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Papadopoulou A.: consulted for Teva, received speaker-fee from Sanofi-Genzyme, travel support from Bayer AG, Teva, UCB-Pharma AG, Roche and research support from the University of Basel and the Swiss National. Science Foundation. Gaetano, L.: former employee of Novartis is currently working for F. Hoffmann-La Roche Ltd. Parmar, K.: holds a grant of the Baasch -Medicus foundation. Her institution (University Hospital Basel) received speakers honoraria from Novartis and ExceMED and travel support by Novartis Switzerland. Ettlin, Th.: Institution (Reha Rheinfelden) received and used exclusively for research support: consultancy fee and speaker fees from Gr\u00fcnenthal; support of educational activities Almirall, A. Menarini, Allergan, Bayer, Biogen, Bristol-Myers Squibb SA, Daiichi-Sankyo, Gr\u00fcnenthal, IBSA Pharma AG, Lundbeck, Mepha, Merck, Merz Pharma, MSD Merck Sharp & Dohme AG, Mundipharma, Pfizer, Sanofi Genzyme, Sigma-Tau, Zambon. Schuster-Amft, C.: Institution (Reha Rheinfelden) received and used exclusively for research support from Innosuisse; Swiss National Physiotherapy Association \u201cphysioswiss\u201d; European Union; Foundation to promote Science, Research, Education, and Health; Frieda Locher Hofmann Foundation; Forschungfonds Canton. Aargau. Wuerfel, J.: CEO of MIAC AG Basel, Switzerland. He served on scientific advisory boards of Actelion, Biogen, Genzyme-Sanofi, Novartis, and Roche. He is or was supported by grants of the EU (Horizon2020), German Federal Ministeries of Education and Research (BMBF) and of Economic Affairs and Energy (BMWI). Kappos, L: Institution (University Hospital Basel) received and used exclusively for research support: steering committee, advisory board, and consultancy fees from Actelion, Addex, Bayer HealthCare, Biogen, Biotica, Celgene\/Receptos, Genzyme, Lilly, Merck, Mitsubishi, Novartis, Ono Pharma, Pfizer, Sanofi, Santhera, Siemens, Teva, UCB, Xenoport; speaker fees from Bayer HealthCare, Biogen, Merck, Novartis, Sanofi, Teva; support of educational activities from Bayer HealthCare, Biogen, CSL Behring, Genzyme, Merck, Novartis, Sanofi, Teva; grants from Bayer HealthCare, Biogen, F. Hoffmann-La Roche Ltd, Merck, Novartis, the European Union, the Roche Research Foundations, the Swiss Multiple Sclerosis Society, the Swiss National Research Foundation. Sprenger, T.: Author\u2019s current and previous institutions have received compensation for author serving on scientific advisory boards\/consultation and speaking from Actelion, ATI, Biogen, Desitin, Electrocore, Novartis, Sanofi, Genzyme, and Teva; research support from Novartis, Swiss MS Society, and Swiss National Science Foundation. Magon, S.: is currently working for F. Hoffmann-La Roche Ltd. He has received research support from Swiss MS Society, Swiss National Science Foundation, University of Basel and Stiftung zur F\u00f6rderung der gastroenterologischen und allgemeinen klinischen Forschung sowie der medizinischen Bildauswertung University Hospital Basel. He also received travel support from Biogen and Genzyme.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was approved by the local ethics committee (Ethikkommission Nordwest- und Zentralschweiz) and was conducted in concordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}