{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T06:45:38Z","timestamp":1769064338789,"version":"3.49.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T00:00:00Z","timestamp":1467417600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100001590","name":"Health Research Board","doi-asserted-by":"publisher","award":["ICE\/2012\/6"],"award-info":[{"award-number":["ICE\/2012\/6"]}],"id":[{"id":"10.13039\/501100001590","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1007\/s00415-016-8215-z","type":"journal-article","created":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T02:40:58Z","timestamp":1467427258000},"page":"1919-1926","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Age-period-cohort analysis of trends in amyotrophic lateral sclerosis incidence"],"prefix":"10.1007","volume":"263","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8537-3273","authenticated-orcid":false,"given":"Katy","family":"Tobin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark S.","family":"Gilthorpe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Heverin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Vajda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Staines","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orla","family":"Hardiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2016,7,2]]},"reference":[{"issue":"4","key":"8215_CR1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1136\/jnnp.2009.183525","volume":"81","author":"G Logroscino","year":"2010","unstructured":"Logroscino G, Traynor BJ, Hardiman O et al (2010) Incidence of amyotrophic lateral sclerosis in Europe. J Neurol Neurosurg Psychiatry 81(4):385\u2013390","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"8215_CR2","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1136\/jnnp.2007.117788","volume":"79","author":"O O\u2019Toole","year":"2008","unstructured":"O\u2019Toole O, Traynor BJ, Brennan P et al (2008) Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004. J Neurol Neurosurg Psychiatry 79:30\u201332","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"23","key":"8215_CR3","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1212\/01.wnl.0000336653.65605.ac","volume":"71","author":"M Murphy","year":"2008","unstructured":"Murphy M, Quinn S, Young J, Parkin P, Taylor B (2008) Increasing incidence of ALS in Canterbury, New Zealand: a 22-year study. Neurology 71(23):1889\u20131895","journal-title":"Neurology"},{"issue":"6","key":"8215_CR4","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3109\/17482968.2011.593037","volume":"12","author":"E Georgoulopoulou","year":"2011","unstructured":"Georgoulopoulou E, Vinceti M, Bonvicini F et al (2011) Changing incidence and subtypes of ALS in Modena, Italy: a 10-years prospective study. Amyotroph Lateral Scler 12(6):451\u2013457","journal-title":"Amyotroph Lateral Scler"},{"issue":"3","key":"8215_CR5","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s004150050330","volume":"246","author":"A Chi\u00f2","year":"1999","unstructured":"Chi\u00f2 A, Cucatto A, Calvo A, Terreni AA, Magnani C, Schiffer D (1999) Amyotrophic lateral sclerosis among the migrant population to Piemonte, northwestern Italy. J Neurol 246(3):175\u2013180","journal-title":"J Neurol"},{"issue":"2","key":"8215_CR6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1159\/000351153","volume":"41","author":"A Chi\u00f2","year":"2013","unstructured":"Chi\u00f2 A, Logroscino G, Traynor BJ et al (2013) Global epidemiology of amyotrophic lateral sclerosis: a systematic review of the published literature. Neuroepidemiology 41(2):118\u2013130","journal-title":"Neuroepidemiology"},{"key":"8215_CR7","unstructured":"European Commission. Eurostat\u2013Statistics Explained. Population Structure and Ageing (Internet). 2015 (cited 2015 Nov 20). http:\/\/ec.europa.eu\/eurostat\/statistics-explained\/index.php\/Population_structure_and_ageing"},{"issue":"6","key":"8215_CR8","doi-asserted-by":"crossref","first-page":"e001097","DOI":"10.1161\/JAHA.114.001097","volume":"3","author":"ES Ford","year":"2014","unstructured":"Ford ES, Roger VL, Dunlay SM, Go AS, Rosamond WD (2014) Challenges of ascertaining national trends in the incidence of coronary heart disease in the United States. J Am Heart Assoc 3(6):e001097","journal-title":"J Am Heart Assoc"},{"issue":"16","key":"8215_CR9","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1136\/heartjnl-2013-303921","volume":"99","author":"K Bennett","year":"2013","unstructured":"Bennett K, Hughes J, Jennings S, Kee F, Shelley E (2013) Comparing the decline in coronary heart disease and stroke mortality in neighbouring countries with different healthcare systems. Heart 99(16):1179\u20131184","journal-title":"Heart"},{"key":"8215_CR10","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1159\/000334632","volume":"38","author":"V Ajdacic-Gross","year":"2012","unstructured":"Ajdacic-Gross V, Schmid M, Tschopp A, Gutzwiller F (2012) Birth cohort effects in neurological diseases: amyotrophic lateral sclerosis, Parkinson\u2019s disease and multiple sclerosis. Neuroepidemiology 38:56\u201363","journal-title":"Neuroepidemiology"},{"issue":"9","key":"8215_CR11","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s10654-011-9595-0","volume":"26","author":"PH Gordon","year":"2011","unstructured":"Gordon PH, Artaud F, Aouba A, Laurent F, Meininger V, Elbaz A (2011) Changing mortality for motor neuron disease in France (1968\u20132007): an age-period-cohort analysis. Eur J Epidemiol 26(9):729\u2013737","journal-title":"Eur J Epidemiol"},{"issue":"8","key":"8215_CR12","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1093\/aje\/kwt116","volume":"178","author":"RM Seals","year":"2013","unstructured":"Seals RM, Hansen J, Gredal O, Weisskopf MG (2013) Age-period-cohort analysis of trends in amyotrophic lateral sclerosis in Denmark, 1970\u20132009. Am J Epidemiol 178(8):1265\u20131271","journal-title":"Am J Epidemiol"},{"issue":"15","key":"8215_CR13","doi-asserted-by":"crossref","first-page":"3018","DOI":"10.1002\/sim.2764","volume":"26","author":"B Carstensen","year":"2007","unstructured":"Carstensen B (2007) Age-period-cohort models for the Lexis diagram. Stat Med 26(15):3018\u20133045","journal-title":"Stat Med"},{"issue":"1","key":"8215_CR14","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1093\/ije\/26.1.32","volume":"26","author":"RJ McNally","year":"1997","unstructured":"McNally RJ, Alexander FE, Staines A, Cartwright RA (1997) A comparison of three methods of analysis for age-period-cohort models with application to incidence data on non-Hodgkin\u2019s lymphoma. Int J Epidemiol 26(1):32\u201346","journal-title":"Int J Epidemiol"},{"issue":"4","key":"8215_CR15","doi-asserted-by":"crossref","first-page":"e19401","DOI":"10.1371\/journal.pone.0019401","volume":"6","author":"YK Tu","year":"2011","unstructured":"Tu YK, Davey Smith G, Gilthorpe MS (2011) A new approach to age-period-cohort analysis using partial least squares regression: the trend in blood pressure in the Glasgow Alumni cohort. PLoS One 6(4):e19401","journal-title":"PLoS One"},{"issue":"1","key":"8215_CR16","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1186\/1471-2458-13-889","volume":"13","author":"T Jiang","year":"2013","unstructured":"Jiang T, Gilthorpe MS, Shiely F et al (2013) Age-period-cohort analysis for trends in body mass index in Ireland. BMC Public Health 13(1):889","journal-title":"BMC Public Health"},{"issue":"8","key":"8215_CR17","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.annepidem.2014.06.002","volume":"24","author":"YK Tu","year":"2014","unstructured":"Tu YK, Keyes K, Davey Smith G (2014) Mortality cohort effects from mid 19th to mid 20th century Britain: did they exist. Ann Epidemiol 24(8):570\u2013574","journal-title":"Ann Epidemiol"},{"issue":"15","key":"8215_CR18","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1212\/WNL.0000000000001477","volume":"84","author":"J Rooney","year":"2015","unstructured":"Rooney J, Vajda A, Heverin M et al (2015) Spatial cluster analysis of population amyotrophic lateral sclerosis risk in Ireland. Neurology 84(15):1537\u20131544","journal-title":"Neurology"},{"key":"8215_CR19","unstructured":"Central Statistics Office. CSO Statistical Databases (Internet). Unknown (cited 2015 May 15). http:\/\/www.cso.ie\/en\/databases\/"},{"key":"8215_CR20","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/EDE.0b013e31824d57a9","volume":"23","author":"YK Tu","year":"2012","unstructured":"Tu YK, Kramer N, Lee WC (2012) Addressing the identification problem in age-period-cohort analysis. A tutorial on the use of partial least squares and principal components analysis. Epidemiology 23:583\u2013593","journal-title":"Epidemiology"},{"key":"8215_CR21","unstructured":"R Core Team (2014) R: a language and environment for statistical computing. R Foundation for Statistical Computing, Vienna. http:\/\/www.R-project.org\/"},{"key":"8215_CR22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v018.i02","volume":"18","author":"BH Mevik","year":"2007","unstructured":"Mevik BH, Wehrens R (2007) The pls package: principal component and partial least squares regression in R. J Stat Softw 18:1\u201324","journal-title":"J Stat Softw"},{"issue":"4","key":"8215_CR23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1207\/s15328031us0304_4","volume":"3","author":"M Haenlein","year":"2004","unstructured":"Haenlein M, Kaplan AM (2004) A beginner\u2019s guide to partial least squares analysis. Underst Stat 3(4):283\u2013297","journal-title":"Underst Stat"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-016-8215-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-016-8215-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-016-8215-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T13:40:26Z","timestamp":1498311626000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-016-8215-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,2]]},"references-count":23,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["8215"],"URL":"https:\/\/doi.org\/10.1007\/s00415-016-8215-z","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,2]]}}}