{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T06:46:20Z","timestamp":1756190780718},"reference-count":6,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T00:00:00Z","timestamp":1466553600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Ministry of Culture and Education of Japan","award":["16390308"],"award-info":[{"award-number":["16390308"]}]},{"name":"Evidence-based Medicine, Ministry of Health, Labor and Welfare of Japan","award":["CCT-B-1803"],"award-info":[{"award-number":["CCT-B-1803"]}]},{"name":"Japan Agency for Medical Research and development, AMED","award":["15ek0109088h0001"],"award-info":[{"award-number":["15ek0109088h0001"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1007\/s00415-016-8069-4","type":"journal-article","created":{"date-parts":[[2016,6,22]],"date-time":"2016-06-22T22:32:31Z","timestamp":1466634751000},"page":"1666-1668","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["l-Arginine intervention at hyper-acute phase protects the prolonged MRI abnormality in MELAS"],"prefix":"10.1007","volume":"263","author":[{"given":"Miyuki","family":"Kitamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Yatsuga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshi","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nataliya","family":"Povalko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reo","family":"Saiki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kikumi","family":"Ushijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yushiro","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutoshi","family":"Koga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,6,22]]},"reference":[{"key":"8069_CR1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1002\/ana.410160409","volume":"16","author":"SG Pavlakis","year":"1984","unstructured":"Pavlakis SG, Phillips PC, DiMauro S, De Vivo DC, Rowland LP (1984) Mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes: a distinctive clinical syndrome. Ann Neurol 16:481\u2013488. doi: 10.1002\/ana.410160409","journal-title":"Ann Neurol"},{"key":"8069_CR2","doi-asserted-by":"publisher","first-page":"2182","DOI":"10.1212\/WNL.53.9.2182","volume":"53","author":"M Yoneda","year":"1999","unstructured":"Yoneda M, Maeda M, Kimura H, Fujii H, Katayama K, Kuriyama M (1999) Vasogenic edema on MELAS: a serial study with diffusion-weighted MR imaging. Neurology 53:2182\u20132184. doi: 10.1212\/WNL.53.9.2182","journal-title":"Neurology"},{"key":"8069_CR3","doi-asserted-by":"publisher","first-page":"61","DOI":"10.2217\/fnl.09.71","volume":"5","author":"T Iizuka","year":"2010","unstructured":"Iizuka T, Sakai F (2010) Pathophysiology of stroke-like episodes in MELAS: neuron\u2013astrocyte uncoupling in neuronal hyperexcitability. Future Neurol 5:61\u201383. doi: 10.2217\/fnl.09.71","journal-title":"Future Neurol"},{"key":"8069_CR4","doi-asserted-by":"publisher","first-page":"1766","DOI":"10.1212\/01.wnl.0000220197.36849.1e","volume":"66","author":"Y Koga","year":"2006","unstructured":"Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Fukiyma R et al (2006) Endothelial dysfunction in MELAS was improved by l-arginine supplementation. Neurology 66:1766\u20131769. doi: 10.1212\/01.wnl.0000220197.36849.1e","journal-title":"Neurology"},{"key":"8069_CR5","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1212\/01.WNL.0000151976.60624.01","volume":"64","author":"Y Koga","year":"2005","unstructured":"Koga Y, Akita Y, Nishioka J, Yatsuga S, Povalko N, Tanabe Y et al (2005) l-arginine improves the symptoms of stroke-like episodes in MELAS. Neurology 64:710\u2013712. doi: 10.1212\/01.WNL.0000151976.60624.01","journal-title":"Neurology"},{"key":"8069_CR6","doi-asserted-by":"publisher","first-page":"15","DOI":"10.3348\/kjr.2011.12.1.15","volume":"12","author":"JH Kim","year":"2011","unstructured":"Kim JH, Lim MK, Jeon TY, Rha JH, Eo H, Yoo SY et al (2011) Diffusion and perfusion characteristics of MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-lie episodes) in thirteen patients. Korean J Radiol 12:15\u201324. doi: 10.3348\/kjr.2011.12.1.15","journal-title":"Korean J Radiol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-016-8069-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-016-8069-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-016-8069-4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2016,8,2]],"date-time":"2016-08-02T11:28:16Z","timestamp":1470137296000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-016-8069-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,22]]},"references-count":6,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["8069"],"URL":"https:\/\/doi.org\/10.1007\/s00415-016-8069-4","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,22]]}}}