{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:19:13Z","timestamp":1792783153867,"version":"4.5.0"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T00:00:00Z","timestamp":1600819200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100004243","name":"Prinses Beatrix Spierfonds","doi-asserted-by":"publisher","award":["W.OR17-21"],"award-info":[{"award-number":["W.OR17-21"]}],"id":[{"id":"10.13039\/501100004243","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University Medical Center Utrecht","id":[{"id":"https:\/\/ror.org\/0575yy874","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study aimed at developing a quantitative approach to assess abnormalities on MRI of the brachial plexus and the cervical roots in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) and to evaluate interrater reliability and its diagnostic value.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We performed a cross-sectional study in 50 patients with CIDP, 31 with MMN and 42 disease controls. We systematically measured cervical nerve root sizes on MRI bilaterally (\n                      <jats:italic>C<\/jats:italic>\n                      5,\n                      <jats:italic>C<\/jats:italic>\n                      6,\n                      <jats:italic>C<\/jats:italic>\n                      7) in the coronal [diameter (mm)] and sagittal planes [area (mm\n                      <jats:sup>2<\/jats:sup>\n                      )], next to the ganglion (\n                      <jats:italic>G<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      ) and 1\u00a0cm distal from the ganglion (\n                      <jats:italic>G<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      ). We determined their diagnostic value using a multivariate binary logistic model and ROC analysis. In addition, we evaluated intra- and interrater reliability.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Nerve root size was larger in patients with CIDP and MMN compared to controls at all predetermined anatomical sites. We found that nerve root diameters in the coronal plane had optimal reliability (intrarater ICC 0.55\u20130.87; interrater ICC 0.65\u20130.90). AUC was 0.78 (95% CI 0.69\u20130.87) for measurements at\n                      <jats:italic>G<\/jats:italic>\n                      <jats:sub>0<\/jats:sub>\n                      and 0.81 (95% CI 0.72\u20130.91) for measurements at\n                      <jats:italic>G<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      . Importantly, our quantitative assessment of brachial plexus MRI identified an additional 10% of patients that showed response to treatment, but were missed by nerve conduction (NCS) and nerve ultrasound studies.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study showed that a quantitative assessment of brachial plexus MRI is reliable. MRI can serve as an important additional diagnostic tool to identify treatment-responsive patients, complementary to NCS and nerve ultrasound.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00415-020-10232-8","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T07:03:38Z","timestamp":1600844618000},"page":"978-988","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Quantitative assessment of brachial plexus MRI for the diagnosis of chronic inflammatory neuropathies"],"prefix":"10.1007","volume":"268","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3959-1373","authenticated-orcid":false,"given":"Marieke H. J.","family":"van Rosmalen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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Witkamp, R.P.A. van Eijk, F. Asselman, S. Mandija and M. Froeling report no competing interests. H.S. Goedee has received research support from the Prinses Beatrix Spierfonds, speaker fee and travel grands from Shire\/Takeda. L.H. van den Berg serves on scientific advisory boards for Orion, Orphazyme and Biogen; received an educational grant from Takeda; serves on the editorial board of Amyotrophic Lateral Sclerosis and the Journal of Neurology, Neurosurgery and Psychiatry; and receives research support from the Prinses Beatrix Spierfonds, Netherlands ALS Foundation, The European Community's Health Seventh Framework Programme (Grant agreement no. 259867), The Netherlands Organization for Health Research and Development (Vici Scheme, JPND (SOPHIA, STRENGTH)). J. Hendrikse has received research support from the Netherlands Organization for Scientific Research (NWO) under Grant no. 91712322 and the European Research Council under Grant agreements no. 637024. W.L. van der Pol has received support from the Prinses Beatrix Spierfonds and Stichting Spieren voor Spieren.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The medical ethical committee of the UMCU approved this study (18-349\/NL 62866.041.17) and this study have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"Written informed consent was obtained from all study participants.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Written informed consent was obtained from all study participants.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}