{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T01:31:12Z","timestamp":1785547872462,"version":"3.56.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2015,8,2]],"date-time":"2015-08-02T00:00:00Z","timestamp":1438473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Tel Aviv Sourasky Medical Center Grant of Excellence"},{"name":"The Kahn Foundation"},{"name":"The Chief Scientist of the Israeli Ministry of Health","award":["3-4893"],"award-info":[{"award-number":["3-4893"]}]},{"name":"The Legacy Heritage Biomedical Science Partnership Program of the Israel Science Foundation","award":["1922\/08"],"award-info":[{"award-number":["1922\/08"]}]},{"DOI":"10.13039\/100000864","name":"Michael J. Fox Foundation for Parkinson's Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1007\/s00415-015-7868-3","type":"journal-article","created":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T02:24:36Z","timestamp":1438395876000},"page":"2443-2447","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The Alzheimer disease BIN1 locus as a modifier of GBA-associated Parkinson disease"],"prefix":"10.1007","volume":"262","author":[{"given":"Z.","family":"Gan-Or","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Amshalom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bar-Shira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Gana-Weisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Mirelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Marder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bressman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Giladi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Orr-Urtreger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2015,8,2]]},"reference":[{"key":"7868_CR1","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","volume":"361","author":"E Sidransky","year":"2009","unstructured":"Sidransky E, Nalls MA, Aasly JO et al (2009) Multicenter analysis of glucocerebrosidase mutations in Parkinson\u2019s disease. N Engl J Med 361:1651\u20131661","journal-title":"N Engl J Med"},{"key":"7868_CR2","doi-asserted-by":"crossref","first-page":"2277","DOI":"10.1212\/01.wnl.0000304039.11891.29","volume":"70","author":"Z Gan-Or","year":"2008","unstructured":"Gan-Or Z, Giladi N, Rozovski U et al (2008) Genotype-phenotype correlations between GBA mutations and Parkinson disease risk and onset. Neurology 70:2277\u20132283","journal-title":"Neurology"},{"issue":"9","key":"7868_CR3","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1212\/WNL.0000000000001315","volume":"84","author":"Z Gan-Or","year":"2015","unstructured":"Gan-Or Z, Amshalom I, Kilarski LL et al (2015) Differential effects of severe vs mild GBA mutations on Parkinson disease. Neurology 84(9):880\u2013887","journal-title":"Neurology"},{"key":"7868_CR4","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s10048-011-0293-6","volume":"12","author":"Z Gan-Or","year":"2011","unstructured":"Gan-Or Z, Bar-Shira A, Gurevich T et al (2011) Homozygosity for the MTX1 c.184T>A (p. S63T) alteration modifies the age of onset in GBA-associated Parkinson\u2019s disease. Neurogenetics 12:325\u2013332","journal-title":"Neurogenetics"},{"issue":"3","key":"7868_CR5","doi-asserted-by":"crossref","first-page":"e32","DOI":"10.1371\/journal.pgen.0010032","volume":"1","author":"BF Voight","year":"2005","unstructured":"Voight BF, Pritchard JK (2005) Confounding from cryptic relatedness in case-control association studies. PLoS Genet 1(3):e32","journal-title":"PLoS Genet"},{"key":"7868_CR6","doi-asserted-by":"crossref","unstructured":"Vacic V, Ozelius LJ, Clark LN et al (2014) Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes. Hum Mol Genet 23(17):4693\u20134702","DOI":"10.1093\/hmg\/ddu158"},{"key":"7868_CR7","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1038\/ng.3043","volume":"46","author":"MA Nalls","year":"2014","unstructured":"Nalls MA, Pankratz N, Lill CM et al (2014) Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson\u2019s disease. Nat Genet 46:989\u2013993","journal-title":"Nat Genet"},{"key":"7868_CR8","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s12031-011-9641-0","volume":"46","author":"Z Gan-Or","year":"2012","unstructured":"Gan-Or Z, Bar-Shira A, Mirelman A et al (2012) The age at motor symptoms onset in LRRK2-associated Parkinson\u2019s disease is affected by a variation in the MAPT locus: a possible interaction. J Mol Neurosci 46:541\u2013544","journal-title":"J Mol Neurosci"},{"key":"7868_CR9","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.parkreldis.2008.10.008","volume":"15","author":"Y Golub","year":"2009","unstructured":"Golub Y, Berg D, Calne DB et al (2009) Genetic factors influencing age at onset in LRRK2-linked Parkinson disease. Parkinsonism Relat Disord 15:539\u2013541","journal-title":"Parkinsonism Relat Disord"},{"key":"7868_CR10","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1001\/jama.2010.574","volume":"303","author":"S Seshadri","year":"2010","unstructured":"Seshadri S, Fitzpatrick AL, Ikram MA et al (2010) Genome-wide analysis of genetic loci associated with Alzheimer disease. JAMA 303:1832\u20131840","journal-title":"JAMA"},{"key":"7868_CR11","author":"G Jun","year":"2015","unstructured":"Jun G, Ibrahim-Verbaas CA, Vronskaya M et al (2015) A novel Alzheimer disease locus located near the gene encoding tau protein. Mol Psychiatry. doi: 10.1038\/mp.2015.23","journal-title":"Mol Psychiatry"},{"issue":"10","key":"7868_CR12","first-page":"1268","volume":"70","author":"V Moskvina","year":"2013","unstructured":"Moskvina V, Harold D, Russo G et al (2013) Analysis of genome-wide association studies of Alzheimer disease and of Parkinson disease to determine if these 2 diseases share a common genetic risk. JAMA Neurol 70(10):1268\u20131276","journal-title":"JAMA Neurol"},{"issue":"12","key":"7868_CR13","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1038\/ng.2802","volume":"45","author":"JC Lambert","year":"2013","unstructured":"Lambert JC, Ibrahim-Verbaas CA, Harold D et al (2013) Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer\u2019s disease. Nat Genet 45(12):1452\u20131458","journal-title":"Nat Genet"},{"key":"7868_CR14","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.molmed.2013.06.004","volume":"19","author":"MS Tan","year":"2013","unstructured":"Tan MS, Yu JT, Tan L (2013) Bridging integrator 1 (BIN1): form, function, and Alzheimer\u2019s disease. Trends Mol Med 19:594\u2013603","journal-title":"Trends Mol Med"},{"key":"7868_CR15","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s12035-011-8226-9","volume":"45","author":"IS Pienaar","year":"2012","unstructured":"Pienaar IS, Burn D, Morris C et al (2012) Synaptic protein alterations in Parkinson\u2019s disease. Mol Neurobiol 45:126\u2013143","journal-title":"Mol Neurobiol"},{"key":"7868_CR16","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/ng2086","volume":"39","author":"AS Nicot","year":"2007","unstructured":"Nicot AS, Toussaint A, Tosch V et al (2007) Mutations in amphiphysin 2 (BIN1) disrupt interaction with dynamin 2 and cause autosomal recessive centronuclear myopathy. Nat Genet 39:1134\u20131139","journal-title":"Nat Genet"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-015-7868-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-015-7868-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-015-7868-3","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T15:22:55Z","timestamp":1559056975000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-015-7868-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,2]]},"references-count":16,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["7868"],"URL":"https:\/\/doi.org\/10.1007\/s00415-015-7868-3","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,2]]}}}