{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:09:08Z","timestamp":1791216548989,"version":"4.1.0"},"reference-count":51,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2019,12]]},"DOI":"10.1007\/s00415-019-09523-6","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T13:02:58Z","timestamp":1567602178000},"page":"3009-3021","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Clinical features, outcomes and prognostic factors of tuberculous meningitis in adults worldwide: systematic review and meta-analysis"],"prefix":"10.1007","volume":"266","author":[{"given":"Lan","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maolin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyuan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8520-7064","authenticated-orcid":false,"given":"Kunyi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,4]]},"reference":[{"key":"9523_CR1","unstructured":"Organization WH. Global tuberculosis report 2018. Available at: \nhttps:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/274453\/9789241565646-eng.pdf?ua=1"},{"issue":"10","key":"9523_CR2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S1474-4422(13)70168-6","volume":"12","author":"GE Thwaites","year":"2013","unstructured":"Thwaites GE, van Toorn R, Schoeman J (2013) Tuberculous meningitis: more questions, still too few answers. Lancet Neurol 12(10):999\u20131010","journal-title":"Lancet Neurol"},{"issue":"10","key":"9523_CR3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nrneurol.2017.120","volume":"13","author":"RJ Wilkinson","year":"2017","unstructured":"Wilkinson RJ, Rohlwink U, Misra UK et al (2017) Tuberculous meningitis. Nat Rev Neurol 13(10):581\u2013598","journal-title":"Nat Rev Neurol"},{"issue":"9","key":"9523_CR4","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.2217\/fmb.12.86","volume":"7","author":"F Brancusi","year":"2012","unstructured":"Brancusi F, Farrar J, Heemskerk D (2012) Tuberculous meningitis in adults: a review of a decade of developments focusing on prognostic factors for outcome. Future Microbiol 7(9):1101\u20131116","journal-title":"Future Microbiol"},{"issue":"9","key":"9523_CR5","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","volume":"25","author":"A Stang","year":"2010","unstructured":"Stang A (2010) Critical evaluation of the Newcastle\u2013Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 25(9):603\u2013605","journal-title":"Eur J Epidemiol"},{"issue":"4","key":"9523_CR6","first-page":"138","volume":"32","author":"JJ Miller","year":"1978","unstructured":"Miller JJ (1978) The inverse of the Freeman\u2013Tukey double arcsine transformation. Am Stat 32(4):138","journal-title":"Am Stat"},{"issue":"11","key":"9523_CR7","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","volume":"21","author":"JP Higgins","year":"2002","unstructured":"Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539\u20131558","journal-title":"Stat Med"},{"issue":"1","key":"9523_CR8","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-2288-9-80","volume":"9","author":"BC Wallace","year":"2009","unstructured":"Wallace BC, Schmid CH, Lau J, Trikalinos TA (2009) Meta-analyst: software for meta-analysis of binary, continuous and diagnostic data. BMC Med Res Methodol 9(1):80","journal-title":"BMC Med Res Methodol"},{"issue":"7109","key":"9523_CR9","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1136\/bmj.315.7109.629","volume":"315","author":"M Egger","year":"1997","unstructured":"Egger M, Smith GD, Schneider M, Minder C (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ Br Med J 315(7109):629\u2013634","journal-title":"BMJ Br Med J"},{"issue":"4","key":"9523_CR10","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","volume":"50","author":"CB Begg","year":"1994","unstructured":"Begg CB, Mazumdar M (1994) Operating characteristics of a rank correlation test for publication bias. Biometrics 50(4):1088\u20131101","journal-title":"Biometrics"},{"issue":"7","key":"9523_CR11","first-page":"553","volume":"2","author":"S Hosoglu","year":"1998","unstructured":"Hosoglu S, Ayaz C, Geyik MF, Kokoglu OF, Ceviz A (1998) Tuberculous meningitis in adults: an eleven-year review. Int J Tuberc Lung Dis 2(7):553\u2013557","journal-title":"Int J Tuberc Lung Dis"},{"issue":"11","key":"9523_CR12","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1017\/S0950268807000258","volume":"136","author":"B Roca","year":"2008","unstructured":"Roca B, Tornador N, Tornador E (2008) Presentation and outcome of tuberculous meningitis in adults in the province of Castellon, Spain: a retrospective study. Epidemiol Infect 136(11):1455\u20131462","journal-title":"Epidemiol Infect"},{"issue":"2","key":"9523_CR13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1097\/MAJ.0b013e3181a590f1","volume":"338","author":"JJ Sheu","year":"2009","unstructured":"Sheu JJ, Yuan RY, Yang CC (2009) Predictors for outcome and treatment delay in patients with tuberculous meningitis. Am J Med Sci 338(2):134\u2013139","journal-title":"Am J Med Sci"},{"issue":"10","key":"9523_CR14","first-page":"1330","volume":"14","author":"KK Yasar","year":"2010","unstructured":"Yasar KK, Pehlivanoglu F, Sengoz G (2010) Predictors of mortality in tuberculous meningitis: a multivariate analysis of 160 cases. Int J Tuberc Lung Dis 14(10):1330\u20131335","journal-title":"Int J Tuberc Lung Dis"},{"issue":"6","key":"9523_CR15","first-page":"592","volume":"61","author":"M Ersoz","year":"2012","unstructured":"Ersoz M, Yildirmak MT, Gedik H et al (2012) Tuberculous meningitis: a report of 60 adult cases. West Indian Med J 61(6):592\u2013597","journal-title":"West Indian Med J"},{"issue":"1","key":"9523_CR16","first-page":"5","volume":"60","author":"F Alarcon","year":"2013","unstructured":"Alarcon F, Moreira J, Rivera J, Salinas R, Duenas G, Van den Ende J (2013) Tuberculous meningitis: do modern diagnostic tools offer better prognosis prediction? Indian J Tuberc 60(1):5\u201314","journal-title":"Indian J Tuberc"},{"issue":"5","key":"9523_CR17","first-page":"1114","volume":"45","author":"K Kongbunkiat","year":"2014","unstructured":"Kongbunkiat K, Deesomsak M, Sawanyawisuth K, Chotmongkol V, Tiamkao S (2014) Clinical factors predictive of functional outcomes in tuberculous meningitis. Southeast Asian J Trop Med Public Health 45(5):1114\u20131118","journal-title":"Southeast Asian J Trop Med Public Health"},{"issue":"1\u20132","key":"9523_CR18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1159\/000368894","volume":"73","author":"YZ Imam","year":"2015","unstructured":"Imam YZ, Ahmedullah HS, Akhtar N et al (2015) Adult tuberculous meningitis in Qatar: a descriptive retrospective study from its referral center. Eur Neurol 73(1\u20132):90\u201397","journal-title":"Eur Neurol"},{"issue":"26","key":"9523_CR19","doi-asserted-by":"crossref","first-page":"e7370","DOI":"10.1097\/MD.0000000000007370","volume":"96","author":"HJ Huang","year":"2017","unstructured":"Huang HJ, Ren ZZ, Dai YN et al (2017) Old age and hydrocephalus are associated with poor prognosis in patients with tuberculous meningitis: a retrospective study in a Chinese adult population. Medicine (Baltimore) 96(26):e7370","journal-title":"Medicine (Baltimore)"},{"issue":"6","key":"9523_CR20","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1080\/14787210.2017.1309974","volume":"15","author":"K Li","year":"2017","unstructured":"Li K, Tang H, Yang Y et al (2017) Clinical features, long-term clinical outcomes, and prognostic factors of tuberculous meningitis in West China: a multivariate analysis of 154 adults. Expert Rev Anti Infect Ther 15(6):629\u2013635","journal-title":"Expert Rev Anti Infect Ther"},{"key":"9523_CR21","first-page":"9316589","volume":"2017","author":"M Raberahona","year":"2017","unstructured":"Raberahona M, Rakotoarivelo RA, Razafinambinintsoa T, Andrianasolo RL, Randria MJ (2017) Clinical features and outcome in adult cases of tuberculous meningitis in tertiary care hospital in Antananarivo. Madagascar Biomed Res Int 2017:9316589","journal-title":"Madagascar Biomed Res Int"},{"issue":"1","key":"9523_CR22","first-page":"64","volume":"6","author":"S Hosoglu","year":"2002","unstructured":"Hosoglu S, Geyik MF, Balik I et al (2002) Predictors of outcome in patients with tuberculous meningitis. Int J Tuberc Lung Dis 6(1):64\u201370","journal-title":"Int J Tuberc Lung Dis"},{"issue":"5","key":"9523_CR23","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1177\/197140090702000508","volume":"20","author":"S.A. Al-Edrus","year":"2007","unstructured":"Al-Edrus SA, Sobrimuda, Nordiyana M, Merican JS (2007) Tuberculous meningitis: neuroimaging features, clinical staging and outcome. J Neuroradiol 20(5): 517.","journal-title":"The Neuroradiology Journal"},{"issue":"1","key":"9523_CR24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s40249-016-0138-5","volume":"5","author":"JM Kirigia","year":"2016","unstructured":"Kirigia JM, Muthuri RD (2016) Productivity losses associated with tuberculosis deaths in the World Health Organization African region. Infect Dis Poverty 5(1):43","journal-title":"Infect Dis Poverty"},{"issue":"11","key":"9523_CR25","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/qjmed\/91.11.743","volume":"91","author":"AS Karstaedt","year":"1998","unstructured":"Karstaedt AS, Valtchanova S, Barriere R, Crewe-Brown HH (1998) Tuberculous meningitis in South African urban adults. QJM 91(11):743\u2013747","journal-title":"QJM"},{"issue":"1","key":"9523_CR26","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/QCO.0000000000000331","volume":"30","author":"NT Mai","year":"2017","unstructured":"Mai NT, Thwaites GE (2017) Recent advances in the diagnosis and management of tuberculous meningitis. Curr Opin Infect Dis 30(1):123\u2013128","journal-title":"Curr Opin Infect Dis"},{"issue":"9517","key":"9523_CR27","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0140-6736(06)68507-3","volume":"367","author":"BB Trunz","year":"2006","unstructured":"Trunz BB, Fine P, Dye C (2006) Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide: a meta-analysis and assessment of cost-effectiveness. Lancet 367(9517):1173\u20131180","journal-title":"Lancet"},{"issue":"2","key":"9523_CR28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S1473-3099(15)00400-4","volume":"16","author":"P Nguipdop-Djomo","year":"2016","unstructured":"Nguipdop-Djomo P, Heldal E, Rodrigues LC, Abubakar I, Mangtani P (2016) Duration of BCG protection against tuberculosis and change in effectiveness with time since vaccination in Norway: a retrospective population-based cohort study. Lancet Infect Dis 16(2):219\u2013226","journal-title":"Lancet Infect Dis"},{"issue":"4","key":"9523_CR29","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1007\/s00415-015-7651-5","volume":"262","author":"H Erdem","year":"2015","unstructured":"Erdem H, Ozturk-Engin D, Tireli H et al (2015) Hamsi scoring in the prediction of unfavorable outcomes from tuberculous meningitis: results of Haydarpasa-II study. J Neurol 262(4):890\u2013898","journal-title":"J Neurol"},{"issue":"2","key":"9523_CR30","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1097\/MCC.0000000000000397","volume":"23","author":"R Sonneville","year":"2017","unstructured":"Sonneville R, Magalhaes E, Meyfroidt G (2017) Central nervous system infections in immunocompromised patients. Curr Opin Crit Care 23(2):128\u2013133","journal-title":"Curr Opin Crit Care"},{"issue":"6503","key":"9523_CR31","first-page":"582","volume":"251","author":"Streptomycin in Tuberculosis Trials Committee MRCJL","year":"1948","unstructured":"Streptomycin in Tuberculosis Trials Commitee MRCJL (1948) STREPTOMYCIN treatment of tuberculous meningitis. Lancet 251(6503):582\u2013596","journal-title":"Lancet"},{"issue":"3","key":"9523_CR32","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s11940-018-0490-9","volume":"20","author":"A Davis","year":"2018","unstructured":"Davis A, Meintjes G, Wilkinson RJ (2018) Treatment of tuberculous meningitis and its complications in adults. Curr Treat Options Neurol 20(3):5","journal-title":"Curr Treat Options Neurol"},{"issue":"10","key":"9523_CR33","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1007\/s00701-015-2501-x","volume":"157","author":"V Rajshekhar","year":"2015","unstructured":"Rajshekhar V (2015) Surgery for brain tuberculosis: a review. Acta Neurochir 157(10):1665\u20131678","journal-title":"Acta Neurochir"},{"key":"9523_CR34","doi-asserted-by":"crossref","unstructured":"Kalantri A, Kalantri S (2018) Can aspirin help? Elife 7","DOI":"10.7554\/eLife.35906"},{"issue":"1","key":"9523_CR35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/BF00593210","volume":"38","author":"LA Rojas-Echeverri","year":"1996","unstructured":"Rojas-Echeverri LA, Soto-Hernandez JL, Garza S et al (1996) Predictive value of digital subtraction angiography in patients with tuberculous meningitis. Neuroradiology 38(1):20\u201324","journal-title":"Neuroradiology"},{"issue":"6","key":"9523_CR36","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s15010-001-1100-3","volume":"29","author":"CH Lu","year":"2001","unstructured":"Lu CH, Chang WN, Chang HW (2001) The prognostic factors of adult tuberculous meningitis. Infection 29(6):299\u2013304","journal-title":"Infection"},{"issue":"10","key":"9523_CR37","first-page":"865","volume":"6","author":"GE Thwaites","year":"2002","unstructured":"Thwaites GE, Chau TT, Caws M et al (2002) Isoniazid resistance, mycobacterial genotype and outcome in Vietnamese adults with tuberculous meningitis. Int J Tuberc Lung Dis 6(10):865\u2013871","journal-title":"Int J Tuberc Lung Dis"},{"issue":"9","key":"9523_CR38","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1093\/qjmed\/hcg108","volume":"96","author":"KH Chan","year":"2003","unstructured":"Chan KH, Cheung RT, Fong CY, Tsang KL, Mak W, Ho SL (2003) Clinical relevance of hydrocephalus as a presenting feature of tuberculous meningitis. QJM 96(9):643\u2013648","journal-title":"QJM"},{"issue":"6","key":"9523_CR39","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s15010-003-3179-1","volume":"31","author":"PN Sutlas","year":"2003","unstructured":"Sutlas PN, Unal A, Forta H, Senol S, Kirbas D (2003) Tuberculous meningitis in adults: review of 61 cases. Infection 31(6):387\u2013391","journal-title":"Infection"},{"issue":"1","key":"9523_CR40","first-page":"86","volume":"14","author":"CH Chou","year":"2010","unstructured":"Chou CH, Lin GM, Ku CH, Chang FY (2010) Comparison of the APACHE II, GCS and MRC scores in predicting outcomes in patients with tuberculous meningitis. Int J Tuberc Lung Dis 14(1):86\u201392","journal-title":"Int J Tuberc Lung Dis"},{"issue":"2","key":"9523_CR41","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S1684-1182(10)60018-7","volume":"43","author":"PC Hsu","year":"2010","unstructured":"Hsu PC, Yang CC, Ye JJ, Huang PY, Chiang PC, Lee MH (2010) Prognostic factors of tuberculous meningitis in adults: a 6-year retrospective study at a tertiary hospital in northern Taiwan. J Microbiol Immunol Infect 43(2):111\u2013118","journal-title":"J Microbiol Immunol Infect"},{"issue":"3","key":"9523_CR42","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ejim.2011.01.007","volume":"22","author":"P Sharma","year":"2011","unstructured":"Sharma P, Garg RK, Verma R, Singh MK, Shukla R (2011) Incidence, predictors and prognostic value of cranial nerve involvement in patients with tuberculous meningitis: a retrospective evaluation. Eur J Intern Med 22(3):289\u2013295","journal-title":"Eur J Intern Med"},{"issue":"1","key":"9523_CR43","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4103\/0028-3886.93583","volume":"60","author":"EL George","year":"2012","unstructured":"George EL, Iype T, Cherian A et al (2012) Predictors of mortality in patients with meningeal tuberculosis. Neurol India 60(1):18\u201322","journal-title":"Neurol India"},{"issue":"4","key":"9523_CR44","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jinf.2012.12.009","volume":"66","author":"T Raut","year":"2013","unstructured":"Raut T, Garg RK, Jain A et al (2013) Hydrocephalus in tuberculous meningitis: Incidence, its predictive factors and impact on the prognosis. J Infect 66(4):330\u2013337","journal-title":"J Infect"},{"issue":"8\u20139","key":"9523_CR45","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.neurol.2014.06.004","volume":"170","author":"CH Chen","year":"2014","unstructured":"Chen CH, Chang YJ, Sy HN, Chen WL, Yen HC (2014) Risk assessment of the outcome for cerebral infarction in tuberculous meningitis. Rev Neurol (Paris) 170(8\u20139):512\u2013519","journal-title":"Rev Neurol (Paris)"},{"issue":"11","key":"9523_CR46","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1136\/jnnp-2013-307178","volume":"85","author":"M Wasay","year":"2014","unstructured":"Wasay M, Farooq S, Khowaja ZA et al (2014) Cerebral infarction and tuberculoma in central nervous system tuberculosis: frequency and prognostic implications. J Neurol Neurosurg Psychiatry 85(11):1260\u20131264","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"3","key":"9523_CR47","first-page":"4487","volume":"8","author":"J Gu","year":"2015","unstructured":"Gu J, Xiao H, Wu F, Ge Y, Ma J, Sun W (2015) Prognostic factors of tuberculous meningitis: a single-center study. Int J Clin Exp Med 8(3):4487\u20134493","journal-title":"Int J Clin Exp Med"},{"key":"9523_CR48","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/s12879-016-1625-9","volume":"16","author":"AK Singh","year":"2016","unstructured":"Singh AK, Malhotra HS, Garg RK et al (2016) Paradoxical reaction in tuberculous meningitis: presentation, predictors and impact on prognosis. BMC Infect Dis 16:306","journal-title":"BMC Infect Dis"},{"issue":"4","key":"9523_CR49","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.ijtb.2017.03.001","volume":"64","author":"R Gupta","year":"2017","unstructured":"Gupta R, Kushwaha S, Thakur R et al (2017) Predictors of adverse outcome in patients of tuberculous meningitis in a multi-centric study from India. Indian J Tuberc 64(4):296\u2013301","journal-title":"Indian J Tuberc"},{"key":"9523_CR50","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.jns.2017.02.051","volume":"375","author":"AE Merkler","year":"2017","unstructured":"Merkler AE, Reynolds AS, Gialdini G et al (2017) Neurological complications after tuberculous meningitis in a multi-state cohort in the United States. J Neurol Sci 375:460\u2013463","journal-title":"J Neurol Sci"},{"key":"9523_CR51","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.clineuro.2017.08.006","volume":"161","author":"M Modi","year":"2017","unstructured":"Modi M, Sharma K, Prabhakar S et al (2017) Clinical and radiological predictors of outcome in tubercular meningitis: a prospective study of 209 patients. Clin Neurol Neurosurg 161:29\u201334","journal-title":"Clin Neurol Neurosurg"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-019-09523-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-019-09523-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-019-09523-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T19:17:51Z","timestamp":1599074271000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-019-09523-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,4]]},"references-count":51,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["9523"],"URL":"https:\/\/doi.org\/10.1007\/s00415-019-09523-6","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,4]]},"assertion":[{"value":"27 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 August 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 September 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"None.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This article does not contain any studies with human participants performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}