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ML received grants, honoraria or funding from Almirall, Bayer, Biogen, Genzyme, Merck, Novartis, Roche and Teva. MW received research grants from Abbvie, Adastra, Bristol Meyer Squibb (BMS), Dracen, Merck, Sharp & Dohme (MSD), Merck (EMD), Novocure, Piqur and Roche, and honoraria for lectures or advisory board participation or consulting from Abbvie, Basilea, Bristol Meyer Squibb (BMS), Celgene, Merck, Sharp and Dohme (MSD), Merck (EMD), Novocure, Orbus, Roche and Tocagen. BZ received honoraria, travel grants, and funding from Biogen and Roche. The other authors declare that there is no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The studies were approved by the Zurich cantonal ethics committee (KEK-2011-0445, KEK-2014-0004) in Switzerland.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"All participants gave written, informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors read and approved the final manuscript and gave consent for publication.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}