{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T06:13:08Z","timestamp":1770358388104,"version":"3.49.0"},"reference-count":17,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T00:00:00Z","timestamp":1588118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1007\/s00415-020-09848-7","type":"journal-article","created":{"date-parts":[[2020,4,29]],"date-time":"2020-04-29T06:02:46Z","timestamp":1588140166000},"page":"2362-2371","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Tolerability and safety of dimethyl fumarate in relapsing multiple sclerosis: a prospective observational multicenter study in a real-life Spanish population"],"prefix":"10.1007","volume":"267","author":[{"name":"DMF Study Group","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Sabin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarai","family":"Urtiaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Belen","family":"Pilo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Israel","family":"Thuissard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victoria","family":"Galan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susana","family":"Sainz de la Maza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucienne","family":"Costa-Frossard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayra","family":"G\u00f3mez-Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judit","family":"D\u00edaz-D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celia","family":"Oreja-Guevara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Luisa","family":"Mart\u00ednez-Gin\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Borrega","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc\u00eda","family":"Ayuso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andy","family":"Castro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Meca-Lallana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"L\u00f3pez de Silanes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Rodriguez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Antonio","family":"Garc\u00eda-Merino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolanda","family":"Aladro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,4,29]]},"reference":[{"key":"9848_CR1","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1002\/ana.24497","volume":"78","author":"JM Frischer","year":"2015","unstructured":"Frischer JM, Weigand SD, Guo Y, Kale N, Parisi JE, Pirko I et al (2015) Clinical and pathological insights into the dynamic nature of the white matter multiple sclerosis plaque. Ann Neurol 78:710\u2013721","journal-title":"Ann Neurol"},{"key":"9848_CR2","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1093\/brain\/awq386","volume":"134","author":"RA Linker","year":"2011","unstructured":"Linker RA, Lee DH, Ryan S, Van Dam AM, Conrad R, Bista P et al (2011) Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway. Brain 134:678\u2013692","journal-title":"Brain"},{"key":"9848_CR3","doi-asserted-by":"publisher","first-page":"1087","DOI":"10.1056\/NEJMoa1206328","volume":"367","author":"RJ Fox","year":"2012","unstructured":"Fox RJ, Miller DH, Phillips JT, Hutchinson M, Havrdova E, Kita M et al (2012) Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis. N Engl J Med 367:1087\u20131097","journal-title":"N Engl J Med"},{"key":"9848_CR4","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1056\/NEJMoa1114287","volume":"367","author":"R Gold","year":"2012","unstructured":"Gold R, Kappos L, Arnold DL, Bar-Or A, Giovannoni G, Selmaj K et al (2012) Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis. N Engl J Med 367:1098\u20131107","journal-title":"N Engl J Med"},{"key":"9848_CR5","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1111\/ene.13272","volume":"24","author":"E Havrdova","year":"2017","unstructured":"Havrdova E, Giovannoni G, Gold R, Fox RJ, Kappos L, Phillips JT et al (2017) Effect of delayed-release dimethyl fumarate on no evidence of disease activity in relapsing\u2013remitting multiple sclerosis: integrated analysis of the phase III DEFINE and CONFIRM studies. Eur J Neurol 24:726\u2013733","journal-title":"Eur J Neurol"},{"key":"9848_CR6","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1177\/1352458516649037","volume":"23","author":"R Gold","year":"2017","unstructured":"Gold R, Arnold DL, Bar-Or A, Hutchinson M, Kappos L, Havrdova E et al (2017) Long-term effects of delayed-release dimethyl fumarate in multiple sclerosis: Interim analysis of ENDORSE, a randomized extension study. Mult Scler 23:253\u2013265","journal-title":"Mult Scler"},{"key":"9848_CR7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/suv035","author":"TA Cohen","year":"2015","unstructured":"Cohen TA, Goto S, Schreiber K, Torp-Pedersen C (2015) Why do we need observational studies of everyday patients in the real-life setting? Eur Heart J Supp. https:\/\/doi.org\/10.1093\/eurheartj\/suv035","journal-title":"Eur Heart J Supp"},{"key":"9848_CR8","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1177\/1352458516662728","volume":"23","author":"T Kalincik","year":"2017","unstructured":"Kalincik T, Kuhle J, Pucci E, Rojas JI, Tsolaki M, Sirbu CA et al (2017) Data quality evaluation for observational multiple sclerosis registries. Mult Scler J 23:647\u2013655","journal-title":"Mult Scler J"},{"key":"9848_CR9","doi-asserted-by":"publisher","first-page":"1850","DOI":"10.1007\/s00415-018-8916-6","volume":"265","author":"G Mallucci","year":"2018","unstructured":"Mallucci G, Annovazzi P, Miante S, Torri-Clerici V, Matta M, La Gioia S et al (2018) Two-year real-life efficacy, tolerability and safety of dimethyl fumarate in an Italian multicentre study. J Neurol 265:1850\u20131859","journal-title":"J Neurol"},{"key":"9848_CR10","doi-asserted-by":"publisher","first-page":"963","DOI":"10.1007\/s40263-018-0543-3","volume":"32","author":"M Mirabella","year":"2018","unstructured":"Mirabella M, Prosperini L, Lucchini M, Boffa L, Borriello G, Buscarinu MC et al (2018) Safety and efficacy of dimethyl fumarate in multiple sclerosis: an Italian, multicenter, real-world Study. CNS Drugs 32:963\u2013970","journal-title":"CNS Drugs"},{"key":"9848_CR11","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1007\/s00415-016-8175-3","volume":"263","author":"A Miclea","year":"2016","unstructured":"Miclea A, Leussink VI, Hartung HP, Gold R, Hoepner R (2016) Safety and efficacy of dimethyl fumarate in multiple sclerosis: a multi-center observational study. J Neurol 263:1626\u20131632","journal-title":"J Neurol"},{"key":"9848_CR12","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.msard.2018.05.007","volume":"24","author":"T Sejbaek","year":"2018","unstructured":"Sejbaek T, Nybo M, Petersen T, Illes Z (2018) Real-life persistence and tolerability with dimethyl fumarate. Mult Scler Relat Disord 24:42\u201346","journal-title":"Mult Scler Relat Disord"},{"key":"9848_CR13","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s40120-017-0080-x","volume":"6","author":"R Alroughani","year":"2017","unstructured":"Alroughani R, Ahmed SF, Behbehani R, Al-Hashel J (2017) Effectiveness and safety of dimethyl fumarate treatment in relapsing multiple sclerosis patients: real-world evidence. Neurol Ther 6:189\u2013196","journal-title":"Neurol Ther"},{"key":"9848_CR14","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1212\/WNL.0000000000003045","volume":"87","author":"F Purchiaroni","year":"2016","unstructured":"Purchiaroni F, Salvetti M, Buscarinu MC, Annibale B (2016) Eosinophilic gastroenteritis in a woman with multiple esclerosis on dimethyl fumarate. Neurlogy 87:952\u2013953","journal-title":"Neurlogy"},{"key":"9848_CR15","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s40120-019-0127-2","volume":"8","author":"J Min","year":"2019","unstructured":"Min J, Cohan S, Alvarez E, Sloane J, Phillips JT, Van der Walt A et al (2019) Real-world characterization of dimethyl fumarate-related gastrointestinal events in multiple sclerosis: management strategies to improve persistence on treatment and patient outcomes. Neurol Ther 8:109\u2013119. https:\/\/doi.org\/10.1007\/s40120-019-0127-2","journal-title":"Neurol Ther"},{"key":"9848_CR16","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1177\/1352458514564489","volume":"21","author":"RA Marrie","year":"2015","unstructured":"Marrie RA, Reider N, Cohen J, Stuve O, Trojano M, Sorensen PS et al (2015) A systematic review of the incidence and prevalence of cancer in multiple sclerosis. Mult Scler J 21:294\u2013304. https:\/\/doi.org\/10.1177\/1352458514564489","journal-title":"Mult Scler J"},{"key":"9848_CR17","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519866600","author":"M Granqvist","year":"2019","unstructured":"Granqvist M, Burman J, Gunnarsson M, Lycke J, Nilsson P, Olsson T et al (2019) Comparative effectiveness of dimethyl fumarate as the initial and secondary treatment for MS. Mult Scler J. https:\/\/doi.org\/10.1177\/1352458519866600","journal-title":"Mult Scler J"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-020-09848-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-020-09848-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-020-09848-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T01:41:01Z","timestamp":1619660461000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-020-09848-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,29]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["9848"],"URL":"https:\/\/doi.org\/10.1007\/s00415-020-09848-7","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,29]]},"assertion":[{"value":"11 February 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 April 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare no conflict of interest for this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}