{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T03:43:10Z","timestamp":1783395790190,"version":"3.54.6"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T00:00:00Z","timestamp":1644192000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Netherlands ALS Foundation"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Home-monitoring of spirometry has the potential to improve care for patients with a motor neuron disease (MND) by enabling early detection of respiratory dysfunction and reducing travel burden. Our aim was to evaluate the validity and feasibility of home-monitoring vital capacity (VC) in patients with MND.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We included 33 patients with amyotrophic lateral sclerosis, progressive muscular atrophy or primary lateral sclerosis who completed a 12-week home-monitoring protocol, consisting of 4-weekly unsupervised home assessments of VC and a functional rating scale. At baseline, during a home visit, patients\/caregivers were trained in performing a VC test, and the investigator performed a supervised VC test, which was repeated at final follow-up during a second home visit. Validity of the unsupervised VC tests was evaluated by the differences between supervised and unsupervised VC tests, and through Bland\u2013Altman 95% limits-of-agreement. Feasibility was assessed by means of a survey of user-experiences.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>The 95% limits-of-agreement were [\u2212\u200914.3; 11.7] %predicted VC, and 88% of unsupervised VC tests fell within 10%predicted of supervised VC. 88% of patients experienced VC testing as easy and not burdensome, however, 15% patients did not think their VC test was performed as well as in the clinic. 94% of patients would like home-monitoring of VC in MND care.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Discussion<\/jats:title>\n                <jats:p>Unsupervised VC testing at home, with prior face-to-face training, is a valid and time-efficient method for the remote monitoring of respiratory function, and well-accepted by patients with MND and their caregivers.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-022-10996-1","type":"journal-article","created":{"date-parts":[[2022,2,7]],"date-time":"2022-02-07T10:03:42Z","timestamp":1644228222000},"page":"3713-3722","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Home-monitoring of vital capacity in people with a motor neuron disease"],"prefix":"10.1007","volume":"269","author":[{"given":"Jochem","family":"Helleman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap N. E.","family":"Bakers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelien","family":"Pirard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard H.","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna M. A.","family":"Visser-Meily","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1269-0710","authenticated-orcid":false,"given":"Anita","family":"Beelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,7]]},"reference":[{"issue":"5","key":"10996_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1371\/journal.pone.0177555","volume":"12","author":"C Burkhardt","year":"2017","unstructured":"Burkhardt C, Neuwirth C, Sommacal A, Andersen PM, Weber M (2017) Is survival improved by the use of NIV and PEG in amyotrophic lateral sclerosis (ALS)? A post-mortem study of 80 ALS patients. PLoS ONE 12(5):1\u201312","journal-title":"PLoS ONE"},{"issue":"1","key":"10996_CR2","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1080\/17482960701656940","volume":"9","author":"P Corcia","year":"2008","unstructured":"Corcia P, Pradat PF, Salachas F, Bruneteau G, le Forestier N, Seilhean D et al (2008) Causes of death in a post-mortem series of ALS patients. Amyotroph Lateral Scler 9(1):59\u201362","journal-title":"Amyotroph Lateral Scler"},{"key":"10996_CR3","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1111\/j.1468-1331.2011.03501.x","volume":"19","author":"PM Andersen","year":"2012","unstructured":"Andersen PM, Abrahams S, Borasio GD, de Carvalho M, Chio A, Van Damme P et al (2012) EFNS guidelines on the Clinical Management of Amyotrophic Lateral Sclerosis (MALS)\u2014revised report of an EFNS task force. Eur J Neurol 19:360\u2013375","journal-title":"Eur J Neurol"},{"key":"10996_CR4","unstructured":"NICE. Motor neurone disease: assessment and Motor neurone disease: assessment and management management NICE guideline [Internet]. 2016 [cited 2019 Aug 30]. Available from: www.nice.org.uk\/guidance\/ng42"},{"key":"10996_CR5","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1212\/WNL.0b013e3181bc0141","volume":"73","author":"RG Miller","year":"2009","unstructured":"Miller RG, Jackson CE, Kasarskis EJ, England JD, Forshew FD, Johnston W et al (2009) Practice parameter update: the care of the patient with amyotrophic lateral sclerosis: drug, nutritional, and respiratory therapies (an evidence-based review). Neurology 73:1218\u20131226","journal-title":"Neurology"},{"issue":"2","key":"10996_CR6","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/S1474-4422(05)70326-4","volume":"5","author":"SC Bourke","year":"2006","unstructured":"Bourke SC, Tomlinson M, Williams TL, Bullock RE, Shaw PJ, Gibson GJ (2006) Effects of non-invasive ventilation on survival and quality of life in patients with amyotrophic lateral sclerosis: a randomised controlled trial. Lancet Neurol 5(2):140\u2013147","journal-title":"Lancet Neurol"},{"issue":"5","key":"10996_CR7","doi-asserted-by":"publisher","first-page":"559","DOI":"10.5664\/jcsm.4704","volume":"11","author":"B Vrijsen","year":"2015","unstructured":"Vrijsen B, Buyse B, Belge C, Robberecht W, Van Damme P, Decramer M et al (2015) Noninvasive ventilation improves sleep in amyotrophic lateral sclerosis: a prospective polysomnographic study. J Clin Sleep Med 11(5):559\u2013566","journal-title":"J Clin Sleep Med"},{"issue":"8","key":"10996_CR8","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1212\/01.wnl.0000208957.88534.11","volume":"66","author":"N Mustfa","year":"2006","unstructured":"Mustfa N, Walsh E, Bryant V, Lyall RA, Addington-Hall J, Goldstein LH et al (2006) The effect of noninvasive ventilation on ALS patients and their caregivers. Neurology 66(8):1211\u20131217","journal-title":"Neurology"},{"issue":"1\u20132","key":"10996_CR9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3109\/21678421.2015.1069851","volume":"17","author":"HE Stephens","year":"2016","unstructured":"Stephens HE, Young J, Felgoise SH, Simmons Z (2016) A qualitative study of multidisciplinary ALS clinic use in the United States. Amyotroph Lateral Scler Front Degener 17(1\u20132):55\u201361","journal-title":"Amyotroph Lateral Scler Front Degener"},{"key":"10996_CR10","doi-asserted-by":"publisher","first-page":"519","DOI":"10.2147\/JMDH.S177563","volume":"11","author":"KL Schellenberg","year":"2018","unstructured":"Schellenberg KL, Hansen G (2018) Patient perspectives on transitioning to amyotrophic lateral sclerosis multidisciplinary clinics. J Multidiscip Healthc 11:519\u2013524","journal-title":"J Multidiscip Healthc"},{"issue":"10","key":"10996_CR11","doi-asserted-by":"publisher","first-page":"e028526","DOI":"10.1136\/bmjopen-2018-028526","volume":"9","author":"E Hobson","year":"2019","unstructured":"Hobson E, Baird W, Bradburn M, Cooper C, Mawson S, Quinn A et al (2019) Process evaluation and exploration of telehealth in motor neuron disease in a UK specialist centre. BMJ Open 9(10):e028526","journal-title":"BMJ Open"},{"issue":"3\u20134","key":"10996_CR12","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1080\/21678421.2020.1718712","volume":"21","author":"J Helleman","year":"2020","unstructured":"Helleman J, Van Eenennaam R, Kruitwagen ET, Kruithof WJ, Slappendel MJ, Van Den Berg LH et al (2020) Telehealth as part of specialized ALS care: feasibility and user experiences with \u201cALS home-monitoring and coaching.\u201d Amyotroph Lateral Scler Front Degener 21(3\u20134):183\u2013192","journal-title":"Amyotroph Lateral Scler Front Degener"},{"issue":"6","key":"10996_CR13","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1007\/s10072-020-04457-8","volume":"41","author":"F De Marchi","year":"2020","unstructured":"De Marchi F, Cantello R, Ambrosini S, Mazzini L, Sarnelli MF, De Marchi I et al (2020) Telemedicine and technological devices for amyotrophic lateral sclerosis in the era of COVID-19. Neurol Sci 41(6):1365\u20131367","journal-title":"Neurol Sci"},{"issue":"7\u20138","key":"10996_CR14","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1080\/21678421.2020.1773502","volume":"21","author":"R Capozzo","year":"2020","unstructured":"Capozzo R, Zoccolella S, Musio M, Barone R, Accogli M, Logroscino G (2020) Telemedicine is a useful tool to deliver care to patients with Amyotrophic Lateral Sclerosis during COVID-19 pandemic: results from Southern Italy. Amyotroph Lateral Scler Front Degener. 21(7\u20138):542\u2013548. https:\/\/doi.org\/10.1080\/21678421.2020.1773502","journal-title":"Amyotroph Lateral Scler Front Degener."},{"issue":"5\u20136","key":"10996_CR15","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1080\/21678421.2017.1313867","volume":"18","author":"SM Selkirk","year":"2017","unstructured":"Selkirk SM, Washington MO, McClellan F, Flynn B, Seton JM, Strozewski R (2017) Delivering tertiary centre specialty care to ALS patients via telemedicine: a retrospective cohort analysis. Amyotroph Lateral Scler Front Degener 18(5\u20136):324\u2013332","journal-title":"Amyotroph Lateral Scler Front Degener"},{"issue":"1\u20132","key":"10996_CR16","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1080\/21678421.2017.1392577","volume":"19","author":"M Van De Rijn","year":"2018","unstructured":"Van De Rijn M, Paganoni S, Levine-Weinberg M, Campbell K, Swartz Ellrodt A, Estrada J et al (2018) Experience with telemedicine in a multi-disciplinary ALS clinic. Amyotroph Lateral Scler Front Degener. 19(1\u20132):143\u2013148. https:\/\/doi.org\/10.1080\/21678421.2017.1392577","journal-title":"Amyotroph Lateral Scler Front Degener."},{"key":"10996_CR17","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-020-10003-5","author":"J Helleman","year":"2020","unstructured":"Helleman J, Kruitwagen-van Reenen ET, Bakers J, Kruithof WJ, van Groenestijn AC, Jaspers Focks RJH et al (2020) Using patient-reported symptoms of dyspnea for screening reduced respiratory function in patients with motor neuron diseases. J Neurol. https:\/\/doi.org\/10.1007\/s00415-020-10003-5","journal-title":"J Neurol"},{"issue":"1\u20132","key":"10996_CR18","doi-asserted-by":"publisher","first-page":"194","DOI":"10.3109\/17482960902991773","volume":"11","author":"F Baumann","year":"2010","unstructured":"Baumann F, Henderson RD, Morrison SC, Brown M, Hutchinson N, Douglas JA et al (2010) Use of respiratory function tests to predict survival in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 11(1\u20132):194\u2013202","journal-title":"Amyotroph Lateral Scler"},{"issue":"6","key":"10996_CR19","doi-asserted-by":"publisher","first-page":"1615","DOI":"10.1007\/s00415-020-09751-1","volume":"267","author":"A Calvo","year":"2020","unstructured":"Calvo A, Vasta R, Moglia C, Matteoni E, Canosa A, Mattei A et al (2020) Prognostic role of slow vital capacity in amyotrophic lateral sclerosis. J Neurol 267(6):1615\u20131621","journal-title":"J Neurol"},{"issue":"3\u20134","key":"10996_CR20","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1080\/21678421.2019.1706581","volume":"21","author":"J Helleman","year":"2020","unstructured":"Helleman J, Kruitwagen ET, van den Berg LH, Visser-Meily JMA, Beelen A (2020) The current use of telehealth in ALS care and the barriers to and facilitators of implementation: a systematic review. Amyotroph Lateral Scler Front Degener 21(3\u20134):167\u2013182","journal-title":"Amyotroph Lateral Scler Front Degener"},{"key":"10996_CR21","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2021.1920982","author":"R Tattersall","year":"2021","unstructured":"Tattersall R, Carty S, Meldrum D, Hardiman O, Murray D (2021) The patient\u2019s perspective of remote respiratory assessments during the COVID-19 pandemic. Amyotroph Lateral Scler Front Degener. https:\/\/doi.org\/10.1080\/21678421.2021.1920982","journal-title":"Amyotroph Lateral Scler Front Degener."},{"issue":"15 supplement","key":"10996_CR22","first-page":"P4.4","volume":"92","author":"L Meng","year":"2019","unstructured":"Meng L, Rudnicki SA, Lechtzin N, Cockroft B, Malik FI, Wolff AA et al (2019) Correlation between slow vital capacity measured in the home and in the clinic for patients with amyotrophic lateral sclerosis. Neurology 92(15 supplement):P4.4-002","journal-title":"Neurology"},{"key":"10996_CR23","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106277","author":"GM Pellegrino","year":"2021","unstructured":"Pellegrino GM, Sferrazza Papa GF, Centanni S, Corbo M, Kvarnberg D, Tobin MJ et al (2021) Measuring vital capacity in amyotrophic lateral sclerosis: effects of interfaces and reproducibility. Respir Med. https:\/\/doi.org\/10.1016\/j.rmed.2020.106277","journal-title":"Respir Med"},{"issue":"1\u20132","key":"10996_CR24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","volume":"169","author":"JM Cedarbaum","year":"1999","unstructured":"Cedarbaum JM, Stambler N, Malta E, Fuller C, Hilt D (1999) The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function. J Neurol Sci 169(1\u20132):13\u201321","journal-title":"J Neurol Sci"},{"issue":"7\u20138","key":"10996_CR25","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1080\/21678421.2019.1634736","volume":"20","author":"RPA van Eijk","year":"2019","unstructured":"van Eijk RPA, Bakers JNE, van Es MA, Eijkemans MJC, van den Berg LH (2019) Implications of spirometric reference values for amyotrophic lateral sclerosis. Amyotroph Lateral Scler Front Degener. 20(7\u20138):473\u201380. https:\/\/doi.org\/10.1080\/21678421.2019.1634736","journal-title":"Amyotroph Lateral Scler Front Degener."},{"issue":"6","key":"10996_CR26","doi-asserted-by":"publisher","first-page":"1324","DOI":"10.1183\/09031936.00080312","volume":"40","author":"PH Quanjer","year":"2012","unstructured":"Quanjer PH, Stanojevic S, Cole TJ, Baur X, Hall GL, Culver BH et al (2012) Multi-ethnic reference values for spirometry for the 3\u201395-yr age range: the global lung function 2012 equations. Eur Respir J 40(6):1324\u20131343","journal-title":"Eur Respir J"},{"issue":"2","key":"10996_CR27","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1080\/17482960601030188","volume":"8","author":"M Mendoza","year":"2007","unstructured":"Mendoza M, Gelinas DF, Moore DH, Miller RG (2007) A comparison of maximal inspiratory pressure and forced vital capacity as potential criteria for initiating non-invasive ventilation in amyotrophic lateral sclerosis. Amyotroph Lateral Scler 8(2):106\u2013111","journal-title":"Amyotroph Lateral Scler"},{"issue":"5\u20136","key":"10996_CR28","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1080\/21678421.2019.1587633","volume":"20","author":"A Geronimo","year":"2019","unstructured":"Geronimo A, Simmons Z (2019) Evaluation of remote pulmonary function testing in motor neuron disease. Amyotroph Lateral Scler Front Degener 20(5\u20136):348\u2013355","journal-title":"Amyotroph Lateral Scler Front Degener"},{"issue":"7","key":"10996_CR29","doi-asserted-by":"publisher","first-page":"e10480","DOI":"10.2196\/10480","volume":"20","author":"S Simblett","year":"2018","unstructured":"Simblett S, Greer B, Matcham F, Curtis H, Polhemus A, Ferr\u00e3o J et al (2018) Barriers to and facilitators of engagement with remote measurement technology for managing health: systematic review and content analysis of findings. J Med Internet Res 20(7):e10480","journal-title":"J Med Internet Res"},{"issue":"11","key":"10996_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2196\/16158","volume":"8","author":"C Edwards","year":"2020","unstructured":"Edwards C, Costello E, Cassidy N, Vick B, Russell AM (2020) Use of the patientMpower app with home-based spirometry to monitor the symptoms and impact of fibrotic lung conditions: longitudinal observational study. JMIR mHealth uHealth 8(11):1\u20139","journal-title":"JMIR mHealth uHealth"},{"issue":"9","key":"10996_CR31","doi-asserted-by":"publisher","first-page":"e28766","DOI":"10.2196\/28766","volume":"23","author":"RPA van Eijk","year":"2021","unstructured":"van Eijk RPA, Beelen A, Kruitwagen ET, Murray D, Radakovic R, Hobson E et al (2021) A road map for remote digital health technology for motor neuron disease. J Med Internet Res 23(9):e28766","journal-title":"J Med Internet Res"},{"key":"10996_CR32","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/S0022-510X(01)00617-7","volume":"191","author":"CE Jackson","year":"2001","unstructured":"Jackson CE, Rosenfeld J, Moore DH, Bryan WW, Barohn RJ, Wrench M et al (2001) A preliminary evaluation of a prospective study of pulmonary function studies and symptoms of hypoventilation in ALS\/MND patients. J Neurol Sci 191:75\u201378","journal-title":"J Neurol Sci"},{"issue":"11","key":"10996_CR33","doi-asserted-by":"publisher","first-page":"866","DOI":"10.1097\/01.PHM.0000091985.22659.30","volume":"82","author":"LB Elman","year":"2003","unstructured":"Elman LB, Siderowf AD, McCluskey LF (2003) Nocturnal oximetry: utility in the respiratory management of amyotrophic lateral sclerosis. Am J Phys Med Rehabil 82(11):866\u2013870","journal-title":"Am J Phys Med Rehabil"},{"issue":"3","key":"10996_CR34","doi-asserted-by":"publisher","first-page":"00044","DOI":"10.1183\/23120541.00044-2019","volume":"5","author":"TS Panchabhai","year":"2019","unstructured":"Panchabhai TS, Mireles Cabodevila E, Pioro EP, Wang X, Han X, Aboussouan LS (2019) Pattern of lung function decline in patients with amyotrophic lateral sclerosis: implications for timing of noninvasive ventilation. ERJ Open Res. 5(3):00044\u201302019. https:\/\/doi.org\/10.1183\/23120541.00044-2019","journal-title":"ERJ Open Res."},{"issue":"9","key":"10996_CR35","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1136\/jnnp-2015-312185","volume":"87","author":"T Prell","year":"2016","unstructured":"Prell T, Ringer TM, Wullenkord K, Garrison P, Gunkel A, Stubendorff B et al (2016) Assessment of pulmonary function in amyotrophic lateral sclerosis: when can polygraphy help evaluate the need for non-invasive ventilation? J Neurol Neurosurg Psychiatry 87(9):1022\u20131026","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"1","key":"10996_CR36","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1002\/mus.20450","volume":"33","author":"EP Schmidt","year":"2006","unstructured":"Schmidt EP, Drachman DB, Wiener CM, Clawson L, Kimball R, Lechtzin N (2006) Pulmonary predictors of survival in amyotrophic lateral sclerosis: use in clinical trial design. Muscle Nerve 33(1):127\u2013132","journal-title":"Muscle Nerve"},{"key":"10996_CR37","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1378\/chest.121.2.436","volume":"121","author":"N Lechtzin","year":"2002","unstructured":"Lechtzin N, Wiener CM, Shade DM, Clawson L, Diette GB (2002) Spirometry in the supine position improves the detection of diaphragmatic weakness in patients with amyotrophic lateral sclerosis. Chest 121:436\u2013442","journal-title":"Chest"},{"issue":"6","key":"10996_CR38","doi-asserted-by":"publisher","first-page":"458","DOI":"10.3109\/17482968.2011.593038","volume":"12","author":"P Carrat\u00fa","year":"2011","unstructured":"Carrat\u00fa P, Cassano A, Gadaleta F, Tedone M, Dongiovanni S, Fanfulla F et al (2011) Association between low sniff nasal-inspiratory pressure (SNIP) and sleep disordered breathing in amyotrophic lateral sclerosis: preliminary results. Amyotroph Lateral Scler 12(6):458\u2013463","journal-title":"Amyotroph Lateral Scler"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-022-10996-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-022-10996-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-022-10996-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,22]],"date-time":"2022-06-22T04:33:19Z","timestamp":1655872399000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-022-10996-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10996"],"URL":"https:\/\/doi.org\/10.1007\/s00415-022-10996-1","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,7]]},"assertion":[{"value":"28 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 January 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 January 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"7 February 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Ethics approval was provided by the Medical Ethical Testing Committee of the University Medical Center Utrecht (No. 20-158); this study was, therefore, performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All individuals who participated in this study were properly informed and signed an informed consent form prior to study participation.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All contributing authors have given their consent for this manuscript to be submitted, and declare that the submitted work has not been published before, and that the work is not under consideration for publication elsewhere.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}