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We aimed to describe the characteristics of spontaneous symptomatic intracerebral haemorrhage (ICH) associated with COVID-19.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We systematically searched PubMed, Embase and the Cochrane Central Database for data from patients with SARS-CoV-2 detected prior to or within 7\u00a0days after symptomatic ICH. We did a pooled analysis of individual patient data, then combined data from this pooled analysis with aggregate-level data.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>We included data from 139 patients (98 with individual data and 41 with aggregate-level data). In our pooled individual data analysis, the median age (IQR) was 60 (53\u201367) years and 64% (95% CI 54\u201373.7%) were male;\u00a079%\u00a0(95% CI\u00a070.0\u201386.9%) had critically severe COVID-19. The pooled prevalence of lobar ICH was 67% (95% CI 56.3\u201376.0%), and of multifocal ICH was 36% (95% CI 26.4\u201347.0%). 71% (95% CI 61.0\u201380.4%) of patients were treated with anticoagulation (58% (95% CI 48\u201367.8%) therapeutic). The median NIHSS was 28 (IQR 15\u201328); mortality was 54% (95% CI 43.7\u201364.2%). Our combined analysis of individual and aggregate data showed similar findings. The pooled incidence of ICH across 12 cohort studies of inpatients with COVID-19 (<jats:italic>n<\/jats:italic>\u2009=\u200963,390) was 0.38% (95% CI 0.22\u20130.58%).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Our data suggest that ICH associated with COVID-19 has different characteristics compared to ICH not associated with COVID-19, including frequent lobar location and multifocality, a high rate of anticoagulation, and high mortality. These observations suggest different underlying mechanisms of ICH in COVID-19 with potential implications for clinical treatment and trials.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-021-10425-9","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T21:04:43Z","timestamp":1612818283000},"page":"3105-3115","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Characteristics of intracerebral haemorrhage associated with COVID-19: a systematic review and pooled analysis of individual patient and aggregate data"],"prefix":"10.1007","volume":"268","author":[{"given":"R.","family":"Beyrouti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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