{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T08:10:59Z","timestamp":1784016659959,"version":"3.55.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2014,7,15]],"date-time":"2014-07-15T00:00:00Z","timestamp":1405382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1007\/s00415-014-7410-z","type":"journal-article","created":{"date-parts":[[2014,7,26]],"date-time":"2014-07-26T11:28:19Z","timestamp":1406374099000},"page":"1811-1817","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["First symptom and initial diagnosis in sporadic CJD patients in Germany"],"prefix":"10.1007","volume":"261","author":[{"given":"Anna","family":"Krasnianski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith","family":"Kaune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans A.","family":"Kretzschmar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Zerr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2014,7,15]]},"reference":[{"key":"7410_CR1","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1176\/appi.neuropsych.13020025","volume":"25","author":"R Ali","year":"2013","unstructured":"Ali R, Baborie A, Larner AJ, White R (2013) Psychiatric presentation of sporadic Creutzfeldt\u2013Jakob disease: a challenge to current diagnostic criteria. J Neuropsychiatry Clin Neurosci 25:335\u2013338","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"7410_CR2","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ana.410350504","volume":"35","author":"P Brown","year":"1994","unstructured":"Brown P, Gibbs CJ Jr, Rodgers-Johnson P, Asher DM, Sulima MP, Bacote A, Goldfarb LG, Gajdusek DC (1994) Human spongiform encephalopathy: the National Institutes of Health series of 300 cases of experimentally transmitted disease. Ann Neurol 35:513\u2013529","journal-title":"Ann Neurol"},{"key":"7410_CR3","doi-asserted-by":"crossref","first-page":"e24231","DOI":"10.1371\/journal.pone.0024231","volume":"6","author":"C Gao","year":"2011","unstructured":"Gao C, Shi Q, Tian C, Chen C, Han J, Zhou w, Zhang BY, Jiang HY, Zhang J, Dong XP (2011) The epidemiological, clinical, and laboratory features of sporadic Creutzfeldt-Jakob disease patients in China: surveillance data from 2006 to 2010. PLoS One 6:e24231","journal-title":"PLoS One"},{"key":"7410_CR4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF02892896","volume":"118","author":"A Heidenhain","year":"1929","unstructured":"Heidenhain A (1929) Klinische und anatomische Untersuchungen \u00fcber eine eigenartige organische Erkrankung des Zentralnervensystems im Praesenium. Z Ges Neurol Psychiatr 118:49\u2013114","journal-title":"Z Ges Neurol Psychiatr"},{"key":"7410_CR5","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1093\/brain\/awm063","volume":"130","author":"U Heinemann","year":"2007","unstructured":"Heinemann U, Krasnianski A, Meissner B, Varges D, Kallenberg K, Schulz-Schaeffer WJ, Steinhoff BJ, Grasbon-Frodl EM, Kretzschmar HA, Zerr I (2007) Creutzfeldt-Jakob disease in Germany: a prospective 12-year surveillance. Brain 130:1350\u20131359","journal-title":"Brain"},{"key":"7410_CR6","first-page":"1285","volume":"140","author":"T Kitamoto","year":"1992","unstructured":"Kitamoto T, Shin RW, Doh-Ura K, Tomokane N, Miyazono M, Muramoto T, Tateishi J (1992) Abnormal isoform of prion proteins accumulates in the synaptic structures of the central nervous system in patients with Creutzfeldt\u2013Jakob disease. Am J Pathol 140:1285\u20131294","journal-title":"Am J Pathol"},{"key":"7410_CR7","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s00439-005-0020-1","volume":"118","author":"GG Kov\u00e1cs","year":"2005","unstructured":"Kov\u00e1cs GG, Puopolo M, Ladogana A, Pocchiari M, Budka H, Van Duijn C, Collins S, Boyd A, Guilivi A, Coulthart M, Delasnerie-Laupretre N, Brandel JP, Zerr I, Kretzschmar H, de Pedro-Cuesta J, Calero-Lara M, Glatzel M, Aguzzi A, Bishop M, Knight R, Belay G, Will R, Mitrova E (2005) Genetic prion disease: the EUROCJD experience. Hum Genet 118:166\u2013174","journal-title":"Hum Genet"},{"key":"7410_CR8","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1001\/archneur.63.6.876","volume":"63","author":"A Krasnianski","year":"2006","unstructured":"Krasnianski A, Meissner B, Schulz-Schaeffer W, Kallenberg K, Bartl M, Heinemann U, Varges D, Kretzschmar H, Zerr I (2006) Clinical features and diagnosis of the MM2 cortical subtype of sporadic Creutzfeldt\u2013Jakob disease. Arch Neurol 63:876\u2013880","journal-title":"Arch Neurol"},{"key":"7410_CR9","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1093\/brain\/awl123","volume":"129","author":"A Krasnianski","year":"2006","unstructured":"Krasnianski A, Schulz-Schaeffer WJ, Kallenberg K, Meissner B, Collie DA, Roeber S, Bartl M, Heinemann U, Varges D, Kretzschmar HA, Zerr I (2006) Clinical findings and diagnostic tests in the MV-2 subtype of sporadic CJD. Brain 129:2288\u20132296","journal-title":"Brain"},{"key":"7410_CR10","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1001\/archneur.1996.00550090125018","volume":"53","author":"HA Kretzschmar","year":"1996","unstructured":"Kretzschmar HA, Ironside JW, DeArmond SJ, Tateishi J (1996) Diagnostic criteria for sporadic Creutzfeldt\u2013Jakob disease. Arch Neurol 53:913\u2013920","journal-title":"Arch Neurol"},{"key":"7410_CR11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0140-6736(98)05208-8","volume":"353","author":"J Lampe","year":"1999","unstructured":"Lampe J, Kitzler H, Walter MC, Lochmuller H, Reichmann H (1999) Methionine homozygosity at prion gene codon 129 may predispose to sporadic inclusion-body myositis [letter]. Lancet 353:465\u2013466","journal-title":"Lancet"},{"key":"7410_CR12","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1212\/01.wnl.0000184674.32924.c9","volume":"65","author":"B Meissner","year":"2005","unstructured":"Meissner B, Westner I, Kallenberg K, Krasnianski A, Bartl M, Varges D, Boesenberg C, Kretzschmar HA, Knauth M, Schulz-Schaeffer WJ, Zerr I (2005) Sporadic Creutzfeldt\u2013Jakob disease: clinical and diagnostic characteristics of the rare VV1 type. Neurology 65:1544\u20131550","journal-title":"Neurology"},{"key":"7410_CR13","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/352340a0","volume":"352","author":"MS Palmer","year":"1991","unstructured":"Palmer MS, Dryden AJ, Hughes JT, Collinge J (1991) Homozygous prion protein genotype predisposes to sporadic Creutzfeldt\u2013Jakob disease [published erratum appears in Nature 1991 Aug 8;352(6335):547] [see comments]. Nature 352:340\u2013342","journal-title":"Nature"},{"key":"7410_CR14","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1002\/1531-8249(199908)46:2<224::AID-ANA12>3.0.CO;2-W","volume":"46","author":"P Parchi","year":"1999","unstructured":"Parchi P, Giese A, Capellari S, Brown P, Schulz-Schaeffer W, Windl O, Zerr I, Budka H, Kopp N, Piccardo P, Poser S, Rojiani A, Streichemberger N, Julien J, Vital C, Ghetti B, Gambetti P, Kretzschmar HA (1999) Classification of sporadic Creutzfeldt\u2013Jakob disease based on molecular and phenotypic analysis of 300 subjects. Ann Neurol 46:224\u2013233","journal-title":"Ann Neurol"},{"key":"7410_CR15","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1212\/01.wnl.0000196440.00297.67","volume":"66","author":"GD Rabinovici","year":"2006","unstructured":"Rabinovici GD, Wang PN, Levin J, Cook L, Pravdin M, Davis J, DeArmond SJ, Barbaro NM, Martindale J, Miller BL, Geschwind M (2006) First symptom in sporadic Creutzfeldt\u2013Jakob disease. Neurology 66:286\u2013287","journal-title":"Neurology"},{"key":"7410_CR16","volume-title":"Diagnostisches und Statistisches Manual Psychischer St\u00f6rungen\u2013Textversion-DSM-IV-TR","author":"H Sass","year":"2003","unstructured":"Sass H, Wittchen HU, Zaudig M, Houben I (2003) Diagnostisches und Statistisches Manual Psychischer St\u00f6rungen\u2013Textversion-DSM-IV-TR. Hogrefe Verlag, G\u00f6ttingen"},{"key":"7410_CR17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0002-9440(10)64705-0","volume":"156","author":"WJ Schulz-Schaeffer","year":"2000","unstructured":"Schulz-Schaeffer WJ, Tschoke S, Kranefuss N, Drose W, Hause-Reitner D, Giese A, Groschup MH, Kretzschmar HA (2000) The paraffin-embedded tissue blot detects PrP(Sc) early in the incubation time in prion diseases. Am J Pathol 156:51\u201356","journal-title":"Am J Pathol"},{"key":"7410_CR18","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1001\/archneur.62.10.1591","volume":"62","author":"K Stoeck","year":"2005","unstructured":"Stoeck K, Bodemer M, Ciesielczyk B, Meissner B, Bartl M, Heinemann U, Zerr I (2005) Interleukin 4 and interleukin 10 levels are elevated in the cerebrospinal fluid of patients with Creutzfeldt\u2013Jakob disease. Arch Neurol 62:1591\u20131594","journal-title":"Arch Neurol"},{"key":"7410_CR19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/bmb\/66.1.241","volume":"66","author":"JD Wadsworth","year":"2003","unstructured":"Wadsworth JD, Hill AF, Beck JA, Collinge J (2003) Molecular and clinical classification of human prion disease. Br Med Bull 66:241\u2013254","journal-title":"Br Med Bull"},{"key":"7410_CR20","first-page":"361","volume":"47","author":"WHO","year":"1998","unstructured":"WHO (1998) Human transmissible spongiform encephalopathies. Wkly Epidemiol Rec 47:361\u2013365","journal-title":"Wkly Epidemiol Rec"},{"key":"7410_CR21","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1002\/ana.410430611","volume":"43","author":"RG Will","year":"1998","unstructured":"Will RG, Alp\u00e9rovitch A, Poser S, Pocchiari M, Hofman A, Mitrova E, de Silva R, D\u2019Alessandro M, Delasnerie-Laupr\u00eatre N, Zerr I, van Duijn C (1998) Descriptive epidemiology of Creutzfeldt\u2013Jakob disease in six European countries, 1993\u20131995. EU Collaborative Study Group for CJD. Ann Neurol 43:763\u2013767","journal-title":"Ann Neurol"},{"key":"7410_CR22","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1093\/brain\/awp191","volume":"132","author":"I Zerr","year":"2009","unstructured":"Zerr I, Kallenberg K, Summers DM, Romero C, Taratuto A, Ladogana A, Schuur M, Haik S, Collins SJ, Jansen GH, Stokin GB, Pimentel J, Hewer E, Collie DA, Smith P, Varges D, Heinemann U, Meissner B, Roberts H, Brandel JP, Van Dujin CM, Pocchiari M, Begue P, Cras P, Will RG, Sanchez-Juan P (2009) Updated clinical diagnostic criteria for sporadic Creutzfeldt\u2013Jakob disease. Brain 132:2659\u20132668","journal-title":"Brain"},{"key":"7410_CR23","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1212\/WNL.55.6.811","volume":"55","author":"I Zerr","year":"2000","unstructured":"Zerr I, Pocchiari M, Collins S, Brandel JP, de Pedro Cuesta J, Knight RSG, Bernheimer H, Cardone F, Delasnerie-Laupr\u00eatre N, Cuadrado Corrales N, Ladogana A, Fletcher A, Bodemer M, Awan T, Ruiz Brem\u00f3n A, Budka H, Laplanche JL, Will RG, Poser S (2000) Analysis of EEG and CSF 14-3-3 proteins as aids to the diagnosis of Creutzfeldt\u2013Jakob disease. Neurology 55:811\u2013815","journal-title":"Neurology"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-014-7410-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-014-7410-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-014-7410-z","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T15:22:40Z","timestamp":1559056960000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-014-7410-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,15]]},"references-count":23,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["7410"],"URL":"https:\/\/doi.org\/10.1007\/s00415-014-7410-z","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,15]]}}}