{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T04:54:48Z","timestamp":1777179288332,"version":"3.51.4"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1007\/s00415-020-10085-1","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:09:42Z","timestamp":1595376582000},"page":"3723-3730","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The importance of physical activity to preserve hippocampal volume in people with multiple sclerosis: a structural MRI study"],"prefix":"10.1007","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7999-0868","authenticated-orcid":false,"given":"Alon","family":"Kalron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shay","family":"Menascu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5339-9495","authenticated-orcid":false,"given":"Chen","family":"Hoffmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2020-3126","authenticated-orcid":false,"given":"Anat","family":"Achiron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,7,22]]},"reference":[{"key":"10085_CR1","doi-asserted-by":"publisher","first-page":"e279","DOI":"10.1212\/nxi.0000000000000279","volume":"3","author":"SC Krieger","year":"2016","unstructured":"Krieger SC, Cook K, De Nino S, Fletcher M (2016) The topographical model of multiple sclerosis: A dynamic visualization of disease course. Neurol Neuroimmunol Neuroinflamm 3:e279. https:\/\/doi.org\/10.1212\/nxi.0000000000000279","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"key":"10085_CR2","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1016\/s0140-6736(08)61620-7","volume":"372","author":"A Compston","year":"2008","unstructured":"Compston A, Coles A (2008) Multiple sclerosis. Lancet 372:1502\u20131517. https:\/\/doi.org\/10.1016\/s0140-6736(08)61620-7","journal-title":"Lancet"},{"key":"10085_CR3","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/s1474-4422(17)30281-8","volume":"16","author":"RW Motl","year":"2017","unstructured":"Motl RW, Sandroff BM, Kwakkel G, Dalgas U, Feinstein A, Heesen C, Feys P, Thompson AJ (2017) Exercise in patients with multiple sclerosis. Lancet Neurol 16:848\u2013856. https:\/\/doi.org\/10.1016\/s1474-4422(17)30281-8","journal-title":"Lancet Neurol"},{"key":"10085_CR4","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1007\/s11910-015-0585-6","volume":"15","author":"RW Motl","year":"2015","unstructured":"Motl RW, Sandroff BM (2015) Benefits of exercise training in multiple sclerosis. Curr Neurol Neurosci Rep 15:62. https:\/\/doi.org\/10.1007\/s11910-015-0585-6","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10085_CR5","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1007\/s11910-019-1002-3","volume":"19","author":"U Dalgas","year":"2019","unstructured":"Dalgas U, Langeskov-Christensen M, Stenager E, Riemenschneider M, Hvid LG (2019) Exercise as medicine in multiple sclerosis-time for a paradigm shift: preventive, symptomatic, and disease-modifying aspects and perspectives. Curr Neurol Neurosci Rep 19:88. https:\/\/doi.org\/10.1007\/s11910-019-1002-3","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10085_CR6","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.neuroimage.2017.11.007","volume":"166","author":"J Firth","year":"2018","unstructured":"Firth J, Stubbs B, Vancampfort D, Schuch F, Lagopoulos Rosenbaum S, Ward PB (2018) Effect of aerobic exercise on hippocampal volume in humans: a systematic review and meta-analysis. Neuroimage 166:230\u2013238. https:\/\/doi.org\/10.1016\/j.neuroimage.2017.11.007","journal-title":"Neuroimage"},{"key":"10085_CR7","doi-asserted-by":"publisher","first-page":"1142","DOI":"10.1093\/geronb\/gby010","volume":"74","author":"S Halloway","year":"2019","unstructured":"Halloway S, Arfanakis K, Wilbur J, Schoeny ME, Pressler SJ (2019) Accelerometer physical activity is associated with greater gray matter volumes in older adults without dementia or mild cognitive impairment. J Gerontol B Psychol Sci Soc Sci 74:1142\u20131151. https:\/\/doi.org\/10.1093\/geronb\/gby010","journal-title":"J Gerontol B Psychol Sci Soc Sci"},{"key":"10085_CR8","doi-asserted-by":"publisher","first-page":"48253666","DOI":"10.1155\/2015\/482536","volume":"2015","author":"RE Klaren","year":"2015","unstructured":"Klaren RE, Hubbard EA, Motl RW, Pilutti LA, Wetter NC, Sutton BP (2015) Objectively measured physical activity is associated with brain volumetric measurements in multiple sclerosis. Behav Neurol 2015:48253666. https:\/\/doi.org\/10.1155\/2015\/482536","journal-title":"Behav Neurol"},{"key":"10085_CR9","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.nicl.2015.02.017","volume":"7","author":"RW Motl","year":"2015","unstructured":"Motl RW, Pilutti LA, Hubbard E, Wetter NC, Sosnoff JJ, Suttom BP (2015) Cardiorespiratory fitness and its association with thalamic, hippocampal, and basal ganglia volumes in multiple sclerosis. Neuroimage Clin 7:661\u2013666. https:\/\/doi.org\/10.1016\/j.nicl.2015.02.017","journal-title":"Neuroimage Clin"},{"key":"10085_CR10","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1080\/13554794.2013.841951","volume":"20","author":"VM Leavitt","year":"2014","unstructured":"Leavitt VM, Cirnigliaro C, Cohen A, Farag A, Brooks M, Wecht JM, Wylie GR, Chiaravalloti ND, DeLuca J, Sumowski JF (2014) Aerobic exercise increases hippocampal volume and improves memory in multiple sclerosis: preliminary findings. Neurocase 20:695\u2013697. https:\/\/doi.org\/10.1080\/13554794.2013.841951","journal-title":"Neurocase"},{"key":"10085_CR11","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00234-016-1767-x","volume":"59","author":"BM Sandroff","year":"2017","unstructured":"Sandroff BM, Johnson CL, Motl RW (2017) Exercise training effects on memory and hippocampal viscoelasticity in multiple sclerosis: a novel application of magnetic resonance elastography. Neuroradiology 59:61\u201367. https:\/\/doi.org\/10.1007\/s00234-016-1767-x","journal-title":"Neuroradiology"},{"key":"10085_CR12","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1177\/1352458517722645","volume":"24","author":"T Kj\u00f8lhede","year":"2018","unstructured":"Kj\u00f8lhede T, Siemonsen S, Wenzel D, Stellmann J-P, Ringgaard S, Pedersen BG, Stenager E, Petersen T, Vissing K, Heesen C, Dalgas U (2018) Can resistance training impact MRI outcomes in relapsing-remitting multiple sclerosis? Mult Scler 24:1356\u20131365. https:\/\/doi.org\/10.1177\/1352458517722645","journal-title":"Mult Scler"},{"key":"10085_CR13","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.msard.2019.04.030","volume":"32","author":"S Menascu","year":"2019","unstructured":"Menascu S, Stern M, Aloni R, Kalron A, Magalshvili D, Achiron A (2019) Assessing cognitive performance in radiologically isolated syndrome. Mult Scler Relat Disord 32:70\u201373. https:\/\/doi.org\/10.1016\/j.msard.2019.04.030","journal-title":"Mult Scler Relat Disord"},{"key":"10085_CR14","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1212\/wnl.0000000000003542","volume":"88","author":"MA Rocca","year":"2017","unstructured":"Rocca MA, Battaglini M, Benedict RH, Stefano De, Geurts JJG, Henry RG, Horsfield MA, Jenkinson M, Pagani E, Filippi M (2017) Brain MRI atrophy quantification in MS: from methods to clinical application. Neurology 88:403\u2013413. https:\/\/doi.org\/10.1212\/wnl.0000000000003542","journal-title":"Neurology"},{"key":"10085_CR15","doi-asserted-by":"publisher","first-page":"804","DOI":"10.3174\/ajnr.a6513","volume":"41","author":"I Kalinin","year":"2020","unstructured":"Kalinin I, Makshakov G, Evdoshenko E (2020) The impact of intracortical lesions on volumes of subcortical structures in multiple sclerosis. AJNR Am J Neuroradiol 41:804\u2013808. https:\/\/doi.org\/10.3174\/ajnr.a6513","journal-title":"AJNR Am J Neuroradiol"},{"key":"10085_CR16","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/j.neuroimage.2012.01.092","volume":"60","author":"A Pfefferbaum","year":"2012","unstructured":"Pfefferbaum A, Rohlfing T, Rosenbloom MJ, Sullivan EV (2012) Combining atlas-based parcellation of regional brain data acquired across scanners at 1.5 T and 3.0 T field strengths. Neuroimage 60:940\u2013951. https:\/\/doi.org\/10.1016\/j.neuroimage.2012.01.092","journal-title":"Neuroimage"},{"key":"10085_CR17","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/ana.22366","volume":"69","author":"CH Polman","year":"2011","unstructured":"Polman CH, Reingold SC, Banwell B et al (2011) Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 69:292\u2013302. https:\/\/doi.org\/10.1002\/ana.22366","journal-title":"Ann Neurol"},{"key":"10085_CR18","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1212\/wnl.33.11.1444","volume":"33","author":"JF Kurtzke","year":"1983","unstructured":"Kurtzke JF (1983) Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology 33:1444\u20131452. https:\/\/doi.org\/10.1212\/wnl.33.11.1444","journal-title":"Neurology"},{"issue":"8","key":"10085_CR19","doi-asserted-by":"publisher","first-page":"e71058","DOI":"10.1371\/journal.pone.0071058","volume":"8","author":"A Achiron","year":"2013","unstructured":"Achiron A, Chapman J, Magalashvili D et al (2013) Modeling of cognitive impairment by disease duration in multiple sclerosis: a cross-sectional study. PLoS ONE 8(8):e71058. https:\/\/doi.org\/10.1371\/journal.pone.0071058","journal-title":"PLoS ONE"},{"key":"10085_CR20","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/s0896-6273(02)00569-x","volume":"33","author":"B Fischl","year":"2002","unstructured":"Fischl B, Salat DH, Busa E et al (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33:341\u2013355. https:\/\/doi.org\/10.1016\/s0896-6273(02)00569-x","journal-title":"Neuron"},{"key":"10085_CR21","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1016\/j.neuroimage.2004.07.016","volume":"23","author":"B Fischl","year":"2004","unstructured":"Fischl B, Salat DH, van der Kouwe AJ, Makris N, Segonne F, Quinn BT, Dale AMI (2004) Sequence- independent segmentation of magnetic resonance images. Neuroimage 23:S69\u2013S84. https:\/\/doi.org\/10.1016\/j.neuroimage.2004.07.016","journal-title":"Neuroimage"},{"key":"10085_CR22","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1212\/wnl.58.5.695","volume":"58","author":"HD Rosas","year":"2004","unstructured":"Rosas HD, Liu AK, Hersch S, Glessner M, Ferrante RJ, Salat DH, van der Kouwe A, Jenkins BG, Dale AM, Fischl B (2004) Regional and progressive thinning of the cortical ribbon in Huntington\u2019s disease. Neurology 58:695\u2013701. https:\/\/doi.org\/10.1212\/wnl.58.5.695","journal-title":"Neurology"},{"key":"10085_CR23","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1001\/archpsyc.60.9.878","volume":"60","author":"GR Kuperberg","year":"2003","unstructured":"Kuperberg GR, Broome MR, McGuire PK et al (2003) Regionally localized thinning of the cerebral cortex in schizophrenia. Arch Gen Psychiatry 60:878\u2013888. https:\/\/doi.org\/10.1001\/archpsyc.60.9.878","journal-title":"Arch Gen Psychiatry"},{"key":"10085_CR24","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1093\/cercor\/bhh032","volume":"14","author":"DH Salat","year":"2004","unstructured":"Salat DH, Buckner RL, Snyder AZ, Greve DN, Desikan RSR, Busa E, Morris JC, Dae AM, Fischl B (2004) Thinning of the cerebral cortex in aging. Cereb Cortex 14:721\u2013730. https:\/\/doi.org\/10.1093\/cercor\/bhh032","journal-title":"Cereb Cortex"},{"key":"10085_CR25","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/j.neuroimage.2006.02.051","volume":"32","author":"X Han","year":"2006","unstructured":"Han X, Jovicich J, Salat D et al (2006) Reliability of MRI-derived measurements of human cerebral cortical thickness: the effects of field strength, scanner upgrade and manufacturer. Neuroimage 32:180\u2013194. https:\/\/doi.org\/10.1016\/j.neuroimage.2006.02.051","journal-title":"Neuroimage"},{"key":"10085_CR26","doi-asserted-by":"publisher","first-page":"023231","DOI":"10.1136\/bmjopen-2018-023231","volume":"8","author":"BM Sandroff","year":"2018","unstructured":"Sandroff BM, Motl RW, Bamman M, Cutter GR, Bolding M, Rinker JR, Wylie GR, Genova H, Deuca J (2018) Rationale and design of a single-blind, randomised controlled trial of exercise training for managing learning and memory impairment in persons with multiple sclerosis. BMJ Open 8:023231. https:\/\/doi.org\/10.1136\/bmjopen-2018-023231","journal-title":"BMJ Open"},{"key":"10085_CR27","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519863644","author":"M Huiskamp","year":"2019","unstructured":"Huiskamp M, Moumdjian L, van Asch P et al (2019) A pilot study of the effects of running training on visuospatial memory in MS: a stronger functional embedding of the hippocampus in the default-mode network? Mult Scler. https:\/\/doi.org\/10.1177\/1352458519863644","journal-title":"Mult Scler"},{"key":"10085_CR28","doi-asserted-by":"publisher","first-page":"35","DOI":"10.2217\/nmt-2017-0040","volume":"7","author":"U Dalgas","year":"2017","unstructured":"Dalgas U (2017) Exercise therapy in multiple sclerosis and its effects on function and the brain. Neurodegener Dis Manag 7:35\u201340. https:\/\/doi.org\/10.2217\/nmt-2017-0040","journal-title":"Neurodegener Dis Manag"},{"key":"10085_CR29","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1016\/j.dib.2016.10.001","volume":"9","author":"O Potvin","year":"2016","unstructured":"Potvin O, Mouiha A, Dieumegarde L, Duchesne S (2016) Alzheimer\u05f3s disease neuroimaging initiative. FreeSurfer subcortical normative data. Data Brief 9:732\u2013736. https:\/\/doi.org\/10.1016\/j.dib.2016.10.001","journal-title":"Data Brief"},{"key":"10085_CR30","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.neuroimage.2016.05.016","volume":"137","author":"O Potvin","year":"2016","unstructured":"Potvin O, Mouiha A, Dieumegarde L, Duchesne S, Alzheimer\u2019s Disease Neuroimaging (2016) Initiative Normative data for subcortical regional volumes over the lifetime of the adult human brain. Neuroimage 137:9\u201320. https:\/\/doi.org\/10.1016\/j.neuroimage.2016.05.016","journal-title":"Neuroimage"},{"issue":"3","key":"10085_CR31","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1037\/0894-4105.20.3.259","volume":"20","author":"JR Crawford","year":"2006","unstructured":"Crawford JR, Garthwaite PH (2006) Comparing patients\u2019 predicted test scores from a regression equation with their obtained scores: a significance test and point estimate of abnormality with accompanying confidence limits. Neuropsychology 20(3):259\u2013271. https:\/\/doi.org\/10.1037\/0894-4105.20.3.259","journal-title":"Neuropsychology"},{"key":"10085_CR32","first-page":"141","volume":"10","author":"G Godin","year":"1985","unstructured":"Godin G, Shephard RJ (1985) A simple method to assess exercise behavior in the community. Can J Appl Sport Sci 10:141\u2013146","journal-title":"Can J Appl Sport Sci"},{"key":"10085_CR33","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1080\/09638288.2018.1424956","volume":"41","author":"EM Sikes","year":"2019","unstructured":"Sikes EM, Richardson EV, Cederberg KJ, Sasaki JE, Sandroff BM, Motl RW (2019) Use of the godin leisure-time exercise questionnaire in multiple sclerosis research: a comprehensive narrative review. Disabil Rehabil 41:1243\u20131267. https:\/\/doi.org\/10.1080\/09638288.2018.1424956","journal-title":"Disabil Rehabil"},{"key":"10085_CR34","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1017\/s1355617711001093","volume":"17","author":"RS Prakash","year":"2011","unstructured":"Prakash RS, Patterson B, Janssen A, Abduljalil A, Boster A (2011) Physical activity associated with increased resting-state functional connectivity in multiple sclerosis. J Int Neuropsychol Soc 17:986\u2013997. https:\/\/doi.org\/10.1017\/s1355617711001093","journal-title":"J Int Neuropsychol Soc"},{"key":"10085_CR35","doi-asserted-by":"publisher","first-page":"1505","DOI":"10.1152\/japplphysiol.00210.2011","volume":"111","author":"MW Voss","year":"1985","unstructured":"Voss MW, Nagamatsu LS, Liu-Ambrose T, Kramer AF (1985) Exercise, brain, and cognition across the life span. J Appl Physiol 111:1505\u20131513. https:\/\/doi.org\/10.1152\/japplphysiol.00210.2011","journal-title":"J Appl Physiol"},{"key":"10085_CR36","doi-asserted-by":"publisher","first-page":"3017","DOI":"10.1073\/pnas.1015950108","volume":"108","author":"KI Erickson","year":"2011","unstructured":"Erickson KI, Voss MW, Prakash RS et al (2011) Exercise training increases size of hippocampus and improves memory. Proc Natl Acad Sci USA 108:3017\u20133022. https:\/\/doi.org\/10.1073\/pnas.1015950108","journal-title":"Proc Natl Acad Sci USA"},{"key":"10085_CR37","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jpsychires.2014.10.003","volume":"60","author":"KL Szuhany","year":"2015","unstructured":"Szuhany KL, Bugatti M, Otto MW (2015) A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor. J Psychiatr Res 60:56\u201364. https:\/\/doi.org\/10.1016\/j.jpsychires.2014.10.003","journal-title":"J Psychiatr Res"},{"key":"10085_CR38","doi-asserted-by":"publisher","first-page":"91","DOI":"10.2165\/00007256-200838020-00001","volume":"38","author":"LJ White","year":"2008","unstructured":"White LJ, Castellano V (2008) Exercise and brain health\u2013implications for multiple sclerosis: part 1\u2013neuronal growth factors. Sports Med 38:91\u2013100. https:\/\/doi.org\/10.2165\/00007256-200838020-00001","journal-title":"Sports Med"},{"key":"10085_CR39","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1097\/phh.0b013e3181d52804","volume":"16","author":"JF Sallis","year":"2010","unstructured":"Sallis JF (2010) Measuring physical activity: practical approaches for program in native American communities. J Public Health Manag Pract 16:404\u2013410. https:\/\/doi.org\/10.1097\/phh.0b013e3181d52804","journal-title":"J Public Health Manag Pract"},{"key":"10085_CR40","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1037\/rep0000162","volume":"63","author":"RW Motl","year":"2018","unstructured":"Motl RW, Bollaert RE, Sandroff BM (2018) Validation of the godin leisure-time exercise questionnaire classification coding system using accelerometry in multiple sclerosis. Rehabil Psychol 63:77\u201382. https:\/\/doi.org\/10.1037\/rep0000162","journal-title":"Rehabil Psychol"},{"issue":"2","key":"10085_CR41","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.acn.2007.10.002","volume":"23","author":"BJ Diamond","year":"2008","unstructured":"Diamond BJ, Johnson SK, Kaufman M, Graves L (2008) Relationships between information processing, depression, fatigue and cognition in multiple sclerosis. Arch Clin Neuropsychol 23(2):189\u2013199. https:\/\/doi.org\/10.1016\/j.acn.2007.10.002","journal-title":"Arch Clin Neuropsychol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-020-10085-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-020-10085-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-020-10085-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,21]],"date-time":"2021-07-21T23:46:20Z","timestamp":1626911180000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-020-10085-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,22]]},"references-count":41,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["10085"],"URL":"https:\/\/doi.org\/10.1007\/s00415-020-10085-1","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,22]]},"assertion":[{"value":"16 June 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2020","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 July 2020","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 July 2020","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study was approved by the Sheba Institutional Review Board Ethics Committee (Ethics ref. 5596\u201008\/141210), in addition to a full exemption from written or verbal consent from the study participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}