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One-third of patients reported disease-related fall events. Walking performance was assessed on a pressure-sensitive carpet under seven conditions: walking at preferred, slow, and maximal speed, with head reclination or eyes closed, and while performing a cognitive or motor dual-task paradigm.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Patients exhibited a significant gait impairment characterized by a broadened base of support (<jats:italic>p<\/jats:italic>\u2009=\u20090.018) with increased spatiotemporal gait variability (<jats:italic>p<\/jats:italic>\u2009=\u20090.010). Walking speed was moderately reduced (<jats:italic>p<\/jats:italic>\u00a0= 0.026)\u00a0with shortened stride length\u00a0(<jats:italic>p<\/jats:italic> = 0.001) and increased periods of double support (<jats:italic>p<\/jats:italic>\u2009=\u20090.001). Gait dysfunction became more pronounced during slow walking (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001); this was not present during fast walking. Walking with eyes closed aggravated gait disability as did walking during cognitive dual task (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>OT is associated with a specific gait disorder with a staggering wide-based walking pattern indicative of a sensory and\/or a cerebellar ataxic gait. The aggravation of gait instability during visual withdrawal and the normalization of walking with faster speeds further suggest a proprioceptive or vestibulo-cerebellar deficit as the primary source of gait disturbance in OT. In addition, the gait decline during cognitive dual task may imply cognitive processing deficits. In the end, OT is presumably a complex network disorder resulting in a specific spino-cerebello-frontocortical gait disorder that goes beyond mere tremor networks.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-020-10177-y","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T09:04:01Z","timestamp":1599815041000},"page":"285-291","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The gait disorder in primary orthostatic tremor"],"prefix":"10.1007","volume":"267","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3112-2134","authenticated-orcid":false,"given":"Ken","family":"M\u00f6hwald","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Wuehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabian","family":"Schenkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Feil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Strupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roman","family":"Schniepp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"issue":"S3","key":"10177_CR1","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1002\/mds.870131303","volume":"13","author":"G Deuschl","year":"1998","unstructured":"Deuschl G, Bain P, Brin M, Committee AHS (1998) Consensus statement of the movement disorder society on tremor. 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M\u00f6hwald, M. Wuehr, F. Schenkel, K. Feil and R. Schniepp report no disclosures or conflicts of interest. M. Strupp is Joint Chief Editor of the Journal of Neurology, Editor in Chief of Frontiers of Neuro-otology and Section Editor of F1000. He has received speaker\u2019s honoraria from Abbott, Actelion, Auris Medical, Bayer, Biogen, Eisai, Gr\u00fcnenthal, GSK, Henning Pharma, Interacoustics, Merck, MSD, Otometrics, Pierre-Fabre, TEVA, and UCB. He is a shareholder of IntraBio. He acts as a consultant for Abbott, Actelion, AurisMedical, Heel, IntraBio and Sensorion.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study procedures have been approved by the Ethics Committee of the University of Munich. All procedures were in accordance with the Declaration of Helsinki and all patients gave their written informed consent.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}}]}}