{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T15:48:35Z","timestamp":1791388115845,"version":"4.3.3"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1007\/s00415-014-7612-4","type":"journal-article","created":{"date-parts":[[2014,12,31]],"date-time":"2014-12-31T02:27:00Z","timestamp":1419992820000},"page":"666-673","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Association of IgM monoclonal gammopathy with progressive muscular atrophy and multifocal motor neuropathy: a case\u2013control study"],"prefix":"10.1007","volume":"262","author":[{"given":"Lotte","family":"Vlam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"Piepers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia A.","family":"Sutedja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart C.","family":"Jacobs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne P.","family":"Tio-Gillen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marloes","family":"Stam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hessel","family":"Franssen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan H.","family":"Veldink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth A.","family":"Cats","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolette C.","family":"Notermans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andries C.","family":"Bloem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renske I.","family":"Wadman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.-Ludo","family":"van der Pol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard H.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"7612_CR1","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1056\/NEJMoa054494","volume":"354","author":"RA Kyle","year":"2006","unstructured":"Kyle RA, Therneau TM, Rajkumar SV, Larson DR, Plevak MF et al (2006) Prevalence of monoclonal gammopathy of undetermined significance. N Engl J Med 354:1362\u20131369","journal-title":"N Engl J Med"},{"key":"7612_CR2","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1182\/blood-2006-03-001164","volume":"108","author":"G Merlini","year":"2006","unstructured":"Merlini G, Stone MJ (2006) Dangerous small B-cell clones. Blood 108:2520\u20132530","journal-title":"Blood"},{"key":"7612_CR3","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1056\/NEJM198009113031105","volume":"303","author":"N Latov","year":"1980","unstructured":"Latov N, Sherman WH, Nemni R, Galassi G, Shyong JS et al (1980) Plasma-cell dyscrasia and peripheral neuropathy with a monoclonal antibody to peripheral-nerve myelin. N Engl J Med 303:618\u2013621","journal-title":"N Engl J Med"},{"issue":"Suppl 1","key":"7612_CR4","doi-asserted-by":"crossref","first-page":"S32","DOI":"10.1002\/ana.410370705","volume":"37","author":"N Latov","year":"1995","unstructured":"Latov N (1995) Pathogenesis and therapy of neuropathies associated with monoclonal gammopathies. Ann Neurol 37(Suppl 1):S32\u2013S42","journal-title":"Ann Neurol"},{"key":"7612_CR5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.4065\/84.8.685","volume":"84","author":"JP Bida","year":"2009","unstructured":"Bida JP, Kyle RA, Therneau TM, Melton LJ 3rd, Plevak MF et al (2009) Disease associations with monoclonal gammopathy of undetermined significance: a population-based study of 17,398 patients. Mayo Clin Proc 84:685\u2013693","journal-title":"Mayo Clin Proc"},{"key":"7612_CR6","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1212\/WNL.0b013e3181ccc6b9","volume":"74","author":"JM Niermeijer","year":"2010","unstructured":"Niermeijer JM, Fischer K, Eurelings M, Franssen H, Wokke JH et al (2010) Prognosis of polyneuropathy due to IgM monoclonal gammopathy: a prospective cohort study. Neurology 74:406\u2013412","journal-title":"Neurology"},{"key":"7612_CR7","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11940-010-0065-x","volume":"12","author":"MC Dalakas","year":"2010","unstructured":"Dalakas MC (2010) Pathogenesis and treatment of anti-MAG neuropathy. Curr Treat Options Neurol 12:71\u201383","journal-title":"Curr Treat Options Neurol"},{"key":"7612_CR8","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1212\/WNL.36.11.1429","volume":"36","author":"ME Shy","year":"1986","unstructured":"Shy ME, Rowland LP, Smith T, Trojaborg W, Latov N et al (1986) Motor neuron disease and plasma cell dyscrasia. Neurology 36:1429\u20131436","journal-title":"Neurology"},{"key":"7612_CR9","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1212\/WNL.40.4.595","volume":"40","author":"DS Younger","year":"1990","unstructured":"Younger DS, Rowland LP, Latov N, Sherman W, Pesce M et al (1990) Motor neuron disease and amyotrophic lateral sclerosis: relation of high CSF protein content to paraproteinemia and clinical syndromes. Neurology 40:595\u2013599","journal-title":"Neurology"},{"key":"7612_CR10","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0022-510X(91)90220-2","volume":"104","author":"F Duarte","year":"1991","unstructured":"Duarte F, Binet S, Lacomblez L, Bouche P, Preud\u2019homme JL et al (1991) Quantitative analysis of monoclonal immunoglobulins in serum of patients with amyotrophic lateral sclerosis. J Neurol Sci 104:88\u201391","journal-title":"J Neurol Sci"},{"key":"7612_CR11","first-page":"1146","volume":"32","author":"T Saito","year":"1992","unstructured":"Saito T, Irie S, Ito H, Kowa H (1992) Paraproteinemia and motor neuron disease. Rinsho Shinkeigaku 32:1146\u20131148","journal-title":"Rinsho Shinkeigaku"},{"key":"7612_CR12","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1212\/WNL.43.2.418","volume":"43","author":"KA Sanders","year":"1993","unstructured":"Sanders KA, Rowland LP, Murphy PL, Younger DS, Latov N et al (1993) Motor neuron diseases and amyotrophic lateral sclerosis: GM1 antibodies and paraproteinemia. Neurology 43:418\u2013420","journal-title":"Neurology"},{"key":"7612_CR13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1159\/000117102","volume":"35","author":"D Lavrnic","year":"1995","unstructured":"Lavrnic D, Vidakovic A, Miletic V, Trikic R, Marinkovic Z et al (1995) Motor neuron disease and monoclonal gammopathy. Eur Neurol 35:104\u2013107","journal-title":"Eur Neurol"},{"key":"7612_CR14","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0960-8966(98)00089-3","volume":"9","author":"J Desai","year":"1999","unstructured":"Desai J, Swash M (1999) IgM paraproteinemia in a patient with primary lateral sclerosis. Neuromuscul Disord 9:38\u201340","journal-title":"Neuromuscul Disord"},{"key":"7612_CR15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0022-510X(99)00219-1","volume":"169","author":"C Bentes","year":"1999","unstructured":"Bentes C, de Carvalho M, Evangelista T, Sales-Luis ML (1999) Multifocal motor neuropathy mimicking motor neuron disease: nine cases. J Neurol Sci 169:76\u201379","journal-title":"J Neurol Sci"},{"key":"7612_CR16","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nrneurol.2011.175","volume":"8","author":"L Vlam","year":"2011","unstructured":"Vlam L, van der Pol WL, Cats EA, Straver DC, Piepers S et al (2011) Multifocal motor neuropathy: diagnosis, pathogenesis and treatment strategies. Nat Rev Neurol 8:48\u201358","journal-title":"Nat Rev Neurol"},{"key":"7612_CR17","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","volume":"1","author":"Brooks BR, Miller RG, Swash M, Munsat TL, World Federation of Neurology Research Group on Motor Neuron Diseases","year":"2000","unstructured":"Brooks BR, Miller RG, Swash M, Munsat TL, World Federation of Neurology Research Group on Motor Neuron Diseases (2000) El escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord 1:293\u2013299","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"key":"7612_CR18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/brain\/awg019","volume":"126","author":"JT Asseldonk Van","year":"2003","unstructured":"Van Asseldonk JT, Van den Berg LH, Van den Berg-Vos RM, Wieneke GH, Wokke JH et al (2003) Demyelination and axonal loss in multifocal motor neuropathy: distribution and relation to weakness. Brain 126:186\u2013198","journal-title":"Brain"},{"key":"7612_CR19","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1212\/01.wnl.0000267322.48364.76","volume":"69","author":"F Brugman","year":"2007","unstructured":"Brugman F, Eymard-Pierre E, van den Berg LH, Wokke JH, Gauthier-Barichard F et al (2007) Adult-onset primary lateral sclerosis is not associated with mutations in the ALS2 gene. Neurology 69:702\u2013704","journal-title":"Neurology"},{"key":"7612_CR20","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1002\/1531-8249(200012)48:6<919::AID-ANA13>3.0.CO;2-J","volume":"48","author":"RM Berg-Vos Van den","year":"2000","unstructured":"Van den Berg-Vos RM, Franssen H, Wokke JH, Van Es HW, Van den Berg LH (2000) Multifocal motor neuropathy: diagnostic criteria that predict the response to immunoglobulin treatment. Ann Neurol 48:919\u2013926","journal-title":"Ann Neurol"},{"key":"7612_CR21","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1212\/WNL.0b013e3181f0738e","volume":"75","author":"EA Cats","year":"2010","unstructured":"Cats EA, van der Pol WL, Piepers S, Franssen H, Jacobs BC et al (2010) Correlates of outcome and response to IVIg in 88 patients with multifocal motor neuropathy. Neurology 75:818\u2013825","journal-title":"Neurology"},{"key":"7612_CR22","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1212\/WNL.57.10.1909","volume":"57","author":"M Eurelings","year":"2001","unstructured":"Eurelings M, Ang CW, Notermans NC, Van Doorn PA, Jacobs BC et al (2001) Antiganglioside antibodies in polyneuropathy associated with monoclonal gammopathy. Neurology 57:1909\u20131912","journal-title":"Neurology"},{"key":"7612_CR23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ana.410240113","volume":"24","author":"A Pestronk","year":"1988","unstructured":"Pestronk A, Cornblath DR, Ilyas AA, Baba H, Quarles RH et al (1988) A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. Ann Neurol 24:73\u201378","journal-title":"Ann Neurol"},{"key":"7612_CR24","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1212\/WNL.0b013e3181ff94c2","volume":"75","author":"EA Cats","year":"2010","unstructured":"Cats EA, Jacobs BC, Yuki N, Tio-Gillen AP, Piepers S et al (2010) Multifocal motor neuropathy: association of anti-GM1 IgM antibodies with clinical features. Neurology 75:1961\u20131967","journal-title":"Neurology"},{"key":"7612_CR25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jns.2005.07.009","volume":"239","author":"ML Kuijf","year":"2005","unstructured":"Kuijf ML, van Doorn PA, Tio-Gillen AP, Geleijns K, Ang CW et al (2005) Diagnostic value of anti-GM1 ganglioside serology and validation of the INCAT-ELISA. J Neurol Sci 239:37\u201344","journal-title":"J Neurol Sci"},{"key":"7612_CR26","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/brain\/awh375","volume":"128","author":"JT Asseldonk Van","year":"2005","unstructured":"Van Asseldonk JT, Van den Berg LH, Kalmijn S, Wokke JH, Franssen H (2005) Criteria for demyelination based on the maximum slowing due to axonal degeneration, determined after warming in water at 37 degrees C: diagnostic yield in chronic inflammatory demyelinating polyneuropathy. Brain 128:880\u2013891","journal-title":"Brain"},{"key":"7612_CR27","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0022-510X(93)90300-N","volume":"114","author":"HJ Willison","year":"1993","unstructured":"Willison HJ, Chancellor AM, Paterson G, Veitch J, Singh S et al (1993) Antiglycolipid antibodies, immunoglobulins and paraproteins in motor neuron disease: a population based case-control study. J Neurol Sci 114:209\u2013215","journal-title":"J Neurol Sci"},{"key":"7612_CR28","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/mus.21565","volume":"41","author":"LP Rowland","year":"2010","unstructured":"Rowland LP (2010) Progressive muscular atrophy and other lower motor neuron syndromes of adults. Muscle Nerve 41:161\u2013165","journal-title":"Muscle Nerve"},{"key":"7612_CR29","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1212\/01.wnl.0000277697.55288.d0","volume":"69","author":"M Slee","year":"2007","unstructured":"Slee M, Selvan A, Donaghy M (2007) Multifocal motor neuropathy: the diagnostic spectrum and response to treatment. Neurology 69:1680\u20131687","journal-title":"Neurology"},{"key":"7612_CR30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/j.1529-8027.2011.00366.x","volume":"16","author":"N Riva","year":"2011","unstructured":"Riva N, Gallia F, Iannaccone S, Corbo M, Terenghi F et al (2011) Chronic motor axonal neuropathy. J Peripher Nerv Syst 16:341\u2013346","journal-title":"J Peripher Nerv Syst"},{"key":"7612_CR31","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1212\/WNL.36.2.273","volume":"36","author":"GJ Parry","year":"1986","unstructured":"Parry GJ, Holtz SJ, Ben-Zeev D, Drori JB (1986) Gammopathy with proximal motor axonopathy simulating motor neuron disease. Neurology 36:273\u2013276","journal-title":"Neurology"},{"key":"7612_CR32","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1093\/brain\/awf272","volume":"125","author":"HJ Willison","year":"2002","unstructured":"Willison HJ, Yuki N (2002) Peripheral neuropathies and anti-glycolipid antibodies. Brain 125:2591\u20132625","journal-title":"Brain"},{"key":"7612_CR33","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1529-8027.2011.00328.x","volume":"16","author":"AM Fitzpatrick","year":"2011","unstructured":"Fitzpatrick AM, Mann CA, Barry S, Brennan K, Overell JR et al (2011) An open label clinical trial of complement inhibition in multifocal motor neuropathy. J Peripher Nerv Syst 16:84\u201391","journal-title":"J Peripher Nerv Syst"},{"key":"7612_CR34","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1046\/j.1440-1711.1998.00778.x","volume":"76","author":"S Petratos","year":"1998","unstructured":"Petratos S, Turnbull VJ, Papadopoulos R, Ayers M, Gonzales MF (1998) Antibodies against peripheral myelin glycolipids in people with HIV infection. Immunol Cell Biol 76:535\u2013541","journal-title":"Immunol Cell Biol"},{"issue":"372\u20134","key":"7612_CR35","first-page":"377","volume":"14","author":"BJ Dezube","year":"2004","unstructured":"Dezube BJ, Aboulafia DM, Pantanowitz L (2004) Plasma cell disorders in HIV-infected patients: from benign gammopathy to multiple myeloma. AIDS Read 14(372\u20134):377\u2013379","journal-title":"AIDS Read"},{"key":"7612_CR36","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1212\/WNL.48.6.1671","volume":"48","author":"PH Gordon","year":"1997","unstructured":"Gordon PH, Rowland LP, Younger DS, Sherman WH, Hays AP et al (1997) Lymphoproliferative disorders and motor neuron disease: an update. Neurology 48:1671\u20131678","journal-title":"Neurology"},{"key":"7612_CR37","first-page":"481","volume":"56","author":"P Jolicoeur","year":"1991","unstructured":"Jolicoeur P, Rassart E, DesGroseillers L, Robitaille Y, Paquette Y et al (1991) Retrovirus-induced motor neuron disease of mice: molecular basis of neurotropism and paralysis. Adv Neurol 56:481\u2013493","journal-title":"Adv Neurol"},{"key":"7612_CR38","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1212\/WNL.57.6.1094","volume":"57","author":"DJ MacGowan","year":"2001","unstructured":"MacGowan DJ, Scelsa SN, Waldron M (2001) An ALS-like syndrome with new HIV infection and complete response to antiretroviral therapy. Neurology 57:1094\u20131097","journal-title":"Neurology"},{"key":"7612_CR39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jns.2005.09.005","volume":"240","author":"A Verma","year":"2006","unstructured":"Verma A, Berger JR (2006) ALS syndrome in patients with HIV-1 infection. J Neurol Sci 240:59\u201364","journal-title":"J Neurol Sci"},{"key":"7612_CR40","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1212\/01.wnl.0000297552.13219.b4","volume":"70","author":"AL McCormick","year":"2008","unstructured":"McCormick AL, Brown RH Jr, Cudkowicz ME, Al-Chalabi A, Garson JA (2008) Quantification of reverse transcriptase in ALS and elimination of a novel retroviral candidate. Neurology 70:278\u2013283","journal-title":"Neurology"},{"issue":"1","key":"7612_CR41","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1468-1331.2012.03767.x","volume":"20","author":"F Galban-Horcajo","year":"2013","unstructured":"Galban-Horcajo F, Fitzpatrick AM, Hutton AJ, Dunn SM, Kalna G et al (2013) Antibodies to heteromeric glycolipid complexes in multifocal motor neuropathy. Eur J Neurol 20(1):62\u201370","journal-title":"Eur J Neurol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-014-7612-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-014-7612-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-014-7612-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T19:22:48Z","timestamp":1559071368000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-014-7612-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":41,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["7612"],"URL":"https:\/\/doi.org\/10.1007\/s00415-014-7612-4","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,1]]}}}