{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T04:48:55Z","timestamp":1791348535751,"version":"4.3.1"},"reference-count":45,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2011,8,18]],"date-time":"2011-08-18T00:00:00Z","timestamp":1313625600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2012,2]]},"DOI":"10.1007\/s00415-011-6172-0","type":"journal-article","created":{"date-parts":[[2011,8,17]],"date-time":"2011-08-17T12:53:10Z","timestamp":1313585590000},"page":"267-276","source":"Crossref","is-referenced-by-count":25,"title":["Comparison of vertical and horizontal saccade measures and their relation to gray matter changes in premanifest and manifest Huntington disease"],"prefix":"10.1007","volume":"259","author":[{"given":"Jason","family":"Rupp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Dzemidzic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Blekher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"West","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siu","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Wojcieszek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Saykin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A.","family":"Kareken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Foroud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,8,18]]},"reference":[{"key":"6172_CR1","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0092-8674(93)90585-E","volume":"72","author":"Huntington\u2019s Disease Collaborative Research Group","year":"1993","unstructured":"Huntington\u2019s Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. Cell 72:971\u2013983","journal-title":"Cell"},{"key":"6172_CR2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1136\/jnnp.69.6.773","volume":"69","author":"SC Kirkwood","year":"2000","unstructured":"Kirkwood SC, Siemers E, Hodes ME, Conneally PM, Christian JC, Foroud T (2000) Subtle changes among presymptomatic carriers of the Huntington\u2019s disease gene. J Neurol Neurosurg Psychiatry 69:773\u2013779","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"6172_CR3","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1001\/archneur.63.6.883","volume":"63","author":"JS Paulsen","year":"2006","unstructured":"Paulsen JS, Hayden M, Stout JC, Langbehn DR, Aylward E, Ross CA, Guttman M, Nance M, Kieburtz K, Oakes D, Shoulson I, Kayson E, Johnson S, Penziner E (2006) Preparing for preventive clinical trials: the predict-HD study. Arch Neurol 63:883\u2013890","journal-title":"Arch Neurol"},{"key":"6172_CR4","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1212\/01.wnl.0000227890.87398.c1","volume":"67","author":"T Blekher","year":"2006","unstructured":"Blekher T, Johnson SA, Marshall J, White K, Hui S, Weaver M, Gray J, Yee R, Stout JC, Beristain X, Wojcieszek J, Foroud T (2006) Saccades in presymptomatic and early stages of Huntington disease. Neurology 67:394\u2013399","journal-title":"Neurology"},{"key":"6172_CR5","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1212\/01.wnl.0000218215.43328.88","volume":"67","author":"CV Golding","year":"2006","unstructured":"Golding CV, Danchaivijitr C, Hodgson TL, Tabrizi SJ, Kennard C (2006) Identification of an oculomotor biomarker of preclinical Huntington disease. Neurology 67:485\u2013487","journal-title":"Neurology"},{"key":"6172_CR6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1212\/01.WNL.0000132965.14653.D1","volume":"63","author":"EH Aylward","year":"2004","unstructured":"Aylward EH, Sparks BF, Field KM, Yallapragada V, Shpritz BD, Rosenblatt A, Brandt J, Gourley LM, Liang K, Zhou H, Margolis RL, Ross CA (2004) Onset and rate of striatal atrophy in preclinical Huntington disease. Neurology 63:66\u201372","journal-title":"Neurology"},{"key":"6172_CR7","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresbull.2010.04.003","volume":"82","author":"JS Paulsen","year":"2010","unstructured":"Paulsen JS, Nopoulos PC, Aylward E, Ross CA, Johnson H, Magnotta VA, Juhl A, Pierson RK, Mills J, Langbehn D, Nance M (2010) Striatal and white matter predictors of estimated diagnosis for Huntington disease. Brain Res Bull 82:201\u2013207","journal-title":"Brain Res Bull"},{"key":"6172_CR8","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1212\/WNL.33.10.1268","volume":"33","author":"RJ Leigh","year":"1983","unstructured":"Leigh RJ, Newman SA, Folstein SE, Lasker AG, Jensen BA (1983) Abnormal ocular motor control in Huntington\u2019s disease. Neurology 33:1268\u20131275","journal-title":"Neurology"},{"key":"6172_CR9","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1097\/WNR.0b013e32821c560d","volume":"18","author":"CA Antoniades","year":"2007","unstructured":"Antoniades CA, Altham PM, Mason SL, Barker RA, Carpenter R (2007) Saccadometry: a new tool for evaluating presymptomatic Huntington patients. Neuroreport 18:1133\u20131136","journal-title":"Neuroreport"},{"key":"6172_CR10","doi-asserted-by":"crossref","first-page":"2729","DOI":"10.1016\/j.visres.2004.06.006","volume":"44","author":"TM Blekher","year":"2004","unstructured":"Blekher TM, Yee RD, Kirkwood SC, Hake AM, Stout JC, Weaver MR, Foroud TM (2004) Oculomotor control in asymptomatic and recently diagnosed individuals with the genetic marker for Huntington\u2019s disease. Vision Res 44:2729\u20132736","journal-title":"Vision Res"},{"key":"6172_CR11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0079-6123(08)00678-X","volume":"171","author":"SL Hicks","year":"2008","unstructured":"Hicks SL, Robert MP, Golding CV, Tabrizi SJ, Kennard C (2008) Oculomotor deficits indicate the progression of Huntington\u2019s disease. Prog Brain Res 171:555\u2013558","journal-title":"Prog Brain Res"},{"key":"6172_CR12","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1016\/S0042-6989(96)00169-1","volume":"37","author":"AG Lasker","year":"1997","unstructured":"Lasker AG, Zee DS (1997) Ocular motor abnormalities in Huntington\u2019s disease. Vision Res 37:3639\u20133645","journal-title":"Vision Res"},{"key":"6172_CR13","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1136\/jnnp.2009.176982","volume":"81","author":"J Rupp","year":"2010","unstructured":"Rupp J, Blekher TM, Jackson JG, Beristain X, Marshall J, Hui SL, Wojcieszek JM, Foroud T (2010) Progression in prediagnostic Huntington disease. J Neurol Neurosurg Psychiatry 81:379\u2013384","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"6172_CR14","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1007\/s00415-010-5632-2","volume":"257","author":"CA Antoniades","year":"2010","unstructured":"Antoniades CA, Xu Z, Mason SL, Carpenter RH, Barker RA (2010) Huntington\u2019s disease: changes in saccades and hand-tapping over 3\u00a0years. J Neurol 257:1890\u20131898","journal-title":"J Neurol"},{"key":"6172_CR15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.brainresrev.2008.04.001","volume":"58","author":"I Bohanna","year":"2008","unstructured":"Bohanna I, Georgiou-Karistianis N, Hannan AJ, Egan GF (2008) Magnetic resonance imaging as an approach towards identifying neuropathological biomarkers for Huntington\u2019s disease. Brain Res Rev 58:209\u2013225","journal-title":"Brain Res Rev"},{"key":"6172_CR16","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1212\/01.wnl.0000194318.74946.b6","volume":"66","author":"SM Hersch","year":"2006","unstructured":"Hersch SM, Gevorkian S, Marder K, Moskowitz C, Feigin A, Cox M, Como P, Zimmerman C, Lin M, Zhang L, Ulug AM, Beal MF, Matson W, Bogdanov M, Ebbel E, Zaleta A, Kaneko Y, Jenkins B, Hevelone N, Zhang H, Yu H, Schoenfeld D, Ferrante R, Rosas HD (2006) Creatine in Huntington disease is safe, tolerable, bioavailable in brain and reduces serum 8OH2\u2019dG. Neurology 66:250\u2013252","journal-title":"Neurology"},{"key":"6172_CR17","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","volume":"8","author":"SJ Tabrizi","year":"2009","unstructured":"Tabrizi SJ, Langbehn DR, Leavitt BR, Roos RA, Durr A, Craufurd D, Kennard C, Hicks SL, Fox NC, Scahill RI, Borowsky B, Tobin AJ, Rosas HD, Johnson H, Reilmann R, Landwehrmeyer B, Stout JC (2009) Biological and clinical manifestations of Huntington\u2019s disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurol 8:791\u2013801","journal-title":"Lancet Neurol"},{"key":"6172_CR18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1196\/annals.1427.034","volume":"1147","author":"HD Rosas","year":"2008","unstructured":"Rosas HD, Salat DH, Lee SY, Zaleta AK, Hevelone N, Hersch SM (2008) Complexity and heterogeneity: what drives the ever-changing brain in Huntington\u2019s disease? Ann N Y Acad Sci 1147:196\u2013205","journal-title":"Ann N Y Acad Sci"},{"key":"6172_CR19","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1212\/WNL.58.5.695","volume":"58","author":"HD Rosas","year":"2002","unstructured":"Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH, van der Kouwe A, Jenkins BG, Dale AM, Fischl B (2002) Regional and progressive thinning of the cortical ribbon in Huntington\u2019s disease. Neurology 58:695\u2013701","journal-title":"Neurology"},{"key":"6172_CR20","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1093\/brain\/awn025","volume":"131","author":"HD Rosas","year":"2008","unstructured":"Rosas HD, Salat DH, Lee SY, Zaleta AK, Pappu V, Fischl B, Greve D, Hevelone N, Hersch SM (2008) Cerebral cortex and the clinical expression of Huntington\u2019s disease: complexity and heterogeneity. Brain 131:1057\u20131068","journal-title":"Brain"},{"key":"6172_CR21","doi-asserted-by":"crossref","first-page":"5707","DOI":"10.1167\/iovs.09-3538","volume":"50","author":"T Blekher","year":"2009","unstructured":"Blekher T, Weaver MR, Cai X, Hui S, Marshall J, Jackson JG, Wojcieszek J, Yee RD, Foroud TM (2009) Test\u2013retest reliability of saccadic measures in subjects at risk for Huntington disease. Invest Ophthalmol Vis Sci 50:5707\u20135711","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"6172_CR22","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1093\/clinchem\/42.5.773","volume":"42","author":"CE Bond","year":"1996","unstructured":"Bond CE, Hodes ME (1996) Direct amplification of the CAG repeat of huntingtin without amplification of CCG. Clin Chem 42:773\u2013774","journal-title":"Clin Chem"},{"key":"6172_CR23","volume-title":"Unified Huntington\u2019s Disease Rating Scale-99","author":"Huntington Study Group","year":"1999","unstructured":"Huntington Study Group (1999) Unified Huntington\u2019s Disease Rating Scale-99. Huntington Study Group, Rochester"},{"key":"6172_CR24","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0004.2004.00241.x","volume":"65","author":"DR Langbehn","year":"2004","unstructured":"Langbehn DR, Brinkman RR, Falush D, Paulsen JS, Hayden MR (2004) A new model for prediction of the age of onset and penetrance for Huntington\u2019s disease based on CAG length. Clin Genet 65:267\u2013277","journal-title":"Clin Genet"},{"key":"6172_CR25","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/jnnp.2007.128728","volume":"79","author":"JS Paulsen","year":"2008","unstructured":"Paulsen JS, Langbehn DR, Stout JC, Aylward E, Ross CA, Nance M, Guttman M, Johnson S, MacDonald M, Beglinger LJ, Duff K, Kayson E, Biglan K, Shoulson I, Oakes D, Hayden M (2008) Detection of Huntingtons disease decades before diagnosis: the predict-HD study. J Neurol Neurosurg Psychiatry 79:874\u2013880","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"6172_CR26","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1037\/0033-2909.112.1.155","volume":"112","author":"J Cohen","year":"1992","unstructured":"Cohen J (1992) A power primer. Psychol Bull 112:155\u2013159","journal-title":"Psychol Bull"},{"key":"6172_CR27","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jmri.21049","volume":"27","author":"CR Jack Jr","year":"2008","unstructured":"Jack CR Jr, Bernstein MA, Fox NC, Thompson P, Alexander G, Harvey D, Borowski B, Britson PJ, Whitwell L, Ward C, Dale AM, Felmlee JP, Gunter JL, Hill DL, Killiany R, Schuff N, Fox-Bosetti S, Lin C, Studholme C, DeCarli CS, Krueger G, Ward HA, Metzger GJ, Scott KT, Mallozzi R, Blezek D, Levy J, Debbins JP, Fleisher AS, Albert M, Green R, Bartzokis G, Glover G, Mugler J, Weiner MW (2008) The Alzheimer\u2019s Disease Neuroimaging Initiative (ADNI): MRI methods. J Magn Reson Imaging 27:685\u2013691","journal-title":"J Magn Reson Imaging"},{"key":"6172_CR28","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1006\/nimg.1998.0395","volume":"9","author":"AM Dale","year":"1999","unstructured":"Dale AM, Fischl B, Sereno MI (1999) Cortical surface-based analysis. I. Segmentation and surface reconstruction. Neuroimage 9:179\u2013194","journal-title":"Neuroimage"},{"key":"6172_CR29","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1006\/nimg.1998.0396","volume":"9","author":"B Fischl","year":"1999","unstructured":"Fischl B, Sereno MI, Dale AM (1999) Cortical surface-based analysis. II: inflation, flattening, and a surface-based coordinate system. Neuroimage 9:195\u2013207","journal-title":"Neuroimage"},{"key":"6172_CR30","doi-asserted-by":"crossref","first-page":"11050","DOI":"10.1073\/pnas.200033797","volume":"97","author":"B Fischl","year":"2000","unstructured":"Fischl B, Dale AM (2000) Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc Natl Acad Sci USA 97:11050\u201311055","journal-title":"Proc Natl Acad Sci USA"},{"key":"6172_CR31","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","volume":"33","author":"B Fischl","year":"2002","unstructured":"Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C, van der Kouwe KA, Killiany R, Kennedy D, Klaveness S, Montillo A, Makris N, Rosen B, Dale AM (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33:341\u2013355","journal-title":"Neuron"},{"key":"6172_CR32","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.bandc.2008.08.016","volume":"68","author":"JE McDowell","year":"2008","unstructured":"McDowell JE, Dyckman KA, Austin BP, Clementz BA (2008) Neurophysiology and neuroanatomy of reflexive and volitional saccades: evidence from studies of humans. Brain Cogn 68:255\u2013270","journal-title":"Brain Cogn"},{"key":"6172_CR33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1097\/WNN.0b013e31815cfef8","volume":"20","author":"JC Stout","year":"2007","unstructured":"Stout JC, Weaver M, Solomon AC, Queller S, Hui S, Johnson SA, Gray J, Beristain X, Wojcieszek J, Foroud T (2007) Are cognitive changes progressive in prediagnostic HD? Cogn Behav Neurol 20:212\u2013218","journal-title":"Cogn Behav Neurol"},{"key":"6172_CR34","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1152\/jn.1995.74.6.2744","volume":"74","author":"EC Dias","year":"1995","unstructured":"Dias EC, Kiesau M, Segraves MA (1995) Acute activation and inactivation of macaque frontal eye field with GABA-related drugs. J Neurophysiol 74:2744\u20132748","journal-title":"J Neurophysiol"},{"key":"6172_CR35","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0006-8993(83)90971-X","volume":"269","author":"EG Keating","year":"1983","unstructured":"Keating EG, Gooley SG, Pratt SE, Kelsey JE (1983) Removing the superior colliculus silences eye movements normally evoked from stimulation of the parietal and occipital eye fields. Brain Res 269:145\u2013148","journal-title":"Brain Res"},{"key":"6172_CR36","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/cne.902350207","volume":"235","author":"JC Lynch","year":"1985","unstructured":"Lynch JC, Graybiel AM, Lobeck LJ (1985) The differential projection of two cytoarchitectonic subregions of the inferior parietal lobule of macaque upon the deep layers of the superior colliculus. J Comp Neurol 235:241\u2013254","journal-title":"J Comp Neurol"},{"key":"6172_CR37","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1152\/jn.2001.85.6.2545","volume":"85","author":"M Pare","year":"2001","unstructured":"Pare M, Wurtz RH (2001) Progression in neuronal processing for saccadic eye movements from parietal cortex area lip to superior colliculus. J Neurophysiol 85:2545\u20132562","journal-title":"J Neurophysiol"},{"key":"6172_CR38","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/brain\/awm275","volume":"131","author":"S Kloppel","year":"2008","unstructured":"Kloppel S, Draganski B, Golding CV, Chu C, Nagy Z, Cook PA, Hicks SL, Kennard C, Alexander DC, Parker GJ, Tabrizi SJ, Frackowiak RS (2008) White matter connections reflect changes in voluntary-guided saccades in pre-symptomatic Huntington\u2019s disease. Brain 131:196\u2013204","journal-title":"Brain"},{"key":"6172_CR39","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1212\/WNL.54.10.1985","volume":"54","author":"R Bhidayasiri","year":"2000","unstructured":"Bhidayasiri R, Plant GT, Leigh RJ (2000) A hypothetical scheme for the brainstem control of vertical gaze. Neurology 54:1985\u20131993","journal-title":"Neurology"},{"key":"6172_CR40","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1136\/jnnp.2007.132290","volume":"79","author":"T Pflugshaupt","year":"2008","unstructured":"Pflugshaupt T, Nyffeler T, von Wartburg R, Hess CW, Muri RM (2008) Loss of exploratory vertical saccades after unilateral frontal eye field damage. J Neurol Neurosurg Psychiatry 79:474\u2013477","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"6172_CR41","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.nbd.2010.07.014","volume":"40","author":"PC Nopoulos","year":"2010","unstructured":"Nopoulos PC, Aylward EH, Ross CA, Johnson HJ, Magnotta VA, Juhl AR, Pierson RK, Mills J, Langbehn DR, Paulsen JS (2010) Cerebral cortex structure in prodromal Huntington disease. Neurobiol Dis 40:544\u2013554","journal-title":"Neurobiol Dis"},{"key":"6172_CR42","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1212\/01.wnl.0000222734.56412.17","volume":"66","author":"N Pavese","year":"2006","unstructured":"Pavese N, Gerhard A, Tai YF, Ho AK, Turkheimer F, Barker RA, Brooks DJ, Piccini P (2006) Microglial activation correlates with severity in Huntington disease: a clinical and PET study. Neurology 66:1638\u20131643","journal-title":"Neurology"},{"key":"6172_CR43","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/0166-2236(90)90107-L","volume":"13","author":"GE Alexander","year":"1990","unstructured":"Alexander GE, Crutcher MD (1990) Functional architecture of basal ganglia circuits: neural substrates of parallel processing. Trends Neurosci 13:266\u2013271","journal-title":"Trends Neurosci"},{"key":"6172_CR44","doi-asserted-by":"crossref","first-page":"10052","DOI":"10.1523\/JNEUROSCI.23-31-10052.2003","volume":"23","author":"K Watanabe","year":"2003","unstructured":"Watanabe K, Lauwereyns J, Hikosaka O (2003) Neural correlates of rewarded and unrewarded eye movements in the primate caudate nucleus. J Neurosci 23:10052\u201310057","journal-title":"J Neurosci"},{"key":"6172_CR45","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1152\/physrev.2000.80.3.953","volume":"80","author":"O Hikosaka","year":"2000","unstructured":"Hikosaka O, Takikawa Y, Kawagoe R (2000) Role of the basal ganglia in the control of purposive saccadic eye movements. Physiol Rev 80:953\u2013978","journal-title":"Physiol Rev"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-011-6172-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-011-6172-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-011-6172-0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,6,22]],"date-time":"2020-06-22T10:42:58Z","timestamp":1592822578000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-011-6172-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,18]]},"references-count":45,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012,2]]}},"alternative-id":["6172"],"URL":"https:\/\/doi.org\/10.1007\/s00415-011-6172-0","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,18]]}}}