{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T22:59:51Z","timestamp":1776121191593,"version":"3.50.1"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2013,8,7]],"date-time":"2013-08-07T00:00:00Z","timestamp":1375833600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1007\/s00415-013-7061-5","type":"journal-article","created":{"date-parts":[[2013,8,6]],"date-time":"2013-08-06T11:37:00Z","timestamp":1375789020000},"page":"2777-2785","source":"Crossref","is-referenced-by-count":16,"title":["The Addenbrooke\u2019s Cognitive Examination-Revised accurately detects cognitive decline in Huntington\u2019s disease"],"prefix":"10.1007","volume":"260","author":[{"given":"Faye","family":"Begeti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian Y. K.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma A.","family":"Cummins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy M.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalie Valle","family":"Guzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah L.","family":"Mason","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger A.","family":"Barker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2013,8,7]]},"reference":[{"key":"7061_CR1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1017\/S1355617706061078","volume":"12","author":"JV Baldo","year":"2006","unstructured":"Baldo JV, Schwartz S, Wilkins D, Dronkers NF (2006) Role of frontal versus temporal cortex in verbal fluency as revealed by voxel-based lesion symptom mapping. J Int Neuropsychol Soc 12:896\u2013900","journal-title":"J Int Neuropsychol Soc"},{"key":"7061_CR2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00001756-199301000-00019","volume":"4","author":"SR Bossi","year":"1993","unstructured":"Bossi SR, Simpson JR, Isacson O (1993) Age dependence of striatal neuronal death caused by mitochondrial dysfunction. NeuroReport 4:73\u201376","journal-title":"NeuroReport"},{"key":"7061_CR3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR (1975) \u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189\u2013198","journal-title":"J Psychiatr Res"},{"key":"7061_CR4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0010-9452(08)70557-4","volume":"37","author":"U Gleissner","year":"2001","unstructured":"Gleissner U, Elger CE (2001) The hippocampal contribution to verbal fluency in patients with temporal lobe epilepsy. Cortex; J Devoted Study Nerv Syst Behav 37:55\u201363","journal-title":"Cortex; J Devoted Study Nerv Syst Behav"},{"key":"7061_CR5","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1037\/0894-4105.14.3.353","volume":"14","author":"ML Gourovitch","year":"2000","unstructured":"Gourovitch ML, Kirkby BS, Goldberg TE, Weinberger DR, Gold JM, Esposito G, Van Horn JD, Berman KF (2000) A comparison of rCBF patterns during letter and semantic fluency. Neuropsychology 14:353\u2013360","journal-title":"Neuropsychology"},{"key":"7061_CR6","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1037\/0894-4105.19.2.243","volume":"19","author":"JD Henry","year":"2005","unstructured":"Henry JD, Crawford JR, Phillips LH (2005) A meta-analytic review of verbal fluency deficits in Huntington\u2019s disease. Neuropsychology 19:243\u2013252","journal-title":"Neuropsychology"},{"key":"7061_CR7","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0006-8993(94)91412-5","volume":"647","author":"R Henshaw","year":"1994","unstructured":"Henshaw R, Jenkins BG, Schulz JB, Ferrante RJ, Kowall NW, Rosen BR, Beal MF (1994) Malonate produces striatal lesions by indirect NMDA receptor activation. Brain Res 647:161\u2013166","journal-title":"Brain Res"},{"key":"7061_CR8","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/mds.22412","volume":"24","author":"AK Ho","year":"2009","unstructured":"Ho AK, Gilbert AS, Mason SL, Goodman AO, Barker RA (2009) Health-related quality of life in Huntington\u2019s disease: which factors matter most? Mov Disord 24:574\u2013578","journal-title":"Mov Disord"},{"key":"7061_CR9","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.psychres.2012.09.022","volume":"207","author":"I Labuschagne","year":"2013","unstructured":"Labuschagne I, Jones R, Callaghan J, Whitehead D, Dumas EM, Say MJ, Hart EP, Justo D, Coleman A, Dar Santos RC, Frost C, Craufurd D, Tabrizi SJ, Stout JC (2013) Emotional face recognition deficits and medication effects in pre-manifest through stage-II Huntington\u2019s disease. Psychiatry Res 207:118\u2013126","journal-title":"Psychiatry Res"},{"key":"7061_CR10","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0004.2004.00241.x","volume":"65","author":"DR Langbehn","year":"2004","unstructured":"Langbehn DR, Brinkman RR, Falush D, Paulsen JS, Hayden MR (2004) A new model for prediction of the age of onset and penetrance for Huntington\u2019s disease based on CAG length. Clin Genet 65:267\u2013277","journal-title":"Clin Genet"},{"key":"7061_CR11","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1093\/brain\/121.7.1329","volume":"121","author":"AD Lawrence","year":"1998","unstructured":"Lawrence AD, Hodges JR, Rosser AE, Kershaw A, ffrench-Constant C, Rubinsztein DC, Robbins TW, Sahakian BJ (1998) Evidence for specific cognitive deficits in preclinical Huntington\u2019s disease. Brain 121:1329\u20131341","journal-title":"Brain"},{"key":"7061_CR12","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/brain\/119.5.1633","volume":"119","author":"AD Lawrence","year":"1996","unstructured":"Lawrence AD, Sahakian BJ, Hodges JR, Rosser AE, Lange KW, Robbins TW (1996) Executive and mnemonic functions in early Huntington\u2019s disease. Brain 119:1633\u20131645","journal-title":"Brain"},{"key":"7061_CR13","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1093\/brain\/121.7.1343","volume":"121","author":"AD Lawrence","year":"1998","unstructured":"Lawrence AD, Weeks RA, Brooks DJ, Andrews TC, Watkins LH, Harding AE, Robbins TW, Sahakian BJ (1998) The relationship between striatal dopamine receptor binding and cognitive performance in Huntington\u2019s disease. Brain 121:1343\u20131355","journal-title":"Brain"},{"key":"7061_CR14","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1212\/WNL.54.2.452","volume":"54","author":"K Marder","year":"2000","unstructured":"Marder K, Zhao H, Myers RH, Cudkowicz M, Kayson E, Kieburtz K, Orme C, Paulsen J, Penney JB Jr, Siemers E, Shoulson I (2000) Rate of functional decline in Huntington\u2019s disease. Huntington study group. Neurology 54:452\u2013458","journal-title":"Neurology"},{"key":"7061_CR15","doi-asserted-by":"crossref","unstructured":"Mason SL, Wijeyekoon R, Swain R, Ho AK, Smith EL, Sahakian B, Barker RA (2010) Cognitive follow up of a small cohort of Huntington\u2019s disease patients over a 5\u00a0year period. PLoS Curr 2","DOI":"10.1371\/currents.RRN1174"},{"key":"7061_CR16","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1177\/0269881105048889","volume":"19","author":"MA Mehta","year":"2005","unstructured":"Mehta MA, Hinton EC, Montgomery AJ, Bantick RA, Grasby PM (2005) Sulpiride and mnemonic function: effects of a dopamine D2 receptor antagonist on working memory, emotional memory and long-term memory in healthy volunteers. J Psychopharmacol 19:29\u201338","journal-title":"J Psychopharmacol"},{"key":"7061_CR17","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s00213-004-1899-2","volume":"176","author":"MA Mehta","year":"2004","unstructured":"Mehta MA, Manes FF, Magnolfi G, Sahakian BJ, Robbins TW (2004) Impaired set-shifting and dissociable effects on tests of spatial working memory following the dopamine D2 receptor antagonist sulpiride in human volunteers. Psychopharmacology 176:331\u2013342","journal-title":"Psychopharmacology"},{"key":"7061_CR18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1007\/s002130051102","volume":"146","author":"MA Mehta","year":"1999","unstructured":"Mehta MA, Sahakian BJ, McKenna PJ, Robbins TW (1999) Systemic sulpiride in young adult volunteers simulates the profile of cognitive deficits in Parkinson\u2019s disease. Psychopharmacology 146:162\u2013174","journal-title":"Psychopharmacology"},{"key":"7061_CR19","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1002\/gps.1610","volume":"21","author":"E Mioshi","year":"2006","unstructured":"Mioshi E, Dawson K, Mitchell J, Arnold R, Hodges JR (2006) The Addenbrooke\u2019s Cognitive Examination Revised (ACE-R): a brief cognitive test battery for dementia screening. Int J Geriatr Psychiatry 21:1078\u20131085","journal-title":"Int J Geriatr Psychiatry"},{"key":"7061_CR20","doi-asserted-by":"crossref","first-page":"c3109","DOI":"10.1136\/bmj.c3109","volume":"340","author":"MJ Novak","year":"2010","unstructured":"Novak MJ, Tabrizi SJ (2010) Huntington\u2019s disease. BMJ 340:c3109","journal-title":"BMJ"},{"key":"7061_CR21","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1111\/j.1471-4159.2009.06501.x","volume":"112","author":"AN Ortiz","year":"2010","unstructured":"Ortiz AN, Kurth BJ, Osterhaus GL, Johnson MA (2010) Dysregulation of intracellular dopamine stores revealed in the R6\/2 mouse striatum. J Neurochem 112:755\u2013761","journal-title":"J Neurochem"},{"key":"7061_CR22","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1136\/jnnp.2007.128728","volume":"79","author":"JS Paulsen","year":"2008","unstructured":"Paulsen JS, Langbehn DR, Stout JC, Aylward E, Ross CA, Nance M, Guttman M, Johnson S, MacDonald M, Beglinger LJ, Duff K, Kayson E, Biglan K, Shoulson I, Oakes D, Hayden M (2008) Detection of Huntington\u2019s disease decades before diagnosis: the Predict-HD study. J Neurol Neurosurg Psychiatry 79:874\u2013880","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"7061_CR23","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1136\/jnnp-2012-303618","volume":"84","author":"T Rittman","year":"2013","unstructured":"Rittman T, Ghosh BC, McColgan P, Breen DP, Evans J, Williams-Gray CH, Barker RA, Rowe JB (2013) The Addenbrooke\u2019s Cognitive Examination for the differential diagnosis and longitudinal assessment of patients with parkinsonian disorders. J Neurol Neurosurg Psychiatry 84:544\u2013551","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"7061_CR24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1017\/S1355617701711046","volume":"7","author":"J Snowden","year":"2001","unstructured":"Snowden J, Craufurd D, Griffiths H, Thompson J, Neary D (2001) Longitudinal evaluation of cognitive disorder in Huntington\u2019s disease. J Int Neuropsychol Soc 7:33\u201344","journal-title":"J Int Neuropsychol Soc"},{"key":"7061_CR25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1076\/jcen.24.2.133.998","volume":"24","author":"JS Snowden","year":"2002","unstructured":"Snowden JS, Craufurd D, Thompson J, Neary D (2002) Psychomotor, Executive, and Memory Function in Preclinical Huntington\u2019s Disease. J Clin Exp Neuropsychol 24:133\u2013145","journal-title":"J Clin Exp Neuropsychol"},{"key":"7061_CR26","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","volume":"8","author":"SJ Tabrizi","year":"2009","unstructured":"Tabrizi SJ, Langbehn DR, Leavitt BR, Roos RA, Durr A, Craufurd D, Kennard C, Hicks SL, Fox NC, Scahill RI, Borowsky B, Tobin AJ, Rosas HD, Johnson H, Reilmann R, Landwehrmeyer B, Stout JC (2009) Biological and clinical manifestations of Huntington\u2019s disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data. Lancet Neurol 8:791\u2013801","journal-title":"Lancet Neurol"},{"key":"7061_CR27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","volume":"10","author":"SJ Tabrizi","year":"2011","unstructured":"Tabrizi SJ, Scahill RI, Durr A, Roos RAC, Leavitt BR, Jones R, Landwehrmeyer GB, Fox NC, Johnson H, Hicks SL, Kennard C, Craufurd D, Frost C, Langbehn DR, Reilmann R, Stout JC (2011) Biological and clinical changes in premanifest and early stage Huntington\u2019s disease in the TRACK-HD study: the 12-month longitudinal analysis. Lancet Neurol 10:31\u201342","journal-title":"Lancet Neurol"},{"key":"7061_CR28","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/s00415-010-5768-0","volume":"258","author":"S Bogaard van den","year":"2011","unstructured":"van den Bogaard S, Dumas E, Acharya T, Johnson H, Langbehn D, Scahill R, Tabrizi S, van Buchem M, van der Grond J, Roos R (2011) Early atrophy of pallidum and accumbens nucleus in Huntington\u2019s disease. J Neurol 258:412\u2013420","journal-title":"J Neurol"},{"key":"7061_CR29","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S0140-6736(07)60111-1","volume":"369","author":"FO Walker","year":"2007","unstructured":"Walker FO (2007) Huntington\u2019s disease. Lancet 369:218\u2013228","journal-title":"Lancet"},{"key":"7061_CR30","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1523\/JNEUROSCI.16-08-02605.1996","volume":"16","author":"BH Westerink","year":"1996","unstructured":"Westerink BH, Kwint HF, deVries JB (1996) The pharmacology of mesolimbic dopamine neurons: a dual-probe microdialysis study in the ventral tegmental area and nucleus accumbens of the rat brain. J Neurosci 16:2605\u20132611","journal-title":"J Neurosci"},{"key":"7061_CR31","doi-asserted-by":"crossref","first-page":"2898","DOI":"10.1073\/pnas.97.6.2898","volume":"97","author":"A Wyttenbach","year":"2000","unstructured":"Wyttenbach A, Carmichael J, Swartz J, Furlong RA, Narain Y, Rankin J, Rubinsztein DC (2000) Effects of heat shock, heat shock protein 40 (HDJ-2), and proteasome inhibition on protein aggregation in cellular models of Huntington\u2019s disease. Proc Natl Acad Sci USA 97:2898\u20132903","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-013-7061-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-013-7061-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-013-7061-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,20]],"date-time":"2019-07-20T12:45:53Z","timestamp":1563626753000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-013-7061-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,8,7]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["7061"],"URL":"https:\/\/doi.org\/10.1007\/s00415-013-7061-5","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,8,7]]}}}