{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:29:59Z","timestamp":1787311799144,"version":"build-2736575974"},"reference-count":20,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2011,8,7]],"date-time":"2011-08-07T00:00:00Z","timestamp":1312675200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2012,3]]},"DOI":"10.1007\/s00415-011-6204-9","type":"journal-article","created":{"date-parts":[[2011,8,6]],"date-time":"2011-08-06T07:45:03Z","timestamp":1312616703000},"page":"474-481","source":"Crossref","is-referenced-by-count":63,"title":["A retrospective clinical study of the treatment of slow-channel congenital myasthenic syndrome"],"prefix":"10.1007","volume":"259","author":[{"given":"Amina","family":"Chaouch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane S.","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velina","family":"Guergueltcheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Dusl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Schara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidosava","family":"Rakocevi\u0107-Stojanovi\u0107","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Lindberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana H.","family":"Scola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lineu C.","family":"Werneck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaume","family":"Colomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan J.","family":"Vilchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Muelas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohar","family":"Argov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Abicht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns","family":"Lochm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2011,8,7]]},"reference":[{"key":"6204_CR1","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1212\/WNL.53.7.1564","volume":"53","author":"A Abicht","year":"1999","unstructured":"Abicht A, Stucka R, Karcagi V, Herczegfalvi A, Horvath R, Mortier W, Schara U, Ramaekers V, Jost W, Brunner J, Janssen G, Seidel U, Schlotter B, Muller-Felber W, Pongratz D, Rudel R, Lochmuller H (1999) A common mutation (epsilon1267delG) in congenital myasthenic patients of Gypsy ethnic origin. Neurology 53:1564\u20131569","journal-title":"Neurology"},{"key":"6204_CR2","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.nmd.2005.05.001","volume":"15","author":"D Beeson","year":"2005","unstructured":"Beeson D, Hantai D, Lochmuller H, Engel AG (2005) 126th International Workshop: congenital myasthenic syndromes, 24\u201326 September 2004, Naarden, the Netherlands. Neuromuscul Disord 15:498\u2013512","journal-title":"Neuromuscul Disord"},{"key":"6204_CR3","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.nmd.2006.02.009","volume":"16","author":"J Colomer","year":"2006","unstructured":"Colomer J, Muller JS, Vernet A, Nascimento A, Pons M, Gonzalez V, Abicht A, Lochmuller H (2006) Long-term improvement of slow-channel congenital myasthenic syndrome with fluoxetine. Neuromuscul Disord 16:329\u2013333","journal-title":"Neuromuscul Disord"},{"key":"6204_CR4","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.nurt.2007.01.001","volume":"4","author":"AG Engel","year":"2007","unstructured":"Engel AG (2007) The therapy of congenital myasthenic syndromes. Neurotherapeutics 4:252\u2013257","journal-title":"Neurotherapeutics"},{"key":"6204_CR5","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/ana.410110603","volume":"11","author":"AG Engel","year":"1982","unstructured":"Engel AG, Lambert EH, Mulder DM, Torres CF, Sahashi K, Bertorini TE, Whitaker JN (1982) A newly recognized congenital myasthenic syndrome attributed to a prolonged open time of the acetylcholine-induced ion channel. Ann Neurol 11:553\u2013569","journal-title":"Ann Neurol"},{"key":"6204_CR6","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1093\/hmg\/5.9.1217","volume":"5","author":"AG Engel","year":"1996","unstructured":"Engel AG, Ohno K, Milone M, Wang HL, Nakano S, Bouzat C, Pruitt JN 2nd, Hutchinson DO, Brengman JM, Bren N, Sieb JP, Sine SM (1996) New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome. Hum Mol Genet 5:1217\u20131227","journal-title":"Hum Mol Genet"},{"key":"6204_CR7","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.coph.2004.12.007","volume":"5","author":"AG Engel","year":"2005","unstructured":"Engel AG, Sine SM (2005) Current understanding of congenital myasthenic syndromes. Curr Opin Pharmacol 5:308\u2013321","journal-title":"Curr Opin Pharmacol"},{"key":"6204_CR8","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1097\/00001756-199806010-00044","volume":"9","author":"T Fukudome","year":"1998","unstructured":"Fukudome T, Ohno K, Brengman JM, Engel AG (1998) Quinidine normalizes the open duration of slow-channel mutants of the acetylcholine receptor. Neuroreport 9:1907\u20131911","journal-title":"Neuroreport"},{"key":"6204_CR9","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/ana.10077","volume":"51","author":"CM Gomez","year":"2002","unstructured":"Gomez CM, Maselli RA, Vohra BP, Navedo M, Stiles JR, Charnet P, Schott K, Rojas L, Keesey J, Verity A, Wollmann RW, Lasalde-Dominicci J (2002) Novel delta subunit mutation in slow-channel syndrome causes severe weakness by novel mechanisms. Ann Neurol 51:102\u2013112","journal-title":"Ann Neurol"},{"key":"6204_CR10","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1097\/00019052-200410000-00004","volume":"17","author":"D Hantai","year":"2004","unstructured":"Hantai D, Richard P, Koenig J, Eymard B (2004) Congenital myasthenic syndromes. Curr Opin Neurol 17:539\u2013551","journal-title":"Curr Opin Neurol"},{"key":"6204_CR11","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/ana.410430411","volume":"43","author":"CM Harper","year":"1998","unstructured":"Harper CM, Engel AG (1998) Quinidine sulfate therapy for the slow-channel congenital myasthenic syndrome. Ann Neurol 43:480\u2013484","journal-title":"Ann Neurol"},{"key":"6204_CR12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1749-6632.1998.tb10929.x","volume":"841","author":"CM Harper","year":"1998","unstructured":"Harper CM, Engel AG (1998) Safety and efficacy of quinidine sulfate in slow-channel congenital myasthenic syndrome. Ann NY Acad Sci 841:203\u2013206","journal-title":"Ann NY Acad Sci"},{"key":"6204_CR13","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1212\/01.WNL.0000061483.11417.1B","volume":"60","author":"CM Harper","year":"2003","unstructured":"Harper CM, Fukodome T, Engel AG (2003) Treatment of slow-channel congenital myasthenic syndrome with fluoxetine. Neurology 60:1710\u20131713","journal-title":"Neurology"},{"key":"6204_CR14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jneuroim.2008.06.026","volume":"201\u2013202","author":"M Kinali","year":"2008","unstructured":"Kinali M, Beeson D, Pitt MC, Jungbluth H, Simonds AK, Aloysius A, Cockerill H, Davis T, Palace J, Manzur AY, Jimenez-Mallebrera C, Sewry C, Muntoni F, Robb SA (2008) Congenital myasthenic syndromes in childhood: diagnostic and management challenges. J Neuroimmunol 201\u2013202:6\u201312","journal-title":"J Neuroimmunol"},{"key":"6204_CR15","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1136\/jnnp.2009.177816","volume":"81","author":"V Mihaylova","year":"2010","unstructured":"Mihaylova V, Scola RH, Gervini B, Lorenzoni PJ, Kay CK, Werneck LC, Stucka R, Guergueltcheva V, von der Hagen M, Huebner A, Abicht A, Muller JS, Lochmuller H (2010) Molecular characterisation of congenital myasthenic syndromes in Southern Brazil. J Neurol Neurosurg Psychiatry 81:973\u2013977","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"6204_CR16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399407000427","volume":"9","author":"JS Muller","year":"2007","unstructured":"Muller JS, Mihaylova V, Abicht A, Lochmuller H (2007) Congenital myasthenic syndromes: spotlight on genetic defects of neuromuscular transmission. Expert Rev Mol Med 9:1\u201320","journal-title":"Expert Rev Mol Med"},{"key":"6204_CR17","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1136\/jnnp.2008.148189","volume":"80","author":"O Outteryck","year":"2009","unstructured":"Outteryck O, Richard P, Lacour A, Fournier E, Zephir H, Gaudon K, Eymard B, Hantai D, Vermersch P, Stojkovic T (2009) Novel epsilon subunit mutation of the muscle acetylcholine receptor causing a slow-channel congenital myasthenic syndrome. J Neurol Neurosurg Psychiatry 80:450\u2013451","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"6204_CR18","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.nurt.2008.07.003","volume":"5","author":"U Schara","year":"2008","unstructured":"Schara U, Lochmuller H (2008) Therapeutic strategies in congenital myasthenic syndromes. Neurotherapeutics 5:542\u2013547","journal-title":"Neurotherapeutics"},{"key":"6204_CR19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/0896-6273(95)90080-2","volume":"15","author":"SM Sine","year":"1995","unstructured":"Sine SM, Ohno K, Bouzat C, Auerbach A, Milone M, Pruitt JN, Engel AG (1995) Mutation of the acetylcholine receptor alpha subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity. Neuron 15:229\u2013239","journal-title":"Neuron"},{"key":"6204_CR20","first-page":"21","volume":"18","author":"CJ Whittington","year":"2005","unstructured":"Whittington CJ, Kendall T, Pilling S (2005) Are the SSRIs and atypical antidepressants safe and effective for children and adolescents? Curr Opin Psychiatry 18:21\u201325","journal-title":"Curr Opin Psychiatry"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-011-6204-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-011-6204-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-011-6204-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T15:13:11Z","timestamp":1559056391000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-011-6204-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8,7]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["6204"],"URL":"https:\/\/doi.org\/10.1007\/s00415-011-6204-9","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8,7]]}}}