{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T07:14:37Z","timestamp":1771053277564,"version":"3.50.1"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2010,7,16]],"date-time":"2010-07-16T00:00:00Z","timestamp":1279238400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1007\/s00415-010-5644-y","type":"journal-article","created":{"date-parts":[[2010,7,15]],"date-time":"2010-07-15T07:24:23Z","timestamp":1279178663000},"page":"1979-1985","source":"Crossref","is-referenced-by-count":34,"title":["Impairment of sensory-motor integration in patients affected by RLS"],"prefix":"10.1007","volume":"257","author":[{"given":"Vincenzo","family":"Rizzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Aric\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Liotta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Ricciardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Mastroeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Morgante","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Allegra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Condurso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Girlanda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Silvestri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Quartarone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,7,16]]},"reference":[{"key":"5644_CR1","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1001\/archinte.165.11.1286","volume":"165","author":"RP Allen","year":"2005","unstructured":"Allen RP, Walters AS, Montplaisir J, Hening W, Myers A, Bell TJ, Ferini-Strambi L (2005) Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med 165:1286\u20131292","journal-title":"Arch Intern Med"},{"key":"5644_CR2","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/j.clinph.2004.03.032","volume":"115","author":"W Hening","year":"2004","unstructured":"Hening W (2004) The clinical neurophysiology of the restless legs syndrome and periodic limb movements. Part I: diagnosis, assessment, and characterization. Clin Neurophysiol 115:1965\u20131974","journal-title":"Clin Neurophysiol"},{"key":"5644_CR3","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/sleep\/9.3.399","volume":"9","author":"SS Mosko","year":"1986","unstructured":"Mosko SS, Nudleman KL (1986) Somatosensory and brainstem auditory evoked responses in sleep-related periodic leg movements. Sleep 9:399\u2013404","journal-title":"Sleep"},{"key":"5644_CR4","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/ana.410410513","volume":"41","author":"SF Bucher","year":"1997","unstructured":"Bucher SF, Seelos KC, Oertel WH, Reiser M, Trenkwalder C (1997) Cerebral generators involved in the pathogenesis of the restless legs syndrome. Ann Neurol 41:639\u2013645","journal-title":"Ann Neurol"},{"issue":"10","key":"5644_CR5","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.sleep.2008.11.008","volume":"10","author":"L Tyvaert","year":"2009","unstructured":"Tyvaert L, Houdayer E, Devanne H, Bourriez JL, Derambure P, Monaca C (2009) Cortical involvement in the sensory and motor symptoms of primary restless legs syndrome. Sleep Med 10(10):1090\u20131096","journal-title":"Sleep Med"},{"key":"5644_CR6","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1212\/WNL.53.6.1201","volume":"53","author":"M Entezari-Taher","year":"1999","unstructured":"Entezari-Taher M, Singleton JR, Jones CR, Meekins G, Petajan JH, Smith AG (1999) Changes in excitability of motor cortical circuitry in primary restless legs syndrome. Neurology 53:1201\u20131205","journal-title":"Neurology"},{"key":"5644_CR7","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1212\/WNL.52.5.1060","volume":"52","author":"F Tergau","year":"1999","unstructured":"Tergau F, Wischer S, Paulus W (1999) Motor system excitability in patients with restless legs syndrome. Neurology 52:1060\u20131063","journal-title":"Neurology"},{"key":"5644_CR8","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/S1388-2457(03)00137-8","volume":"114","author":"R Quatrale","year":"2003","unstructured":"Quatrale R, Manconi M, Gastaldo E, Eleopra R, Tugnoli V, Tola MR, Granieri E (2003) Neurophysiological study of corticomotor pathways in restless legs syndrome. Clin Neurophysiol 114:1638\u20131645","journal-title":"Clin Neurophysiol"},{"key":"5644_CR9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.sleep.2004.01.011","volume":"5","author":"A Scalise","year":"2004","unstructured":"Scalise A, Cadore IP, Gigli GL (2004) Motor cortex excitability in restless legs syndrome. Sleep Med 5:393\u2013396","journal-title":"Sleep Med"},{"key":"5644_CR10","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1600-0404.2006.00669.x","volume":"114","author":"R Nardone","year":"2006","unstructured":"Nardone R, Ausserer H, Bratti A, Covi M, Lochner P, Marth R, Tezzon F (2006) Cabergoline reverses cortical hyperexcitability in patients with restless legs syndrome. Acta Neurol Scand 114:244\u2013249","journal-title":"Acta Neurol Scand"},{"key":"5644_CR11","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/WNP.0b013e31815a0038","volume":"24","author":"A Gorsler","year":"2007","unstructured":"Gorsler A, Liepert J (2007) Influence of cabergoline on motor excitability in patients with restless legs syndrome. J Clin Neurophysiol 24:456\u2013460","journal-title":"J Clin Neurophysiol"},{"issue":"1","key":"5644_CR12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.sleep.2009.05.003","volume":"11","author":"A Scalise","year":"2010","unstructured":"Scalise A, Pittaro-Cadore I, Janes F, Marinig R, Gigli GL (2010) Changes of cortical excitability after dopaminergic treatment in restless legs syndrome. Sleep Med 11(1):75\u201381","journal-title":"Sleep Med"},{"key":"5644_CR13","doi-asserted-by":"crossref","first-page":"S87","DOI":"10.1212\/WNL.58.suppl_1.S87","volume":"58","author":"CL Comella","year":"2002","unstructured":"Comella CL (2002) Restless legs syndrome: treatment with dopaminergic agents. Neurology 58:S87\u2013S92","journal-title":"Neurology"},{"issue":"Pt 2","key":"5644_CR14","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1469-7793.2000.t01-1-00503.x","volume":"523","author":"H Tokimura","year":"2000","unstructured":"Tokimura H, Di Lazzaro V, Tokimura Y, Oliviero A, Profice P, Insola A, Mazzone P, Tonali P, Rothwell JC (2000) Short latency inhibition of human hand motor cortex by somatosensory input from the hand. J Physiol 523(Pt 2):503\u2013513","journal-title":"J Physiol"},{"key":"5644_CR15","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0028-3932(71)90067-4","volume":"9","author":"RC Oldfield","year":"1971","unstructured":"Oldfield RC (1971) The assessment and analysis of handedness: the Edinburgh inventory. Neuropsychologia 9:97\u2013113","journal-title":"Neuropsychologia"},{"key":"5644_CR16","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1002\/mds.870100517","volume":"10","author":"AS Walters","year":"1995","unstructured":"Walters AS (1995) Toward a better definition of the restless legs syndrome. The International Restless Legs Syndrome Study Group. Mov Disord 10:634\u2013642","journal-title":"Mov Disord"},{"key":"5644_CR17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S1389-9457(03)00010-8","volume":"4","author":"RP Allen","year":"2003","unstructured":"Allen RP, Picchietti D, Hening WA, Trenkwalder C, Walters AS, Montplaisi J (2003) Restless legs syndrome: diagnostic criteria, special considerations, and epidemiology. A report from the restless legs syndrome diagnosis and epidemiology workshop at the National Institutes of Health. Sleep Med 4:101\u2013119","journal-title":"Sleep Med"},{"key":"5644_CR18","volume-title":"The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications.","author":"C Iber","year":"2007","unstructured":"Iber C, Ancoli-Israel S, Chesson A, and Quan SF for the American Academy of Sleep Medicine. The AASM Manual for the Scoring of Sleep and Associated Events: Rules, Terminology and Technical Specifications."},{"key":"5644_CR19","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00221-007-0960-x","volume":"181","author":"MV Sale","year":"2007","unstructured":"Sale MV, Ridding MC, Nordstrom MA (2007) Factors influencing the magnitude and reproducibility of corticomotor excitability changes induced by paired associative stimulation. Exp Brain Res 181:615\u2013626","journal-title":"Exp Brain Res"},{"key":"5644_CR20","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1113\/jphysiol.1993.sp019912","volume":"471","author":"T Kujirai","year":"1993","unstructured":"Kujirai T, Caramia MD, Rothwell JC, Day BL, Thompson PD, Ferbert A, Wroe S, Asselman P, Marsden CD (1993) Corticocortical inhibition in human motor cortex. J Physiol 471:501\u2013519","journal-title":"J Physiol"},{"key":"5644_CR21","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/mus.20427","volume":"33","author":"Y Kutukcu","year":"2006","unstructured":"Kutukcu Y, Dogruer E, Yetkin S, Ozgen F, Vural O, Aydin H (2006) Evaluation of periodic leg movements and associated transcranial magnetic stimulation parameters in restless legs syndrome. Muscle Nerve 33:133\u2013137","journal-title":"Muscle Nerve"},{"key":"5644_CR22","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/BF00228633","volume":"109","author":"U Ziemann","year":"1996","unstructured":"Ziemann U, Lonnecker S, Steinhoff BJ, Paulus W (1996) The effect of lorazepam on the motor cortical excitability in man. Exp Brain Res 109:127\u2013135","journal-title":"Exp Brain Res"},{"key":"5644_CR23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0022-510X(96)00100-1","volume":"140","author":"R Hanajima","year":"1996","unstructured":"Hanajima R, Ugawa Y, Terao Y, Ogata K, Kanazawa I (1996) Ipsilateral cortico-cortical inhibition of the motor cortex in various neurological disorders. J Neurol Sci 140:109\u2013116","journal-title":"J Neurol Sci"},{"key":"5644_CR24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/S0924-980X(97)00050-7","volume":"105","author":"U Ziemann","year":"1997","unstructured":"Ziemann U, Tergau F, Bruns D, Baudewig J, Paulus W (1997) Changes in human motor cortex excitability induced by dopaminergic and anti-dopaminergic drugs. Electroencephalogr Clin Neurophysiol 105:430\u2013437","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"5644_CR25","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j.1469-7793.2001.0307l.x","volume":"530","author":"TD Sanger","year":"2001","unstructured":"Sanger TD, Garg RR, Chen R (2001) Interactions between two different inhibitory systems in the human motor cortex. J Physiol 530:307\u2013317","journal-title":"J Physiol"},{"key":"5644_CR26","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/brain\/124.3.537","volume":"124","author":"G Abbruzzese","year":"2001","unstructured":"Abbruzzese G, Marchese R, Buccolieri A, Gasparetto B, Trompetto C (2001) Abnormalities of sensorimotor integration in focal dystonia: a transcranial magnetic stimulation study. Brain 124:537\u2013545","journal-title":"Brain"},{"key":"5644_CR27","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s002210000543","volume":"135","author":"V Lazzaro Di","year":"2000","unstructured":"Di Lazzaro V, Oliviero A, Profice P, Pennisi MA, Di Giovanni S, Zito G, Tonali P, Rothwell JC (2000) Muscarinic receptor blockade has differential effects on the excitability of intracortical circuits in the human motor cortex. Exp Brain Res 135:455\u2013461","journal-title":"Exp Brain Res"},{"key":"5644_CR28","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1113\/jphysiol.2004.061747","volume":"564","author":"V Di Lazzaro","year":"2005","unstructured":"Di Lazzaro V, Oliviero A, Saturno E, Dileone M, Pilato F, Nardone R, Ranieri F, Musumeci G, Fiorilla T, Tonali P (2005) Effects of lorazepam on short latency afferent inhibition and short latency intracortical inhibition in humans. J Physiol 564:661\u2013668","journal-title":"J Physiol"},{"key":"5644_CR29","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1136\/jnnp.2003.018127","volume":"75","author":"V Lazzaro Di","year":"2004","unstructured":"Di Lazzaro V, Oliviero A, Pilato F, Saturno E, Dileone M, Marra C, Daniele A, Ghirlanda S, Gainotti G, Tonali PA (2004) Motor cortex hyperexcitability to transcranial magnetic stimulation in Alzheimer\u2019s disease. J Neurol Neurosurg Psychiatry 75:555\u2013559","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"5644_CR30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/mds.1137","volume":"16","author":"R Kaji","year":"2001","unstructured":"Kaji R, Murase N (2001) Sensory function of basal ganglia. Mov Disord 16:593\u2013594","journal-title":"Mov Disord"},{"key":"5644_CR31","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0165-0173(85)90010-4","volume":"356","author":"TI Lidsky","year":"1985","unstructured":"Lidsky TI, Manetto C, Schneider JS (1985) A consideration of sensory factors involved in motor functions of the basal ganglia. Brain Res 356:133\u2013146","journal-title":"Brain Res"},{"key":"5644_CR32","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1212\/WNL.52.5.932","volume":"52","author":"N Turjanski","year":"1999","unstructured":"Turjanski N, Lees AJ, Brooks DJ (1999) Striatal dopaminergic function in restless legs syndrome: 18F-dopa and 11C-raclopride PET studies. Neurology 52:932\u2013937","journal-title":"Neurology"},{"key":"5644_CR33","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1093\/brain\/awl163","volume":"129","author":"S Cervenka","year":"2006","unstructured":"Cervenka S, Palhagen SE, Comley RA, Panagiotidis G, Cselenyi Z, Matthews JC, Lai RY, Halldin C, Farde L (2006) Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding. Brain 129:2017\u20132028","journal-title":"Brain"},{"key":"5644_CR34","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1126\/science.182.4111.499","volume":"182","author":"AM Thierry","year":"1973","unstructured":"Thierry AM, Blanc G, Sobel A, Stinus L, Golwinski J (1973) Dopaminergic terminals in the rat cortex. Science 182:499\u2013501","journal-title":"Science"},{"key":"5644_CR35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.903250102","volume":"325","author":"P Gaspar","year":"1992","unstructured":"Gaspar P, Stepniewska I, Kaas JH (1992) Topography and collateralization of the dopaminergic projections to motor and lateral prefrontal cortex in owl monkeys. J Comp Neurol 325:1\u201321","journal-title":"J Comp Neurol"},{"key":"5644_CR36","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0006-8993(02)03969-0","volume":"963","author":"K Huda","year":"2003","unstructured":"Huda K, Matsunami K (2003) Influence of dopamine on ventrolateral thalamic inputs in cat motor cortex. Brain Res 963:178\u2013189","journal-title":"Brain Res"},{"key":"5644_CR37","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1212\/01.wnl.0000252812.95774.aa","volume":"68","author":"A Sailer","year":"2007","unstructured":"Sailer A, Cunic DI, Paradiso GO, Gunraj CA, Wagle-Shukla A, Moro E, Lozano AM, Lang AE, Chen R (2007) Subthalamic nucleus stimulation modulates afferent inhibition in Parkinson disease. Neurology 68:356\u2013363","journal-title":"Neurology"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-010-5644-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-010-5644-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-010-5644-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T19:12:59Z","timestamp":1559070779000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-010-5644-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7,16]]},"references-count":37,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2010,12]]}},"alternative-id":["5644"],"URL":"https:\/\/doi.org\/10.1007\/s00415-010-5644-y","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,7,16]]}}}