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Therefore, the key words were amended to include hemicraniectomy and malignant edema.","order":7,"name":"change_details","label":"Change Details","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"This study was carried out in accordance with the declaration of Helsinki and the recommendations and approval of the protocol of the leading ethics committee, Germany (University of Ulm, EK64\/16, 10.03.2016), and the local committees of the other participating centers. As ESTIMATE is a retrospective study, the boards waived the need for patient consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Dr. Beck has nothing to disclose. Dr. Fuhrer has nothing to disclose. Dr. Gerner has nothing to disclose. Dr. Huttner has nothing to disclose. Dr. Kieser has nothing to disclose. Dr. Meckel reports personal fees from Acandis GmbH, other from Covidien\/Medtronic; Microvention; Stryker, grants from Bracco S.p.A., outside the submitted work; Dr. Meyne reports non-financial support from Boehringer Ingelheim, non-financial support from Daiichi Sankyo, outside the submitted work; Dr. M\u00f6hlenbruch reports personal fees from Board Membership, grants and personal fees from Consultancy, grants from Grant, grants and personal fees from Payment for lectures including \u00d0ervice on speakers bureaus, outside the submitted work; Dr. Neugebauer has nothing to disclose. Dr. Niesen has nothing to disclose. Dr. Ringleb reports personal fees from Boehringer Ingelheim, personal fees from Bayer, personal fees from Pfizer, personal fees from BMS, outside the submitted work; Dr. Schocke has nothing to disclose. Dr. Sch\u00f6nenberger has nothing to disclose. Svenja Seide has nothing to disclose. Christoph Vollmuth has nothing to disclose. Dr. Wodarg has nothing to disclose.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}