusini P, Cutuli D, Gigli GL (2007) Nerve fibre layer analysis with GDx with a variable corneal compensator in patients with multiple sclerosis. Ophthalmologica 221:186\u2013189","journal-title":"Ophthalmologica"},{"key":"5589_CR24","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/sj.eye.6703013","volume":"23","author":"M Iester","year":"2009","unstructured":"Iester M, Cioli F, Uccelli A et al (2009) Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients. Eye 23:407\u2013412","journal-title":"Eye"},{"key":"5589_CR25","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1136\/jnnp.64.4.505","volume":"64","author":"DH Steel","year":"1998","unstructured":"Steel DH, Waldock A (1998) Measurement of the retinal nerve fibre layer with scanning laser polarimetry in patients with previous demyelinating optic neuritis. J Neurol Neurosurg Psychiatry 64:505\u2013509","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"5589_CR26","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1167\/iovs.05-1489","volume":"47","author":"C Bowd","year":"2006","unstructured":"Bowd C, Zangwill LM, Medeiros FA et al (2006) Structure-function relationships using confocal scanning laser ophthalmoscopy, optical coherence tomography, and scanning laser polarimetry. Invest Ophthalmol Vis Sci 47:2889\u20132895","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"5589_CR27","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1177\/1352458507087326","volume":"14","author":"V Pueyo","year":"2008","unstructured":"Pueyo V, Martin J, Fernandez J et al (2008) Axonal loss in the retinal nerve fiber layer in patients with multiple sclerosis. Mult Scler 14:609\u2013614","journal-title":"Mult Scler"},{"key":"5589_CR28","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1001\/archneur.65.7.924","volume":"65","author":"MS Zaveri","year":"2008","unstructured":"Zaveri MS, Conger A, Salter A et al (2008) Retinal imaging by laser polarimetry and optical coherence tomography evidence of axonal degeneration in multiple sclerosis. Arch Neurol 65:924\u2013928","journal-title":"Arch Neurol"},{"key":"5589_CR29","doi-asserted-by":"crossref","unstructured":"Pueyo V, Aza JR, Almarcegui C et al (2009) Sub-clinical atrophy of the retinal nerve fibre layer in multiple sclerosis. Acta Ophthalmol (in press)","DOI":"10.1111\/j.1755-3768.2009.01527.x"},{"key":"5589_CR30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1177\/112067211002000123","volume":"20","author":"E Garcia-Martin","year":"2010","unstructured":"Garcia-Martin E, Pueyo V, Martin J et al (2010) Progressive changes in the retinal nerve fibre layer in patients with multiple sclerosis. Eur J Ophthalmol 20:167\u2013173","journal-title":"Eur J Ophthalmol"},{"key":"5589_CR31","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jns.2009.04.010","volume":"282","author":"E Frohman","year":"2009","unstructured":"Frohman E, Dwyer MG, Frohman T et al (2009) Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: a pilot study. J Neurol Sci 282:96\u2013105","journal-title":"J Neurol Sci"},{"key":"5589_CR32","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1002\/ana.20703","volume":"58","author":"CH Polman","year":"2005","unstructured":"Polman CH, Reingold SC, Edan G et al (2005) Diagnostic criteria for multiple sclerosis: 2005 revisions to the \u201cMcDonald Criteria\u201d. Ann Neurol 58:840\u2013846","journal-title":"Ann Neurol"},{"key":"5589_CR33","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1093\/brain\/124.5.962","volume":"124","author":"J Hobart","year":"2001","unstructured":"Hobart J, Lamping D, Fitzpatrick R, Riazi A, Thompson A (2001) The Multiple Sclerosis Impact Scale (MSIS-29): a new patient-based outcome measure. Brain 124:962\u2013973","journal-title":"Brain"},{"key":"5589_CR34","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1212\/01.WNL.0000156155.19270.F8","volume":"64","author":"RH Roxburgh","year":"2005","unstructured":"Roxburgh RH, Seaman SR, Masterman T et al (2005) Multiple Sclerosis Severity Score: using disability and disease duration to rate disease severity. Neurology 64:1144\u20131451","journal-title":"Neurology"},{"key":"5589_CR35","first-page":"117","volume-title":"Optic nerve head and retinal nerve fiber analysis","author":"R Knighton","year":"2005","unstructured":"Knighton R, Zhou Q (2005) Nerve fiber analyzer GDx: new techniques. In: Iester M, Garway-Heath DF, Lemij HG (eds) Optic nerve head and retinal nerve fiber analysis. Dogma, Savona, pp 117\u2013119"},{"key":"5589_CR36","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1056\/NEJM200011163432001","volume":"343","author":"C Confavreux","year":"2000","unstructured":"Confavreux C, Vukusic S, Moreau T, Adeleine P (2000) Relapses and progression of disability in multiple sclerosis. N Engl J Med 343:1430\u20131438","journal-title":"N Engl J Med"},{"key":"5589_CR37","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S1474-4422(07)70243-0","volume":"6","author":"DH Miller","year":"2007","unstructured":"Miller DH, Leary SM (2007) Primary-progressive multiple sclerosis. Lancet Neurol 6:903\u2013912","journal-title":"Lancet Neurol"},{"key":"5589_CR38","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1136\/bjo.87.1.32","volume":"87","author":"ML Monteiro","year":"2003","unstructured":"Monteiro ML, Medeiros FA, Ostroscki MR (2003) Quantitative analysis of axonal loss in band atrophy of the optic nerve using scanning laser polarimetry. Br J Ophthalmol 87:32\u201337","journal-title":"Br J Ophthalmol"},{"key":"5589_CR39","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1177\/1352458508090221","volume":"14","author":"J Toledo","year":"2008","unstructured":"Toledo J, Sepulcre J, Salinas-Alaman A et al (2008) Retinal nerve fiber layer atrophy is associated with physical and cognitive disability in multiple sclerosis. Mult Scler 14:906\u2013912","journal-title":"Mult Scler"},{"key":"5589_CR40","volume-title":"Handbook of neurologic rating scales","author":"RM Herndon","year":"2006","unstructured":"Herndon RM (2006) Handbook of neurologic rating scales, 2nd edn. Demos Medical Pub, New York","edition":"2"},{"key":"5589_CR41","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1212\/01.WNL.0000094315.19931.90","volume":"61","author":"LJ Balcer","year":"2003","unstructured":"Balcer LJ, Baier ML, Cohen JA et al (2003) Contrast letter acuity as a visual component for the multiple sclerosis functional composite. Neurology 61:1367\u20131373","journal-title":"Neurology"},{"key":"5589_CR42","doi-asserted-by":"crossref","unstructured":"Henderson AP, Trip SA, Schlottmann PG et al (2010) A preliminary longitudinal study of the retinal nerve fiber layer in progressive multiple sclerosis. J Neurol (in press)","DOI":"10.1007\/s00415-010-5467-x"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1007\/s00415-010-5589-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T23:32:50Z","timestamp":1559086370000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-010-5589-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5,12]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2010,10]]}},"alternative-id":["5589"],"URL":"https:\/\/doi.org\/10.1007\/s00415-010-5589-1","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5,12]]}}}