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Such visual induced dizziness is well-known in patients with vestibular deficits, in whom it indicates an overreliance on visual cues in sensory integration. Considering that optokinetic after-nystagmus (OKAN) reflects the response of the central network integrating visual and vestibular self-motion signals (velocity storage network), we investigated OKAN in 71 patients [17 (23.9%) females, 30.36\u2009\u00b1\u20099.05\u00a0years old] who suffered from persistent symptoms after a concussion and presented clinical signs suggesting visual dependence. Data were retrospectively compared with 21 healthy individuals [13 (61.9%) females, 26.29\u2009\u00b1\u200910.00\u00a0years old]. The median values of the slow cumulative eye position and of the time constant of OKAN were significantly higher in patients than in healthy individuals (slow cumulative eye position: 124.15\u2009\u00b1\u200955.61\u00b0 in patients and 77.87\u2009\u00b1\u200945.63\u00b0 in healthy individuals\u2014<jats:italic>p<\/jats:italic>\u2009=\u20090.012; time constant: 25.17\u2009\u00b1\u200910.27\u00a0s in patients and 13.95\u2009\u00b1\u20094.92\u00a0s in healthy individuals\u2014<jats:italic>p<\/jats:italic>\u2009=\u20090.003). The receiving operating curve (ROC) estimated on the time constant had an overall area under the curve of 0.73. Analysis of the ROC suggests that a test measuring the OKAN time constant could obtain a sensitivity of 0.73 and specificity of 0.72 in determining the origin of the visual-related disturbances in those patients (threshold 16.6\u00a0s). In a subset of 43 patients who also performed the Sensory Organization Test (SOT), the proposed OKAN test was twice as sensitive as the SOT. This study suggests that concussed patients with persisting visual symptoms may have an underlying impairment of the velocity storage mechanism and that measuring the OKAN time constant can objectify such impairment.<\/jats:p>","DOI":"10.1007\/s00415-020-10359-8","type":"journal-article","created":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T07:02:42Z","timestamp":1608966162000},"page":"1747-1761","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Measuring optokinetic after-nystagmus: potential for detecting patients with signs of visual dependence following concussion"],"prefix":"10.1007","volume":"268","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2428-9454","authenticated-orcid":false,"given":"Giovanni","family":"Bertolini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominik","family":"Straumann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine","family":"Keller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Palla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Feddermann-Demont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2020,12,26]]},"reference":[{"key":"10359_CR1","doi-asserted-by":"crossref","unstructured":"McCrory P, Feddermann-Demont N, Dvo\u00f8\u00e1k J et al (2017) What is the definition of sports-related concussion: a systematic review. 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