{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:51:20Z","timestamp":1790164280910,"version":"4.1.0"},"reference-count":37,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T00:00:00Z","timestamp":1573689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H29-Nanchitou (Nan)-Ippan-036"],"award-info":[{"award-number":["H29-Nanchitou (Nan)-Ippan-036"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K09768"],"award-info":[{"award-number":["17K09768"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s00415-019-09629-x","type":"journal-article","created":{"date-parts":[[2019,11,14]],"date-time":"2019-11-14T15:03:13Z","timestamp":1573743793000},"page":"731-738","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Successful treatment of non-HIV progressive multifocal leukoencephalopathy: case report and literature review"],"prefix":"10.1007","volume":"267","author":[{"given":"Mai","family":"Hamaguchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0320-8993","authenticated-orcid":false,"given":"Keisuke","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeo","family":"Uzuka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadzki","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Shishido-Hara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Kikuchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Nakamichi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Saijo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Hirata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,11,14]]},"reference":[{"key":"9629_CR1","doi-asserted-by":"publisher","first-page":"324","DOI":"10.5692\/clinicalneurol.cn-001166","volume":"58","author":"Y Akagawa","year":"2018","unstructured":"Akagawa Y, Ueno A, Ikeda J, Ishii W, Shishido-Hara Y, Sekijima Y (2018) Two patients with progressive multifocal leukoencephalopathy with immune response against JC virus showing good long-term outcome by combination therapy of mefloquine, mirtazapine, and risperidone. Rinsho Shinkeigaku 58:324\u2013331","journal-title":"Rinsho Shinkeigaku"},{"issue":"Suppl 1","key":"9629_CR2","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1080\/13550280390195388","volume":"9","author":"A Antinori","year":"2003","unstructured":"Antinori A, Cingolani A, Lorenzini P, Giancola ML, Uccella I, Bossolasco S, Grisetti S, Moretti F, Vigo B, Bongiovanni M, Del Grosso B, Arcidiacono MI, Fibbia GC, Mena M, Finazzi MG, Guaraldi G, Ammassari A, d'Arminio Monforte A, Cinque P, De Luca A, Italian Registry Investigative Neuro ASG (2003) Clinical epidemiology and survival of progressive multifocal leukoencephalopathy in the era of highly active antiretroviral therapy: data from the Italian Registry Investigative Neuro AIDS (IRINA). J Neurovirol 9(Suppl 1):47\u201353","journal-title":"J Neurovirol"},{"key":"9629_CR3","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1111\/j.1527-3458.2001.tb00198.x","volume":"7","author":"SA Anttila","year":"2001","unstructured":"Anttila SA, Leinonen EV (2001) A review of the pharmacological and clinical profile of mirtazapine. CNS Drug Rev 7:249\u2013264","journal-title":"CNS Drug Rev"},{"key":"9629_CR4","doi-asserted-by":"publisher","first-page":"1645","DOI":"10.2169\/internalmedicine.55.6649","volume":"55","author":"Y Aotsuka","year":"2016","unstructured":"Aotsuka Y, Uzawa A, Nishimura K, Kojima K, Yamaguchi M, Makino T, Nakamichi K, Saijo M, Kuwabara S (2016) Progressive multifocal leukoencephalopathy localized in the cerebellum and brainstem associated with idiopathic CD4(+) T lymphocytopenia. Intern Med 55:1645\u20131647","journal-title":"Intern Med"},{"key":"9629_CR5","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1046\/j.0919-6544.2001.00424.x","volume":"22","author":"Y Arai","year":"2002","unstructured":"Arai Y, Tsutsui Y, Nagashima K, Shinmura Y, Kosugi T, Wakai M, Nishikage H, Yamamoto J (2002) Autopsy case of the cerebellar form of progressive multifocal leukoencephalopathy without immunodeficiency. Neuropathology 22:48\u201356","journal-title":"Neuropathology"},{"key":"9629_CR6","doi-asserted-by":"publisher","first-page":"1214","DOI":"10.1038\/sj.bjp.0705721","volume":"141","author":"S Barraud de Lagerie","year":"2004","unstructured":"Barraud de Lagerie S, Comets E, Gautrand C, Fernandez C, Auchere D, Singlas E, Mentre F, Gimenez F (2004) Cerebral uptake of mefloquine enantiomers with and without the P-gp inhibitor elacridar (GF1210918) in mice. Br J Pharmacol 141:1214\u20131222","journal-title":"Br J Pharmacol"},{"key":"9629_CR7","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.2169\/internalmedicine.51.6810","volume":"51","author":"M Beppu","year":"2012","unstructured":"Beppu M, Kawamoto M, Nukuzuma S, Kohara N (2012) Mefloquine improved progressive multifocal leukoencephalopathy in a patient with systemic lupus erythematosus. Intern Med 51:1245\u20131247","journal-title":"Intern Med"},{"key":"9629_CR8","doi-asserted-by":"publisher","first-page":"1430","DOI":"10.1212\/WNL.0b013e31828c2fa1","volume":"80","author":"JR Berger","year":"2013","unstructured":"Berger JR, Aksamit AJ, Clifford DB, Davis L, Koralnik IJ, Sejvar JJ, Bartt R, Major EO, Nath A (2013) PML diagnostic criteria: consensus statement from the AAN neuroinfectious disease section. Neurology 80:1430\u20131438","journal-title":"Neurology"},{"key":"9629_CR9","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/ana.410440309","volume":"44","author":"JR Berger","year":"1998","unstructured":"Berger JR, Levy RM, Flomenhoft D, Dobbs M (1998) Predictive factors for prolonged survival in acquired immunodeficiency syndrome-associated progressive multifocal leukoencephalopathy. Ann Neurol 44:341\u2013349","journal-title":"Ann Neurol"},{"key":"9629_CR10","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1080\/13550280701469178","volume":"13","author":"F Bernal-Cano","year":"2007","unstructured":"Bernal-Cano F, Joseph JT, Koralnik IJ (2007) Spinal cord lesions of progressive multifocal leukoencephalopathy in an acquired immunodeficiency syndrome patient. J Neurovirol 13:474\u2013476","journal-title":"J Neurovirol"},{"key":"9629_CR11","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1086\/427698","volume":"40","author":"S Bossolasco","year":"2005","unstructured":"Bossolasco S, Calori G, Moretti F, Boschini A, Bertelli D, Mena M, Gerevini S, Bestetti A, Pedale R, Sala S, Sala S, Lazzarin A, Cinque P (2005) Prognostic significance of JC virus DNA levels in cerebrospinal fluid of patients with HIV-associated progressive multifocal leukoencephalopathy. Clin Infect Dis 40:738\u2013744","journal-title":"Clin Infect Dis"},{"key":"9629_CR12","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nrneurol.2010.164","volume":"6","author":"BJ Brew","year":"2010","unstructured":"Brew BJ, Davies NW, Cinque P, Clifford DB, Nath A (2010) Progressive multifocal leukoencephalopathy and other forms of JC virus disease. Nat Rev Neurol 6:667\u2013679","journal-title":"Nat Rev Neurol"},{"key":"9629_CR13","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/S0733-8619(18)31105-8","volume":"2","author":"BR Brooks","year":"1984","unstructured":"Brooks BR, Walker DL (1984) Progressive multifocal leukoencephalopathy. Neurol Clin 2:299\u2013313","journal-title":"Neurol Clin"},{"issue":"Suppl 1","key":"9629_CR14","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1080\/13550280390195315","volume":"9","author":"RA Du Pasquier","year":"2003","unstructured":"Du Pasquier RA, Koralnik IJ (2003) Inflammatory reaction in progressive multifocal leukoencephalopathy: harmful or beneficial? J Neurovirol 9(Suppl 1):25\u201331","journal-title":"J Neurovirol"},{"key":"9629_CR15","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1016\/j.clineuro.2011.12.010","volume":"114","author":"M Hirayama","year":"2012","unstructured":"Hirayama M, Nosaki Y, Matsui K, Terao S, Kuwayama M, Tateyama H, Yoshida M, Hashizume Y (2012) Efficacy of mefloquine to progressive multifocal leukoencephalopathy initially presented with parkinsonism. Clin Neurol Neurosurg 114:728\u2013731","journal-title":"Clin Neurol Neurosurg"},{"key":"9629_CR16","doi-asserted-by":"publisher","first-page":"218","DOI":"10.2169\/internalmedicine.31.218","volume":"31","author":"T Irie","year":"1992","unstructured":"Irie T, Kasai M, Abe N, Seto K, Naohara T, Kawamura K, Higa T, Sano K, Takahashi H, Nagashima K (1992) Cerebellar form of progressive multifocal leukoencephalopathy in a patient with chronic renal failure. Intern Med 31:218\u2013223","journal-title":"Intern Med"},{"key":"9629_CR17","doi-asserted-by":"publisher","first-page":"481","DOI":"10.5692\/clinicalneurol.cn-000873","volume":"56","author":"D Ito","year":"2016","unstructured":"Ito D, Yasui K, Hasegawa Y, Nakamichi K, Katsuno M, Takahashi A (2016) Progressive multifocal leukoencephalopathy with bilateral middle cerebellar peduncle lesions confirmed by repeated CSF-JC virus tests and coexistence of JC virus granule cell neuronopathy. Report of a case. Rinsho Shinkeigaku 56:481\u2013485","journal-title":"Rinsho Shinkeigaku"},{"key":"9629_CR18","doi-asserted-by":"publisher","first-page":"2509","DOI":"10.2169\/internalmedicine.49.3227","volume":"49","author":"S Kishida","year":"2010","unstructured":"Kishida S, Tanaka K (2010) Mefloquine treatment in a patient suffering from progressive multifocal leukoencephalopathy after umbilical cord blood transplant. Intern Med 49:2509\u20132513","journal-title":"Intern Med"},{"key":"9629_CR19","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jns.2012.11.004","volume":"324","author":"Z Kobayashi","year":"2013","unstructured":"Kobayashi Z, Akaza M, Numasawa Y, Ishihara S, Tomimitsu H, Nakamichi K, Saijo M, Morio T, Shimizu N, Sanjo N, Shintani S, Mizusawa H (2013) Failure of mefloquine therapy in progressive multifocal leukoencephalopathy: report of two Japanese patients without human immunodeficiency virus infection. J Neurol Sci 324:190\u2013194","journal-title":"J Neurol Sci"},{"key":"9629_CR20","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1212\/WNL.0b013e3181c0d4a1","volume":"73","author":"A Marzocchetti","year":"2009","unstructured":"Marzocchetti A, Tompkins T, Clifford DB, Gandhi RT, Kesari S, Berger JR, Simpson DM, Prosperi M, De Luca A, Koralnik IJ (2009) Determinants of survival in progressive multifocal leukoencephalopathy. Neurology 73:1551\u20131558","journal-title":"Neurology"},{"key":"9629_CR21","doi-asserted-by":"publisher","first-page":"496","DOI":"10.2146\/ajhp110392","volume":"69","author":"RP Moenster","year":"2012","unstructured":"Moenster RP, Jett RA (2012) Mirtazapine and mefloquine therapy for progressive multifocal leukoencephalopathy in a patient infected with human immunodeficiency virus. Am J Health Syst Pharm 69:496\u2013498","journal-title":"Am J Health Syst Pharm"},{"key":"9629_CR22","doi-asserted-by":"publisher","first-page":"438","DOI":"10.4329\/wjr.v7.i12.438","volume":"7","author":"H Morales","year":"2015","unstructured":"Morales H, Tomsick T (2015) Middle cerebellar peduncles: Magnetic resonance imaging and pathophysiologic correlate. World J Radiol 7:438\u2013447","journal-title":"World J Radiol"},{"key":"9629_CR23","doi-asserted-by":"publisher","first-page":"843","DOI":"10.5692\/clinicalneurol.53.843","volume":"53","author":"A Morimoto","year":"2013","unstructured":"Morimoto A, Ueno H, Fujii H, Nakamura T, Nakamichi K, Saijo M, Yukitake M, Matsumoto M (2013) Ineffective mefloquine therapy in progressive multifocal leukoencephalopathy complicated with malignant lymphoma: finding and usefulness of susceptibility-weighted imaging. Rinsho Shinkeigaku 53:843\u2013847","journal-title":"Rinsho Shinkeigaku"},{"key":"9629_CR24","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1186\/1471-2377-12-121","volume":"12","author":"K Nakamichi","year":"2012","unstructured":"Nakamichi K, Mizusawa H, Yamada M, Kishida S, Miura Y, Shimokawa T, Takasaki T, Lim CK, Kurane I, Saijo M (2012) Characteristics of progressive multifocal leukoencephalopathy clarified through internet-assisted laboratory surveillance in Japan. BMC Neurol 12:121","journal-title":"BMC Neurol"},{"key":"9629_CR25","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.3038-19","author":"R Nishigori","year":"2019","unstructured":"Nishigori R, Warabi Y, Shishido-Hara Y, Nakamichi K, Nakata Y, Komori T, Isozaki E (2019) Inflammatory cerebellar PML with a CD4\/CD8 ratio of 2.9 showed a favorable prognosis in a patient with rheumatoid arthritis: a case report. Intern Med. https:\/\/doi.org\/10.2169\/internalmedicine.3038-19","journal-title":"Intern Med"},{"key":"9629_CR26","doi-asserted-by":"publisher","first-page":"705","DOI":"10.5692\/clinicalneurol.cn-000928","volume":"56","author":"E Ohnuki","year":"2016","unstructured":"Ohnuki E, Asayama S, Asayama T, Nakamichi K, Saijo M, Kosaka S (2016) A case of progressive multifocal leukoencephalopathy with chronic renal failure, whose JC virus in cerebrospinal fluid disappeared after mefloquine-mirtazapine dual therapy. Rinsho Shinkeigaku 56:705\u2013708","journal-title":"Rinsho Shinkeigaku"},{"key":"9629_CR27","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1017\/S031716710011950X","volume":"6","author":"J Parr","year":"1979","unstructured":"Parr J, Horoupian DS, Winkelman AC (1979) Cerebellar form of progressive multifocal leukoencephalopathy (PML). Can J Neurol Sci 6:123\u2013128","journal-title":"Can J Neurol Sci"},{"key":"9629_CR28","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1136\/jnnp-2011-300511","volume":"83","author":"R Phan-Ba","year":"2012","unstructured":"Phan-Ba R, Lommers E, Tshibanda L, Calay P, Dubois B, Moonen G, Clifford D, Belachew S (2012) MRI preclinical detection and asymptomatic course of a progressive multifocal leucoencephalopathy (PML) under natalizumab therapy. J Neurol Neurosurg Psychiatry 83:224\u2013226","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"9629_CR29","doi-asserted-by":"publisher","first-page":"738","DOI":"10.1590\/0004-282X20130162","volume":"71","author":"AJ Rocha","year":"2013","unstructured":"Rocha AJ, Littig IA, Nunes RH, Tilbery CP (2013) Central nervous system infectious diseases mimicking multiple sclerosis: recognizing distinguishable features using MRI. Arq Neuropsiquiatr 71:738\u2013746","journal-title":"Arq Neuropsiquiatr"},{"key":"9629_CR30","doi-asserted-by":"publisher","first-page":"e53","DOI":"10.1086\/500400","volume":"42","author":"MA Rueger","year":"2006","unstructured":"Rueger MA, Miletic H, Dorries K, Wyen C, Eggers C, Deckert M, Faetkenheuer G, Jacobs AH (2006) Long-term remission in progressive multifocal leukoencephalopathy caused by idiopathic CD4+ T lymphocytopenia: a case report. Clin Infect Dis 42:e53\u201356","journal-title":"Clin Infect Dis"},{"key":"9629_CR31","doi-asserted-by":"publisher","first-page":"1060","DOI":"10.1111\/j.1468-1331.2011.03597.x","volume":"19","author":"MA Sahraian","year":"2012","unstructured":"Sahraian MA, Radue EW, Eshaghi A, Besliu S, Minagar A (2012) Progressive multifocal leukoencephalopathy: a review of the neuroimaging features and differential diagnosis. Eur J Neurol 19:1060\u20131069","journal-title":"Eur J Neurol"},{"key":"9629_CR32","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1016\/j.crad.2010.03.001","volume":"65","author":"R Shah","year":"2010","unstructured":"Shah R, Bag AK, Chapman PR, Cure JK (2010) Imaging manifestations of progressive multifocal leukoencephalopathy. Clin Radiol 65:431\u2013439","journal-title":"Clin Radiol"},{"key":"9629_CR33","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1007\/s00401-010-0694-x","volume":"120","author":"Y Shishido-Hara","year":"2010","unstructured":"Shishido-Hara Y (2010) Progressive multifocal leukoencephalopathy and promyelocytic leukemia nuclear bodies: a review of clinical, neuropathological, and virological aspects of JC virus-induced demyelinating disease. Acta Neuropathol 120:403\u2013417","journal-title":"Acta Neuropathol"},{"key":"9629_CR34","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1097\/NEN.0b013e31816a1dd3","volume":"67","author":"Y Shishido-Hara","year":"2008","unstructured":"Shishido-Hara Y, Higuchi K, Ohara S, Duyckaerts C, Hauw JJ, Uchihara T (2008) Promyelocytic leukemia nuclear bodies provide a scaffold for human polyomavirus JC replication and are disrupted after development of viral inclusions in progressive multifocal leukoencephalopathy. J Neuropathol Exp Neurol 67:299\u2013308","journal-title":"J Neuropathol Exp Neurol"},{"key":"9629_CR35","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1016\/S1474-4422(10)70040-5","volume":"9","author":"CS Tan","year":"2010","unstructured":"Tan CS, Koralnik IJ (2010) Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis. Lancet Neurol 9:425\u2013437","journal-title":"Lancet Neurol"},{"key":"9629_CR36","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1212\/WNL.0b013e31822e55e7","volume":"77","author":"IL Tan","year":"2011","unstructured":"Tan IL, McArthur JC, Clifford DB, Major EO, Nath A (2011) Immune reconstitution inflammatory syndrome in natalizumab-associated PML. Neurology 77:1061\u20131067","journal-title":"Neurology"},{"key":"9629_CR37","doi-asserted-by":"publisher","first-page":"133","DOI":"10.2463\/mrms.3.133","volume":"3","author":"A Uchino","year":"2004","unstructured":"Uchino A, Sawada A, Takase Y, Kudo S (2004) Symmetrical lesions of the middle cerebellar peduncle: MR imaging and differential diagnosis. Magn Reson Med Sci 3:133\u2013140","journal-title":"Magn Reson Med Sci"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-019-09629-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-019-09629-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-019-09629-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T00:43:47Z","timestamp":1659055427000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-019-09629-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,14]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["9629"],"URL":"https:\/\/doi.org\/10.1007\/s00415-019-09629-x","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,14]]},"assertion":[{"value":"25 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2019","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 November 2019","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 November 2019","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no potential conflicts of interest in relation to this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from the patient included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}