{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:39:13Z","timestamp":1778859553281,"version":"3.51.4"},"reference-count":43,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100010809","name":"Jascha Fonden","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fonden for Neurologisk Forskning"},{"DOI":"10.13039\/100008361","name":"Scleroseforeningen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008361","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003035","name":"Aase og Ejnar Danielsens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003035","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Knud og Edith Eriksens Fond"},{"DOI":"10.13039\/501100004954","name":"Augustinus Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004954","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006088","name":"Direkt\u00f8r Emil C. Hertz og Hustru Inger Hertz Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010346","name":"Else og Mogens Wedell Wedellsborgs Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010346","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008264","name":"Karen A. Tolstrups Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012526","name":"Sundhedsvidenskabelige Fakultet, Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012526","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1007\/s00415-021-10543-4","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T16:05:13Z","timestamp":1617811513000},"page":"3861-3870","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Cortical diffusion kurtosis imaging and thalamic volume are associated with cognitive and walking performance in relapsing\u2013remitting multiple sclerosis"],"prefix":"10.1007","volume":"268","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9450-7544","authenticated-orcid":false,"given":"Mikkel K. E.","family":"Nygaard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Langeskov-Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrik","family":"Dalgas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon F.","family":"Eskildsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"issue":"2","key":"10543_CR1","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/ana.22366","volume":"69","author":"CH Polman","year":"2011","unstructured":"Polman CH, Reingold SC, Banwell B et al (2011) Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol 69(2):292\u2013302. https:\/\/doi.org\/10.1002\/ana.22366","journal-title":"Ann Neurol"},{"issue":"9","key":"10543_CR2","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1177\/1352458511404916","volume":"17","author":"SD Roosendaal","year":"2011","unstructured":"Roosendaal SD, Bendfeldt K, Vrenken H et al (2011) Grey matter volume in a large cohort of MS patients: relation to MRI parameters and disability. Mult Scler J 17(9):1098\u20131106. https:\/\/doi.org\/10.1177\/1352458511404916","journal-title":"Mult Scler J"},{"issue":"2","key":"10543_CR3","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1002\/ana.25145","volume":"83","author":"A Eshaghi","year":"2018","unstructured":"Eshaghi A, Prados F, Brownlee WJ et al (2018) Deep gray matter volume loss drives disability worsening in multiple sclerosis. Ann Neurol 83(2):210\u2013222. https:\/\/doi.org\/10.1002\/ana.25145","journal-title":"Ann Neurol"},{"issue":"3","key":"10543_CR4","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.pscychresns.2015.10.004","volume":"234","author":"L Debernard","year":"2015","unstructured":"Debernard L, Melzer TR, Alla S et al (2015) Deep grey matter MRI abnormalities and cognitive function in relapsing-remitting multiple sclerosis. Psychiatry Res Neuroimaging 234(3):352\u2013361. https:\/\/doi.org\/10.1016\/j.pscychresns.2015.10.004","journal-title":"Psychiatry Res Neuroimaging"},{"issue":"2","key":"10543_CR5","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/ana.25150","volume":"83","author":"CJ Azevedo","year":"2018","unstructured":"Azevedo CJ, Cen SY, Khadka S et al (2018) Thalamic atrophy in multiple sclerosis: a magnetic resonance imaging marker of neurodegeneration throughout disease. Ann Neurol 83(2):223\u2013234. https:\/\/doi.org\/10.1002\/ana.25150","journal-title":"Ann Neurol"},{"issue":"1","key":"10543_CR6","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1002\/mrm.22603","volume":"65","author":"J Veraart","year":"2011","unstructured":"Veraart J, Poot DHJ, Van Hecke W et al (2011) More accurate estimation of diffusion tensor parameters using diffusion kurtosis imaging. Magn Reson Med 65(1):138\u2013145. https:\/\/doi.org\/10.1002\/mrm.22603","journal-title":"Magn Reson Med"},{"issue":"6","key":"10543_CR7","doi-asserted-by":"publisher","first-page":"1432","DOI":"10.1002\/mrm.20508","volume":"53","author":"JH Jensen","year":"2005","unstructured":"Jensen JH, Helpern JA, Ramani A, Lu H, Kaczynski K (2005) Diffusional kurtosis imaging: the quantification of non-Gaussian water diffusion by means of magnetic resonance imaging. Magn Reson Med 53(6):1432\u20131440. https:\/\/doi.org\/10.1002\/mrm.20508","journal-title":"Magn Reson Med"},{"issue":"6","key":"10543_CR8","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1002\/jmri.21604","volume":"28","author":"MF Falangola","year":"2008","unstructured":"Falangola MF, Jensen JH, Babb JS et al (2008) Age-related non-Gaussian diffusion patterns in the prefrontal brain. J Magn Reson Imaging 28(6):1345\u20131350. https:\/\/doi.org\/10.1002\/jmri.21604","journal-title":"J Magn Reson Imaging"},{"key":"10543_CR9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3389\/fnagi.2013.00071","volume":"5","author":"SH Ng","year":"2013","unstructured":"Ng SH, Hsu WC, Wai YY et al (2013) Sex dimorphism of cortical water diffusion in normal aging measured by magnetic resonance imaging. Front Aging Neurosci 5:1\u201314. https:\/\/doi.org\/10.3389\/fnagi.2013.00071","journal-title":"Front Aging Neurosci"},{"issue":"7","key":"10543_CR10","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1177\/1352458514556295","volume":"21","author":"M Bester","year":"2015","unstructured":"Bester M, Jensen JH, Babb JS et al (2015) Non-Gaussian diffusion MRI of gray matter is associated with cognitive impairment in multiple sclerosis. Mult Scler J 21(7):935\u2013944. https:\/\/doi.org\/10.1177\/1352458514556295","journal-title":"Mult Scler J"},{"key":"10543_CR11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2018.03.048","volume":"403","author":"S De Santis","year":"2018","unstructured":"De Santis S, Bastiani M, Droby A et al (2018) Characterizing microstructural tissue properties in multiple sclerosis with diffusion MRI at 7 T and 3 T: the impact of the experimental design. Neuroscience 403:1\u201310. https:\/\/doi.org\/10.1016\/j.neuroscience.2018.03.048","journal-title":"Neuroscience"},{"key":"10543_CR12","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.0000000000011241","author":"M Langeskov-Christensen","year":"2020","unstructured":"Langeskov-Christensen M, Gr\u00f8ndahl Hvid L, Nygaard MKE et al (2020) Efficacy of high-intensity aerobic exercise on brain MRI measures in multiple sclerosis. Neurology. https:\/\/doi.org\/10.1212\/wnl.0000000000011241","journal-title":"Neurology"},{"issue":"9","key":"10543_CR13","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3390\/jcm7090272","volume":"7","author":"M Langeskov-Christensen","year":"2018","unstructured":"Langeskov-Christensen M, Eskildsen S, Stenager E et al (2018) Aerobic capacity is not associated with most cognitive domains in patients with multiple sclerosis\u2014a cross-sectional investigation. J Clin Med. 7(9):272. https:\/\/doi.org\/10.3390\/jcm7090272","journal-title":"J Clin Med."},{"key":"10543_CR14","volume-title":"A manual for the brief repeatable battery of neuropsychology tests in multiple sclerosis","author":"SM Rao","year":"1990","unstructured":"Rao SM, Cognitive Function Study Group N (1990) A manual for the brief repeatable battery of neuropsychology tests in multiple sclerosis. National Multiple Sclerosis Society, New York"},{"issue":"4","key":"10543_CR15","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1191\/1352458506ms1293oa","volume":"12","author":"MM Nieuwenhuis","year":"2006","unstructured":"Nieuwenhuis MM, Van Tongeren H, S\u00f8rensen PS, Ravnborg M (2006) The Six Spot Step Test: a new measurement for walking ability in multiple sclerosis. Mult Scler 12(4):495\u2013500. https:\/\/doi.org\/10.1191\/1352458506ms1293oa","journal-title":"Mult Scler"},{"issue":"3","key":"10543_CR16","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1177\/1352458507082607","volume":"14","author":"MD Goldman","year":"2008","unstructured":"Goldman MD, Marrie RA, Cohen JA (2008) Evaluation of the six-minute walk in multiple sclerosis subjects and healthy controls. Mult Scler 14(3):383\u2013390. https:\/\/doi.org\/10.1177\/1352458507082607","journal-title":"Mult Scler"},{"issue":"5","key":"10543_CR17","doi-asserted-by":"publisher","first-page":"1455","DOI":"10.1002\/mrm.26055","volume":"76","author":"B Hansen","year":"2016","unstructured":"Hansen B, Lund TE, Sangill R, Stubbe E, Finsterbusch J, Jespersen SN (2016) Experimental considerations for fast kurtosis imaging. Magn Reson Med 76(5):1455\u20131468. https:\/\/doi.org\/10.1002\/mrm.26055","journal-title":"Magn Reson Med"},{"issue":"4","key":"10543_CR18","doi-asserted-by":"publisher","first-page":"3774","DOI":"10.1016\/J.NEUROIMAGE.2011.11.032","volume":"59","author":"P Schmidt","year":"2012","unstructured":"Schmidt P, Gaser C, Arsic M et al (2012) An automated tool for detection of FLAIR-hyperintense white-matter lesions in multiple sclerosis. Neuroimage 59(4):3774\u20133783. https:\/\/doi.org\/10.1016\/J.NEUROIMAGE.2011.11.032","journal-title":"Neuroimage"},{"issue":"12","key":"10543_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0144693","volume":"10","author":"C Thaler","year":"2015","unstructured":"Thaler C, Faizy T, Sedlacik J et al (2015) T1-Thresholds in black holes increase clinical-radiological correlation in multiple sclerosis patients. PLoS ONE 10(12):1\u201313. https:\/\/doi.org\/10.1371\/journal.pone.0144693","journal-title":"PLoS ONE"},{"key":"10543_CR20","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.neuroimage.2013.05.065","volume":"82","author":"B Aubert-Broche","year":"2013","unstructured":"Aubert-Broche B, Fonov VS, Garc\u00eda-Lorenzo D et al (2013) A new method for structural volume analysis of longitudinal brain MRI data and its application in studying the growth trajectories of anatomical brain structures in childhood. Neuroimage 82:393\u2013402. https:\/\/doi.org\/10.1016\/j.neuroimage.2013.05.065","journal-title":"Neuroimage"},{"issue":"4","key":"10543_CR21","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1109\/tmi.2007.906087","volume":"27","author":"P Coupe","year":"2008","unstructured":"Coupe P, Kervrann C, Barillot C, Yger P, Prima S, Hellier P (2008) An optimized blockwise nonlocal means denoising filter for 3-D magnetic resonance images. IEEE Trans Med Imaging 27(4):425\u2013441. https:\/\/doi.org\/10.1109\/tmi.2007.906087","journal-title":"IEEE Trans Med Imaging"},{"issue":"4","key":"10543_CR22","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.media.2010.03.001","volume":"14","author":"P Coup\u00e9","year":"2010","unstructured":"Coup\u00e9 P, Manj\u00f3n JV, Gedamu E, Arnold D, Robles M, Collins DL (2010) Robust Rician noise estimation for MR images. Med Image Anal 14(4):483\u2013493. https:\/\/doi.org\/10.1016\/j.media.2010.03.001","journal-title":"Med Image Anal"},{"issue":"1","key":"10543_CR23","doi-asserted-by":"publisher","first-page":"87","DOI":"10.1109\/42.668698","volume":"17","author":"JG Sled","year":"1998","unstructured":"Sled JG, Zijdenbos AP, Evans AC (1998) A nonparametric method for automatic correction of intensity nonuniformity in MRI data. IEEE Trans Med Imaging 17(1):87\u201397. https:\/\/doi.org\/10.1109\/42.668698","journal-title":"IEEE Trans Med Imaging"},{"issue":"2","key":"10543_CR24","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1097\/00004728-199403000-00005","volume":"18","author":"DL Collins","year":"1994","unstructured":"Collins DL, Neelin P, Peters TM, Evans AC (1994) Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space. J Comput Assist Tomogr 18(2):192\u2013205. https:\/\/doi.org\/10.1097\/00004728-199403000-00005","journal-title":"J Comput Assist Tomogr"},{"key":"10543_CR25","doi-asserted-by":"publisher","first-page":"44","DOI":"10.3389\/fninf.2014.00044","volume":"8","author":"BB Avants","year":"2014","unstructured":"Avants BB, Tustison NJ, Stauffer M, Song G, Wu B, Gee JC (2014) The insight ToolKit image registration framework. Front Neuroinform 8:44. https:\/\/doi.org\/10.3389\/fninf.2014.00044","journal-title":"Front Neuroinform"},{"issue":"4","key":"10543_CR26","doi-asserted-by":"publisher","first-page":"3736","DOI":"10.1016\/j.neuroimage.2011.10.080","volume":"59","author":"VS Fonov","year":"2011","unstructured":"Fonov VS, Manj\u00f3n JV, Collins DL, Coup\u00e9 P, Eskildsen SF (2011) Simultaneous segmentation and grading of anatomical structures for patient\u2019s classification: application to Alzheimer\u2019s disease. Neuroimage 59(4):3736\u20133747. https:\/\/doi.org\/10.1016\/j.neuroimage.2011.10.080","journal-title":"Neuroimage"},{"issue":"2","key":"10543_CR27","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1016\/J.NEUROIMAGE.2010.09.018","volume":"54","author":"P Coup\u00e9","year":"2011","unstructured":"Coup\u00e9 P, Manj\u00f3n JV, Fonov V, Pruessner J, Robles M, Collins DL (2011) Patch-based segmentation using expert priors: application to hippocampus and ventricle segmentation. Neuroimage 54(2):940\u2013954. https:\/\/doi.org\/10.1016\/J.NEUROIMAGE.2010.09.018","journal-title":"Neuroimage"},{"key":"10543_CR28","doi-asserted-by":"publisher","unstructured":"Eskildsen SF, Uldahl M, Ostergaard LR (2005) Extraction of the cerebral cortical boundaries from MRI for measurement of cortical thickness. In: Fitzpatrick JM, Reinhardt JM (eds) Proceedings of SPIE, vol 5747. Medical Imaging, San Diego, p 1400. https:\/\/doi.org\/10.1117\/12.595145","DOI":"10.1117\/12.595145"},{"issue":"11","key":"10543_CR29","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1007\/11866763","volume":"9","author":"SF Eskildsen","year":"2006","unstructured":"Eskildsen SF, Ostergaard LR (2006) Active surface approach for extraction of the human cerebral cortex from MRI. Med Image Comput Comput Assist Interv 9(11):823\u2013830. https:\/\/doi.org\/10.1007\/11866763","journal-title":"Med Image Comput Comput Assist Interv"},{"key":"10543_CR30","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1016\/j.neuroimage.2016.08.016","volume":"142","author":"J Veraart","year":"2016","unstructured":"Veraart J, Novikov DS, Christiaens D, Ades-Aron B, Sijbers J, Fieremans E (2016) Denoising of diffusion MRI using random matrix theory. Neuroimage 142:394\u2013406. https:\/\/doi.org\/10.1016\/j.neuroimage.2016.08.016","journal-title":"Neuroimage"},{"issue":"5","key":"10543_CR31","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1002\/mrm.26054","volume":"76","author":"E Kellner","year":"2016","unstructured":"Kellner E, Dhital B, Kiselev VG, Reisert M (2016) Gibbs-ringing artifact removal based on local subvoxel-shifts. Magn Reson Med 76(5):1574\u20131581. https:\/\/doi.org\/10.1002\/mrm.26054","journal-title":"Magn Reson Med"},{"key":"10543_CR32","doi-asserted-by":"publisher","first-page":"1063","DOI":"10.1016\/j.neuroimage.2015.10.019","volume":"125","author":"JLR Andersson","year":"2016","unstructured":"Andersson JLR, Sotiropoulos SN (2016) An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. Neuroimage 125:1063\u20131078. https:\/\/doi.org\/10.1016\/j.neuroimage.2015.10.019","journal-title":"Neuroimage"},{"key":"10543_CR33","doi-asserted-by":"publisher","unstructured":"Eskildsen SF, \u00d8stergaard LR (2008) Evaluation of five algorithms for mapping brain cortical surfaces. In: Proceedings\u201421st Brazilian symposium on computer graphics and image processing, SIBGRAPI 2008. IEEE, pp 137\u2013144. https:\/\/doi.org\/10.1109\/SIBGRAPI.2008.16","DOI":"10.1109\/SIBGRAPI.2008.16"},{"issue":"4","key":"10543_CR34","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1191\/135245801680209385","volume":"7","author":"JB Boringa","year":"2001","unstructured":"Boringa JB, Lazeron RHC, Reuling IEW et al (2001) The brief repeatable battery of neuropsychological tests: normative values allow application in multiple sclerosis clinical practice. Mult Scler 7(4):263\u2013267. https:\/\/doi.org\/10.1191\/135245801680209385","journal-title":"Mult Scler"},{"issue":"2","key":"10543_CR35","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1191\/1352458506ms1258oa","volume":"12","author":"J Sepulcre","year":"2006","unstructured":"Sepulcre J, Vannotti S, Hern\u00e1ndez R et al (2006) Cognitive impairment in patients with multiple sclerosis using the Brief Repeatable Battery-Neuropsychology test. Mult Scler 12(2):187\u2013195. https:\/\/doi.org\/10.1191\/1352458506ms1258oa","journal-title":"Mult Scler"},{"key":"10543_CR36","doi-asserted-by":"publisher","first-page":"S102","DOI":"10.1016\/s1053-8119(09)70882-1","volume":"47","author":"K Worsley","year":"2009","unstructured":"Worsley K, Duerden E, Evans A et al (2009) SurfStat: a Matlab toolbox for the statistical analysis of univariate and multivariate surface and volumetric data using linear mixed effects models and random field theory. Neuroimage 47:S102. https:\/\/doi.org\/10.1016\/s1053-8119(09)70882-1","journal-title":"Neuroimage"},{"key":"10543_CR37","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/978-3-540-74686-7","volume":"1","author":"R Core Team","year":"2020","unstructured":"R Core Team (2020) R: a language and environment for statistical computing. R Found Stat Comput 1:409. https:\/\/doi.org\/10.1007\/978-3-540-74686-7","journal-title":"R Found Stat Comput"},{"issue":"1","key":"10543_CR38","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1002\/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O","volume":"4","author":"KJ Worsley","year":"1996","unstructured":"Worsley KJ, Marrett S, Neelin P, Vandal AC, Friston KJ, Evans AC (1996) A unified statistical approach for determining significant signals in images of cerebral activation. Hum Brain Mapp 4(1):58\u201373. https:\/\/doi.org\/10.1002\/(SICI)1097-0193(1996)4:1%3c58::AID-HBM4%3e3.0.CO;2-O","journal-title":"Hum Brain Mapp"},{"issue":"4","key":"10543_CR39","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1214\/aos\/1013699998","volume":"29","author":"Y Benjamini","year":"2001","unstructured":"Benjamini Y, Heller R (2001) The control of the false discovery rate in multiple testing under dependency. Ann Stat 29(4):1165\u20131188","journal-title":"Ann Stat"},{"issue":"3","key":"10543_CR40","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1212\/WNL.56.3.304","volume":"56","author":"M Filippi","year":"2001","unstructured":"Filippi M, Cercignani M, Inglese M, Horsfield MA, Comi G (2001) Diffusion tensor magnetic resonance imaging in multiple sclerosis. Neurology 56(3):304\u2013311. https:\/\/doi.org\/10.1212\/WNL.56.3.304","journal-title":"Neurology"},{"issue":"9","key":"10543_CR41","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1001\/archneur.59.9.1406","volume":"59","author":"M Rovaris","year":"2003","unstructured":"Rovaris M, Bozzali M, Iannucci G et al (2003) Assessment of normal-appearing white and gray matter in patients with primary progressive multiple sclerosis. Arch Neurol 59(9):1406\u20131412. https:\/\/doi.org\/10.1001\/archneur.59.9.1406","journal-title":"Arch Neurol"},{"key":"10543_CR42","unstructured":"Cercignani M, Inglese M, Pagani E, Comi G, Filippi M (2001) Mean diffusivity and fractional anisotropy histograms of patients with multiple sclerosis. Am J Neuroradiol 22(5):952\u2013958. papers3:\/\/publication\/uuid\/4F01DD03-295B-4F8E-B32E-27327AB8CFA5. Accessed 10 Apr 2019"},{"issue":"7","key":"10543_CR43","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.3174\/ajnr.A2983","volume":"33","author":"S Hannoun","year":"2012","unstructured":"Hannoun S, Durand-Dubief F, Confavreux C et al (2012) Diffusion tensor-MRI evidence for extra-axonal neuronal degeneration in caudate and thalamic nuclei of patients with multiple sclerosis. Am J Neuroradiol 33(7):1363\u20131368. https:\/\/doi.org\/10.3174\/ajnr.A2983","journal-title":"Am J Neuroradiol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-021-10543-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-021-10543-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-021-10543-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,24]],"date-time":"2021-09-24T17:57:59Z","timestamp":1632506279000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-021-10543-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,7]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10543"],"URL":"https:\/\/doi.org\/10.1007\/s00415-021-10543-4","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,7]]},"assertion":[{"value":"18 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 March 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 April 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 April 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"UD has received research support, travel grants, and\/or teaching honorary from Biogen Idec, Merck Serono, Novartis, Bayer Schering, and Sanofi Aventis as well as honoraria from serving on scientific advisory boards of Biogen Idec and Genzyme.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}}]}}