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Accordingly, being carpal tunnel syndrome (CTS) common in the general population, the EFNS\/PNS guidelines recommend excluding the DML of the median nerve when DML prolongation may be consistent with median neuropathy at the wrist from CTS. The main aims of this study were to verify whether the inclusion of DML of the median nerve (when consistent with CTS) could improve electrophysiological diagnostic accuracy for CIDP and if the median nerve at the carpal tunnel was more prone to demyelination. We analyzed electrophysiological data from 499 patients included consecutively into the Italian CIDP Database. According to the EFNS\/PNS criteria, 352 patients had a definite, 10 a probable, and 57 a possible diagnosis of CIDP, while 80 were not fulfilling the diagnostic criteria. The inclusion of DML prolongation of median nerve did not improve significantly the diagnostic accuracy for CIDP; overall diagnostic class changed in 6 out of 499 patients (1.2%) and electrodiagnostic class of CIDP changed from not fulfilling to possible in only 2 patients (2.5% of not-fulfilling patients). In conclusion, we can infer that excluding DML prolongation of median nerve does not increase the risk of missing a diagnosis of CIDP thus corroborating the current EFNS\/PNS criteria.<\/jats:p>","DOI":"10.1007\/s00415-021-10672-w","type":"journal-article","created":{"date-parts":[[2021,6,26]],"date-time":"2021-06-26T11:02:55Z","timestamp":1624705375000},"page":"907-912","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prolonged distal motor latency of median nerve does not improve diagnostic accuracy for CIDP"],"prefix":"10.1007","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5123-2459","authenticated-orcid":false,"given":"Emanuele","family":"Spina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro 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G.L. reported travel Grants to attend scientific meetings from CSL Behring and Kedrion. D.C. reported honoraria for lecturing from Shire, CSL Behring, and Kedrion and travel Grants to attend scientific meeting from Shire, Kedrion, and CSL Behring. R.F. has served on scientific advisory boards for CSL Behring and has received travel Grants from Kedrion and CSL Behring to attend scientific meeting. C.B. has served on scientific advisory boards for Pfizer and has received travel Grants from Kedrion and CSL Behring to attend scientific meeting. M.F. has served on scientific advisory boards for CSL Behring and Sarepta Therapeutics and has received travel Grants from Sanofi Genzyme, Kedrion, Baxter and CSL Behring to attend scientific meeting. G.A. reported honoraria for lecturing from Kedrion and Sanofi-genzyme, travel Grants from Kedrion, Sanofi-Genzyme and LJ Pharma. G.C. reported travel Grants to attend scientific meetings from CSL Behring and Kedrion. S.J. reported research Grants from Grifols, outside this work, and travel Grants from Grifols and Kedrion. A.M. reported travel Grants from Kedrion and CSL Behring to attend scientific meeting. A.C. reported travel Grants to attend scientific meetings from Kedrion. G.A.M. reported consulence fees and travel fundings from CSL Behring, Kedrion, Shire and Grifols. M.C. reported travel Grants to attend scientific meetings from Kedrion. M.L. reported honoraria for scientific board from Pfeizer and Alnylam and travel Grants from Pfeizer, Grifols and Kedrion to attend scientific meeting. G.C. reported honoraria for lecturing and travel Grants to attend scientific meetings from Kedrion. E.P. reported travel Grants to attend scientific meetings from CSL Behring. L.G. reported travel Grants from Kedrion and CSL Behring to attend scientific meeting. G.M. reported consulence fees and travel fundings from CSL Behring, Kedrion, Shire and Grifols. L.S. reported personal fees for scientific events from CSL Behring and has received travel Grants to attend scientific meetings from CSL Behring and Kedrion. E.N.O. reported personal fees for Advisory or Scientific Board from Kedrion, Italy, Baxter, Italy, Novartis, Switzerland, CSL-Behring, Italy, LFB, France, Astellas, the Netherlands, outside the submitted work and travel Grants to attend Scientific Meeting from Baxter, Grifols, Kedrion, and Novartis, Italy. F.M. reported personal fees for scientific events from CSL Behring and has received travel Grants to attend scientific meetings from CSL Behring and Kedrion. The other authors declare no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was approved by the ethical committee of each participating center.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from all participants for enrolment.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}