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Post-stroke fatigue is associated with reduced motor cortical excitability, specifically of the affected hemisphere.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The aim of this exploratory study was to assess whether fatigue symptoms can be reduced by increasing cortical excitability using anodal transcranial direct current stimulation (tDCS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this sham-controlled, double-blind intervention study, tDCS was applied bilaterally over the primary motor cortex in a single session in thirty stroke survivors with high severity of fatigue. A questionnaire-based measure of trait fatigue (primary outcome) was obtained before, after a week and 5 weeks post stimulation. Secondary outcome measures of state fatigue, motor cortex neurophysiology and perceived effort were also assessed pre, immediately post, a week and 5 weeks post stimulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Anodal tDCS significantly improved fatigue symptoms a week after real stimulation when compared to sham stimulation. There was also a significant change in motor cortex neurophysiology of the affected hemisphere and perceived effort, a week after stimulation. The degree of improvement in fatigue was associated with baseline anxiety levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>A single session of anodal tDCS improves fatigue symptoms with the effect lasting up to a week post stimulation. tDCS may therefore be a useful tool for managing fatigue symptoms post-stroke.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>NCT04634864<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Date of registration<\/jats:title>\n                    <jats:p>17\/11\/2020\u2013\u201cretrospectively registered\u201d.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00415-021-10442-8","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T11:04:05Z","timestamp":1617275045000},"page":"2831-2842","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Effect of transcranial direct current stimulation on post-stroke fatigue"],"prefix":"10.1007","volume":"268","clinical-trial-number":[{"clinical-trial-number":"nct04634864","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7835-6937","authenticated-orcid":false,"given":"William","family":"De Doncker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sasha","family":"Ondobaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annapoorna","family":"Kuppuswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,2,17]]},"reference":[{"key":"10442_CR1","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1177\/1747493016669861","volume":"11","author":"TB Cumming","year":"2016","unstructured":"Cumming TB, Packer M, Kramer SF, English C (2016) The prevalence of fatigue after stroke: a systematic review and meta-analysis. 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