{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T16:28:57Z","timestamp":1792945737750,"version":"4.5.0"},"reference-count":50,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,4,7]],"date-time":"2018-04-07T00:00:00Z","timestamp":1523059200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100010573","name":"Dioraphte Foundation","doi-asserted-by":"crossref","award":["Grant 09-02-03-00"],"award-info":[{"award-number":["Grant 09-02-03-00"]}],"id":[{"id":"10.13039\/501100010573","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Association for Frontemporal Dementias Research","award":["Grant 2009"],"award-info":[{"award-number":["Grant 2009"]}]},{"DOI":"10.13039\/501100010969","name":"Alzheimer Nederland","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010969","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Memorabel ZonMw","award":["Grant 733050102"],"award-info":[{"award-number":["Grant 733050102"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1007\/s00415-018-8850-7","type":"journal-article","created":{"date-parts":[[2018,4,7]],"date-time":"2018-04-07T06:15:04Z","timestamp":1523081704000},"page":"1381-1392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia"],"prefix":"10.1007","volume":"265","author":[{"given":"Lize C.","family":"Jiskoot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Panman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"van Asseldonk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanne","family":"Franzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lieke H. H.","family":"Meeter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Donker Kaat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma L.","family":"van der Ende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise G. P.","family":"Dopper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinier","family":"Timman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"van Minkelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"van Swieten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janne M.","family":"Papma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,4,7]]},"reference":[{"key":"8850_CR1","doi-asserted-by":"publisher","first-page":"3091","DOI":"10.1093\/brain\/awl267","volume":"129","author":"JS Snowden","year":"2006","unstructured":"Snowden JS, Pickering-Brown SM, Mackenzie IR et al (2006) Progranulin gene mutations associated with frontotemporal dementia and progressive non-fluent aphasia. Brain 129:3091\u20133102","journal-title":"Brain"},{"key":"8850_CR2","doi-asserted-by":"publisher","first-page":"f4827","DOI":"10.1136\/bmj.f4827","volume":"347","author":"JD Warren","year":"2013","unstructured":"Warren JD, Rohrer JD, Rossor MN (2013) Clinical review. Frontotemporal dementia. BMJ 347:f4827","journal-title":"BMJ"},{"key":"8850_CR3","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1093\/brain\/awr179","volume":"134","author":"K Rascovsky","year":"2011","unstructured":"Rascovsky K, Hodges JR, Knopman D et al (2011) Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia. Brain 134:2456\u20132477","journal-title":"Brain"},{"key":"8850_CR4","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1136\/jnnp.2010.212225","volume":"82","author":"H Seelaar","year":"2011","unstructured":"Seelaar H, Rohrer JD, Pijnenburg Y et al (2011) Clinical, genetic and pathological heterogeneity of frontotemporal dementia: a review. J Neurol Neurosurg Psychiatry 82:476\u2013486","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"8850_CR5","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.neuropsychologia.2009.08.001","volume":"48","author":"M Adenzato","year":"2010","unstructured":"Adenzato M, Cavallo M, Enrici I (2010) Theory of mind ability in the behavioural variant of frontotemporal dementia: an analysis of the neural, cognitive, and social levels. Neuropsychologia 48:2\u201312","journal-title":"Neuropsychologia"},{"issue":"11","key":"8850_CR6","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1212\/WNL.0b013e31821103e6","volume":"76","author":"ML Gorno-Tempini","year":"2011","unstructured":"Gorno-Tempini ML, Hillis AE, Weintraub S et al (2011) Classification of primary progressive aphasia and its variants. Neurology 76(11):1006\u20131014","journal-title":"Neurology"},{"issue":"6","key":"8850_CR7","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1097\/WCO.0b013e32834cd442","volume":"24","author":"JD Rohrer","year":"2011","unstructured":"Rohrer JD, Warren JD (2011) Phenotypic signatures of genetic frontotemporal dementia. Curr Opin Neurol 24(6):542\u2013549","journal-title":"Curr Opin Neurol"},{"key":"8850_CR8","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1212\/WNL.0000000000002895","volume":"87","author":"LC Jiskoot","year":"2016","unstructured":"Jiskoot LC, Dopper EGP, den Heijer T et al (2016) Presymptomatic cognitive decline in familial frontotemporal dementia: a longitudinal study. Neurology 87:384\u2013391","journal-title":"Neurology"},{"key":"8850_CR9","doi-asserted-by":"publisher","first-page":"e19","DOI":"10.1212\/WNL.0000000000000583","volume":"83","author":"EG Dopper","year":"2014","unstructured":"Dopper EG, Rombouts SA, Jiskoot LC et al (2014) Structural and functional brain connectivity in presymptomatic familial frontotemporal dementia. Neurology 83:e19\u2013e26","journal-title":"Neurology"},{"key":"8850_CR10","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/S1474-4422(14)70324-2","volume":"14","author":"JD Rohrer","year":"2015","unstructured":"Rohrer JD, Nicholas JM, Cash DM et al (2015) Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the genetic frontotemporal dementia initiative (GENFI) study: a cross-sectional analysis. Lancet Neurol 14:253\u2013262","journal-title":"Lancet Neurol"},{"key":"8850_CR11","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/ana.10024","volume":"50","author":"DH Geschwind","year":"2001","unstructured":"Geschwind DH, Robidoux J, Alarc\u00f3n M et al (2001) Dementia and neurodevelopmental predisposition: cognitive dysfunction in presymptomatic subjects precedes dementia by decades in frontotemporal dementia. Ann Neurol 50:741\u2013746","journal-title":"Ann Neurol"},{"key":"8850_CR12","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1017\/S1355617714000551","volume":"20","author":"BJ Hallam","year":"2014","unstructured":"Hallam BJ, Jacova C, Hsiung GYR et al (2014) Early neuropsychological characteristics of progranulin mutation carriers. J Int Neuropsychol Soc 20:694\u2013703","journal-title":"J Int Neuropsychol Soc"},{"key":"8850_CR13","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.nicl.2016.08.001","volume":"12","author":"EG Dopper","year":"2016","unstructured":"Dopper EG, Chalos V, Ghariq E et al (2016) Cerebral blood flow in presymptomatic MAPT and GRN mutation carriers: a longitudinal arterial spin labeling study. Neuroimage Clin 12:460\u2013465","journal-title":"Neuroimage Clin"},{"issue":"2","key":"8850_CR14","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1176\/jnp.12.2.233","volume":"12","author":"DI Kaufer","year":"2000","unstructured":"Kaufer DI, Cummings JL, Ketchel P et al (2000) Validation of the NPI-Q, a brief clinical form of the neuropsychatric inventory. J Neuropsychiatry Clin Neurosci 12(2):233\u2013239","journal-title":"J Neuropsychiatry Clin Neurosci"},{"issue":"3","key":"8850_CR15","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR (1975) \u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189\u2013198","journal-title":"J Psychiatr Res"},{"issue":"11","key":"8850_CR16","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1212\/WNL.55.11.1621","volume":"55","author":"B Dubois","year":"2000","unstructured":"Dubois B, Slachevsky A, Litvan I, Pillon B (2000) The FAB: a frontal assessment battery at bedside. Neurology 55(11):1621\u20131626","journal-title":"Neurology"},{"key":"8850_CR17","volume-title":"The Boston Naming Test","author":"E Kaplan","year":"1978","unstructured":"Kaplan E, Goodglass H, Weintraub S (1978) The Boston Naming Test. Lea & Febiger, Philadelphia"},{"key":"8850_CR18","volume-title":"Semantische Associatie test","author":"E Visch-Brink","year":"2005","unstructured":"Visch-Brink E, Stronks D, Denes G (2005) Semantische Associatie test. Swets & Zeitlinger, Lisse"},{"issue":"8","key":"8850_CR19","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1007\/s00415-003-1134-9","volume":"250","author":"SJ Doesborgh","year":"2003","unstructured":"Doesborgh SJ, van de Sandt-Koenderman WM, Dippel DW et al (2003) Linguistic deficits in the acute phase of stroke. J Neurol 250(8):977\u2013982","journal-title":"J Neurol"},{"key":"8850_CR20","volume-title":"Primary mental abilities","author":"LLT Thurstone","year":"1962","unstructured":"Thurstone LLT, Thurstone TG (1962) Primary mental abilities. Science Research Associates, Chicago"},{"key":"8850_CR21","volume-title":"Manual of directions and scoring","author":"Army Individual Test Battery","year":"1994","unstructured":"Battery Army Individual Test (1994) Manual of directions and scoring. War Department, Adjutant General\u2019s office, Washington, DC"},{"key":"8850_CR22","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1037\/h0054651","volume":"18","author":"JR Stroop","year":"1935","unstructured":"Stroop JR (1935) Studies of interference in serial verbal reactions. J Exp Psychol 18:643\u2013662","journal-title":"J Exp Psychol"},{"key":"8850_CR23","volume-title":"WAIS-III nederlandse bewerking, technische handleiding","author":"D Wechsler","year":"2005","unstructured":"Wechsler D (2005) WAIS-III nederlandse bewerking, technische handleiding. Harcourt Test Publishers, Lisse"},{"key":"8850_CR24","volume-title":"Maastricht aging study: determinants of cognitive aging","author":"J Jolles","year":"1995","unstructured":"Jolles J, Houx PJ, van Boxtel MPJ, Ponds RWHM (1995) Maastricht aging study: determinants of cognitive aging. Neuropsych Publishers, Maastricht"},{"key":"8850_CR25","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/S0010-9452(76)80035-4","volume":"12","author":"HE Nelson","year":"1976","unstructured":"Nelson HE (1976) A modified card sorting test sensitive to frontal lobe defects. Cortex 12:313\u2013324","journal-title":"Cortex"},{"issue":"3","key":"8850_CR26","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/S0010-0277(99)00005-0","volume":"70","author":"F Happe","year":"1999","unstructured":"Happe F, Brownell H, Winner E (1999) Acquired \u2018theory of mind\u2019 impairments following stroke. Cognition 70(3):211\u2013240","journal-title":"Cognition"},{"key":"8850_CR27","volume-title":"Pictures of facial affect","author":"P Ekman","year":"1976","unstructured":"Ekman P, Friesen WV (1976) Pictures of facial affect. Consulting Psychologists Press, Palo Alto"},{"key":"8850_CR28","volume-title":"L\u2019examen clinique en psychologie","author":"A Rey","year":"1958","unstructured":"Rey A (1958) L\u2019examen clinique en psychologie. Presses Universitaires de France, Paris"},{"issue":"2","key":"8850_CR29","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1136\/jnnp.73.2.126","volume":"73","author":"J Lindeboom","year":"2002","unstructured":"Lindeboom J, Schmand B, Tulner L et al (2002) Visual association test to detect early dementia of the Alzheimer type. J Neurol Neurosurg Psychiatry 73(2):126\u2013133","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"8850_CR30","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1136\/jnnp.64.5.588","volume":"64","author":"DR Royall","year":"1998","unstructured":"Royall DR, Cordes JA, Polk M (1998) CLOX: an executive clock drawing task. J Neurol Neurosurg Psychiatry 64:588\u2013594","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"8850_CR31","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1001\/archpsyc.1961.01710120031004","volume":"4","author":"AT Beck","year":"1961","unstructured":"Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561\u2013571","journal-title":"Arch Gen Psychiatry"},{"key":"8850_CR32","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1002\/1097-0142(1950)3:1<32::AID-CNCR2820030106>3.0.CO;2-3","volume":"3","author":"WJ Youden","year":"1950","unstructured":"Youden WJ (1950) Index for rating diagnostic tests. Cancer 3:32\u201335","journal-title":"Cancer"},{"key":"8850_CR33","first-page":"1086","volume":"18","author":"M Barandiaran","year":"2012","unstructured":"Barandiaran M, Estanga A, Moreno F et al (2012) Neuropsychological features of asymptomatic c.709-1G\u2009>\u2009A progranulin mutation carriers. JINS 18:1086\u20131090","journal-title":"JINS"},{"issue":"2","key":"8850_CR34","first-page":"162","volume":"76","author":"JC Janssen","year":"2005","unstructured":"Janssen JC, Schott JM, Cipolotti L et al (2005) Mapping the onset and progression of atrophy in familial frontotemporal lobar degeneration. JNNP 76(2):162\u2013168","journal-title":"JNNP"},{"issue":"8","key":"8850_CR35","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1038\/ncpneuro0869","volume":"4","author":"JD Rohrer","year":"2008","unstructured":"Rohrer JD, Warren JD, Barnes J et al (2008) Mapping the progression of progranulin-associated frontotemporal lobar degeneration. Nat Clin Pract Neurol 4(8):455\u2013460","journal-title":"Nat Clin Pract Neurol"},{"issue":"5","key":"8850_CR36","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/S1353-8020(02)00098-6","volume":"9","author":"TJ Ferman","year":"2003","unstructured":"Ferman TJ, McRae CA, Arvanitakis Z et al (2003) Early and pre-symptomatic neuropsychological dysfunction in the PPND family with the N279K tau mutation. Parkinsonism Relat Disord 9(5):265\u2013270","journal-title":"Parkinsonism Relat Disord"},{"key":"8850_CR37","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/2047-9158-3-12","volume":"3","author":"JB Miller","year":"2014","unstructured":"Miller JB, Banks SJ, L\u00e9ger GC, Cummings JL (2014) Randomized controlled trials in frontotemporal dementia: cognitive and behavioral outcomes. Transl Neurodegener 3:12","journal-title":"Transl Neurodegener"},{"key":"8850_CR38","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1212\/01.wnl.0000343851.46573.67","volume":"72","author":"JL Whitwell","year":"2009","unstructured":"Whitwell JL, Jack CR, Boeve BF et al (2009) Voxel-based morphometry patterns of atrophy in FTLD with mutations in MAPT or PGRN. Neurology 72:813\u2013820","journal-title":"Neurology"},{"key":"8850_CR39","doi-asserted-by":"publisher","first-page":"1070","DOI":"10.1016\/j.neuroimage.2009.12.088","volume":"53","author":"JD Rohrer","year":"2010","unstructured":"Rohrer JD, Ridgway GR, Modat M et al (2010) Distinct profiles of brain atrophy in frontotemporal lobar degeneration caused by progranulin and tau mutations. Neuroimage 53:1070\u20131076","journal-title":"Neuroimage"},{"issue":"9","key":"8850_CR40","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1093\/brain\/aww163","volume":"139","author":"R Smith","year":"2017","unstructured":"Smith R, Puschmann A, Sch\u00f6ll M et al (2017) 18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers. Brain 139(9):2372\u20132379","journal-title":"Brain"},{"key":"8850_CR41","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1097\/WAD.0b013e3181cf35ec","volume":"24","author":"N Tolboom","year":"2010","unstructured":"Tolboom N, Koedam ELGE, Schott JM et al (2010) Dementia mimicking Alzheimer\u2019s disease owing to a tau mutation: CSF and PET findings. Alzheimers Dis Assoc Disord 24:303\u2013307","journal-title":"Alzheimers Dis Assoc Disord"},{"key":"8850_CR42","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1093\/brain\/aws011","volume":"135","author":"M Hornberger","year":"2012","unstructured":"Hornberger M, Piguet O (2012) Episodic memory in frontotemporal dementia: a critical review. Brain 135:678\u2013692","journal-title":"Brain"},{"issue":"8","key":"8850_CR43","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1212\/WNL.0000000000003636","volume":"88","author":"S Spina","year":"2017","unstructured":"Spina S, Schonhaut D, Boeve BF et al (2017) Frontotemporal dementia with the V337M MAPT mutation. Neurology 88(8):758\u2013766","journal-title":"Neurology"},{"key":"8850_CR44","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3109\/21678421.2015.1074700","volume":"16","author":"JS Snowden","year":"2015","unstructured":"Snowden JS, Adams J, Harris J et al (2015) Distinct clinical and pathological phenotypes in frontotemporal dementia associated with MAPT, PGRN and C9orf72 mutations. Amyotroph Lateral Scler Frontotemp Degener 16:497\u2013505","journal-title":"Amyotroph Lateral Scler Frontotemp Degener"},{"issue":"7","key":"8850_CR45","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1016\/j.jalz.2016.06.687","volume":"12","author":"J Hassenstab","year":"2016","unstructured":"Hassenstab J, Aschenbrenner AJ, Balota DA et al (2016) Cognitive trajectories in DIAN: relationships with symptom onset, mutation types and clinical status. Alzheimers Dement 12(7):368","journal-title":"Alzheimers Dement"},{"issue":"7","key":"8850_CR46","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/nrneurol.2017.75","volume":"13","author":"LH Meeter","year":"2017","unstructured":"Meeter LH, Donker Kaat L, Rohrer JD, van Swieten JC (2017) Imaging and fluid biomarkers in frontotemporal dementia. Nat Rev Neurol 13(7):406\u2013419","journal-title":"Nat Rev Neurol"},{"issue":"5","key":"8850_CR47","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1177\/0891988716654986","volume":"29","author":"TA Rosness","year":"2016","unstructured":"Rosness TA, Engedal K, Chemali Z (2016) Frontotemporal dementia: an updated clinician\u2019s guide. J Geriatr Psychiatry 29(5):271\u2013280","journal-title":"J Geriatr Psychiatry"},{"key":"8850_CR48","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.cortex.2013.05.009","volume":"55","author":"SVS Pakhomov","year":"2014","unstructured":"Pakhomov SVS, Hemmy LS (2014) A computational linguistic measure of clustering behavior on semantic verbal fluency task predicts risk of future dementia in the Nun study. Cortex 55:97\u2013106","journal-title":"Cortex"},{"key":"8850_CR49","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1159\/000477538","volume":"44","author":"E Berg van den","year":"2017","unstructured":"van den Berg E, Jiskoot LC, Grosveld MJH et al (2017) Qualitative assessment of verbal fluency performance in frontotemporal dementia. Dement Geriatr Cogn Disord 44:35\u201344","journal-title":"Dement Geriatr Cogn Disord"},{"key":"8850_CR50","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1007\/s00415-009-5073-y","volume":"256","author":"M Laisney","year":"2009","unstructured":"Laisney M, Matuszewski V, M\u00e9zenge F et al (2009) The underlying mechanisms of verbal fluency deficit in frontotemporal dementia and semantic dementia. J Neurol 256:1083","journal-title":"J Neurol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-018-8850-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-018-8850-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-018-8850-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T14:44:27Z","timestamp":1660833867000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-018-8850-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,7]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["8850"],"URL":"https:\/\/doi.org\/10.1007\/s00415-018-8850-7","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,7]]},"assertion":[{"value":"21 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 March 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 March 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"LCJ, JLP, LvA, LHM, LDK, ELvdE, EGPD, RT, RvM, JvS, EvdB, JMP report no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee, and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}