{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T07:17:03Z","timestamp":1784099823396,"version":"3.55.0"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100011110","name":"UCB","doi-asserted-by":"publisher","award":["Unrestricted grant"],"award-info":[{"award-number":["Unrestricted grant"]}],"id":[{"id":"10.13039\/100011110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1007\/s00415-018-09179-8","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T04:01:27Z","timestamp":1546488087000},"page":"636-641","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Daytime sleepiness may be an independent symptom unrelated to sleep quality in Parkinson\u2019s disease"],"prefix":"10.1007","volume":"266","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2845-1332","authenticated-orcid":false,"given":"Claudio","family":"Liguori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola Biagio","family":"Mercuri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Albanese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrica","family":"Olivola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Pierantozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,1,3]]},"reference":[{"key":"9179_CR1","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S1474-4422(06)70373-8","volume":"5","author":"KR Chaudhuri","year":"2006","unstructured":"Chaudhuri KR, Healy DG, Schapira AH, National Institute for Clinical Excellence (2006) Non-motor symptoms of Parkinson\u2019s disease: diagnosis and management. Lancet Neurol 5:235\u2013245","journal-title":"Lancet Neurol"},{"key":"9179_CR2","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/mds.23462","volume":"26","author":"P Martinez-Martin","year":"2011","unstructured":"Martinez-Martin P, Rodriguez-Blazquez C, Kurtis MM, Chaudhuri KR, NMSS Validation Group (2011) The impact of non-motor symptoms on health-related quality of life of patients with Parkinson\u2019s disease. Mov Disord 26:399\u2013406. \n                    https:\/\/doi.org\/10.1002\/mds.23462","journal-title":"Mov Disord"},{"issue":"Suppl 3","key":"9179_CR3","doi-asserted-by":"publisher","first-page":"S101","DOI":"10.1016\/S1353-8020(09)70792-8","volume":"15","author":"I Arnulf","year":"2009","unstructured":"Arnulf I, Leu-Semenescu S (2009) Sleepiness in Parkinson\u2019s disease. Parkinsonism Relat Disord 15(Suppl 3):S101\u2013S104. \n                    https:\/\/doi.org\/10.1016\/S1353-8020(09)70792-8","journal-title":"Parkinsonism Relat Disord"},{"key":"9179_CR4","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1001\/archneur.59.6.986","volume":"59","author":"PE O\u2019Suilleabhain","year":"2002","unstructured":"O\u2019Suilleabhain PE, Dewey RB Jr (2002) Contributions of dopaminergic drugs and disease severity to daytime sleepiness in Parkinson disease. Arch Neurol 59:986\u2013689","journal-title":"Arch Neurol"},{"key":"9179_CR5","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/j.parkreldis.2016.01.020","volume":"24","author":"K Zhu","year":"2016","unstructured":"Zhu K, van Hilten JJ, Marinus J (2016) Course and risk factors for excessive daytime sleepiness in Parkinson\u2019s disease. Parkinsonism Relat Disord 24:34\u201340. \n                    https:\/\/doi.org\/10.1016\/j.parkreldis.2016.01.020","journal-title":"Parkinsonism Relat Disord"},{"key":"9179_CR6","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1136\/jnnp-2016-315023","volume":"88","author":"AW Amara","year":"2017","unstructured":"Amara AW, Chahine LM, Caspell-Garcia C, Long JD, Coffey C, H\u00f6gl B, Videnovic A, Iranzo A, Mayer G, Foldvary-Schaefer N, Postuma R, Oertel W, Lasch S, Marek K, Simuni T, Parkinson\u2019s Progression Markers Initiative (2017) Longitudinal assessment of excessive daytime sleepiness in early Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 88:653\u2013662. \n                    https:\/\/doi.org\/10.1136\/jnnp-2016-315023","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"9179_CR7","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1016\/j.sleep.2017.03.026","volume":"35","author":"JA Albers","year":"2017","unstructured":"Albers JA, Chand P, Anch AM (2017) Multifactorial sleep disturbance in Parkinson\u2019s disease. Sleep Med 35:41\u201348. \n                    https:\/\/doi.org\/10.1016\/j.sleep.2017.03.026","journal-title":"Sleep Med"},{"key":"9179_CR8","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1212\/01.wnl.0000233980.25978.9d","volume":"67","author":"MD Gjerstad","year":"2006","unstructured":"Gjerstad MD, Alves G, Wentzel-Larsen T, Aarsland D, Larsen JP (2006) Excessive daytime sleepiness in Parkinson disease: is it the drugs or the disease? Neurology 67:853\u2013858","journal-title":"Neurology"},{"key":"9179_CR9","doi-asserted-by":"publisher","first-page":"1908","DOI":"10.1212\/WNL.52.9.1908","volume":"52","author":"S Frucht","year":"1999","unstructured":"Frucht S, Rogers JD, Greene PE, Gordon MF, Fahn S (1999) Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology 52:1908\u20131910","journal-title":"Neurology"},{"key":"9179_CR10","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1212\/WNL.57.8.1392","volume":"57","author":"WG Ondo","year":"2001","unstructured":"Ondo WG, Dat Vuong K, Khan H, Atassi F, Kwak C, Jankovic J (2001) Daytime sleepiness and other sleep disorders in Parkinson\u2019s disease. Neurology 57:1392\u20131396","journal-title":"Neurology"},{"key":"9179_CR11","doi-asserted-by":"publisher","first-page":"1242","DOI":"10.1001\/archneur.62.8.1242","volume":"62","author":"J Avorn","year":"2005","unstructured":"Avorn J, Schneeweiss S, Sudarsky LR, Benner J, Kiyota Y, Levin R, Glynn RJ (2005) Sudden uncontrollable somnolence and medication use in Parkinson disease. Arch Neurol 62:1242\u20131248","journal-title":"Arch Neurol"},{"issue":"8","key":"9179_CR12","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1007\/s00415-006-0483-6","volume":"254","author":"S Happe","year":"2007","unstructured":"Happe S, Baier PC, Helmschmied K, Meller J, Tatsch K, Paulus W (2007) Association of daytime sleepiness with nigrostriatal dopaminergic degeneration in early Parkinson\u2019s disease. J Neurol 254(8):1037\u20131043","journal-title":"J Neurol"},{"key":"9179_CR13","doi-asserted-by":"publisher","first-page":"1019","DOI":"10.1212\/WNL.58.7.1019","volume":"58","author":"I Arnulf","year":"2002","unstructured":"Arnulf I, Konofal E, Merino-Andreu M, Houeto JL, Mesnage V, Welter ML, Lacomblez L, Golmard JL, Derenne JP, Agid Y (2002) Parkinson\u2019s disease and sleepiness: an integral part of PD. Neurology 58:1019\u20131024","journal-title":"Neurology"},{"key":"9179_CR14","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1038\/ncpneuro0775","volume":"4","author":"VC Cock De","year":"2008","unstructured":"De Cock VC, Vidailhet M, Arnulf I (2008) Sleep disturbances in patients with parkinsonism. Nat Clin Pract Neurol 4:254\u2013266. \n                    https:\/\/doi.org\/10.1038\/ncpneuro0775","journal-title":"Nat Clin Pract Neurol"},{"key":"9179_CR15","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00415-005-0614-5","volume":"252","author":"C Baumann","year":"2005","unstructured":"Baumann C, Ferini-Strambi L, Waldvogel D, Werth E, Bassetti CL (2005) Parkinsonism with excessive daytime sleepiness\u2014a narcolepsy-like disorder? J Neurol 252:139\u2013145","journal-title":"J Neurol"},{"issue":"4","key":"9179_CR16","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1097\/WCO.0b013e328305044d","volume":"21","author":"I Arnulf","year":"2008","unstructured":"Arnulf I, Leu S, Oudiette D (2008) Abnormal sleep and sleepiness in Parkinson\u2019s disease. Curr Opin Neurol 21(4):472\u2013477","journal-title":"Curr Opin Neurol"},{"key":"9179_CR17","doi-asserted-by":"publisher","first-page":"463","DOI":"10.1001\/jamaneurol.2013.6239","volume":"71","author":"A Videnovic","year":"2014","unstructured":"Videnovic A, Noble C, Reid KJ, Peng J, Turek FW, Marconi A, Rademaker AW, Simuni T, Zadikoff C, Zee PC (2014) Circadian melatonin rhythm and excessive daytime sleepiness in Parkinson disease. JAMA Neurol 71:463\u2013469. \n                    https:\/\/doi.org\/10.1001\/jamaneurol.2013.6239","journal-title":"JAMA Neurol"},{"key":"9179_CR18","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1002\/mds.21727","volume":"23","author":"D Verbaan","year":"2008","unstructured":"Verbaan D, van Rooden SM, Visser M, Marinus J, van Hilten JJ (2008) Nighttime sleep problems and daytime sleepiness in Parkinson\u2019s disease. Mov Disord 23:35\u201341","journal-title":"Mov Disord"},{"key":"9179_CR19","doi-asserted-by":"publisher","first-page":"967","DOI":"10.1093\/sleep\/27.5.967","volume":"27","author":"S Stevens","year":"2004","unstructured":"Stevens S, Cormella CL, Stepanski EJ (2004) Daytime sleepiness and alertness in patients with Parkinson disease. Sleep 27:967\u2013972","journal-title":"Sleep"},{"key":"9179_CR20","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1111\/ane.12378","volume":"132","author":"A H\u00f6glund","year":"2015","unstructured":"H\u00f6glund A, Broman JE, Palhagen S, Fredrikson S, Hagell P (2015) Is excessive daytime sleepiness a separate manifestation in Parkinson\u2019s disease? Acta Neurol Scand 132:97\u2013104. \n                    https:\/\/doi.org\/10.1111\/ane.12378","journal-title":"Acta Neurol Scand"},{"key":"9179_CR21","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.sleep.2016.01.016","volume":"21","author":"M Pierantozzi","year":"2016","unstructured":"Pierantozzi M, Placidi F, Liguori C, Albanese M, Imbriani P, Marciani MG, Mercuri NB, Stanzione P, Stefani A (2016) Rotigotine may improve sleep architecture in Parkinson\u2019s disease: a double-blind, randomized, placebo-controlled polysomnographic study. Sleep Med 21:140\u2013144. \n                    https:\/\/doi.org\/10.1016\/j.sleep.2016.01.016","journal-title":"Sleep Med"},{"issue":"2","key":"9179_CR22","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1007\/s40261-013-0150-5","volume":"34","author":"W Cawello","year":"2014","unstructured":"Cawello W, Kim SR, Braun M, Elshoff JP, Ikeda J, Funaki T (2014) Pharmacokinetics, safety and tolerability of rotigotine transdermal patch in healthy Japanese and Caucasian subjects. Clin Drug Investig 34(2):95\u2013105","journal-title":"Clin Drug Investig"},{"key":"9179_CR23","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1136\/jnnp.55.3.181","volume":"55","author":"AJ Hughes","year":"1992","unstructured":"Hughes AJ, Daniel SE, Kilford L, Lees AJ (1992) Accuracy of clinical diagnosis of idiopathic Parkinson\u2019s disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 55:181\u2013184","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"9179_CR24","volume-title":"The AASM manual for the scoring of sleep and associated events: rules, terminology, and technical specification","year":"2007","unstructured":"Iber C, Ancoli-Israel S, Chesson A, Quan SF (eds) (2007) The AASM manual for the scoring of sleep and associated events: rules, terminology, and technical specification, 1st edn. American Academy of Sleep Medicine, Westchester","edition":"1"},{"key":"9179_CR25","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1007\/s10072-011-0826-7","volume":"33","author":"MT Pellecchia","year":"2012","unstructured":"Pellecchia MT, Antonini A, Bonuccelli U, Fabbrini G, Ferini Strambi L, Stocchi F, Battaglia A, Barone P (2012) Observational study of sleep-related disorders in Italian patients with Parkinson\u2019s disease: usefulness of the Italian version of Parkinson\u2019s disease sleep scale. Neurol Sci 33:689\u2013694. \n                    https:\/\/doi.org\/10.1007\/s10072-011-0826-7","journal-title":"Neurol Sci"},{"key":"9179_CR26","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1093\/sleep\/14.6.540","volume":"14","author":"MW Johns","year":"1991","unstructured":"Johns MW (1991) A new method for measuring daytime sleepiness: the Epworth sleepiness scale. Sleep 14:540\u2013545","journal-title":"Sleep"},{"key":"9179_CR27","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1007\/s100720300004","volume":"23","author":"L Vignatelli","year":"2003","unstructured":"Vignatelli L, Plazzi G, Barbato A, Ferini-Strambi L, Manni R, Pompei F, D\u2019Alessandro R, GINSEN (Gruppo Italiano Narcolessia Studio Epidemiologico Nazionale) (2003) Italian version of the Epworth sleepiness scale: external validity. Neurol Sci 23:295\u2013300","journal-title":"Neurol Sci"},{"key":"9179_CR28","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","volume":"24","author":"H Braak","year":"2003","unstructured":"Braak H, Del Tredici K, R\u00fcb U, de Vos RA, Jansen Steur EN, Braak E (2003) Staging of brain pathology related to sporadic Parkinson\u2019s disease. Neurobiol Aging 24:197\u2013211","journal-title":"Neurobiol Aging"},{"key":"9179_CR29","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1002\/mds.27200","volume":"32","author":"S Sohail","year":"2017","unstructured":"Sohail S, Yu L, Schneider JA, Bennett DA, Buchman AS, Lim ASP (2017) Sleep fragmentation and Parkinson\u2019s disease pathology in older adults without Parkinson\u2019s disease. Mov Disord 32:1729\u20131737. \n                    https:\/\/doi.org\/10.1002\/mds.27200","journal-title":"Mov Disord"},{"key":"9179_CR30","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1093\/brain\/awm097","volume":"130","author":"TC Thannickal","year":"2007","unstructured":"Thannickal TC, Lai YY, Siegel JM (2007) Hypocretin (orexin) cell loss in Parkinson\u2019s disease. Brain 130:1586\u20131595","journal-title":"Brain"},{"key":"9179_CR31","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00441-004-0956-9","volume":"318","author":"H Braak","year":"2004","unstructured":"Braak H, Ghebremedhin E, Rub U, Bratzke H, Del Tredici K (2004) Stages in the development of Parkinson\u2019s disease-related pathology. Cell Tissue Res 318:121\u2013134","journal-title":"Cell Tissue Res"},{"key":"9179_CR32","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.smrv.2011.12.003","volume":"16","author":"CW Berridge","year":"2012","unstructured":"Berridge CW, Schmeichel BE, Espana RA (2012) Noradrenergic modulation of wakefulness\/arousal. Sleep Med Rev 16:187\u2013197. \n                    https:\/\/doi.org\/10.1016\/j.smrv.2011.12.003","journal-title":"Sleep Med Rev"},{"key":"9179_CR33","doi-asserted-by":"publisher","first-page":"1442","DOI":"10.1212\/01.wnl.0000183056.89590.0d","volume":"65","author":"RD Abbott","year":"2005","unstructured":"Abbott RD, Ross GW, White LR, Tanner CM, Masaki KH, Nelson JS, Curb JD, Petrovitch H (2005) Excessive daytime sleepiness and subsequent development of Parkinson disease. Neurology 65:1442\u20131446","journal-title":"Neurology"},{"key":"9179_CR34","doi-asserted-by":"publisher","first-page":"1032","DOI":"10.1093\/aje\/kwq478","volume":"173","author":"J Gao","year":"2011","unstructured":"Gao J, Huang X, Park Y, Hollenbeck A, Blair A, Schatzkin A, Chen H (2011) Daytime napping, nighttime sleeping, and Parkinson disease. Am J Epidemiol 173:1032\u20131038. \n                    https:\/\/doi.org\/10.1093\/aje\/kwq478","journal-title":"Am J Epidemiol"},{"key":"9179_CR35","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1002\/mds.26077","volume":"30","author":"C Pont-Sunyer","year":"2015","unstructured":"Pont-Sunyer C, Hotter A, Gaig C, Seppi K, Compta Y, Katzenschlager R, Mas N, Hofeneder D, Br\u00fccke T, Bay\u00e9s A, Wenzel K, Infante J, Zach H, Pirker W, Posada IJ, \u00c1lvarez R, Ispierto L, De F\u00e0bregues O, Call\u00e9n A, Palas\u00ed A, Aguilar M, Mart\u00ed MJ, Valldeoriola F, Salamero M, Poewe W, Tolosa E (2015) The onset of nonmotor symptoms in Parkinson\u2019s disease (the ONSET PD study). Mov Disord 30:229\u2013237. \n                    https:\/\/doi.org\/10.1002\/mds.26077","journal-title":"Mov Disord"},{"key":"9179_CR36","doi-asserted-by":"publisher","first-page":"3724148","DOI":"10.1155\/2016\/3724148","volume":"2016","author":"G Calandra-Buonaura","year":"2016","unstructured":"Calandra-Buonaura G, Guaraldi P, Doria A, Zanigni S, Nassetti S, Favoni V, Cevoli S, Provini F, Cortelli P (2016) Rotigotine objectively improves sleep in Parkinson\u2019s disease: an open-label pilot study with actigraphic recording. Parkinsons Dis 2016:3724148. \n                    https:\/\/doi.org\/10.1155\/2016\/3724148","journal-title":"Parkinsons Dis"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-018-09179-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-018-09179-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-018-09179-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T19:39:34Z","timestamp":1577993974000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-018-09179-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["9179"],"URL":"https:\/\/doi.org\/10.1007\/s00415-018-09179-8","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,3]]},"assertion":[{"value":"14 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 December 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 December 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This work was supported by an unrestricted grant from UCB. The authors declare no other financial disclosures or conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The trial was approved by the local ethic committee (Tor Vergata CE135\/2011; code EU 2011\/004757\/12) and was registered at Clinical Trials and reported according to CONSORT guidelines.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"All patients gave written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}