{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T20:19:45Z","timestamp":1778962785272,"version":"3.51.4"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T00:00:00Z","timestamp":1550102400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1007\/s00415-019-09236-w","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T22:30:22Z","timestamp":1550097022000},"page":"1091-1094","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Cerebral microbleeds are associated with cognitive decline early after ischemic stroke"],"prefix":"10.1007","volume":"266","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2848-6842","authenticated-orcid":false,"given":"Nicolas","family":"Christ","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viola","family":"Mocke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Fluri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,2,14]]},"reference":[{"key":"9236_CR1","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1159\/000492920","volume":"46","author":"M Barbay","year":"2018","unstructured":"Barbay M, Diouf M, Roussel M et al (2018) Systematic review and meta-analysis of prevalence in post-stroke neurocognitive disorders in hospital-based studies. Dement Geriatr Cogn Disord 46:322\u2013334","journal-title":"Dement Geriatr Cogn Disord"},{"key":"9236_CR2","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/S1474-4422(05)70221-0","volume":"4","author":"D Leys","year":"2005","unstructured":"Leys D, H\u00e9non H, Mackowiak-Cordoliani M-A, Pasquier F (2005) Poststroke dementia. Lancet Neurol 4:752\u2013759","journal-title":"Lancet Neurol"},{"key":"9236_CR3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1002\/1531-8249(200002)47:2<145::AID-ANA3>3.0.CO;2-P","volume":"47","author":"JC Groot de","year":"2000","unstructured":"de Groot JC, de Leeuw FE, Oudkerk M et al (2000) Cerebral white matter lesions and cognitive function: t he Rotterdam Scan Study. Ann Neurol 47:145\u2013151","journal-title":"Ann Neurol"},{"key":"9236_CR4","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1212\/WNL.0000000000003983","volume":"88","author":"J Ding","year":"2017","unstructured":"Ding J, Sigur\u00f0sson S, J\u00f3nsson PV et al (2017) Space and location of cerebral microbleeds, cognitive decline, and dementia in the community. Neurology 88:2089\u20132097","journal-title":"Neurology"},{"key":"9236_CR5","doi-asserted-by":"publisher","first-page":"934","DOI":"10.1001\/jamaneurol.2016.1017","volume":"73","author":"S Akoudad","year":"2016","unstructured":"Akoudad S, Wolters FJ, Viswanathan A et al (2016) Association of cerebral microbleeds with cognitive decline and dementia. JAMA Neurol 73:934\u2013943","journal-title":"JAMA Neurol"},{"key":"9236_CR6","doi-asserted-by":"publisher","first-page":"2265","DOI":"10.1093\/brain\/awh253","volume":"127","author":"DJ Werring","year":"2004","unstructured":"Werring DJ, Frazer DW, Coward LJ et al (2004) Cognitive dysfunction in patients with cerebral microbleeds on T2*-weighted gradient-echo MRI. Brain 127:2265\u20132275","journal-title":"Brain"},{"key":"9236_CR7","doi-asserted-by":"publisher","first-page":"1267","DOI":"10.1161\/STROKEAHA.111.000245","volume":"44","author":"SM Gregoire","year":"2013","unstructured":"Gregoire SM, Scheffler G, J\u00e4ger HR et al (2013) Strictly lobar microbleeds are associated with executive impairment in patients with ischemic stroke or transient ischemic attack. Stroke 44:1267\u20131272","journal-title":"Stroke"},{"key":"9236_CR8","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1212\/WNL.0b013e3182452928","volume":"78","author":"MMF Poels","year":"2012","unstructured":"Poels MMF, Ikram MA, van der Lugt A et al (2012) Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study. Neurology 78:326\u2013333","journal-title":"Neurology"},{"key":"9236_CR9","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1212\/WNL.0b013e318232ab1d","volume":"77","author":"ACGM Es van","year":"2011","unstructured":"van Es ACGM, van der Grond J, de Craen AJM et al (2011) Cerebral microbleeds and cognitive functioning in the PROSPER study. Neurology 77:1446\u20131452","journal-title":"Neurology"},{"key":"9236_CR10","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/j.jns.2010.08.034","volume":"299","author":"DJ Werring","year":"2010","unstructured":"Werring DJ, Gregoire SM, Cipolotti L (2010) Cerebral microbleeds and vascular cognitive impairment. J Neurol Sci 299:131\u2013135","journal-title":"J Neurol Sci"},{"key":"9236_CR11","doi-asserted-by":"publisher","first-page":"e0185145","DOI":"10.1371\/journal.pone.0185145","volume":"12","author":"X Li","year":"2017","unstructured":"Li X, Yuan J, Yang L et al (2017) The significant effects of cerebral microbleeds on cognitive dysfunction: An updated meta-analysis. PLoS One 12:e0185145. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0185145","journal-title":"PLoS One"},{"key":"9236_CR12","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1177\/0269215514553012","volume":"29","author":"CM Heugten Van","year":"2015","unstructured":"Van Heugten CM, Walton L, Hentschel U (2015) Can we forget the mini-mental state examination? A systematic review of the validity of cognitive screening instruments within one month after stroke. Clin Rehabil 29:694\u2013704","journal-title":"Clin Rehabil"},{"key":"9236_CR13","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1212\/WNL.44.4.609","volume":"44","author":"KA Welsh","year":"1994","unstructured":"Welsh KA, Butters N, Mohs RC et al (1994) The consortium to establish a registry for alzheimer\u2019s disease (CERAD). Part V. A normative study of the neuropsychological battery. Neurology 44:609\u2013614","journal-title":"Neurology"},{"key":"9236_CR14","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2214\/ajr.149.2.351","volume":"149","author":"F Fazekas","year":"1987","unstructured":"Fazekas F, Chawluk J, Alavi A et al (1987) MR signal abnormalities at 1.5 T in Alzheimer\u2019s dementia and normal aging. Am J Roentgenol 149:351\u2013356","journal-title":"Am J Roentgenol"},{"key":"9236_CR15","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1159\/000336237","volume":"33","author":"SM Gregoire","year":"2012","unstructured":"Gregoire SM, Smith K, J\u00e4ger HR et al (2012) Cerebral microbleeds and long-term cognitive outcome: longitudinal cohort study of stroke clinic patients. Cerebrovasc Dis 33:430\u2013435","journal-title":"Cerebrovasc Dis"},{"key":"9236_CR16","doi-asserted-by":"publisher","first-page":"1719","DOI":"10.1161\/STROKEAHA.117.020461","volume":"49","author":"SJ Ahn","year":"2018","unstructured":"Ahn SJ, Anrather J, Nishimura N, Schaffer CB (2018) Diverse inflammatory response after cerebral microbleeds includes coordinated microglial migration and proliferation. Stroke 49:1719\u20131726","journal-title":"Stroke"},{"key":"9236_CR17","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1093\/brain\/awq321","volume":"134","author":"C Cordonnier","year":"2011","unstructured":"Cordonnier C, van der Flier WM (2011) Brain microbleeds and Alzheimer\u2019s disease: innocent observation or key player? Brain 134:335\u2013344","journal-title":"Brain"},{"key":"9236_CR18","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1017\/cjn.2016.296","volume":"43","author":"AA Sepehry","year":"2016","unstructured":"Sepehry AA, Rauscher A, Hsiung G-Y, Lang DJ (2016) Microbleeds in Alzheimer\u2019s disease: a neuropsychological overview and meta-analysis. Can J Neurol Sci 43:753\u2013759","journal-title":"Can J Neurol Sci"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-019-09236-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-019-09236-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-019-09236-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,13]],"date-time":"2020-02-13T19:27:35Z","timestamp":1581622055000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-019-09236-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,14]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["9236"],"URL":"https:\/\/doi.org\/10.1007\/s00415-019-09236-w","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,14]]},"assertion":[{"value":"25 October 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 February 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 February 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"All authors report no disclosures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}