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Grant agreement: 888692"],"award-info":[{"award-number":["Marie Sklodowska-Curie fellowship. Grant agreement: 888692"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["FIS\/FEDER"],"award-info":[{"award-number":["FIS\/FEDER"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005774","name":"Universitat de Barcelona","doi-asserted-by":"publisher","award":["APIF predoctoral fellowship"],"award-info":[{"award-number":["APIF predoctoral fellowship"]}],"id":[{"id":"10.13039\/501100005774","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>The presence of rapid eye movement sleep behavior disorder (RBD) contributes to increase cognitive impairment and brain atrophy in Parkinson\u2019s disease (PD), but the impact of sex is unclear. We aimed to investigate sex differences in cognition and brain atrophy in PD patients with and without probable RBD (pRBD).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Magnetic resonance imaging and cognition data were obtained for 274 participants from the Parkinson's Progression Marker Initiative database: 79 PD with pRBD (PD-pRBD; male\/female, 54\/25), 126 PD without pRBD (PD-non pRBD; male\/female, 73\/53), and 69 healthy controls (male\/female, 40\/29). FreeSurfer was used to obtain volumetric and cortical thickness data.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Males showed greater global cortical and subcortical gray matter atrophy than females in the PD-pRBD group. Significant group-by-sex interactions were found in the pallidum. Structures showing a within-group sex effect in the deep gray matter differed, with significant volume reductions for males in one structure in in PD-non pRBD (brainstem), and three in PD-pRBD (caudate, pallidum and brainstem). Significant group-by-sex interactions were found in Montreal Cognitive Assessment (MoCA) and Symbol Digits Modalities Test (SDMT). Males performed worse than females in MoCA, phonemic fluency and SDMT in the PD-pRBD group.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>Male sex is related to increased cognitive impairment and subcortical atrophy in de novo PD-pRBD. Accordingly, we suggest that sex differences are relevant and should be considered in future clinical and translational research.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-021-10728-x","type":"journal-article","created":{"date-parts":[[2021,8,3]],"date-time":"2021-08-03T19:16:16Z","timestamp":1628018176000},"page":"1591-1599","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Sex differences in brain atrophy and cognitive impairment in Parkinson\u2019s disease patients with and without probable rapid eye movement sleep behavior disorder"],"prefix":"10.1007","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9268-4504","authenticated-orcid":false,"given":"Javier","family":"Oltra","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9673-5479","authenticated-orcid":false,"given":"Barbara","family":"Segura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1415-687X","authenticated-orcid":false,"given":"Carme","family":"Uribe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3532-2224","authenticated-orcid":false,"given":"Gemma C.","family":"Mont\u00e9-Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2833-4884","authenticated-orcid":false,"given":"Anna","family":"Campabadal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0879-5875","authenticated-orcid":false,"given":"Anna","family":"Inguanzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4665-4213","authenticated-orcid":false,"given":"J\u00e8ssica","family":"Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-967X","authenticated-orcid":false,"given":"Maria J.","family":"Marti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6443-0104","authenticated-orcid":false,"given":"Yaroslau","family":"Compta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8680-4274","authenticated-orcid":false,"given":"Francesc","family":"Valldeoriola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5618-8271","authenticated-orcid":false,"given":"Alex","family":"Iranzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6381-3063","authenticated-orcid":false,"given":"Carme","family":"Junque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,8,3]]},"reference":[{"key":"10728_CR1","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41582-018-0032-9","volume":"14","author":"MT Ferretti","year":"2018","unstructured":"Ferretti MT, Iulita MF, Cavedo E et al (2018) Sex differences in Alzheimer disease\u2014the gateway to precision medicine. 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Fox Foundation for Parkinson\u2019s Research (MJFF): MJF_PPMI_10_001, PI044024. YC has received funding in the past 5\u00a0years from Union Chimique Belge (UCB pharma), Teva, Medtronic,\u00a0Abbvie, Novartis, Merz, Piramal Imaging, and Esteve, Bial, and Zambon. YC is currently an associate editor for Parkinsonism & Related Disorders.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All participating PPMI sites received approval from an ethical standards committee prior to study initiation.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participating PPMI sites obtained written informed consent for research from all participants in the study as described in the PPMI study protocol, available in .","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate and consent to publication"}}]}}