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Barbara Casolla and Hilde Henon served as investigator for clinical trials (Astra-Zeneca, Boehringer-Ingelheim, Daiichi-Sankyo, Pfizer). All fees were paid to ADRINORD or the Lille University Hospital research account, no personal funding. Charlotte\u00a0Cordonnier\u00a0served for advisory boards (Bayer, Medtronics, Daiichi-Sankyo) and an investigator for clinical trials (Astra-Zeneca, Boehringer-Ingelheim, Daiichi-Sankyo, Pfizer). All fees were paid to ADRINORD or the Lille University Hospital research account, no personal funding.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The ethical committee (Comit\u00e9 de protection des personnes Nord Ouest IV) classified the study as observational on March 9, 2010 and approved the study by December 21, 2010(n\u00b0 10. 677). The patient and their relatives gave an informed consent to participate. 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