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Primary outcomes were haematoma volume (in ml), HE, and mortality (in-hospital and 3-month). We calculated odds ratios (ORs) using the Mantel\u2013Haenszel random-effects method and corresponding 95% confidence intervals (95%CI) and determined the mean ICH volume difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 19 studies including data from 16,546 patients with VKA-ICH and 128,561 patients with non-OAC ICH. Only 2 studies reported data on 4943 patients with NOAC-ICH. Patients with VKA-ICH were significantly older than patients with non-OAC ICH (mean age difference: 5.55\u00a0years, 95%CI 4.03\u20137.07,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001,<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200992%,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Haematoma volume was significantly larger in VKA-ICH with a mean difference of 9.66\u00a0ml (95%CI 6.24\u201313.07\u00a0ml,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200942%,<jats:italic>p<\/jats:italic>\u2009=\u20090.05). HE occurred significantly more often in VKA-ICH (OR 2.96, 95%CI 1.74\u20134.97,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001;<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200965%). VKA-ICH was associated with significantly higher in-hospital mortality (VKA-ICH: 32.8% vs. non-OAC ICH: 22.4%; OR 1.83, 95%CI 1.61\u20132.07,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001,<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200920%,<jats:italic>p<\/jats:italic>\u2009=\u20090.27) and 3-month mortality (VKA-ICH: 47.1% vs. non-OAC ICH: 25.5%; OR 2.24, 95%CI 1.52\u20133.31,<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001,<jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u2009=\u200971%,<jats:italic>p<\/jats:italic>\u2009=\u20090.001). We did not find sufficient data for a meta-analysis comparing NOAC-ICH and non-OAC-ICH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This meta-analysis confirms, refines and expands findings from prior studies. We provide precise estimates of key prognostic factors and outcomes for VKA-ICH, which has larger haematoma volume, increased rate of HE and higher mortality compared to non-OAC ICH. There are insufficient data on NOACs.<\/jats:p><\/jats:sec>","DOI":"10.1007\/s00415-019-09536-1","type":"journal-article","created":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T09:17:55Z","timestamp":1568971075000},"page":"3126-3135","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":87,"title":["Meta-analysis of haematoma volume, haematoma expansion and mortality in intracerebral haemorrhage associated with oral anticoagulant use"],"prefix":"10.1007","volume":"266","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3890-3849","authenticated-orcid":false,"given":"David J.","family":"Seiffge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina B.","family":"Goeldlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turgut","family":"Tatlisumak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Lyrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan T.","family":"Engelter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Werring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,9,20]]},"reference":[{"issue":"6","key":"9536_CR1","doi-asserted-by":"publisher","first-page":"660","DOI":"10.1136\/jnnp-2013-306476","volume":"85","author":"MT Poon","year":"2014","unstructured":"Poon MT, Fonville AF, Al-Shahi Salman R (2014) Long-term prognosis after intracerebral haemorrhage: systematic review and meta-analysis. 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Stroke 47(4):1124\u20131126","journal-title":"Stroke"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-019-09536-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00415-019-09536-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-019-09536-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,23]],"date-time":"2024-07-23T20:12:11Z","timestamp":1721765531000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00415-019-09536-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,20]]},"references-count":43,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12]]}},"alternative-id":["9536"],"URL":"https:\/\/doi.org\/10.1007\/s00415-019-09536-1","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,20]]},"assertion":[{"value":"5 July 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 September 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 September 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 September 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"DJS: scientific advisory boards: Bayer and Pfizer. Compensation for educational efforts: Stago. MBG: no disclosures. TT: academic grants from Helsinki University Central Hospital, University of Gothenburg, Sahlgrenska University Hospital, and Sigrid Juselius Foundation for research on intracerebral hemorrhages. TT has or has had research contracts with Boehringer-Ingelheim, Bayer, Pfizer, and Portola Pharm. Advisory board membership for Boehringer-Ingelheim, Bayer, Pfizer, and Lumosa Pharm. PAL: scientific advisory boards: Bayer, Daiichi-Sankyo and Boehringer Ingelheim. Funding for travel or speaker honoraria: Bayer and Boehringer Ingelheim. Research funding: Boehringer Ingelheim. UF: consultant for Medtronic and Stryker, a Co-PI of the SWITCH trial and the ELAN trial (both supported by the Swiss National Science Foundation and the Swiss Heart Foundation) and of the SWIFT DIRECT trial (supported by Medtronic). Speaker honoraria payed to the institution by AMGEN. STE: received funding for travel or speaker honoraria from Bayer, Boehringer Ingelheim and Daiichi-Sankyo. He has served on scientific advisory boards for Bayer, Boehringer Ingelheim, BMS\/Pfizer, and MindMaze and on the editorial board of Stroke. His institutions have received an educational grant from Pfizer, compensation from Stago for educational efforts and research support from Daiichi-Sankyo, the Science Funds [Wissenschaftsfonds] of the University Hospital Basel, the University Basel, the \u201cFreiwillige Akademische Gesellschaft Basel\u201d, the Swiss Heart Foundation, and the Swiss National Science Foundation. DJW: speaker honoraria from Bayer AG. MP reports honoraria as a member of the speaker bureau of Aspen, Sanofi-Aventis, Boehringer Ingelheim, Bayer AG, Bristol-Myers Squibb, Medtronic, and Pfizer.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This aricle does not contain any studies with human participants or anmals performed by any of the authors.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standard"}}]}}