{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:55:35Z","timestamp":1762005335151,"version":"3.37.3"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T00:00:00Z","timestamp":1617408000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T00:00:00Z","timestamp":1617408000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01NS44233","U54NS065736","K23NS075141","R01 FD004789","R01 NS092625"],"award-info":[{"award-number":["P01NS44233","U54NS065736","K23NS075141","R01 FD004789","R01 NS092625"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cure MSA Foundation"},{"DOI":"10.13039\/100011542","name":"Center for Clinical and Translational Science, Mayo Clinic","doi-asserted-by":"crossref","award":["UL1 TR002377"],"award-info":[{"award-number":["UL1 TR002377"]}],"id":[{"id":"10.13039\/100011542","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s00415-021-10531-8","type":"journal-article","created":{"date-parts":[[2021,4,3]],"date-time":"2021-04-03T20:02:28Z","timestamp":1617480148000},"page":"3852-3860","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Clinical presentation and autonomic profile in Ross syndrome"],"prefix":"10.1007","volume":"268","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4048-6095","authenticated-orcid":false,"given":"Guillaume","family":"Lamotte","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Sandroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy K.","family":"Cutsforth-Gregory","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah E.","family":"Berini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo E.","family":"Benarroch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamal","family":"Shouman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle L.","family":"Mauermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Phillip A.","family":"Low","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Singer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Coon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,3]]},"reference":[{"key":"10531_CR1","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1136\/annrheumdis-2013-203863","volume":"73","author":"N Agmon-Levin","year":"2014","unstructured":"Agmon-Levin N, Damoiseaux J, Kallenberg C, Sack U, Witte T, Herold M, Bossuyt X, Musset L, Cervera R, Plaza-Lopez A, Dias C, Sousa MJ, Radice A, Eriksson C, Hultgren O, Viander M, Khamashta M, Regenass S, Andrade LE, Wiik A, Tincani A, R\u00f6nnelid J, Bloch DB, Fritzler MJ, Chan EK, Garcia-De La Torre I, Konstantinov KN, Lahita R, Wilson M, Vainio O, Fabien N, Sinico RA, Meroni P, Shoenfeld Y (2014) International recommendations for the assessment of autoantibodies to cellular antigens referred to as anti-nuclear antibodies. Ann Rheum Dis 73:17\u201323","journal-title":"Ann Rheum Dis"},{"key":"10531_CR2","doi-asserted-by":"publisher","first-page":"394","DOI":"10.4103\/0976-3147.139997","volume":"5","author":"A Baran","year":"2014","unstructured":"Baran A, Balbaba M, Demir CF, Ozdemir HH (2014) A case of Ross syndrome presented with Horner and chronic cough. J Neurosci Rural Pract 5:394\u2013397","journal-title":"J Neurosci Rural Pract"},{"key":"10531_CR3","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1007\/s00415-004-0531-z","volume":"251","author":"C Beier","year":"2004","unstructured":"Beier C, Ernemann U, Gerloff C (2004) Moving along with Ross syndrome\u2014a patient with a 50 years history. J Neurol 251:1402\u20131403","journal-title":"J Neurol"},{"key":"10531_CR4","doi-asserted-by":"publisher","first-page":"1790","DOI":"10.1002\/(SICI)1097-4598(199812)21:12<1790::AID-MUS26>3.0.CO;2-I","volume":"21","author":"I Bergmann","year":"1998","unstructured":"Bergmann I, Dauphin M, Naumann M, Flachenecker P, M\u00fcllges W, Koltzenburg M, Sommer C (1998) Selective degeneration of sudomotor fibers in Ross syndrome and successful treatment of compensatory hyperhidrosis with botulinum toxin. Muscle Nerve 21:1790\u20131793","journal-title":"Muscle Nerve"},{"key":"10531_CR5","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.autneu.2016.01.001","volume":"196","author":"WP Cheshire Jr","year":"2016","unstructured":"Cheshire WP Jr (2016) Thermoregulatory disorders and illness related to heat and cold stress. Auton Neurosci Basic Clin 196:91\u2013104","journal-title":"Auton Neurosci Basic Clin"},{"key":"10531_CR6","first-page":"116","volume":"26","author":"EA Coon","year":"2020","unstructured":"Coon EA, Cheshire WP Jr (2020) Sweating disorders. Continuum (Minneapolis, Minn) 26:116\u2013137","journal-title":"Continuum (Minneapolis, Minn)"},{"key":"10531_CR7","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.3748\/wjg.v12.i9.1485","volume":"12","author":"T Csak","year":"2006","unstructured":"Csak T, Folhoffer A, Horvath A, Hal\u00e1sz J, Diczh\u00e1zi C, Schaff Z, Szalay F (2006) Holmes-Adie syndrome, autoimmune hepatitis and celiac disease: a case report. World J Gastroenterol 12:1485\u20131487","journal-title":"World J Gastroenterol"},{"key":"10531_CR8","doi-asserted-by":"publisher","first-page":"1327","DOI":"10.1136\/jnnp.2009.198135","volume":"81","author":"V Donadio","year":"2010","unstructured":"Donadio V, Cortelli P, Elam M, Di Stasi V, Montagna P, Holmberg B, Giannoccaro MP, Bugiardini E, Avoni P, Baruzzi A, Liguori R (2010) Autonomic innervation in multiple system atrophy and pure autonomic failure. J Neurol Neurosurg Psychiatry 81:1327\u20131335","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10531_CR9","doi-asserted-by":"publisher","first-page":"1639","DOI":"10.1016\/j.clinph.2011.11.263","volume":"123","author":"V Donadio","year":"2012","unstructured":"Donadio V, Cortelli P, Giannoccaro MP, Nolano M, Di Stasi V, Baruzzi A, Liguori R (2012) Muscle and skin sympathetic activities in Ross syndrome. Clin Neurophysiol 123:1639\u20131643","journal-title":"Clin Neurophysiol"},{"key":"10531_CR10","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1016\/S0025-6196(12)65338-5","volume":"64","author":"RD Fealey","year":"1989","unstructured":"Fealey RD, Low PA, Thomas JE (1989) Thermoregulatory sweating abnormalities in diabetes mellitus. Mayo Clin Proc 64:617\u2013628","journal-title":"Mayo Clin Proc"},{"key":"10531_CR11","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.autneu.2017.08.003","volume":"208","author":"E Fileccia","year":"2017","unstructured":"Fileccia E, Liguori R, Cortelli P, Donadio V (2017) Absent cardiac and muscle sympathetic nerve activities involvement in Ross syndrome: a follow-up study. Auton Neurosci Basic Clin 208:161\u2013164","journal-title":"Auton Neurosci Basic Clin"},{"key":"10531_CR12","doi-asserted-by":"publisher","first-page":"132","DOI":"10.1159\/000507186","volume":"12","author":"Z Filikci","year":"2020","unstructured":"Filikci Z, Horsten HH, Lindelof M (2020) Ross syndrome: a patient with a 23-year history. Case Rep Neurol 12:132\u2013135","journal-title":"Case Rep Neurol"},{"key":"10531_CR13","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1093\/brain\/91.3.401","volume":"91","author":"DG Harriman","year":"1968","unstructured":"Harriman DG, Garland H (1968) The pathology of Adie\u2019s syndrome. Brain 91:401\u2013418","journal-title":"Brain"},{"key":"10531_CR14","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1136\/jnnp.65.4.583","volume":"65","author":"J Kimber","year":"1998","unstructured":"Kimber J, Mitchell D, Mathias CJ (1998) Chronic cough in the Holmes-Adie syndrome: association in five cases with autonomic dysfunction. J Neurol Neurosurg Psychiatry 65:583\u2013586","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10531_CR15","doi-asserted-by":"publisher","first-page":"1501","DOI":"10.1212\/WNL.0b013e3181bf995f","volume":"73","author":"K Kimpinski","year":"2009","unstructured":"Kimpinski K, Iodice V, Sandroni P, Fealey RD, Vernino S, Low PA (2009) Sudomotor dysfunction in autoimmune autonomic ganglionopathy. Neurology 73:1501\u20131506","journal-title":"Neurology"},{"key":"10531_CR16","doi-asserted-by":"crossref","unstructured":"Lamotte G, Sandroni P (2021) A case of Ross syndrome associated with systemic sclerosis. Clin Auton Res\n(Online ahead of print)","DOI":"10.1007\/s10286-021-00773-x"},{"key":"10531_CR17","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1097\/00004691-199301000-00003","volume":"10","author":"PA Low","year":"1993","unstructured":"Low PA (1993) Autonomic nervous system function. J Clin Neurophysiol 10:14\u201327","journal-title":"J Clin Neurophysiol"},{"key":"10531_CR18","doi-asserted-by":"publisher","first-page":"748","DOI":"10.1016\/S0025-6196(12)60631-4","volume":"68","author":"PA Low","year":"1993","unstructured":"Low PA (1993) Composite autonomic scoring scale for laboratory quantification of generalized autonomic failure. Mayo Clin Proc 68:748\u2013752","journal-title":"Mayo Clin Proc"},{"key":"10531_CR19","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1016\/j.clinph.2004.01.023","volume":"115","author":"PA Low","year":"2004","unstructured":"Low PA (2004) Evaluation of sudomotor function. Clin Neurophysiol 115:1506\u20131513","journal-title":"Clin Neurophysiol"},{"key":"10531_CR20","doi-asserted-by":"publisher","first-page":"635","DOI":"10.3389\/fnins.2020.00635","volume":"14","author":"M Ma","year":"2020","unstructured":"Ma M, Yao J, Chen Y, Liu H, Xia D, Tian H, Wang X, Wu E, Wang X, Ding X (2020) Is ross syndrome a new type of synucleinopathy? A Brief Research Report. Front Neurosci 14:635","journal-title":"Front Neurosci"},{"key":"10531_CR21","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1016\/j.clinph.2011.12.016","volume":"123","author":"VG Macefield","year":"2012","unstructured":"Macefield VG (2012) Selective autonomic failure: Ross syndrome. Clin Neurophysiol 123:1479\u20131480","journal-title":"Clin Neurophysiol"},{"key":"10531_CR22","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1017\/cjn.2016.417","volume":"44","author":"AK Mishra","year":"2017","unstructured":"Mishra AK, Kharkongor M, Kuriakose CK, George AA, Peter D, Carey RAB, Mathew V, Hansdak SG (2017) Is ross syndrome an autoimmune entity? A case series of 11 patients. Can J Neurol Sci 44:318\u2013321","journal-title":"Can J Neurol Sci"},{"key":"10531_CR23","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1093\/brain\/awl175","volume":"129","author":"M Nolano","year":"2006","unstructured":"Nolano M, Provitera V, Perretti A, Stancanelli A, Saltalamacchia AM, Donadio V, Manganelli F, Lanzillo B, Santoro L (2006) Ross syndrome: a rare or a misknown disorder of thermoregulation? A skin innervation study on 12 subjects. Brain 129:2119\u20132131","journal-title":"Brain"},{"key":"10531_CR24","doi-asserted-by":"crossref","unstructured":"Pashnina IA, Krivolapova IM, Fedotkina TV, Ryabkova VA, Chereshneva MV, Churilov LP, Chereshnev VA (2021) Antinuclear autoantibodies in health: autoimmunity is not a synonym of autoimmune disease. Antibodies (Basel) 10","DOI":"10.3390\/antib10010009"},{"key":"10531_CR25","first-page":"392","volume":"31","author":"TG Pickering","year":"1969","unstructured":"Pickering TG, Sleight P (1969) Quantitative index of baroreflex activity in normal and hypertensive subjects using Valsalva\u2019s manoeuvre. Br Heart J 31:392","journal-title":"Br Heart J"},{"key":"10531_CR26","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1212\/WNL.8.11.809","volume":"8","author":"AT Ross","year":"1958","unstructured":"Ross AT (1958) Progressive selective sudomotor denervation; a case with coexisting Adie\u2019s syndrome. Neurology 8:809\u2013817","journal-title":"Neurology"},{"key":"10531_CR27","doi-asserted-by":"publisher","first-page":"1841","DOI":"10.1212\/WNL.55.12.1841","volume":"55","author":"RK Shin","year":"2000","unstructured":"Shin RK, Galetta SL, Ting TY, Armstrong K, Bird SJ (2000) Ross syndrome plus: beyond horner, Holmes-Adie, and harlequin. Neurology 55:1841\u20131846","journal-title":"Neurology"},{"key":"10531_CR28","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/ana.10256","volume":"52","author":"C Sommer","year":"2002","unstructured":"Sommer C, Lindenlaub T, Zillikens D, Toyka KV, Naumann M (2002) Selective loss of cholinergic sudomotor fibers causes anhidrosis in Ross syndrome. Ann Neurol 52:247\u2013250","journal-title":"Ann Neurol"},{"key":"10531_CR29","doi-asserted-by":"publisher","first-page":"274","DOI":"10.4103\/0019-5154.70694","volume":"55","author":"B Vasudevan","year":"2010","unstructured":"Vasudevan B, Sawhney M, Vishal S (2010) Ross syndrome with ana positivity: a clue to possible autoimmune origin and treatment with intravenous immunoglobulin. Indian J Dermatol 55:274\u2013276","journal-title":"Indian J Dermatol"},{"key":"10531_CR30","doi-asserted-by":"publisher","first-page":"1533","DOI":"10.1212\/01.wnl.0000184504.13173.ef","volume":"65","author":"ER Vogel","year":"2005","unstructured":"Vogel ER, Sandroni P, Low PA (2005) Blood pressure recovery from Valsalva maneuver in patients with autonomic failure. Neurology 65:1533\u20131537","journal-title":"Neurology"},{"key":"10531_CR31","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1007\/BF00839146","volume":"239","author":"M Weller","year":"1992","unstructured":"Weller M, Wilhelm H, Sommer N, Dichgans J, Wieth\u00f6lter H (1992) Tonic pupil, areflexia, and segmental anhidrosis: two additional cases of Ross syndrome and review of the literature. J Neurol 239:231\u2013234","journal-title":"J Neurol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-021-10531-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-021-10531-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-021-10531-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T17:58:06Z","timestamp":1632506286000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-021-10531-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,3]]},"references-count":31,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10531"],"URL":"https:\/\/doi.org\/10.1007\/s00415-021-10531-8","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"type":"print","value":"0340-5354"},{"type":"electronic","value":"1432-1459"}],"subject":[],"published":{"date-parts":[[2021,4,3]]},"assertion":[{"value":"18 February 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 March 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 March 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 April 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"None of the authors has a conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}