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In the tract-specific analysis according to the proposed sequential cerebral pathology pattern of ALS, the flail arm syndrome patients showed significant alterations of the specific tract systems that were identical to \u2018classical\u2019 ALS if compared to controls<jats:italic>.<\/jats:italic><\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>The DTI study including the tract-of-interest-based analysis showed a microstructural involvement pattern in the brains of flail arm syndrome patients, supporting the hypothesis that flail arm syndrome is a phenotypical variant of ALS.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-021-10854-6","type":"journal-article","created":{"date-parts":[[2021,10,21]],"date-time":"2021-10-21T20:32:23Z","timestamp":1634848343000},"page":"2619-2626","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Involvement of cortico-efferent tracts in flail arm syndrome: a tract-of-interest-based DTI study"],"prefix":"10.1007","volume":"269","author":[{"given":"Angela","family":"Rosenbohm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Del Tredici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Braak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-J\u00fcrgen","family":"Huppertz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert C.","family":"Ludolph","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Peter","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7106-9270","authenticated-orcid":false,"given":"Jan","family":"Kassubek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,21]]},"reference":[{"key":"10854_CR1","doi-asserted-by":"publisher","first-page":"708","DOI":"10.1038\/nrneurol.2013.221","volume":"9","author":"H Braak","year":"2013","unstructured":"Braak H, Brettschneider J, Ludolph AC et al (2013) Amyotrophic lateral sclerosis\u2014a model of corticofugal axonal spread. 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