{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:17:05Z","timestamp":1793132225110,"version":"4.5.0"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2013,2,23]],"date-time":"2013-02-23T00:00:00Z","timestamp":1361577600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1007\/s00415-013-6877-3","type":"journal-article","created":{"date-parts":[[2013,2,22]],"date-time":"2013-02-22T12:40:42Z","timestamp":1361536842000},"page":"1782-1797","source":"Crossref","is-referenced-by-count":28,"title":["ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis"],"prefix":"10.1007","volume":"260","author":[{"given":"Hirotaka","family":"Tanaka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Shimazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideo","family":"Kaneko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Tsuruma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsunehiko","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Warita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsunori","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Hozumi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Minatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Inuzuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,2,23]]},"reference":[{"key":"6877_CR1","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1440-1789.2005.00611.x","volume":"25","author":"M Aoki","year":"2005","unstructured":"Aoki M, Kato S, Nagai M, Itoyama Y (2005) Development of a rat model of amyotrophic lateral sclerosis expressing a human SOD1 transgene. Neuropathology 25:365\u2013370","journal-title":"Neuropathology"},{"key":"6877_CR2","unstructured":"Association AP (1994) 4th ed. DSM-IV. Washington D.C"},{"key":"6877_CR3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0165-0173(97)00045-3","volume":"25","author":"JS Bains","year":"1997","unstructured":"Bains JS, Shaw CA (1997) Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death. Brain Res Brain Res Rev 25:335\u2013358","journal-title":"Brain Res Brain Res Rev"},{"key":"6877_CR4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2003.12.016","volume":"16","author":"P Ballabh","year":"2004","unstructured":"Ballabh P, Braun A, Nedergaard M (2004) The blood-brain barrier: an overview: structure, regulation, and clinical implications. Neurobiol Dis 16:1\u201313","journal-title":"Neurobiol Dis"},{"key":"6877_CR5","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.bbadis.2006.03.008","volume":"1762","author":"SC Barber","year":"2006","unstructured":"Barber SC, Mead RJ, Shaw PJ (2006) Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target. Biochim Biophys Acta 1762:1051\u20131067","journal-title":"Biochim Biophys Acta"},{"key":"6877_CR6","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.freeradbiomed.2009.11.018","volume":"48","author":"SC Barber","year":"2010","unstructured":"Barber SC, Shaw PJ (2010) Oxidative stress in ALS: key role in motor neuron injury and therapeutic target. Free Radic Biol Med 48:629\u2013641","journal-title":"Free Radic Biol Med"},{"key":"6877_CR7","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1123511","volume":"312","author":"S Boillee","year":"2006","unstructured":"Boillee S, Yamanaka K, Lobsiger CS, Copeland NG, Jenkins NA, Kassiotis G, Kollias G, Cleveland DW (2006) Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312:1389\u20131392","journal-title":"Science"},{"key":"6877_CR8","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1038\/nn.2660","volume":"13","author":"DA Bosco","year":"2011","unstructured":"Bosco DA, Morfini G, Karabacak NM, Song Y, Gros-Louis F, Pasinelli P, Goolsby H, Fontaine BA, Lemay N, McKenna-Yasek D, Frosch MP, Agar JN, Julien JP, Brady ST, Brown RH Jr (2011) Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nat Neurosci 13:1396\u20131403","journal-title":"Nat Neurosci"},{"key":"6877_CR9","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","volume":"1","author":"BR Brooks","year":"2000","unstructured":"Brooks BR, Miller RG, Swash M, Munsat TL (2000) El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Later Scler Other Motor Neuron Disord 1:293\u2013299","journal-title":"Amyotroph Later Scler Other Motor Neuron Disord"},{"key":"6877_CR10","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1093\/jb\/117.2.400","volume":"117","author":"NH Choi-Miura","year":"1995","unstructured":"Choi-Miura NH, Sano Y, Oda E, Nakano Y, Tobe T, Yanagishita T, Taniyama M, Katagiri T, Tomita M (1995) Purification and characterization of a novel glycoprotein which has significant homology to heavy chains of inter-alpha-trypsin inhibitor family from human plasma. J Biochem 117:400\u2013407","journal-title":"J Biochem"},{"key":"6877_CR11","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/35097565","volume":"2","author":"DW Cleveland","year":"2001","unstructured":"Cleveland DW, Rothstein JD (2001) From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat Rev Neurosci 2:806\u2013819","journal-title":"Nat Rev Neurosci"},{"key":"6877_CR12","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1006\/nbdi.2000.0292","volume":"7","author":"L Dupuis","year":"2000","unstructured":"Dupuis L, de Tapia M, Rene F, Lutz-Bucher B, Gordon JW, Mercken L, Pradier L, Loeffler JP (2000) Differential screening of mutated SOD1 transgenic mice reveals early up-regulation of a fast axonal transport component in spinal cord motor neurons. Neurobiol Dis 7:274\u2013285","journal-title":"Neurobiol Dis"},{"key":"6877_CR13","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1046\/j.1471-4159.1997.69052064.x","volume":"69","author":"RJ Ferrante","year":"1997","unstructured":"Ferrante RJ, Browne SE, Shinobu LA, Bowling AC, Baik MJ, MacGarvey U, Kowall NW, Brown RH Jr, Beal MF (1997) Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J Neurochem 69:2064\u20132074","journal-title":"J Neurochem"},{"key":"6877_CR14","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/ijc.20928","volume":"115","author":"ET Fung","year":"2005","unstructured":"Fung ET, Yip TT, Lomas L, Wang Z, Yip C, Meng XY, Lin S, Zhang F, Zhang Z, Chan DW, Weinberger SR (2005) Classification of cancer types by measuring variants of host response proteins using SELDI serum assays. Int J Cancer 115:783\u2013789","journal-title":"Int J Cancer"},{"key":"6877_CR15","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.neulet.2005.03.038","volume":"382","author":"Y Hirata","year":"2005","unstructured":"Hirata Y, Matsuda H, Nemoto K, Ohnishi T, Hirao K, Yamashita F, Asada T, Iwabuchi S, Samejima H (2005) Voxel-based morphometry to discriminate early Alzheimer\u2019s disease from controls. Neurosci Lett 382:269\u2013274","journal-title":"Neurosci Lett"},{"key":"6877_CR16","doi-asserted-by":"crossref","first-page":"26725","DOI":"10.1016\/S0021-9258(19)74373-7","volume":"268","author":"L Huang","year":"1993","unstructured":"Huang L, Yoneda M, Kimata K (1993) A serum-derived hyaluronan-associated protein (SHAP) is the heavy chain of the inter alpha-trypsin inhibitor. J Biol Chem 268:26725\u201326730","journal-title":"J Biol Chem"},{"key":"6877_CR17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","volume":"55","author":"AJ Hughes","year":"1992","unstructured":"Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181\u2013184","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"6877_CR18","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jconrel.2006.01.005","volume":"112","author":"T Ishida","year":"2006","unstructured":"Ishida T, Ichihara M, Wang X, Yamamoto K, Kimura J, Majima E, Kiwada H (2006) Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes. J Control Release 112:15\u201325","journal-title":"J Control Release"},{"key":"6877_CR19","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/clinchem\/27.4.586","volume":"27","author":"R Ito","year":"1981","unstructured":"Ito R, Statland BE (1981) Centrifugal analysis for plasma kallikrein activity, with use of the chromogenic substrate S-2302. Clin Chem 27:586\u2013593","journal-title":"Clin Chem"},{"key":"6877_CR20","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/BF03256203","volume":"10","author":"C Kolarcik","year":"2006","unstructured":"Kolarcik C, Bowser R (2006) Plasma and cerebrospinal fluid-based protein biomarkers for motor neuron disease. Mol Diagn Ther 10:281\u2013292","journal-title":"Mol Diagn Ther"},{"key":"6877_CR21","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0304-3940(93)90236-E","volume":"163","author":"RA Lanius","year":"1993","unstructured":"Lanius RA, Krieger C, Wagey R, Shaw CA (1993) Increased [35S] glutathione binding sites in spinal cords from patients with sporadic amyotrophic lateral sclerosis. Neurosci Lett 163:89\u201392","journal-title":"Neurosci Lett"},{"key":"6877_CR22","doi-asserted-by":"crossref","first-page":"e19247","DOI":"10.1371\/journal.pone.0019247","volume":"6","author":"JM Lubieniecka","year":"2011","unstructured":"Lubieniecka JM, Streijger F, Lee JH, Stoynov N, Liu J, Mottus R, Pfeifer T, Kwon BK, Coorssen JR, Foster LJ, Grigliatti TA, Tetzlaff W (2011) Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats. PLoS ONE 6:e19247","journal-title":"PLoS ONE"},{"key":"6877_CR23","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1172\/JCI31265","volume":"117","author":"JJ Marden","year":"2007","unstructured":"Marden JJ, Harraz MM, Williams AJ, Nelson K, Luo M, Paulson H, Engelhardt JF (2007) Redox modifier genes in amyotrophic lateral sclerosis in mice. J Clin Invest 117:2913\u20132919","journal-title":"J Clin Invest"},{"key":"6877_CR24","first-page":"731","volume":"28","author":"H Matsuda","year":"2007","unstructured":"Matsuda H, Mizumura S, Nagao T, Ota T, Iizuka T, Nemoto K, Takemura N, Arai H, Homma A (2007) Automated discrimination between very early Alzheimer disease and controls using an easy Z-score imaging system for multicenter brain perfusion single-photon emission tomography. AJNR Am J Neuroradiol 28:731\u2013736","journal-title":"AJNR Am J Neuroradiol"},{"key":"6877_CR25","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/elps.200700828","volume":"29","author":"E Mohamed","year":"2008","unstructured":"Mohamed E, Abdul-Rahman PS, Doustjalali SR, Chen Y, Lim BK, Omar SZ, Bustam AZ, Singh VA, Mohd-Taib NA, Yip CH, Hashim OH (2008) Lectin-based electrophoretic analysis of the expression of the 35\u00a0kDa inter-alpha-trypsin inhibitor heavy chain H4 fragment in sera of patients with five different malignancies. Electrophoresis 29:2645\u20132650","journal-title":"Electrophoresis"},{"key":"6877_CR26","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0022-510X(97)00109-3","volume":"151","author":"R Moumen","year":"1997","unstructured":"Moumen R, Nouvelot A, Duval D, Lechevalier B, Viader F (1997) Plasma superoxide dismutase and glutathione peroxidase activity in sporadic amyotrophic lateral sclerosis. J Neurol Sci 151:35\u201339","journal-title":"J Neurol Sci"},{"key":"6877_CR27","doi-asserted-by":"crossref","first-page":"9246","DOI":"10.1523\/JNEUROSCI.21-23-09246.2001","volume":"21","author":"M Nagai","year":"2001","unstructured":"Nagai M, Aoki M, Miyoshi I, Kato M, Pasinelli P, Kasai N, Brown RH Jr, Itoyama Y (2001) Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: associated mutations develop motor neuron disease. J Neurosci 21:9246\u20139254","journal-title":"J Neurosci"},{"key":"6877_CR28","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0014-5793(94)01364-7","volume":"357","author":"H Nishimura","year":"1995","unstructured":"Nishimura H, Kakizaki I, Muta T, Sasaki N, Pu PX, Yamashita T, Nagasawa S (1995) cDNA and deduced amino acid sequence of human PK-120, a plasma kallikrein-sensitive glycoprotein. FEBS Lett 357:207\u2013211","journal-title":"FEBS Lett"},{"key":"6877_CR29","first-page":"2199","volume":"13","author":"I Nygren","year":"2002","unstructured":"Nygren I, Larsson A, Johansson A, Askmark H (2002) VEGF is increased in serum but not in spinal cord from patients with amyotrophic lateral sclerosis. Neuro Report 13:2199\u20132201","journal-title":"Neuro Report"},{"key":"6877_CR30","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1136\/jnnp.67.2.189","volume":"67","author":"S Orimo","year":"1999","unstructured":"Orimo S, Ozawa E, Nakade S, Sugimoto T, Mizusawa H (1999) 123I-metaiodobenzylguanidine myocardial scintigraphy in Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 67:189\u2013194","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"6877_CR31","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nrn1971","volume":"7","author":"P Pasinelli","year":"2006","unstructured":"Pasinelli P, Brown RH (2006) Molecular biology of amyotrophic lateral sclerosis: insights from genetics. Nat Rev Neurosci 7:710\u2013723","journal-title":"Nat Rev Neurosci"},{"key":"6877_CR32","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/0167-4838(94)90122-8","volume":"1208","author":"XP Pu","year":"1994","unstructured":"Pu XP, Iwamoto A, Nishimura H, Nagasawa S (1994) Purification and characterization of a novel substrate for plasma kallikrein (PK-120) in human plasma. Biochim Biophys Acta 1208:338\u2013343","journal-title":"Biochim Biophys Acta"},{"key":"6877_CR33","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s004019900173","volume":"100","author":"N Shibata","year":"2000","unstructured":"Shibata N, Nagai R, Miyata S, Jono T, Horiuchi S, Hirano A, Kato S, Sasaki S, Asayama K, Kobayashi M (2000) Nonoxidative protein glycation is implicated in familial amyotrophic lateral sclerosis with superoxide dismutase-1 mutation. Acta Neuropathol 100:275\u2013284","journal-title":"Acta Neuropathol"},{"key":"6877_CR34","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1373\/clinchem.2005.065722","volume":"52","author":"J Song","year":"2006","unstructured":"Song J, Patel M, Rosenzweig CN, Chan-Li Y, Sokoll LJ, Fung ET, Choi-Miura NH, Goggins M, Chan DW, Zhang Z (2006) Quantification of fragments of human serum inter-alpha-trypsin inhibitor heavy chain 4 by a surface-enhanced laser desorption\/ionization-based immunoassay. Clin Chem 52:1045\u20131053","journal-title":"Clin Chem"},{"key":"6877_CR35","doi-asserted-by":"crossref","first-page":"6537","DOI":"10.1523\/JNEUROSCI.22-15-06537.2002","volume":"22","author":"W Sun","year":"2002","unstructured":"Sun W, Funakoshi H, Nakamura T (2002) Overexpression of HGF retards disease progression and prolongs life span in a transgenic mouse model of ALS. J Neurosci 22:6537\u20136548","journal-title":"J Neurosci"},{"key":"6877_CR36","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1755-5949.2010.00180.x","volume":"17","author":"H Tanaka","year":"2011","unstructured":"Tanaka H, Shimazaki H, Kimura M, Izuta H, Tsuruma K, Shimazawa M, Hara H (2011) Apoptosis-inducing factor and cyclophilin a cotranslocate to the motor neuronal nuclei in amyotrophic lateral sclerosis model mice. CNS Neurosci Ther 17:294\u2013304","journal-title":"CNS Neurosci Ther"},{"key":"6877_CR37","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1172\/JCI26022","volume":"116","author":"J Villanueva","year":"2006","unstructured":"Villanueva J, Shaffer DR, Philip J, Chaparro CA, Erdjument-Bromage H, Olshen AB, Fleisher M, Lilja H, Brogi E, Boyd J, Sanchez-Carbayo M, Holland EC, Cordon-Cardo C, Scher HI, Tempst P (2006) Differential exoprotease activities confer tumor-specific serum peptidome patterns. J Clin Invest 116:271\u2013284","journal-title":"J Clin Invest"},{"key":"6877_CR38","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0169-328X(01)00029-8","volume":"89","author":"H Warita","year":"2001","unstructured":"Warita H, Hayashi T, Murakami T, Manabe Y, Abe K (2001) Oxidative damage to mitochondrial DNA in spinal motoneurons of transgenic ALS mice. Brain Res Mol Brain Res 89:147\u2013152","journal-title":"Brain Res Mol Brain Res"},{"key":"6877_CR39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0098-2997(03)00024-4","volume":"24","author":"K Zarkovic","year":"2003","unstructured":"Zarkovic K (2003) 4-hydroxynonenal and neurodegenerative diseases. Mol Aspects Med 24:293\u2013303","journal-title":"Mol Aspects Med"},{"key":"6877_CR40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.7150\/ijms.5.92","volume":"5","author":"Z Zhao","year":"2008","unstructured":"Zhao Z, Lange DJ, Ho L, Bonini S, Shao B, Salton SR, Thomas S, Pasinetti GM (2008) Vgf is a novel biomarker associated with muscle weakness in amyotrophic lateral sclerosis (ALS), with a potential role in disease pathogenesis. Int J Med Sci 5:92\u201399","journal-title":"Int J Med Sci"},{"key":"6877_CR41","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/nn2073","volume":"11","author":"Z Zhong","year":"2008","unstructured":"Zhong Z, Deane R, Ali Z, Parisi M, Shapovalov Y, O\u2019Banion MK, Stojanovic K, Sagare A, Boillee S, Cleveland DW, Zlokovic BV (2008) ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration. Nat Neurosci 11:420\u2013422","journal-title":"Nat Neurosci"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-013-6877-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-013-6877-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-013-6877-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T07:58:55Z","timestamp":1644393535000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-013-6877-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2,23]]},"references-count":41,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2013,7]]}},"alternative-id":["6877"],"URL":"https:\/\/doi.org\/10.1007\/s00415-013-6877-3","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,2,23]]}}}