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Canu has received research supports from the Italian Ministry of Health. M. Leocadi, V. Bessi, S. Padiglioni, B. Nacmias, S. Sorbi report no disclosures. M. Filippi is Editor-in-Chief of the <i>Journal of Neurology<\/i>; has received compensation for consulting services and\/or speaking activities from Biogen Idec, Merck Serono, Novartis, and Teva Pharmaceutical Industries; and receives research support from Biogen Idec, Teva Pharmaceutical Industries, Novartis, Merck Serono, Roche,\u00a0Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA). F. Agosta is Section Editor of <i>NeuroImage: Clinical<\/i>; has received speaker honoraria from Biogen Idec and Novartis; and receives or has received research supports from the Italian Ministry of Health, AriSLA (Fondazione Italiana di Ricerca per la SLA), and the European Research Council.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study has been approved by the local ethics committee and has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments. The patient gave her informed consent prior to their inclusion in the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}