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Median survival times range from 11 to 84\u00a0months. Beyond surgery, no treatment standard has been established. We investigated clinical and radiological data to assess prognostic features providing support for treatment decisions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>34 BSG patients treated between 2000 and 2019 and aged\u2009\u2265\u200918\u00a0years at the time of diagnosis were retrospectively identified from the databases of the two largest Austrian Neuro-Oncology centres. Clinical data including baseline characteristics, clinical disease course, applied therapies, the outcome as well as neuroradiological and neuropathological findings were gathered and analysed. The tumour apparent diffusion coefficient (ADC), volumetry of contrast-enhancing and non-contrast-enhancing lesions were determined on magnetic resonance imaging scans performed at diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The median age at diagnosis was 38.5\u00a0years (range 18\u201371\u00a0years). Tumour progression occurred in 26\/34 (76.5%) patients after a median follow up time of 19\u00a0months (range 0.9\u2013236.2). Median overall survival (OS) and progression-free survival (PFS) was 24.1\u00a0months (range 0.9\u2013236.2; 95% CI 18.1\u201330.1) and 14.5\u00a0months (range 0.7\u2013178.5; 95% CI 5.1\u201323.9), respectively. Low-performance status, high body mass index (BMI) at diagnosis and WHO grading were associated with shorter PFS and OS at univariate analysis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05, log rank test, respectively). ADC values below the median were significantly associated with shorter OS (14.9 vs 44.2\u00a0months,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>ECOG, BMI, WHO grade and ADC values were associated with the survival prognosis of BSG patients and should be included in the prognostic assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00415-021-10725-0","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T11:43:50Z","timestamp":1627991030000},"page":"1574-1590","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Prognostic factors in adult brainstem glioma: a tertiary care center analysis and review of the literature"],"prefix":"10.1007","volume":"269","author":[{"given":"Annette","family":"Leibetseder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Leitner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian J.","family":"Mair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Meckel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes A.","family":"Hainfellner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Aichholzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Widhalm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Dieckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serge","family":"Weis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Furtner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"von Oertzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Preusser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josef","family":"Pichler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Sophie","family":"Berghoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"10725_CR1","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1212\/WNL.13.4.292","volume":"13","author":"HH White","year":"1963","unstructured":"White HH (1963) Brain stem tumors occurring in adults. 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The following for-profit companies have supported clinical trials and contracted research conducted by MP with payments made to his institution: B\u00f6hringer-Ingelheim, Bristol-Myers Squibb, Roche, Daiichi Sankyo, Merck Sharp & Dome, Novocure, GlaxoSmithKline, AbbVie. ASB has research support from Daiichi Sankyo (\u2264\u200910,000\u20ac), Roche (>\u200910,000\u20ac) and honoraria for lectures, consultation or advisory board participation from Roche Bristol-Meyers Squibb, Merck, Daiichi Sankyo (all\u2009<\u20095,000\u20ac) as well as travel support from Roche, Amgen and AbbVie. Tim von Oertzen reports grants, personal fees and non-financial support from Novartis Phama, personal fees from Roche Pharma, Biogen Idec Austria, Liva Nova, Arvelle and GW Pharma, grants from Grossegger & Drbal GmbH, grants from Merck, personal fees from Indivior Austria GmbH, personal fees and non-financial support from gtec GmbH Austria, grants and non-financial support from Boehringer-Ingelheim, personal fees from Philips, personal fees and non-financial support from UCB Pharma, personal fees from Almirall, personal fees from Eisai, outside the submitted work; and he is co-chair of the Communication Committee of the European Academy of Neurology (EAN), co-chair of the EAN scientific panel for epilepsy, and president of the \u00d6sterreichische Gesellschaft f\u00fcr Epileptologie (Austrian ILAE chapter). All other authors report no conflicts of interest related to the study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interests"}},{"value":"This retrospective chart review study was performed in accordance with the ethical standards of the Ethics Committee of the Medical University of Vienna and Johannes Kepler University Linz (Approval No. 1166\/2019 and 1274\/2019) and with the Helsinki Declaration of 1964 and its later amendment.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"No informed consent was obtained in accordance with the local ethics committees due to the retrospective design of the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}}]}}