{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T17:48:48Z","timestamp":1770486528445,"version":"3.49.0"},"reference-count":16,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T00:00:00Z","timestamp":1534377600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1007\/s00415-018-9006-5","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T06:52:54Z","timestamp":1534402374000},"page":"2363-2369","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Does normal substantia nigra echogenicity make a difference in Parkinson\u2019s disease diagnosis? A real clinical practice follow-up study"],"prefix":"10.1007","volume":"265","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1702-2655","authenticated-orcid":false,"given":"Araceli","family":"Alonso-Canovas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose Luis","family":"Lopez-Sendon Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier","family":"Buisan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Sainz de la Maza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucienne","family":"Costa-Frossard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Garcia-Ribas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alicia","family":"de Felipe-Mimbrera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Consuelo","family":"Matute-Lozano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Zarza Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Toledano Delgado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I\u00f1igo","family":"Corral","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Masjuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Martinez-Castrillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,8,16]]},"reference":[{"key":"9006_CR1","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1111\/ene.12022","volume":"20","author":"A Berardelli","year":"2013","unstructured":"Berardelli A, Wenning GK, Antonini A, Berg D, Bloem BR, Bonifati V, Brooks D, Burn DJ, Colosimo C, Fanciulli A, Ferreira J, Gasser T, Grandas F, Kanovsky P, Kostic V, Kulisevsky J, Oertel W, Poewe W, Reese JP, Relja M, Ruzicka E, Schrag A, Seppi K, Taba P, Vidailhet M (2013) EFNS\/MDS-ES recommendations for the diagnosis of Parkinson\u2019s disease. Eur J Neurol 20:16\u201334. \n                    https:\/\/doi.org\/10.1111\/ene.12022","journal-title":"Eur J Neurol"},{"key":"9006_CR2","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1001\/archneur.57.3.369","volume":"57","author":"J Jankovic","year":"2000","unstructured":"Jankovic J, Rajput AH, Mcdermott MP, Perl DP (2000) The evolution of diagnosis in early Parkinson disease. Parkinson Study Group. Arch Neurol 57:369\u2013372. \n                    https:\/\/doi.org\/10.1001\/archneur.57.3.369","journal-title":"Arch Neurol"},{"key":"9006_CR3","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1002\/mds.26424","volume":"30","author":"RB Postuma","year":"2015","unstructured":"Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G (2015) MDS clinical diagnostic criteria for Parkinson\u2019s disease. Mov Disord 30:1591\u20131601. \n                    https:\/\/doi.org\/10.1002\/mds.26424","journal-title":"Mov Disord"},{"key":"9006_CR4","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1186\/s13550-015-0087-1","volume":"5","author":"SR Suwijn","year":"2015","unstructured":"Suwijn SR, van Boheemen CJ, de Haan RJ, Tissingh G, Booij J, de Bie RM (2015) The diagnostic accuracy of dopamine transporter SPECT imaging to detect nigrostriatal cell loss in patients with Parkinson\u2019s disease or clinically uncertain parkinsonism: a systematic review. EJNMMI Res 5:12. \n                    https:\/\/doi.org\/10.1186\/s13550-015-0087-1","journal-title":"EJNMMI Res"},{"key":"9006_CR5","doi-asserted-by":"publisher","first-page":"20863","DOI":"10.1038\/srep20863","volume":"6","author":"DH Li","year":"2016","unstructured":"Li DH, He YC, Liu J, Chen SD (2016) Diagnostic accuracy of transcranial sonography of the substantia nigra in parkinson\u2019s disease: a systematic review and meta-analysis. Sci Rep 6:20863. \n                    https:\/\/doi.org\/10.1038\/srep20863","journal-title":"Sci Rep"},{"key":"9006_CR6","doi-asserted-by":"publisher","first-page":"1044","DOI":"10.1016\/S1474-4422(08)70239-4","volume":"7","author":"D Berg","year":"2008","unstructured":"Berg D, Godau J, Walter U (2008) Transcranial sonography in movement disorders. Lancet Neurol 7:1044\u20131055. \n                    https:\/\/doi.org\/10.1016\/S1474-4422(08)70239-4","journal-title":"Lancet Neurol"},{"key":"9006_CR7","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.7863\/ultra.32.10.1837","volume":"32","author":"U Walter","year":"2013","unstructured":"Walter U (2013) How to measure substantia nigra hyperechogenicity in Parkinson disease: detailed guide with video. J Ultrasound Med 32:1837\u20131843. \n                    https:\/\/doi.org\/10.7863\/ultra.32.10.1837","journal-title":"J Ultrasound Med"},{"key":"9006_CR8","doi-asserted-by":"publisher","first-page":"2069","DOI":"10.7863\/ultra.33.12.2069","volume":"33","author":"A Alonso-C\u00e1novas","year":"2014","unstructured":"Alonso-C\u00e1novas A, L\u00f3pez-Send\u00f3n JL, Buis\u00e1n J, deFelipe-Mimbrera A, Guill\u00e1n M, Garc\u00eda-Barrag\u00e1n N, Corral I, Matute-Lozano MC, Masjuan J, Mart\u00ednez-Castrillo JC, Walter U (2014) Sonography for diagnosis of Parkinson disease-from theory to practice: a study on 300 participants. J Ultrasound Med 33:2069\u20132074. \n                    https:\/\/doi.org\/10.7863\/ultra.33.12.2069","journal-title":"J Ultrasound Med"},{"key":"9006_CR9","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1471-2377-10-9","volume":"10","author":"S Mehnert","year":"2010","unstructured":"Mehnert S, Reuter I, Schepp K, Maaser P, Stolz E, Kaps M (2010) Transcranial sonography for diagnosis of Parkinson\u2019s disease. BMC Neurol 10:9. \n                    https:\/\/doi.org\/10.1186\/1471-2377-10-9","journal-title":"BMC Neurol"},{"key":"9006_CR10","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/S1474-4422(08)70067-X","volume":"7","author":"A Gaenslen","year":"2008","unstructured":"Gaenslen A, Unmuth B, Godau J, Liepelt I, Di Santo A, Schweitzer KJ, Gasser T, Machulla HJ, Reimold M, Marek K, Berg D (2008) The specificity and sensitivity of transcranial ultrasound in the differential diagnosis of Parkinson\u2019s disease: a prospective blinded study. Lancet Neurol 7:417\u2013424. \n                    https:\/\/doi.org\/10.1016\/S1474-4422(08)70067-X","journal-title":"Lancet Neurol"},{"key":"9006_CR11","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1136\/jnnp-2011-301719","volume":"83","author":"K Busse","year":"2012","unstructured":"Busse K, Heilmann R, Kleinschmidt S, Abu-Mugheisib M, H\u00f6ppner J, Wunderlich C, Gemende I, Kaulitz L, Wolters A, Benecke R, Walter U (2012) Value of combined midbrain sonography, olfactory and motor function assessment in the differential diagnosis of early Parkinson\u2019s disease. J Neurol Neurosurg Psychiatry 83:441\u2013447. \n                    https:\/\/doi.org\/10.1136\/jnnp-2011-301719","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"9006_CR12","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1002\/mds.25080","volume":"27","author":"P Mahlknecht","year":"2012","unstructured":"Mahlknecht P, Stockner H, Nocker M, Kiechl S, Willeit J, Scherfler C, Sojer M, Gasperi A, Rungger G, Poewe W, Seppi K (2012) A follow-up study of substantia nigra echogenicity in healthy adults. Mov Disord 27:1196\u20131197. \n                    https:\/\/doi.org\/10.1002\/mds.25080","journal-title":"Mov Disord"},{"key":"9006_CR13","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1007\/s00415-013-7171-0","volume":"261","author":"S Lerche","year":"2014","unstructured":"Lerche S, Seppi K, Behnke S, Liepelt-Scarfone I, Godau J, Mahlknecht P, Gaenslen A, Brockmann K, Srulijes K, Huber H, Wurster I, Stockner H, Kiechl S, Willeit J, Gasperi A, Fassbender K, Poewe W, Berg D (2014) Risk factors and prodromal markers and the development of Parkinson\u2019s disease. J Neurol 261:180\u2013187. \n                    https:\/\/doi.org\/10.1007\/s00415-013-7171-0","journal-title":"J Neurol"},{"issue":"4","key":"9006_CR14","doi-asserted-by":"publisher","first-page":"e002613","DOI":"10.1136\/bmjopen-2013-002613","volume":"3","author":"Angela E P Bouwmans","year":"2013","unstructured":"Bouwmans AE, Vlaar AM, Mess WH, Kessels A, Weber WE (2013) Specificity and sensitivity of transcranial sonography of the substantia nigra in the diagnosis of Parkinson\u2019s disease: prospective cohort study in 196 patients. BMJ Open 3(4) \n                    https:\/\/doi.org\/10.1136\/bmjopen-2013-002613","journal-title":"BMJ Open"},{"key":"9006_CR15","doi-asserted-by":"publisher","first-page":"e0165869","DOI":"10.1371\/journal.pone.0165869","volume":"11","author":"H Fujita","year":"2016","unstructured":"Fujita H, Suzuki K, Numao A, Watanabe Y, Uchiyama T, Miyamoto T, Miyamoto M, Hirata K (2016) Usefulness of cardiac MIBG scintigraphy, olfactory testing and substantia nigra hyperechogenicity as additional diagnostic markers for distinguishing between Parkinson\u2019s disease and atypical parkinsonian syndromes. PLoS One 11:e0165869. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0165869","journal-title":"PLoS One"},{"key":"9006_CR16","doi-asserted-by":"publisher","first-page":"1439","DOI":"10.1002\/mds.27125","volume":"32","author":"P Turcano","year":"2017","unstructured":"Turcano P, Mielke MM, Josephs KA, Bower JH, Parisi JE, Boeve BF, Savica R (2017) Clinicopathologic discrepancies in a population-based incidence study of parkinsonism in olmsted county: 1991\u20132010. Mov Disord 32:1439\u20131446","journal-title":"Mov Disord"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-018-9006-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-018-9006-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-018-9006-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T19:08:07Z","timestamp":1565896087000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-018-9006-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,16]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["9006"],"URL":"https:\/\/doi.org\/10.1007\/s00415-018-9006-5","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,8,16]]},"assertion":[{"value":"12 July 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 August 2018","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 August 2018","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 August 2018","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Approval of the institution Ethics Committee was obtained, as it was written informed consent from participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}