{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T11:06:20Z","timestamp":1781694380691,"version":"3.54.5"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T00:00:00Z","timestamp":1642377600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1007\/s00415-021-10926-7","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T14:05:08Z","timestamp":1642428308000},"page":"3495-3500","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["NFL during acute spinal cord lesions in MS: a hurdle for the detection of inflammatory activity"],"prefix":"10.1007","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4799-7579","authenticated-orcid":false,"given":"C.","family":"Alcal\u00e1","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cubas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Carratal\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gasc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Quintanilla-Bord\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gil-Perot\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Gorriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"P\u00e9rez-Miralles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Gasque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Castillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Casanova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,1,17]]},"reference":[{"key":"10926_CR1","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1212\/wnl.46.4.907","volume":"46","author":"FD Lublin","year":"1996","unstructured":"Lublin FD, Reingold SC (1996) Defining the clinical course of multiple sclerosis: results of an international survey. National Multiple Sclerosis Society (USA) Advisory Committee on Clinical Trials of New Agents in Multiple Sclerosis. Neurology 46:907\u2013911. https:\/\/doi.org\/10.1212\/wnl.46.4.907","journal-title":"Neurology"},{"key":"10926_CR2","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1212\/wnl.46.2.373","volume":"46","author":"JW Thorpe","year":"1996","unstructured":"Thorpe JW, Kidd D, Moseley IF et al (1996) Serial gadolinium-enhanced MRI of the brain and spinal cord in early relapsing-remitting multiple sclerosis. Neurology 46:373\u2013378. https:\/\/doi.org\/10.1212\/wnl.46.2.373","journal-title":"Neurology"},{"key":"10926_CR3","doi-asserted-by":"publisher","first-page":"1691","DOI":"10.1177\/1352458519885613","volume":"26","author":"J Kuhle","year":"2020","unstructured":"Kuhle J, Plavina T, Barro C et al (2020) Neurofilament light levels are associated with long-term outcomes in multiple sclerosis. Mult Scler 26:1691\u20131699. https:\/\/doi.org\/10.1177\/1352458519885613","journal-title":"Mult Scler"},{"key":"10926_CR4","doi-asserted-by":"publisher","first-page":"2382","DOI":"10.1093\/brain\/awy154","volume":"141","author":"C Barro","year":"2018","unstructured":"Barro C, Benkert P, Disanto G et al (2018) Serum neurofilament as a predictor of disease worsening and brain and spinal cord atrophy in multiple sclerosis. Brain 141:2382\u20132391. https:\/\/doi.org\/10.1093\/brain\/awy154","journal-title":"Brain"},{"key":"10926_CR5","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1177\/1352458518765666","volume":"25","author":"N Siller","year":"2019","unstructured":"Siller N, Kuhle J, Muthuraman M et al (2019) Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis. Mult Scler 25:678\u2013686. https:\/\/doi.org\/10.1177\/1352458518765666","journal-title":"Mult Scler"},{"key":"10926_CR6","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/brain\/124.1.154","volume":"124","author":"GJ Nijeholt","year":"2001","unstructured":"Nijeholt GJ, Bergers E, Kamphorst W et al (2001) Post-mortem high-resolution MRI of the spinal cord in multiple sclerosis: a correlative study with conventional MRI, histopathology and clinical phenotype. Brain 124:154\u2013166. https:\/\/doi.org\/10.1093\/brain\/124.1.154","journal-title":"Brain"},{"key":"10926_CR7","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1111\/j.1750-3639.2006.00018.x","volume":"16","author":"CP Gilmore","year":"2006","unstructured":"Gilmore CP, B\u00f6 L, Owens T et al (2006) Spinal cord gray matter demyelination in multiple sclerosis-a novel pattern of residual plaque morphology. Brain Pathol 16:202\u2013208. https:\/\/doi.org\/10.1111\/j.1750-3639.2006.00018.x","journal-title":"Brain Pathol"},{"key":"10926_CR8","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S1474-4422(14)70294-7","volume":"14","author":"A Gass","year":"2015","unstructured":"Gass A, Rocca MA, Agosta F et al (2015) MRI monitoring of pathological changes in the spinal cord in patients with multiple sclerosis. Lancet Neurol 14:443\u2013454. https:\/\/doi.org\/10.1016\/S1474-4422(14)70294-7","journal-title":"Lancet Neurol"},{"key":"10926_CR9","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1016\/S1474-4422(15)70037-2","volume":"14","author":"H Lassmann","year":"2015","unstructured":"Lassmann H (2015) Spinal cord pathology in multiple sclerosis. Lancet Neurol 14:348\u2013349. https:\/\/doi.org\/10.1016\/S1474-4422(15)70037-2","journal-title":"Lancet Neurol"},{"key":"10926_CR10","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1093\/brain\/awh323","volume":"128","author":"N Evangelou","year":"2005","unstructured":"Evangelou N, DeLuca GC, Owens T, Esiri MM (2005) Pathological study of spinal cord atrophy in multiple sclerosis suggests limited role of local lesions. Brain 128:29\u201334. https:\/\/doi.org\/10.1093\/brain\/awh323","journal-title":"Brain"},{"key":"10926_CR11","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/nbt.1641","volume":"28","author":"DM Rissin","year":"2010","unstructured":"Rissin DM, Kan CW, Campbell TG et al (2010) Single-molecule enzyme-linked immunosorbent assay detects serum proteins at subfemtomolar concentrations. Nat Biotechnol 28:595\u2013599. https:\/\/doi.org\/10.1038\/nbt.1641","journal-title":"Nat Biotechnol"},{"key":"10926_CR12","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1046\/j.1468-1331.1999.640455.x","volume":"6","author":"O Ciccarelli","year":"1999","unstructured":"Ciccarelli O, Giugni E, Paolillo A et al (1999) Magnetic resonance outcome of new enhancing lesions in patients with relapsing-remitting multiple sclerosis. Eur J Neurol 6:455\u2013459. https:\/\/doi.org\/10.1046\/j.1468-1331.1999.640455.x","journal-title":"Eur J Neurol"},{"key":"10926_CR13","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1212\/wnl.57.4.731","volume":"57","author":"M Filippi","year":"2001","unstructured":"Filippi M, Rovaris M, Rocca MA et al (2001) Glatiramer acetate reduces the proportion of new MS lesions evolving into \u201cblack holes.\u201d Neurology 57:731\u2013733. https:\/\/doi.org\/10.1212\/wnl.57.4.731","journal-title":"Neurology"},{"key":"10926_CR14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1600-0404.2009.01221.x","volume":"122","author":"MA Sahraian","year":"2010","unstructured":"Sahraian MA, Radue E-W, Haller S, Kappos L (2010) Black holes in multiple sclerosis: definition, evolution, and clinical correlations. Acta Neurol Scand 122:1\u20138. https:\/\/doi.org\/10.1111\/j.1600-0404.2009.01221.x","journal-title":"Acta Neurol Scand"},{"key":"10926_CR15","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1111\/jon.12439","volume":"27","author":"S Andermatt","year":"2017","unstructured":"Andermatt S, Papadopoulou A, Radue E-W et al (2017) Tracking the evolution of cerebral gadolinium-enhancing lesions to persistent T1 black holes in multiple sclerosis: validation of a semiautomated pipeline. J Neuroimaging 27:469\u2013475. https:\/\/doi.org\/10.1111\/jon.12439","journal-title":"J Neuroimaging"},{"issue":"Pt 9","key":"10926_CR16","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1093\/brain\/123.9.1845","volume":"123","author":"N Evangelou","year":"2000","unstructured":"Evangelou N, Konz D, Esiri MM et al (2000) Regional axonal loss in the corpus callosum correlates with cerebral white matter lesion volume and distribution in multiple sclerosis. Brain 123(Pt 9):1845\u20131849. https:\/\/doi.org\/10.1093\/brain\/123.9.1845","journal-title":"Brain"},{"key":"10926_CR17","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1056\/NEJM199801293380502","volume":"338","author":"BD Trapp","year":"1998","unstructured":"Trapp BD, Peterson J, Ransohoff RM et al (1998) Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338:278\u2013285. https:\/\/doi.org\/10.1056\/NEJM199801293380502","journal-title":"N Engl J Med"},{"issue":"Pt 3","key":"10926_CR18","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1093\/brain\/120.3.393","volume":"120","author":"B Ferguson","year":"1997","unstructured":"Ferguson B, Matyszak MK, Esiri MM, Perry VH (1997) Axonal damage in acute multiple sclerosis lesions. Brain 120(Pt 3):393\u2013399. https:\/\/doi.org\/10.1093\/brain\/120.3.393","journal-title":"Brain"},{"key":"10926_CR19","doi-asserted-by":"publisher","first-page":"205521731774309","DOI":"10.1177\/2055217317743098","volume":"3","author":"S Mariotto","year":"2017","unstructured":"Mariotto S, Farinazzo A, Monaco S et al (2017) Serum neurofilament light chain in NMOSD and related disorders: comparison according to aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies status. Mult Scler J Exp Transl Clin 3:2055217317743098. https:\/\/doi.org\/10.1177\/2055217317743098","journal-title":"Mult Scler J Exp Transl Clin"},{"key":"10926_CR20","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1161\/STROKEAHA.120.031482","volume":"52","author":"E Sechi","year":"2021","unstructured":"Sechi E, Mariotto S, McKeon A et al (2021) Serum neurofilament to magnetic resonance imaging lesion area ratio differentiates spinal cord infarction from acute myelitis. Stroke 52:645\u2013654. https:\/\/doi.org\/10.1161\/STROKEAHA.120.031482","journal-title":"Stroke"},{"key":"10926_CR21","doi-asserted-by":"publisher","first-page":"857","DOI":"10.1002\/ana.24954","volume":"81","author":"G Disanto","year":"2017","unstructured":"Disanto G, Barro C, Benkert P et al (2017) Serum neurofilament light: a biomarker of neuronal damage in multiple sclerosis. Ann Neurol 81:857\u2013870. https:\/\/doi.org\/10.1002\/ana.24954","journal-title":"Ann Neurol"},{"key":"10926_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.654942","volume":"15","author":"S Thebault","year":"2021","unstructured":"Thebault S, Booth RA, Rush CA et al (2021) Serum neurofilament light chain measurement in MS: hurdles to clinical translation. Front Neurosci 15:654942. https:\/\/doi.org\/10.3389\/fnins.2021.654942","journal-title":"Front Neurosci"},{"key":"10926_CR23","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1007\/s004150170229","volume":"248","author":"NC Silver","year":"2001","unstructured":"Silver NC, Good CD, Sormani MP et al (2001) A modified protocol to improve the detection of enhancing brain and spinal cord lesions in multiple sclerosis. J Neurol 248:215\u2013224. https:\/\/doi.org\/10.1007\/s004150170229","journal-title":"J Neurol"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-021-10926-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-021-10926-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-021-10926-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:31:20Z","timestamp":1655872280000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-021-10926-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,17]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10926"],"URL":"https:\/\/doi.org\/10.1007\/s00415-021-10926-7","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,17]]},"assertion":[{"value":"6 July 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 November 2021","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 November 2021","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"17 January 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors report no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional (University and Polytechnic Hospital La Fe, Valencia, Spain) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}