{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:57:09Z","timestamp":1792130229478,"version":"4.4.0"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T00:00:00Z","timestamp":1530057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1007\/s00415-018-8946-0","type":"journal-article","created":{"date-parts":[[2018,6,27]],"date-time":"2018-06-27T01:11:54Z","timestamp":1530061914000},"page":"2015-2022","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Autonomic function testing in Friedreich\u2019s ataxia"],"prefix":"10.1007","volume":"265","author":[{"given":"Elisabetta","family":"Indelicato","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Fanciulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Pierre","family":"Ndayisaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Nachbauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Eigentler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Granata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Wanschitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Poewe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor K.","family":"Wenning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia","family":"Boesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"issue":"Suppl 1","key":"8946_CR1","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/jnc.12317","volume":"126","author":"MH Parkinson","year":"2013","unstructured":"Parkinson MH, Boesch S, Nachbauer W, Mariotti C, Giunti P (2013) Clinical features of Friedreich\u2019s ataxia: classical and atypical phenotypes. J Neurochem 126(Suppl 1):103\u2013117","journal-title":"J Neurochem"},{"issue":"5254","key":"8946_CR2","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1126\/science.271.5254.1423","volume":"271","author":"V Campuzano","year":"1996","unstructured":"Campuzano V, Montermini L, Molto MD, Pianese L, Cossee M, Cavalcanti F et al (1996) Friedreich\u2019s ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion. Science 271(5254):1423\u20131427","journal-title":"Science"},{"issue":"Suppl 1","key":"8946_CR3","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1111\/jnc.12220","volume":"126","author":"A Pastore","year":"2013","unstructured":"Pastore A, Puccio H (2013) Frataxin: a protein in search for a function. J Neurochem 126(Suppl 1):43\u201352","journal-title":"J Neurochem"},{"issue":"13","key":"8946_CR4","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1016\/S1474-4422(16)30287-3","volume":"15","author":"K Reetz","year":"2016","unstructured":"Reetz K, Dogan I, Hilgers RD, Giunti P, Mariotti C, Durr A et al (2016) Progression characteristics of the European Friedreich\u2019s ataxia consortium for translational studies (EFACTS): a 2 year cohort study. Lancet Neurol 15(13):1346\u20131354","journal-title":"Lancet Neurol"},{"issue":"7","key":"8946_CR5","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/nrneurol.2014.88","volume":"10","author":"EE Benarroch","year":"2014","unstructured":"Benarroch EE (2014) The clinical approach to autonomic failure in neurological disorders. Nat Rev Neurol 10(7):396\u2013407","journal-title":"Nat Rev Neurol"},{"issue":"2","key":"8946_CR6","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1007\/s10286-011-0119-5","volume":"21","author":"R Freeman","year":"2011","unstructured":"Freeman R, Wieling W, Axelrod FB, Benditt DG, Benarroch E, Biaggioni I et al (2011) Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome. Clin Auton Res 21(2):69\u201372","journal-title":"Clin Auton Res"},{"issue":"1","key":"8946_CR7","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1007\/s00401-010-0675-0","volume":"120","author":"JA Morral","year":"2010","unstructured":"Morral JA, Davis AN, Qian J, Gelman BB, Koeppen AH (2010) Pathology and pathogenesis of sensory neuropathy in Friedreich\u2019s ataxia. Acta Neuropathol 120(1):97\u2013108","journal-title":"Acta Neuropathol"},{"issue":"1","key":"8946_CR8","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1002\/ana.1283","volume":"50","author":"M Nolano","year":"2001","unstructured":"Nolano M, Provitera V, Crisci C, Saltalamacchia AM, Wendelschafer-Crabb G, Kennedy WR et al (2001) Small fibers involvement in Friedreich\u2019s ataxia. Ann Neurol 50(1):17\u201325","journal-title":"Ann Neurol"},{"issue":"6","key":"8946_CR9","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1007\/BF00315657","volume":"237","author":"A Filla","year":"1990","unstructured":"Filla A, DeMichele G, Caruso G, Marconi R, Campanella G (1990) Genetic data and natural history of Friedreich\u2019s disease: a study of 80 Italian patients. J Neurol 237(6):345\u2013351","journal-title":"J Neurol"},{"issue":"1","key":"8946_CR10","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1186\/s13023-017-0709-y","volume":"12","author":"M Lad","year":"2017","unstructured":"Lad M, Parkinson MH, Rai M, Pandolfo M, Bogdanova-Mihaylova P, Walsh RA et al (2017) Urinary, bowel and sexual symptoms in a cohort of patients with Friedreich\u2019s ataxia. Orphanet J Rare Dis 12(1):158","journal-title":"Orphanet J Rare Dis"},{"issue":"2","key":"8946_CR11","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1136\/jnnp.54.2.162","volume":"54","author":"TJ Ingall","year":"1991","unstructured":"Ingall TJ, McLeod JG (1991) Autonomic function in Friedreich\u2019s ataxia. J Neurol Neurosurg Psychiatry 54(2):162\u2013164","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"5","key":"8946_CR12","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1007\/s10286-015-0310-1","volume":"25","author":"JP Ndayisaba","year":"2015","unstructured":"Ndayisaba JP, Fanciulli A, Granata R, Duerr S, Hintringer F, Goebel G et al (2015) Sex and age effects on cardiovascular autonomic function in healthy adults. Clin Auton Res 25(5):317\u2013326","journal-title":"Clin Auton Res"},{"issue":"11","key":"8946_CR13","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1212\/01.wnl.0000219042.60538.92","volume":"66","author":"T Schmitz-Hubsch","year":"2006","unstructured":"Schmitz-Hubsch T, du Montcel ST, Baliko L, Berciano J, Boesch S, Depondt C et al (2006) Scale for the assessment and rating of ataxia: development of a new clinical scale. Neurology 66(11):1717\u20131720","journal-title":"Neurology"},{"issue":"Suppl 1","key":"8946_CR14","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1111\/jnc.12318","volume":"126","author":"K Burk","year":"2013","unstructured":"Burk K, Schulz SR, Schulz JB (2013) Monitoring progression in Friedreich ataxia (FRDA): the use of clinical scales. J Neurochem 126(Suppl 1):118\u2013124","journal-title":"J Neurochem"},{"issue":"7","key":"8946_CR15","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1212\/01.WNL.0000156802.15466.79","volume":"64","author":"SH Subramony","year":"2005","unstructured":"Subramony SH, May W, Lynch D, Gomez C, Fischbeck K, Hallett M et al (2005) Measuring Friedreich ataxia: Interrater reliability of a neurologic rating scale. Neurology 64(7):1261\u20131262","journal-title":"Neurology"},{"issue":"11","key":"8946_CR16","doi-asserted-by":"publisher","first-page":"1985","DOI":"10.1002\/mds.23742","volume":"26","author":"A Pavy-Le Traon","year":"2011","unstructured":"Pavy-Le Traon A, Amarenco G, Duerr S, Kaufmann H, Lahrmann H, Shaftman SR et al (2011) The Movement Disorders task force review of dysautonomia rating scales in Parkinson\u2019s disease with regard to symptoms of orthostatic hypotension. Mov Disord 26(11):1985\u20131992","journal-title":"Mov Disord"},{"issue":"3","key":"8946_CR17","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s10198-003-0182-5","volume":"4","author":"W Greiner","year":"2003","unstructured":"Greiner W, Weijnen T, Nieuwenhuizen M, Oppe S, Badia X, Busschbach J et al (2003) A single European currency for EQ-5D health states. Results from a six-country study. Eur J Health Econ 4(3):222\u2013231","journal-title":"Eur J Health Econ"},{"issue":"7","key":"8946_CR18","doi-asserted-by":"publisher","first-page":"1291","DOI":"10.1007\/s00415-014-7339-2","volume":"261","author":"A Fanciulli","year":"2014","unstructured":"Fanciulli A, Strano S, Ndayisaba JP, Goebel G, Gioffre L, Rizzo M et al (2014) Detecting nocturnal hypertension in Parkinson\u2019s disease and multiple system atrophy: proposal of a decision-support algorithm. J Neurol 261(7):1291\u20131299","journal-title":"J Neurol"},{"issue":"2","key":"8946_CR19","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1161\/01.HYP.12.2.214","volume":"12","author":"G Parati","year":"1988","unstructured":"Parati G, Di Rienzo M, Bertinieri G, Pomidossi G, Casadei R, Groppelli A et al (1988) Evaluation of the baroreceptor-heart rate reflex by 24-hour intra-arterial blood pressure monitoring in humans. Hypertension 12(2):214\u2013222","journal-title":"Hypertension"},{"issue":"7","key":"8946_CR20","doi-asserted-by":"publisher","first-page":"912","DOI":"10.1001\/archneurol.2011.834","volume":"69","author":"M Anheim","year":"2012","unstructured":"Anheim M, Mariani LL, Calvas P, Cheuret E, Zagnoli F, Odent S et al (2012) Exonic deletions of FXN and early onset Friedreich ataxia. Arch Neurol 69(7):912\u2013916","journal-title":"Arch Neurol"},{"issue":"3","key":"8946_CR21","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1002\/ana.25170","volume":"83","author":"L Norcliffe-Kaufmann","year":"2018","unstructured":"Norcliffe-Kaufmann L, Kaufmann H, Palma JA, Shibao CA, Biaggioni I, Peltier AC et al (2018) Orthostatic heart rate changes in patients with autonomic failure caused by neurodegenerative synucleinopathies. Ann Neurol 83(3):522\u2013531","journal-title":"Ann Neurol"},{"issue":"8","key":"8946_CR22","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1016\/j.parkreldis.2013.04.007","volume":"19","author":"CB Silva da","year":"2013","unstructured":"da Silva CB, Chevis CF, D\u2019Abreu A, Lopes-Cendes I, Franca MC (2013) Jr. Fatigue is frequent and multifactorial in Friedreich\u2019s ataxia. Parkinsonism Relat Disord 19(8):766\u2013767","journal-title":"Parkinsonism Relat Disord"},{"issue":"7","key":"8946_CR23","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1016\/S0002-9149(97)89245-4","volume":"78","author":"F Pousset","year":"1996","unstructured":"Pousset F, Kalotka H, Durr A, Isnard R, Lechat P, Le Heuzey JY et al (1996) Parasympathetic activity in Friedrich\u2019s ataxia. Am J Cardiol 78(7):847\u2013850","journal-title":"Am J Cardiol"},{"issue":"Pt 12","key":"8946_CR24","doi-asserted-by":"publisher","first-page":"2131","DOI":"10.1093\/brain\/120.12.2131","volume":"120","author":"L Schols","year":"1997","unstructured":"Schols L, Amoiridis G, Przuntek H, Frank G, Epplen JT, Epplen C (1997) Friedreich\u2019s ataxia. Revision of the phenotype according to molecular genetics. Brain 120(Pt 12):2131\u20132140","journal-title":"Brain"},{"issue":"1","key":"8946_CR25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1111\/j.1600-0404.2011.01494.x","volume":"125","author":"J Montes-Brown","year":"2012","unstructured":"Montes-Brown J, Machado A, Estevez M, Carricarte C, Velazquez-Perez L (2012) Autonomic dysfunction in presymptomatic spinocerebellar ataxia type-2. Acta Neurol Scand 125(1):24\u201329","journal-title":"Acta Neurol Scand"},{"issue":"7","key":"8946_CR26","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1111\/ene.12717","volume":"22","author":"R Treister","year":"2015","unstructured":"Treister R, O\u2019Neil K, Downs HM, Oaklander AL (2015) Validation of the composite autonomic symptom scale 31 (COMPASS-31) in patients with and without small fiber polyneuropathy. Eur J Neurol 22(7):1124\u20131130","journal-title":"Eur J Neurol"},{"issue":"6","key":"8946_CR27","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1590\/S1677-5538.IBJU.2013.06.14","volume":"39","author":"AF Musegante","year":"2013","unstructured":"Musegante AF, Almeida PN, Monteiro RT, Barroso U Jr. (2013) Urinary symptoms and urodynamics findings in patients with Friedreich\u2019s ataxia. Int Braz J Urol 39(6):867\u2013874","journal-title":"Int Braz J Urol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-018-8946-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-018-8946-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-018-8946-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T19:14:27Z","timestamp":1561576467000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-018-8946-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,27]]},"references-count":27,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["8946"],"URL":"https:\/\/doi.org\/10.1007\/s00415-018-8946-0","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,27]]},"assertion":[{"value":"10 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 June 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 June 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 June 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest related to the present paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}