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Little is known about impact of preexisting dependency on stroke outcome after endovascular treatment (EVT).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We compared prospectively collected baseline and outcome data of previously dependent vs. independent stroke patients (prestroke modified Rankin Scale score of 3\u20135 vs. 0\u20132) treated with EVT. Outcome measures were favorable 3-month outcome (mRS\u2009\u2264\u20093 for previously dependent and mRS\u2009\u2264\u20092 for independent patients, respectively), death and symptomatic intracranial hemorrhage (sICH).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Among 1247 patients, 84 (6.7%) were dependent before stroke. They were older (81 vs. 72\u00a0years of age), more often female (61.9% vs. 46%), had a higher stroke severity at baseline (NIHSS 18 vs. 15 points), more often history of previous stroke (32.9% vs. 9.1%) and more vascular risk factors than independent patients. Favorable outcome and mortality were to the disadvantage of independent patients (26.2% vs. 44.4% and 46.4% vs. 25.5%, respectively), whereas sICH was comparable in both cohorts (4.9% vs. 5%). However, preexisting dependency was not associated with clinical outcome and mortality after adjusting for outcome predictors (OR 1.076, 95% CI 0.612\u20131.891; <jats:italic>p<\/jats:italic>\u2009=\u20090.799 and OR 1.267, 95% CI 0.758\u20132.119; <jats:italic>p<\/jats:italic>\u2009=\u20090.367, respectively).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Our study underscores the need for careful selection of care-dependent stroke patients when considering EVT, given a less favorable outcome observed in this cohort. Nonetheless, EVT should not systematically be withheld in patients with preexisting disability, since prior dependency does not significantly influence outcome.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-020-10172-3","type":"journal-article","created":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T15:04:03Z","timestamp":1598886243000},"page":"541-548","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Impact of pre-stroke dependency on outcome after endovascular therapy in acute ischemic stroke"],"prefix":"10.1007","volume":"268","author":[{"given":"Lisa","family":"Oesch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Bernasconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Kaesmacher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Urs","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascal J.","family":"Mosimann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Meinel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Goeldlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirjam","family":"Heldner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bastian","family":"Volbers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Gralla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Sarikaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"key":"10172_CR1","doi-asserted-by":"publisher","DOI":"10.1177\/0898264318822364","author":"S Schnitzer","year":"2019","unstructured":"Schnitzer S, Bluher S, Teti A, Schaeffner E, Ebert N, Martus P, Suhr R, Kuhlmey A (2019) Risk profiles for care dependency: cross-sectional findings of a population-based cohort study in Germany. 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Professor Fischer is a global PI for the SWIFT DIRECT study (Medtronic) and receives research grants from Swiss National Science Foundation (SNSF). Dr. Mosimann receives research grants from Swiss National Science Foundation (SNSF) to study new therapeutic options for cerebral aneurysms and cerebral vasospasm. Mr. Kaesmacher received travel support by Stryker and Pfizer. Dr. Volbers reports personal fees from Pfizer AG\/Bristol-Myers Squibb SA, personal fees from Bayer AG, and grants from Institutional grant (Inselspital) outside the submitted work. All other authors have nothing to disclose.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}