{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T10:52:27Z","timestamp":1768647147028,"version":"3.49.0"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T00:00:00Z","timestamp":1512777600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1007\/s00415-017-8696-4","type":"journal-article","created":{"date-parts":[[2017,12,9]],"date-time":"2017-12-09T04:13:53Z","timestamp":1512792833000},"page":"308-314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Spontaneous cervical artery dissection is accompanied by a hypercoagulable state and simultaneous inflammatory condition"],"prefix":"10.1007","volume":"265","author":[{"given":"Johann Otto","family":"Pelz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Harms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Metze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominik","family":"Michalski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,12,9]]},"reference":[{"key":"8696_CR1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0140-6736(13)61953-4","volume":"383","author":"VL Feigin","year":"2014","unstructured":"Feigin VL, Forouzanfar MH, Krishnamurthi R, Mensah GA, Connor M, Bennett DA et al (2014) Global and regional burden of stroke during 1990\u20132010: findings from the Global Burden of Disease Study 2010. Lancet 383:245\u2013254","journal-title":"Lancet"},{"key":"8696_CR2","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0140-6736(14)61682-2","volume":"385","author":"GBD 2013 Mortality and Causes of Death Collaborators","year":"2015","unstructured":"GBD 2013 Mortality and Causes of Death Collaborators (2015) Global, regional, and national age\u2013sex specific all-cause and cause-specific mortality for 240 causes of death, 1990\u20132013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 385:117\u2013171","journal-title":"Lancet"},{"key":"8696_CR3","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/S1474-4422(10)70251-9","volume":"9","author":"JM Ferro","year":"2010","unstructured":"Ferro JM, Massaro AR, Mas J (2010) Aetiological diagnosis of ischaemic stroke in young adults. Lancet Neurol 9:1085\u20131096","journal-title":"Lancet Neurol"},{"key":"8696_CR4","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1212\/WNL.0000000000001027","volume":"83","author":"S Debette","year":"2014","unstructured":"Debette S, Goeggel Simonetti B, Schilling S, Martin JJ, Kloss M, Sarikaya H et al (2014) Familial occurrence and heritable connective tissue disorders in cervical artery dissection. Neurology 83:2023\u20132031","journal-title":"Neurology"},{"key":"8696_CR5","doi-asserted-by":"crossref","first-page":"e1006367","DOI":"10.1371\/journal.pgen.1006367","volume":"12","author":"SR Kiando","year":"2016","unstructured":"Kiando SR, Tucker NR, Castro-Vega LJ, Katz A, D\u2019Escamard V, Tr\u00e9ard C et al (2016) PHACTR1 is a genetic susceptibility locus for fibromuscular dysplasia supporting its complex genetic pattern of inheritance. PLoS Genet 12:e1006367","journal-title":"PLoS Genet"},{"key":"8696_CR6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.2174\/1389202917666160805152627","volume":"18","author":"C Grond-Ginsbach","year":"2017","unstructured":"Grond-Ginsbach C, Chen B, Krawczak M, Pjontek R, Ginsbach P, Jiang Y et al (2017) Genetic imbalance in patients with cervical artery dissection. Curr Genom 18:206\u2013213","journal-title":"Curr Genom"},{"key":"8696_CR7","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1212\/01.WNL.0000159739.24607.98","volume":"64","author":"W V\u00f6lker","year":"2005","unstructured":"V\u00f6lker W, Besselmann M, Dittrich R, Nabavi D, Konrad C, Dziewas R et al (2005) Generalized arteriopathy in patients with cervical artery dissection. Neurology 64:1508\u20131513","journal-title":"Neurology"},{"key":"8696_CR8","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1212\/WNL.0b013e318217e71c","volume":"76","author":"W V\u00f6lker","year":"2011","unstructured":"V\u00f6lker W, Dittrich R, Grewe S, Nassenstein I, Csiba L, Herczeg L et al (2011) The outer arterial wall layers are primarily affected in spontaneous cervical artery dissection. Neurology 76:1463\u20131471","journal-title":"Neurology"},{"key":"8696_CR9","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/WCO.0000000000000056","volume":"27","author":"S Debette","year":"2014","unstructured":"Debette S (2014) Pathophysiology and risk factors of cervical artery dissection: what have we learnt from large hospital-based cohorts? Curr Opin Neurol 27:20\u201328","journal-title":"Curr Opin Neurol"},{"key":"8696_CR10","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11910-017-0769-3","volume":"17","author":"ST Engelter","year":"2017","unstructured":"Engelter ST, Traenka C, Lyrer P (2017) Dissection of cervical and cerebral arteries. Curr Neurol Neurosci Rep 17:59","journal-title":"Curr Neurol Neurosci Rep"},{"key":"8696_CR11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12873-016-0088-z","volume":"16","author":"JE Kray","year":"2016","unstructured":"Kray JE, Dombrovskiy VY, Vogel T (2016) Carotid artery dissection and motor vehicle trauma: patient demographics, associated injuries and impact of treatment on cost and length of stay. BMC Emerg Med 16:23","journal-title":"BMC Emerg Med"},{"key":"8696_CR12","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/archneur.56.7.851","volume":"56","author":"AJ Grau","year":"1999","unstructured":"Grau AJ, Brandt T, Buggle F, Orberk E, Mytilineos J, Werle E et al (1999) Association of cervical artery dissection with recent infection. Arch Neurol 56:851\u2013856","journal-title":"Arch Neurol"},{"key":"8696_CR13","doi-asserted-by":"crossref","first-page":"e79","DOI":"10.1161\/01.STR.0000078309.56307.5C","volume":"34","author":"B Guillon","year":"2003","unstructured":"Guillon B, Berthet K, Benslamia L, Bertrand M, Bousser M, Tzourio C (2003) Infection and the risk of spontaneous cervical artery dissection: a case-control study. Stroke 34:e79\u201381","journal-title":"Stroke"},{"key":"8696_CR14","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1007\/s00330-009-1415-5","volume":"19","author":"O Naggara","year":"2009","unstructured":"Naggara O, Touz\u00e9 E, Marsico R, Leclerc X, Nguyen T, Mas J et al (2009) High-resolution MR imaging of periarterial edema associated with biological inflammation in spontaneous carotid dissection. Eur Radiol 19:2255\u20132260","journal-title":"Eur Radiol"},{"key":"8696_CR15","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1161\/STROKEAHA.110.599548","volume":"42","author":"T Pfefferkorn","year":"2011","unstructured":"Pfefferkorn T, Saam T, Rominger A, Habs M, Gerdes L, Schmidt C et al (2011) Vessel wall inflammation in spontaneous cervical artery dissection: a prospective, observational positron emission tomography, computed tomography, and magnetic resonance imaging study. Stroke 42:1563\u20131568","journal-title":"Stroke"},{"key":"8696_CR16","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00415-006-0109-z","volume":"253","author":"K Forster","year":"2006","unstructured":"Forster K, Poppert H, Conrad B, Sander D (2006) Elevated inflammatory laboratory parameters in spontaneous cervical artery dissection as compared to traumatic dissection: a retrospective case-control study. J Neurol 253:741\u2013745","journal-title":"J Neurol"},{"key":"8696_CR17","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1161\/01.STR.0000158911.74006.d6","volume":"36","author":"J Genius","year":"2005","unstructured":"Genius J, Dong-Si T, Grau AP, Lichy C (2005) Postacute C-reactive protein levels are elevated in cervical artery dissection. Stroke 36:e42\u201344","journal-title":"Stroke"},{"key":"8696_CR18","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/CIRCRESAHA.116.306853","volume":"118","author":"JH Foley","year":"2016","unstructured":"Foley JH, Conway E (2016) Cross talk pathways between coagulation and inflammation. Circ Res 118:1392\u20131408","journal-title":"Circ Res"},{"key":"8696_CR19","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/CCM.0b013e3181c98d21","volume":"38","author":"M Levi","year":"2010","unstructured":"Levi M, van der Poll Tom (2010) Inflammation and coagulation. Crit Care Med 38:26\u201334","journal-title":"Crit Care Med"},{"key":"8696_CR20","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1055\/s-0042-114742","volume":"43","author":"EB Ringelstein","year":"2016","unstructured":"Ringelstein EB, Dittrich R, Sitzer M, Arnold M, Haring HP, Frese A (2016) Spontaneous dissections of extracranial and intracranial brain arteries. Akt Neurol 43:418\u2013427","journal-title":"Akt Neurol"},{"key":"8696_CR21","first-page":"3072098","volume":"2017","author":"J Peng","year":"2017","unstructured":"Peng J, Liu Z, Luo C, Chen L, Hou X, Xiao L, Zhou Z (2017) Treatment of cervical artery dissection: antithrombotics, thrombolysis, and endovascular therapy. Biomed Res Int 2017:3072098","journal-title":"Biomed Res Int"},{"key":"8696_CR22","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1161\/STROKEAHA.110.595199","volume":"41","author":"JG Morris","year":"2010","unstructured":"Morris JG, Singh S, Fisher M (2010) Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good? Stroke 41:2985\u20132990","journal-title":"Stroke"},{"key":"8696_CR23","doi-asserted-by":"crossref","first-page":"2028","DOI":"10.1136\/annrheumdis-2014-205663","volume":"74","author":"S Sciascia","year":"2015","unstructured":"Sciascia S, Sanna G, Khamashta MA, Cuadrado MJ, Erkan D, Andreoli L, Bertolaccini M (2015) The estimated frequency of antiphospholipid antibodies in young adults with cerebrovascular events: a systematic review. Ann Rheum Dis 74:2028\u20132033","journal-title":"Ann Rheum Dis"},{"key":"8696_CR24","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/MBC.0b013e3283365770","volume":"21","author":"A Mina","year":"2010","unstructured":"Mina A, Favaloro EJ, Mohammed S, Koutts J (2010) A laboratory evaluation into the short activated partial thromboplastin time. Blood Coagul Fibrinolysis 21:152\u2013157","journal-title":"Blood Coagul Fibrinolysis"},{"key":"8696_CR25","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1161\/01.CIR.100.7.736","volume":"100","author":"AR Folsom","year":"1999","unstructured":"Folsom AR, Rosamond WD, Shahar E, Cooper LS, Aleksic N, Nieto F et al (1999) Prospective study of markers of hemostatic function with risk of ischemic stroke. The Atherosclerosis Risk in Communities (ARIC) Study Investigators. Circulation 100:736\u2013742","journal-title":"Circulation"},{"key":"8696_CR26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.2174\/1567202612666150102153447","volume":"12","author":"CY Kuo","year":"2015","unstructured":"Kuo CY, Lin CH, Kuo YW, Huang YC, Hsu HL, Lin YH et al (2015) Factor VIII levels are associated with ischemic stroke, stroke subtypes and neurological worsening. Curr Neurovasc Res 12:85\u201390","journal-title":"Curr Neurovasc Res"},{"key":"8696_CR27","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1161\/01.ATV.21.5.731","volume":"21","author":"PW Kamphuisen","year":"2001","unstructured":"Kamphuisen PW, Eikenboom JCJ, Bertina R (2001) Elevated factor VIII levels and the risk of thrombosis. Arterioscler Thromb Vasc Biol 21:731\u2013738","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"8696_CR28","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s00415-015-7954-6","volume":"263","author":"M Kneihsl","year":"2016","unstructured":"Kneihsl M, Enzinger C, Wunsch G, Khalil M, Culea V, Urbanic-Purkart T et al (2016) Poor short-term outcome in patients with ischaemic stroke and active cancer. J Neurol 263:150\u2013156","journal-title":"J Neurol"},{"key":"8696_CR29","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1001\/jamaneurol.2016.3774","volume":"73","author":"EC Miller","year":"2016","unstructured":"Miller EC, Gatollari HJ, Too G, Boehme AK, Leffert L, Elkind MSV, Willey J (2016) Risk of pregnancy-associated stroke across age groups in New York State. JAMA Neurol 73:1461\u20131467","journal-title":"JAMA Neurol"},{"key":"8696_CR30","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1182\/blood-2004-03-1042","volume":"104","author":"A Tripodi","year":"2004","unstructured":"Tripodi A, Chantarangkul V, Martinelli I, Bucciarelli P, Mannucci P (2004) A shortened activated partial thromboplastin time is associated with the risk of venous thromboembolism. Blood 104:3631\u20133634","journal-title":"Blood"},{"key":"8696_CR31","first-page":"99","volume":"28","author":"A Pinelli","year":"2014","unstructured":"Pinelli A, Trivulzio S, Rossoni G (2014) Activated partial thromboplastin time correlates with methoxyhydroxyphenylglycol in acute myocardial infarction patients: therapeutic implications for patients at cardiovascular risk. In Vivo 28:99\u2013104","journal-title":"In Vivo"},{"key":"8696_CR32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.trsl.2010.02.001","volume":"155","author":"WZ Abdullah","year":"2010","unstructured":"Abdullah WZ, Moufak SK, Yusof Z, Mohamad MS, Kamarul I (2010) Shortened activated partial thromboplastin time, a hemostatic marker for hypercoagulable state during acute coronary event. Transl Res 155:315\u2013319","journal-title":"Transl Res"},{"key":"8696_CR33","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.06.008","volume":"24","author":"C-H Lin","year":"2015","unstructured":"Lin C-H, Kuo Y-W, Kuo C-Y, Huang Y-C, Hsu C-Y, Hsu H-L et al (2015) Shortened activated partial thromboplastin time is associated with acute ischemic stroke, stroke severity, and neurological worsening. J Stroke Cerebrovasc Dis 24:2270\u20132276","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"8696_CR34","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.amjcard.2010.12.027","volume":"107","author":"A Shimony","year":"2011","unstructured":"Shimony A, Filion KB, Mottillo S, Dourian T, Eisenberg M (2011) Meta-analysis of usefulness of D-dimer to diagnose acute aortic dissection. Am J Cardiol 107:1227\u20131234","journal-title":"Am J Cardiol"},{"key":"8696_CR35","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1001\/jama.2014.2135","volume":"311","author":"M Righini","year":"2014","unstructured":"Righini M, van Es J, Den Exter PL, Roy P-M, Verschuren F, Ghuysen A et al (2014) Age-adjusted D-dimer cutoff levels to rule out pulmonary embolism: the ADJUST-PE study. JAMA 311:1117\u20131124","journal-title":"JAMA"},{"key":"8696_CR36","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1161\/01.STR.0000089015.51603.CC","volume":"34","author":"PJ Lindsberg","year":"2003","unstructured":"Lindsberg PJ, Grau A (2003) Inflammation and infections as risk factors for ischemic stroke. Stroke 34:2518\u20132532","journal-title":"Stroke"},{"key":"8696_CR37","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1111\/ene.12201","volume":"20","author":"C Grond-Ginsbach","year":"2013","unstructured":"Grond-Ginsbach C, Giossi A, Aksay SS, Engelter ST, Lyrer PA, Metso T et al (2013) Elevated peripheral leukocyte counts in acute cervical artery dissection. Eur J Neurol 20:1405\u20131410","journal-title":"Eur J Neurol"},{"key":"8696_CR38","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00134-002-1209-6","volume":"28","author":"P P\u00f3voa","year":"2002","unstructured":"P\u00f3voa P (2002) C-reactive protein: a valuable marker of sepsis. Intensive Care Med 28:235\u2013243","journal-title":"Intensive Care Med"},{"key":"8696_CR39","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00415-003-0174-5","volume":"250","author":"R Dziewas","year":"2003","unstructured":"Dziewas R, Konrad C, Drager B, Evers S, Besselmann M, Ludemann P et al (2003) Cervical artery dissection\u2014clinical features, risk factors, therapy and outcome in 126 patients. J Neurol 250:1179\u20131184","journal-title":"J Neurol"},{"key":"8696_CR40","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1212\/01.wnl.0000265595.50915.1e","volume":"69","author":"R Dittrich","year":"2007","unstructured":"Dittrich R, Nassenstein I, Bachmann R, Maintz D, Nabavi DG, Heindel W et al (2007) Polyarterial clustered recurrence of cervical artery dissection seems to be the rule. Neurology 69:180\u2013186","journal-title":"Neurology"},{"key":"8696_CR41","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1212\/WNL.55.11.1738","volume":"55","author":"CA Molina","year":"2000","unstructured":"Molina CA, Alvarez-Sab\u00edn J, Schonewille W, Montaner J, Rovira A, Abilleira S et al (2000) Cerebral microembolism in acute spontaneous internal carotid artery dissection. Neurology 55:1738\u20131740","journal-title":"Neurology"},{"key":"8696_CR42","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S1474-4422(15)70018-9","volume":"14","author":"HS Markus","year":"2015","unstructured":"Markus HS, Hayter E, Levi C, Feldman A, Venables G, Norris J, CADISS trial investigators (2015) Antiplatelet treatment compared with anticoagulation treatment for cervical artery dissection (CADISS): a randomised trial. Lancet Neurol 14:361\u2013367","journal-title":"Lancet Neurol"},{"key":"8696_CR43","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1161\/01.STR.26.9.1520","volume":"26","author":"AJ Grau","year":"1995","unstructured":"Grau AJ, Buggle F, Steichen-Wiehn C, Heindl S, Banerjee T, Seitz R et al (1995) Clinical and biochemical analysis in infection-associated stroke. Stroke 26:1520\u20131526","journal-title":"Stroke"},{"key":"8696_CR44","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/00001721-200112000-00015","volume":"12","author":"JW Yarnell","year":"2001","unstructured":"Yarnell JW, Sweetnam PM, Rumley A, Lowe GD (2001) Lifestyle factors and coagulation activation markers: the Caerphilly Study. Blood Coagul Fibrinolysis 12:721\u2013728","journal-title":"Blood Coagul Fibrinolysis"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-017-8696-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-017-8696-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-017-8696-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,2,10]],"date-time":"2018-02-10T09:33:37Z","timestamp":1518255217000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-017-8696-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,9]]},"references-count":44,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["8696"],"URL":"https:\/\/doi.org\/10.1007\/s00415-017-8696-4","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,9]]}}}