{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:23:32Z","timestamp":1785551012333,"version":"3.56.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Tiroler Wirtschaftsf\u00f6rderungsfonds","award":["UNI-0404\/2245"],"award-info":[{"award-number":["UNI-0404\/2245"]}]},{"name":"University of Innsbruck and Medical University of Innsbruck"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Gait impairment is a pivotal feature of parkinsonian syndromes and increased gait variability is associated with postural instability and a higher risk of falls.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Objectives<\/jats:title>\n                <jats:p>We compared gait variability at different walking velocities between and within groups of patients with Parkinson-variant multiple system atrophy, idiopathic Parkinson\u2019s disease, and a control group of older adults.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Gait metrics were recorded in 11 multiple system atrophy, 12 Parkinson\u2019s disease patients, and 18 controls using sensor-based gait analysis. Gait variability was analyzed for stride, swing and stance time, stride length and gait velocity. Values were compared between and within the groups at self-paced comfortable, fast and slow walking speed.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Multiple system atrophy patients displayed higher gait variability except for stride time at all velocities compared with controls, while Parkinson\u2019s patients did not. Compared with Parkinson\u2019s disease, multiple system atrophy patients displayed higher variability of swing time, stride length and gait velocity at comfortable speed and at slow speed for swing and stance time, stride length and gait velocity (all <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Stride time variability was significantly higher in slow compared to comfortable walking in patients with multiple system atrophy (<jats:italic>P<\/jats:italic>\u2009=\u20090.014). Variability parameters significantly correlated with the postural instability\/gait difficulty subscore in both disease groups. Conversely, significant correlations between variability parameters and MDS-UPDRS III score was observed only for multiple system atrophy patients.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This analysis suggests that gait variability parameters reflect the major axial impairment and postural instability displayed by multiple system atrophy patients compared with Parkinson\u2019s disease patients and controls.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-020-10355-y","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T05:02:25Z","timestamp":1609390945000},"page":"1770-1779","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Characterization of gait variability in multiple system atrophy and Parkinson\u2019s disease"],"prefix":"10.1007","volume":"268","author":[{"given":"Victoria","family":"Sidoroff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6857-2860","authenticated-orcid":false,"given":"Cecilia","family":"Raccagni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Kaindlstorfer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Eschlboeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Fanciulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Granata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Eskofier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Seppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Werner","family":"Poewe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Willeit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Kiechl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Mahlknecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heike","family":"Stockner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Marini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Schorr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregorio","family":"Rungger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Klucken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Wenning","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Ga\u00dfner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"key":"10355_CR1","doi-asserted-by":"publisher","first-page":"5","DOI":"10.3389\/fneur.2019.00005","volume":"10","author":"H Gassner","year":"2019","unstructured":"Gassner H, Raccagni C, Eskofier BM, Klucken J, Wenning GK (2019) The diagnostic scope of sensor-based gait analysis in atypical Parkinsonism: further observations. 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Cecilia Raccagni: none. Christine Kaindlstorfer: none. Sabine Eschlboeck: none. Alessandra Fanciulli: none concerning this project. A.F. reports royalties from springer Nature, speaker fees and honoraria from the Ordensklinikum Linz, Austrian Parkinson Society, International Parkinson Disease and Movement Disorder Society and Theravance Biopharma and research grant from Stitching Parkinson Fond and the \u00d6sterreichischer Austauschdienst outside of the submitted work. Roberta Granata: none. Bj\u00f6rn Eskofier: none concerning this project. B.E. is supported by Mobilise-D from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement no. 820820. He further received an institutional research grant from the Bavarian Ministry of Economic Affairs and Media, Energy and Technology, Germany (Medical Valley Award, FallRiskPD). Klaus Seppi: none concerning this project. K.S. reports personal fees from Teva, UCB, Lundbeck, AOP Orphan Pharmaceuticals AG, Roche, Gr\u00fcnenthal and Abbvie, honoraria from the International Parkinson and Movement Disorders Society, research grants from FWF Austrian Science Fund, Michael J. Fox Foundation, and International Parkinson and Movement Disorder Society, outside the submitted work. Werner Poewe: none concerning this project. W.P. reports personal fees from AbbVie, Affiris, AstraZeneca, BIAL, Britannia, Intec, Ipsen, Lundbeck, Neuroderm, Denali Pharmaceuticals, Novartis, Orion Pharma, Roche, Teva, UCB and Zambon (<i>consultancy and lecture fees in relation to clinical drug development programmes for PD<\/i>). Johann Willeit: none. Stefan Kiechl: none concerning this project. S.K. is CSO of VASCage, a COMET Research Centre of the Austria Research Promotion Agency. Philipp Mahlknecht: none. Heike Stockner: none. Kathrin Marini: K. M. was supported by a research grant from the Tiroler Wirtschaftsf\u00f6rderung (grant number UNI-0404\/2245). Oliver Schorr: none. Gregorio Rungger: none. Jochen Klucken: none concerning this project. J.K. is supported by Mobilise-D from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement no. 820820. He further received an institutional research grant from the Bavarian Ministry of Economic Affairs and Media, Energy and Technology, Germany (Medical Valley Award, FallRiskPD) and reports institutional research grants from EIT-Health; EIT-Digital; EU (H2020), German Research Foundation (DFG). Industry sponsored institutional IITs and grants from Alpha-Telemed AG. Compensation and honoraria from serving on scientific advisory boards and lecturing from Ever Neuro Pharma GmbH, TEVA Pharma GmbH, Bial Deutschland GmbH; Celgene GmbH, and Magisan GmbH. Gregor K. Wenning: none concerning this project. G.W. reports personal fees from Biohaven, Theravance, UCB, Lundbeck, and Ono, honoraria from the Austrian Autonomic Society, research grants from FWF Austrian Science Fund, International Parkinson and Movement Disorder Society, and US MSA Coalition, outside of the submitted work. Heiko Ga\u00dfner: none concerning this project. H.G. is supported by Mobilise-D from the Innovative Medicines Initiative 2 Joint Undertaking under grant Agreement No. 820820. He further received an institutional research grant from the Bavarian Ministry of Economic Affairs and Media, Energy and Technology, Germany (Medical Valley Award, FallRiskPD). HG received an institutional research grant by the Federal Ministry of Education and Research (project: treatHSP) and Huntington-Stiftung of the Deutsche Huntington Hilfe e.V. HG received further support by the Medical Research Foundation at the University Hospital Erlangen and the F\u00f6rderverein f\u00fcr HSP-Forschung e.V. outside of the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1975 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all the patients included in the study. The study was approved by local ethics committees (IRB-approval\u2013No 0365, 344\/4.25 378\/5.3, 20.10.2017).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}},{"value":"All study participants gave written informed consent for participation and publication prior to participation according to the Declaration of Helsinki.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}