{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T11:37:30Z","timestamp":1775475450261,"version":"3.50.1"},"reference-count":36,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s00415-021-10687-3","type":"journal-article","created":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T10:03:15Z","timestamp":1625220195000},"page":"1007-1012","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Blink reflex recovery cycle distinguishes patients with idiopathic normal pressure hydrocephalus from elderly subjects"],"prefix":"10.1007","volume":"269","author":[{"given":"Alessandro","family":"Mechelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Quattrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Nistic\u00f2","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Cras\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"La Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basilio","family":"Vescio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2001-957X","authenticated-orcid":false,"given":"Aldo","family":"Quattrone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,7,2]]},"reference":[{"issue":"11","key":"10687_CR1","doi-asserted-by":"publisher","first-page":"775","DOI":"10.2176\/nmc.52.775","volume":"52","author":"E Mori","year":"2012","unstructured":"Mori E, Ishikawa M, Kato T, Kazui H, Miyake H, Miyajima M, Nakajima M, Hashimoto M, Kuriyama N, Tokuda T, Ishii K, Kaijima M, Hirata Y, Saito M, Arai H, Japanese Society of Normal Pressure H (2012) Guidelines for management of idiopathic normal pressure hydrocephalus: second edition. Neurol Med Chir (Tokyo) 52(11):775\u2013809. https:\/\/doi.org\/10.2176\/nmc.52.775","journal-title":"Neurol Med Chir (Tokyo)"},{"issue":"1","key":"10687_CR2","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1212\/CON.0000000000000689","volume":"25","author":"NR Graff-Radford","year":"2019","unstructured":"Graff-Radford NR, Jones DT (2019) Normal pressure hydrocephalus. Continuum (Minneap Minn) 25(1):165\u2013186. https:\/\/doi.org\/10.1212\/CON.0000000000000689","journal-title":"Continuum (Minneap Minn)"},{"issue":"5","key":"10687_CR3","doi-asserted-by":"publisher","first-page":"2103","DOI":"10.1016\/j.juro.2006.07.029","volume":"176","author":"JT Anger","year":"2006","unstructured":"Anger JT, Saigal CS, Stothers L, Thom DH, Rodriguez LV, Litwin MS, Urologic Diseases of America P (2006) The prevalence of urinary incontinence among community dwelling men: results from the National Health and Nutrition Examination survey. J Urol 176(5):2103\u20132108. https:\/\/doi.org\/10.1016\/j.juro.2006.07.029 (discussion 2108)","journal-title":"J Urol"},{"issue":"4","key":"10687_CR4","doi-asserted-by":"publisher","first-page":"1302","DOI":"10.1097\/01.ju.0000155503.12545.4e","volume":"173","author":"L Stothers","year":"2005","unstructured":"Stothers L, Thom D, Calhoun E (2005) Urologic diseases in America project: urinary incontinence in males\u2013demographics and economic burden. J Urol 173(4):1302\u20131308. https:\/\/doi.org\/10.1097\/01.ju.0000155503.12545.4e","journal-title":"J Urol"},{"key":"10687_CR5","first-page":"773","volume":"39","author":"J Kimura","year":"1983","unstructured":"Kimura J (1983) Clinical uses of the electrically elicited blink reflex. Adv Neurol 39:773\u2013786","journal-title":"Adv Neurol"},{"issue":"22","key":"10687_CR6","doi-asserted-by":"publisher","first-page":"7318","DOI":"10.1523\/JNEUROSCI.16-22-07318.1996","volume":"16","author":"MA Basso","year":"1996","unstructured":"Basso MA, Evinger C (1996) An explanation for reflex blink hyperexcitability in Parkinson\u2019s disease. II. Nucleus raphe magnus. J Neurosci 16(22):7318\u20137330","journal-title":"J Neurosci"},{"key":"10687_CR7","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.parkreldis.2018.06.005","volume":"56","author":"G Arabia","year":"2018","unstructured":"Arabia G, Lupo A, Manfredini LI, Vescio B, Nistico R, Barbagallo G, Salsone M, Morelli M, Novellino F, Nicoletti G, Quattrone A, Cascini GL, Louis ED, Quattrone A (2018) Clinical, electrophysiological, and imaging study in essential tremor-Parkinson\u2019s disease syndrome. Parkinsonism Relat Disord 56:20\u201326. https:\/\/doi.org\/10.1016\/j.parkreldis.2018.06.005","journal-title":"Parkinsonism Relat Disord"},{"issue":"8","key":"10687_CR8","doi-asserted-by":"publisher","first-page":"1100","DOI":"10.1111\/ene.13673","volume":"25","author":"G Sciacca","year":"2018","unstructured":"Sciacca G, Nicoletti A, Mostile G, Luca A, Raciti L, Dibilio V, Drago F, Salomone S, Zappia M (2018) Blink reflex recovery cycle to differentiate progressive supranuclear palsy from corticobasal syndrome. Eur J Neurol 25(8):1100-e1185. https:\/\/doi.org\/10.1111\/ene.13673","journal-title":"Eur J Neurol"},{"issue":"7","key":"10687_CR9","doi-asserted-by":"publisher","first-page":"610","DOI":"10.1212\/WNL.0b013e31820c3074","volume":"76","author":"P Schwingenschuh","year":"2011","unstructured":"Schwingenschuh P, Katschnig P, Edwards MJ, Teo JT, Korlipara LV, Rothwell JC, Bhatia KP (2011) The blink reflex recovery cycle differs between essential and presumed psychogenic blepharospasm. Neurology 76(7):610\u2013614. https:\/\/doi.org\/10.1212\/WNL.0b013e31820c3074","journal-title":"Neurology"},{"issue":"17","key":"10687_CR10","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1212\/WNL.0b013e3182518316","volume":"78","author":"R Nistico","year":"2012","unstructured":"Nistico R, Pirritano D, Salsone M, Valentino P, Novellino F, Condino F, Bono F, Quattrone A (2012) Blink reflex recovery cycle in patients with dystonic tremor: a cross-sectional study. Neurology 78(17):1363\u20131365. https:\/\/doi.org\/10.1212\/WNL.0b013e3182518316","journal-title":"Neurology"},{"issue":"2","key":"10687_CR11","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.parkreldis.2013.10.006","volume":"20","author":"R Nistico","year":"2014","unstructured":"Nistico R, Salsone M, Vescio B, Morelli M, Trotta M, Barbagallo G, Arabia G, Quattrone A (2014) Blink reflex recovery cycle distinguishes essential tremor with resting tremor from de novo Parkinson\u2019s disease: an exploratory study. Parkinsonism Relat Disord 20(2):153\u2013156. https:\/\/doi.org\/10.1016\/j.parkreldis.2013.10.006","journal-title":"Parkinsonism Relat Disord"},{"issue":"22","key":"10687_CR12","doi-asserted-by":"publisher","first-page":"7308","DOI":"10.1523\/JNEUROSCI.16-22-07308.1996","volume":"16","author":"MA Basso","year":"1996","unstructured":"Basso MA, Powers AS, Evinger C (1996) An explanation for reflex blink hyperexcitability in Parkinson\u2019s disease. I. Superior colliculus. J Neurosci 16(22):7308\u20137317","journal-title":"J Neurosci"},{"issue":"6","key":"10687_CR13","doi-asserted-by":"publisher","first-page":"1859","DOI":"10.1007\/s00415-020-09900-6","volume":"267","author":"G Sciacca","year":"2020","unstructured":"Sciacca G, Mostile G, Disilvestro I, Donzuso G, Manna R, Portaro G, Rascuna C, Salomone S, Drago F, Nicoletti A, Zappia M (2020) Asymmetry index of Blink Reflex Recovery Cycle differentiates Parkinson\u2019s disease from atypical Parkinsonian syndromes. J Neurol 267(6):1859\u20131863. https:\/\/doi.org\/10.1007\/s00415-020-09900-6","journal-title":"J Neurol"},{"issue":"3","key":"10687_CR14","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","volume":"12","author":"MF Folstein","year":"1975","unstructured":"Folstein MF, Folstein SE, McHugh PR (1975) \u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12(3):189\u2013198. https:\/\/doi.org\/10.1016\/0022-3956(75)90026-6","journal-title":"J Psychiatr Res"},{"issue":"15","key":"10687_CR15","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1002\/mds.22340","volume":"23","author":"CG Goetz","year":"2008","unstructured":"Goetz CG, Tilley BC, Shaftman SR, Stebbins GT, Fahn S, Martinez-Martin P, Poewe W, Sampaio C, Stern MB, Dodel R, Dubois B, Holloway R, Jankovic J, Kulisevsky J, Lang AE, Lees A, Leurgans S, LeWitt PA, Nyenhuis D, Olanow CW, Rascol O, Schrag A, Teresi JA, van Hilten JJ, LaPelle N, Movement Disorder Society URTF (2008) Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): scale presentation and clinimetric testing results. Mov Disord 23(15):2129\u20132170. https:\/\/doi.org\/10.1002\/mds.22340","journal-title":"Mov Disord"},{"issue":"1","key":"10687_CR16","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000111149","volume":"25","author":"Y Kubo","year":"2008","unstructured":"Kubo Y, Kazui H, Yoshida T, Kito Y, Kimura N, Tokunaga H, Ogino A, Miyake H, Ishikawa M, Takeda M (2008) Validation of grading scale for evaluating symptoms of idiopathic normal-pressure hydrocephalus. Dement Geriatr Cogn Disord 25(1):37\u201345. https:\/\/doi.org\/10.1159\/000111149","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"2","key":"10687_CR17","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.apmr.2004.02.010","volume":"86","author":"HJ van Hedel","year":"2005","unstructured":"van Hedel HJ, Wirz M, Dietz V (2005) Assessing walking ability in subjects with spinal cord injury: validity and reliability of 3 walking tests. Arch Phys Med Rehabil 86(2):190\u2013196. https:\/\/doi.org\/10.1016\/j.apmr.2004.02.010","journal-title":"Arch Phys Med Rehabil"},{"issue":"5","key":"10687_CR18","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1161\/01.str.19.5.604","volume":"19","author":"JC van Swieten","year":"1988","unstructured":"van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J (1988) Interobserver agreement for the assessment of handicap in stroke patients. Stroke 19(5):604\u2013607. https:\/\/doi.org\/10.1161\/01.str.19.5.604","journal-title":"Stroke"},{"issue":"8","key":"10687_CR19","doi-asserted-by":"publisher","first-page":"1406","DOI":"10.1002\/mds.28087","volume":"35","author":"A Quattrone","year":"2020","unstructured":"Quattrone A, Sarica A, La Torre D, Morelli M, Vescio B, Nigro S, Barbagallo G, Nistico R, Salsone M, Arcuri PP, Novellino F, Bianco MG, Arabia G, Cascini G, Quattrone A (2020) Magnetic resonance imaging biomarkers distinguish normal pressure hydrocephalus from progressive supranuclear palsy. Mov Disord 35(8):1406\u20131415. https:\/\/doi.org\/10.1002\/mds.28087","journal-title":"Mov Disord"},{"issue":"1","key":"10687_CR20","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1148\/radiol.2017161216","volume":"285","author":"N Miskin","year":"2017","unstructured":"Miskin N, Patel H, Franceschi AM, Ades-Aron B, Le A, Damadian BE, Stanton C, Serulle Y, Golomb J, Gonen O, Rusinek H, George AE, Alzheimer\u2019s Disease Neuroimaging I (2017) Diagnosis of normal-pressure hydrocephalus: use of traditional measures in the era of volumetric MR imaging. Radiology 285(1):197\u2013205. https:\/\/doi.org\/10.1148\/radiol.2017161216","journal-title":"Radiology"},{"issue":"11","key":"10687_CR21","doi-asserted-by":"publisher","first-page":"2678","DOI":"10.1007\/s00330-008-1044-4","volume":"18","author":"K Ishii","year":"2008","unstructured":"Ishii K, Kanda T, Harada A, Miyamoto N, Kawaguchi T, Shimada K, Ohkawa S, Uemura T, Yoshikawa T, Mori E (2008) Clinical impact of the callosal angle in the diagnosis of idiopathic normal pressure hydrocephalus. Eur Radiol 18(11):2678\u20132683. https:\/\/doi.org\/10.1007\/s00330-008-1044-4","journal-title":"Eur Radiol"},{"issue":"1","key":"10687_CR22","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1148\/radiol.2453061703","volume":"246","author":"A Quattrone","year":"2008","unstructured":"Quattrone A, Nicoletti G, Messina D, Fera F, Condino F, Pugliese P, Lanza P, Barone P, Morgante L, Zappia M, Aguglia U, Gallo O (2008) MR imaging index for differentiation of progressive supranuclear palsy from Parkinson disease and the Parkinson variant of multiple system atrophy. Radiology 246(1):214\u2013221. https:\/\/doi.org\/10.1148\/radiol.2453061703","journal-title":"Radiology"},{"issue":"6","key":"10687_CR23","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1002\/mds.28007","volume":"35","author":"S Nigro","year":"2020","unstructured":"Nigro S, Antonini A, Vaillancourt DE, Seppi K, Ceravolo R, Strafella AP, Augimeri A, Quattrone A, Morelli M, Weis L, Fiorenzato E, Biundo R, Burciu RG, Krismer F, McFarland NR, Mueller C, Gizewski ER, Cosottini M, Del Prete E, Mazzucchi S, Quattrone A (2020) Automated MRI classification in progressive supranuclear palsy: a large international cohort study. Mov Disord 35(6):976\u2013983. https:\/\/doi.org\/10.1002\/mds.28007","journal-title":"Mov Disord"},{"issue":"1","key":"10687_CR24","doi-asserted-by":"publisher","first-page":"21","DOI":"10.2967\/jnmt.118.222349","volume":"47","author":"JE Brogley","year":"2019","unstructured":"Brogley JE (2019) DaTQUANT: the future of diagnosing Parkinson disease. J Nucl Med Technol 47(1):21\u201326. https:\/\/doi.org\/10.2967\/jnmt.118.222349","journal-title":"J Nucl Med Technol"},{"key":"10687_CR25","doi-asserted-by":"publisher","first-page":"11","DOI":"10.3389\/fncom.2017.00011","volume":"11","author":"DA Peterson","year":"2017","unstructured":"Peterson DA, Sejnowski TJ (2017) A dynamic circuit hypothesis for the pathogenesis of Blepharospasm. Front Comput Neurosci 11:11. https:\/\/doi.org\/10.3389\/fncom.2017.00011","journal-title":"Front Comput Neurosci"},{"issue":"1","key":"10687_CR26","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/0022-510x(85)90018-8","volume":"67","author":"J Kimura","year":"1985","unstructured":"Kimura J, Wilkinson JT, Damasio H, Adams HR Jr, Shivapour E, Yamada T (1985) Blink reflex in patients with hemispheric cerebrovascular accident (CVA). Blink reflex in CVA. J Neurol Sci 67(1):15\u201328. https:\/\/doi.org\/10.1016\/0022-510x(85)90018-8","journal-title":"J Neurol Sci"},{"issue":"2","key":"10687_CR27","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1097\/00004691-200403000-00005","volume":"21","author":"A Spissu","year":"2004","unstructured":"Spissu A, Cossu G, Cannas A (2004) Late blink reflex changes in patients with pure sensory stroke due to geniculo-thalamic infarct: a contribution to the long loop theory. J Clin Neurophysiol 21(2):105\u2013109. https:\/\/doi.org\/10.1097\/00004691-200403000-00005","journal-title":"J Clin Neurophysiol"},{"issue":"3","key":"10687_CR28","doi-asserted-by":"publisher","first-page":"874","DOI":"10.1212\/wnl.49.3.874","volume":"49","author":"LG Chia","year":"1997","unstructured":"Chia LG (1997) Late blink reflex changes in lesions of thalamus and internal capsule. Neurology 49(3):874\u2013876. https:\/\/doi.org\/10.1212\/wnl.49.3.874","journal-title":"Neurology"},{"issue":"1","key":"10687_CR29","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S0987-7053(99)80039-2","volume":"29","author":"A Esteban","year":"1999","unstructured":"Esteban A (1999) A neurophysiological approach to brainstem reflexes Blink reflex. Neurophysiol Clin 29(1):7\u201338. https:\/\/doi.org\/10.1016\/S0987-7053(99)80039-2","journal-title":"Neurophysiol Clin"},{"issue":"4","key":"10687_CR30","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1227\/01.NEU.0000232655.78335.D5","volume":"59","author":"J Mocco","year":"2006","unstructured":"Mocco J, Tomey MI, Komotar RJ, Mack WJ, Frucht SJ, Goodman RR, McKhann GM 2nd (2006) Ventriculoperitoneal shunting of idiopathic normal pressure hydrocephalus increases midbrain size: a potential mechanism for gait improvement. Neurosurgery 59(4):847\u2013850. https:\/\/doi.org\/10.1227\/01.NEU.0000232655.78335.D5 (discussion 850\u2013841)","journal-title":"Neurosurgery"},{"issue":"4","key":"10687_CR31","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1111\/ane.13205","volume":"141","author":"VC Constantinides","year":"2020","unstructured":"Constantinides VC, Paraskevas GP, Velonakis G, Toulas P, Stefanis L, Kapaki E (2020) Midbrain morphology in idiopathic normal pressure hydrocephalus: a progressive supranuclear palsy mimic. Acta Neurol Scand 141(4):328\u2013334. https:\/\/doi.org\/10.1111\/ane.13205","journal-title":"Acta Neurol Scand"},{"issue":"8","key":"10687_CR32","doi-asserted-by":"publisher","first-page":"958","DOI":"10.1007\/s00415-005-0791-2","volume":"252","author":"PH Lee","year":"2005","unstructured":"Lee PH, Yong SW, Ahn YH, Huh K (2005) Correlation of midbrain diameter and gait disturbance in patients with idiopathic normal pressure hydrocephalus. J Neurol 252(8):958\u2013963. https:\/\/doi.org\/10.1007\/s00415-005-0791-2","journal-title":"J Neurol"},{"issue":"1","key":"10687_CR33","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1002\/mds.28336","volume":"36","author":"A Sarica","year":"2021","unstructured":"Sarica A, Quattrone A, Quarantelli M, Arcuri PP, Mechelli A, La Torre D, Vaccaro MG, Cascini GL, Quattrone A (2021) Reduced striatal DAT uptake normalizes after shunt in normal-pressure hydrocephalus. Mov Disord 36(1):261\u2013262. https:\/\/doi.org\/10.1002\/mds.28336","journal-title":"Mov Disord"},{"key":"10687_CR34","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012064","author":"M Todisco","year":"2021","unstructured":"Todisco M, Zangaglia R, Minafra B, Pisano P, Trifiro G, Bossert I, Pozzi NG, Brumberg J, Ceravolo R, Isaias IU, Fasano A, Pacchetti C (2021) Clinical outcome and striatal dopaminergic function after shunt surgery in patients with idiopathic normal pressure hydrocephalus. Neurology. https:\/\/doi.org\/10.1212\/WNL.0000000000012064","journal-title":"Neurology"},{"issue":"8","key":"10687_CR35","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1212\/WNL.0000000000002432","volume":"86","author":"Practice Guideline","year":"2016","unstructured":"Practice Guideline (2016) Idiopathic normal pressure hydrocephalus: response to shunting and predictors of response: report of the guideline development, dissemination, and implementation subcommittee of the American Academy of Neurology. Neurology 86(8):793. https:\/\/doi.org\/10.1212\/WNL.0000000000002432","journal-title":"Neurology"},{"issue":"2 Dementia","key":"10687_CR36","doi-asserted-by":"publisher","first-page":"579","DOI":"10.1212\/CON.0000000000000305","volume":"22","author":"MA Williams","year":"2016","unstructured":"Williams MA, Malm J (2016) Diagnosis and Treatment of Idiopathic Normal Pressure Hydrocephalus. Continuum (Minneap Minn) 22(2 Dementia):579\u2013599. https:\/\/doi.org\/10.1212\/CON.0000000000000305","journal-title":"Continuum (Minneap Minn)"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-021-10687-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-021-10687-3\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-021-10687-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T15:16:34Z","timestamp":1642778194000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-021-10687-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,2]]},"references-count":36,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["10687"],"URL":"https:\/\/doi.org\/10.1007\/s00415-021-10687-3","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,2]]},"assertion":[{"value":"14 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 June 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 July 2021","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no financial or other conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All the study procedures and ethical aspects were approved by the institutional review board of Magna Graecia University, Catanzaro, Italy.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Written informed consent was obtained from each participant included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not applicable.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}