{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:56:53Z","timestamp":1790654213253,"version":"4.1.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2014,6,4]],"date-time":"2014-06-04T00:00:00Z","timestamp":1401840000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2014,8]]},"DOI":"10.1007\/s00415-014-7376-x","type":"journal-article","created":{"date-parts":[[2014,7,26]],"date-time":"2014-07-26T15:27:22Z","timestamp":1406388442000},"page":"1584-1597","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Progressive myoclonus epilepsy in Down syndrome patients with dementia"],"prefix":"10.1007","volume":"261","author":[{"name":"On behalf of the Apulian Study Group on Senile Myoclonic Epilepsy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"d\u2019Orsi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi M.","family":"Specchio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,6,4]]},"reference":[{"key":"7376_CR1","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1001\/archneur.1989.00520440031017","volume":"46","author":"F Lai","year":"1989","unstructured":"Lai F, Williams RS (1989) A prospective study of Alzheimer\u2019s disease in Down syndrome. Arch Neurol 46:849\u2013853","journal-title":"Arch Neurol"},{"key":"7376_CR2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1002\/mrdd.1025","volume":"7","author":"IT Lott","year":"2001","unstructured":"Lott IT, Head E (2001) Down syndrome and Alzheimer\u2019s disease: a link between development and aging. Ment Retard Dev Disabil Res Rev 7:172\u2013178","journal-title":"Ment Retard Dev Disabil Res Rev"},{"key":"7376_CR3","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1742-1241.2001.tb11087.x","volume":"55","author":"BK Puri","year":"2001","unstructured":"Puri BK, Ho KW, Singh I (2001) Age of seizure onset in adults with Down\u2019s syndrome. Int J Clin Pract 55:442\u2013444","journal-title":"Int J Clin Pract"},{"key":"7376_CR4","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/gps.930081106","volume":"8","author":"VP Prasher","year":"1993","unstructured":"Prasher VP, Corbett JA (1993) Onset of seizures as a poor indicator of longevity in people with Down\u2019s syndrome. Int J Geriatr Psychiatry 8:923\u2013927","journal-title":"Int J Geriatr Psychiatry"},{"key":"7376_CR5","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1192\/bjp.164.4.528","volume":"164","author":"RW Mc Vicker","year":"1994","unstructured":"Mc Vicker RW, Shanks OEP, McClelland RJ (1994) Prevalence and associated features of epilepsy in adults with Down\u2019s syndrome. Br J Psychiatry 164:528\u2013532","journal-title":"Br J Psychiatry"},{"key":"7376_CR6","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.braindev.2004.07.008","volume":"27","author":"M Menendez","year":"2005","unstructured":"Menendez M (2005) Down syndrome, Alzheimer\u2019s disease and seizures. Brain Dev 27:246\u2013252","journal-title":"Brain Dev"},{"key":"7376_CR7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1528-1167.2010.02909.x","volume":"52","author":"J Noebels","year":"2011","unstructured":"Noebels J (2011) A perfect storm: converging paths of epilepsy and Alzheimer\u2019s dementia intersect in hippocampal formation. Epilepsia 52:39\u201346","journal-title":"Epilepsia"},{"key":"7376_CR8","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1001\/archneur.1990.00530030029011","volume":"47","author":"HM Evenhuis","year":"1990","unstructured":"Evenhuis HM (1990) The natural history of dementia in Down\u2019s syndrome. Arch Neurol 47:263\u2013267","journal-title":"Arch Neurol"},{"key":"7376_CR9","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1684\/epd.2011.0426","volume":"13","author":"A Vignoli","year":"2011","unstructured":"Vignoli A, Zambrelli E, Chiesa V et al (2011) Epilepsy in adult patients with Down syndrome: a clinical video EEG study. Epileptic Disord 13:125\u2013132","journal-title":"Epileptic Disord"},{"key":"7376_CR10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/WNP.0b013e318230da76","volume":"28","author":"S Lefter","year":"2011","unstructured":"Lefter S, Costello DJ, McNamara B, Sweeney B (2011) Clinical and EEG features of seizures in adults with Down syndrome. J Clin Neurophysiol 28:469\u2013473","journal-title":"J Clin Neurophysiol"},{"key":"7376_CR11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3233\/JAD-2012-111613","volume":"29","author":"IT Lott","year":"2012","unstructured":"Lott IT, Doran E, Nguyen VQ et al (2012) Down syndrome and dementia: seizures and cognitive decline. J Alzheimers Dis 29:177\u2013185","journal-title":"J Alzheimers Dis"},{"key":"7376_CR12","first-page":"613","volume":"31","author":"Pedersen","year":"1990","unstructured":"Pedersen (1990) Epilepsy of late onset in Down\u2019s syndrome: a new epileptic syndrome. Epilepsia 31:613","journal-title":"Epilepsia"},{"key":"7376_CR13","first-page":"13","volume":"35","author":"P Genton","year":"1994","unstructured":"Genton P, Paglia G (1994) Senile myoclonic epilepsy: late onset of myoclonic seizures associated with dementia in three Down syndrome patients. Epilepsia 35:13","journal-title":"Epilepsia"},{"issue":"4","key":"7376_CR14","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1590\/S0004-282X1995000500014","volume":"53","author":"LM Li","year":"1995","unstructured":"Li LM, O\u2019Donoghue MF, Sander JW (1995) Myoclonic epilepsy of late onset in trisomy 21. Arq Neuropsiquiatr 53(4):792\u2013794","journal-title":"Arq Neuropsiquiatr"},{"issue":"107","key":"7376_CR15","first-page":"215","volume":"106","author":"L Vignatelli","year":"1999","unstructured":"Vignatelli L, Meletti S, Ambrosetto G (1999) \u201cEpilessia mioclonica progressiva\u201d in paziente affetta da sindrome di Down con malattia di Alzheimer. Boll Lega It Epil 106(107):215\u2013216","journal-title":"Boll Lega It Epil"},{"key":"7376_CR16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1053\/seiz.2000.0500","volume":"10","author":"JC Moller","year":"2001","unstructured":"Moller JC, Hamer HM, Oertel WH, Rosenow F (2001) Late onset myoclonic epilepsy in Down\u2019s syndrome (LOMEDS). Seizure 10:303\u2013305","journal-title":"Seizure"},{"issue":"3","key":"7376_CR17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1684\/j.1950-6945.2006.tb00191.x","volume":"8","author":"R Simone De","year":"2006","unstructured":"De Simone R, Daquin G, Genton P (2006) Senile myoclonic epilepsy in Down syndrome: a video and EEG presentation of two cases. Epileptic Disord 8(3):223\u2013227","journal-title":"Epileptic Disord"},{"key":"7376_CR18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.eplepsyres.2007.09.002","volume":"77","author":"A Crespel","year":"2007","unstructured":"Crespel A, Gonzalez V, Coubes P, Gelisse P (2007) Senile myoclonic epilepsy of Genton: two cases in Down syndrome with dementia and late onset epilepsy. Epilepsy Res 77:165\u2013168","journal-title":"Epilepsy Res"},{"issue":"2","key":"7376_CR19","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1684\/epd.2010.0306","volume":"12","author":"M Sangani","year":"2010","unstructured":"Sangani M, Shahid A, Amina Shahram, Koubeissi M (2010) Improvement of myoclonic epilepsy in Down syndrome treated with Levetiracetam. Epileptic Disord 12(2):151\u2013154","journal-title":"Epileptic Disord"},{"key":"7376_CR20","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.seizure.2010.04.008","volume":"19","author":"R Simone De","year":"2010","unstructured":"De Simone R, Puig XS, Gelisse P et al (2010) Senile myoclonic epilepsy: delineation of a common condition associated with Alzheimer\u2019s disease in Down syndrome. Seizure 19:383\u2013389","journal-title":"Seizure"},{"key":"7376_CR21","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1111\/j.0013-9580.2004.56902.x","volume":"45","author":"A Magaudda","year":"2004","unstructured":"Magaudda A, Gelisse P, Genton P (2004) Antimyoclonic effect of levetiracetam in 13 patients with Unverricht-Lundborg disease: clinical obervations. Epilepsia 45:678\u2013681","journal-title":"Epilepsia"},{"key":"7376_CR22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1365-2788.1997.tb00692.x","volume":"41","author":"EH Aylward","year":"1997","unstructured":"Aylward EH, Burt DB, Thorpe LU et al (1997) Diagnosis of dementia in individuals with intellectual disability. J Intellect Disabil Res 41:152\u2013164","journal-title":"J Intellect Disabil Res"},{"key":"7376_CR23","unstructured":"American Psychiatric Association (2000) Diagnostic and statistical manual of mental disorders (IV-TR). 4th edn-text revisited, Washington, DC"},{"key":"7376_CR24","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1192\/bjp.bp.106.024984","volume":"190","author":"S Deb","year":"2007","unstructured":"Deb S, Hare M, Prior L, Bhaumik S (2007) Dementia screening questionnaire for individuals with intellectual disabilities. Br J Psichiatry 190:440\u2013444","journal-title":"Br J Psichiatry"},{"key":"7376_CR25","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1212\/WNL.52.8.1555","volume":"52","author":"F Hulstaert","year":"1999","unstructured":"Hulstaert F, Blennow K, Ivanoiu A et al (1999) Improved discrimination of AD patients using \u03b2-amyloid (1-42) and tau levels in CSF. Neurology 52:1555\u20131562","journal-title":"Neurology"},{"key":"7376_CR26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ana.410280129","volume":"28","author":"Marseille consensus group","year":"1990","unstructured":"Marseille consensus group (1990) Classification of progressive myoclonus epilepsies and related disorders. Ann Neurol 28:113\u2013116","journal-title":"Ann Neurol"},{"key":"7376_CR27","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1212\/WNL.49.6.1732","volume":"49","author":"M Melanson","year":"1997","unstructured":"Melanson M, Nalbantoglu J, Berkovic S et al (1997) Progressive myoclonus epilepsy in young adults with neuropathologic features of Alzheimer\u2019s disease. Neurology 49:1732\u20131733","journal-title":"Neurology"},{"key":"7376_CR28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0013-4694(98)00058-3","volume":"107","author":"CA Tassinari","year":"1998","unstructured":"Tassinari CA, Rubboli G, Shibasaki H (1998) Neurophysiology of positive and negative myoclonus. Electroencephalogr Clin Neurophysiol 107:181\u2013195","journal-title":"Electroencephalogr Clin Neurophysiol"},{"key":"7376_CR29","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1001\/archneurol.2009.15","volume":"66","author":"J Palop","year":"2009","unstructured":"Palop J, Mucke L (2009) Epilepsy and cognitive impairments in Alzheimer disease. Arch Neurol 66:435\u2013440","journal-title":"Arch Neurol"},{"key":"7376_CR30","doi-asserted-by":"crossref","first-page":"3453","DOI":"10.1523\/JNEUROSCI.5215-08.2009","volume":"29","author":"R Minkeviciene","year":"2009","unstructured":"Minkeviciene R, Rheims S, Dobszay M et al (2009) Amyloid beta-induced neuronal hyperexcitability triggers progressive epilepsy. J Neurosci 29:3453\u20133462","journal-title":"J Neurosci"},{"key":"7376_CR31","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1001\/archneurol.2011.189","volume":"68","author":"C Schmidt","year":"2011","unstructured":"Schmidt C, Wolff M, Weitz M et al (2011) Rapidly progressive Alzheimer\u2019s disease. Arch Neurol 68:1124\u20131130","journal-title":"Arch Neurol"},{"key":"7376_CR32","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000278692","volume":"29","author":"C Schmidt","year":"2010","unstructured":"Schmidt C, Redyk K, Meissner B et al (2010) Clinical features of rapidly progressive Alzheimer\u2019s disease. Dement Geriatr Cogn Disord 29:371\u2013378","journal-title":"Dement Geriatr Cogn Disord"},{"key":"7376_CR33","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1159\/000119730","volume":"25","author":"C Giannattasio","year":"2008","unstructured":"Giannattasio C, Poleggi A, Puopolo M et al (2008) Survival in Alzheimer\u2019s disease is shorter in women carrying heterozygosity at codon 129 of the PRNP gene and no APOE epsilon 4 allele. Dement Geriatr Cogn Disord 25:354\u2013358","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"11","key":"7376_CR34","doi-asserted-by":"crossref","first-page":"e27845","DOI":"10.1371\/journal.pone.0027845","volume":"6","author":"V Brault","year":"2011","unstructured":"Brault V, Martin B, Costet N, Bizot JC, H\u00e9rault Y (2011) Characterization of PTZ-induced seizure susceptibility in a down syndrome mouse model that overexpresses CSTB. PLoS ONE 6(11):e27845","journal-title":"PLoS ONE"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-014-7376-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-014-7376-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-014-7376-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T13:02:49Z","timestamp":1717160569000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-014-7376-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,4]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,8]]}},"alternative-id":["7376"],"URL":"https:\/\/doi.org\/10.1007\/s00415-014-7376-x","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,4]]}}}