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Val\u00e9rie Rigau reports no disclosure relevant to this manuscript. Benoit Lhermitte reports no disclosure relevant to this manuscript. Thierry Vincent reports no disclosure relevant to this manuscript. Nicolas Menjot de Champfleur reports no disclosure relevant to this manuscript. Clarisse Carra-Dalliere reports no disclosure relevant to this manuscript. Mahmoud Charif reports no disclosure relevant to this manuscript. Nicolas Collongues reports no disclosure relevant to this manuscript. J\u00e9r\u00f4me de Seze reports no disclosure relevant to this manuscript. Sonia Hebbadj reports no disclosure relevant to this manuscript. Guido Ahle reports no disclosure relevant to this manuscript. H\u00e9l\u00e8ne Oesterl\u00e9 reports no disclosure relevant to this manuscript. Fran\u00e7ois Cotton reports no disclosure relevant to this manuscript. Fran\u00e7oise Durand-Dubief reports no disclosure relevant to this manuscript. Romain Marignier serves on scientific advisory board for MedImmune and has received funding for travel and honoraria from Biogen Idec, Merck Serono, Novartis, Sanofi-Genzyme and Teva. Fr\u00e9d\u00e9ric Taithe reports no disclosure relevant to this manuscript. Mikael Cohen reports no disclosure relevant to this manuscript. Anne-Marie Guennoc reports no disclosure relevant to this manuscript. Anne Kerbrat reports no disclosure relevant to this manuscript. Gilles Edan reports no disclosure relevant to this manuscript. B\u00e9atrice Carsin-Nicol reports no disclosure relevant to this manuscript. Thibaut Allou reports no disclosure relevant to this manuscript. Denis Sablot reports no disclosure relevant to this manuscript. Eric Thouvenot reports no disclosure relevant to this manuscript. Aur\u00e9lie Ruet or her institution received research grants and\/or consulting fees from Novartis, Biogen, Merck-Serono, Bayer Healthcare, Roche, Teva, and Genzyme unrelated to the submitted work. Laurent Magy has received Honoraria, housing and consultancies from CSL Behring, Biogen, Teva Pharma, Octapharma, Pharnext, Sanofi Genzyme, Novartis. Marie-Paule Boncoeur-Martel reports no disclosure relevant to this manuscript. Pierre Labauge reports no disclosure relevant to this manuscript. St\u00e9phane Kremer reports no disclosure relevant to this manuscript.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was approved by Montpellier University Hospital Ethical Committee (Q-2017-03-02) and was registered on ClinicalTrial.gov (NCT03121105).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}