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Here, we examined potential synergistic effects of nGVS when combined with standardized vestibular rehabilitation training (VRT).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>23 patients with confirmed BVP received a 30-min vestibular rehabilitation training (VRT) program three times a week for 2 weeks. The intervention group (<jats:italic>n<\/jats:italic>\u2009=\u200912) was stimulated with nGVS (at individually determined optimal amplitudes) during training, whereas the control group (<jats:italic>n<\/jats:italic>\u2009=\u200911) received zero-amplitude nGVS (sham stimulation) during training. Outcome measurements assessed at baseline, after 2 weeks of training, and at 2-week follow-up included quantitative posturography, instrumented gait analysis, Timed Up and Go Test (TUG), Functional Gait Assessment (FGA), and clinical scores related to quality of life and balance confidence.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>After 2 weeks of VRT, all patients showed moderate improvement in balance. Irrespective of nGVS treatment, performance improved in the TUG (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.013), and in the FGA (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.040). Furthermore, base of support when walking with closed eyes was reduced after 2-week training (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.003). Postural sway did not change. There was no difference between groups and thereby no evidence for an additional influence of nGVS on the VRT treatment effects.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>nGVS does not induce synergistic treatment effects in combination with VRT in patients with BVP when applied during treatment sessions. Hence, rather than being applied in parallel, nGVS and VRT might be complementary therapeutic options with nGVS being used during postural activities in daily life, e.g., walking.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-022-11033-x","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T09:02:41Z","timestamp":1645779761000},"page":"5731-5737","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Combining vestibular rehabilitation with noisy galvanic vestibular stimulation for treatment of bilateral vestibulopathy"],"prefix":"10.1007","volume":"269","author":[{"given":"Josefine","family":"Eder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvy","family":"Kellerer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Amberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aram","family":"Keywan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Dlugaiczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Wuehr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1669-3652","authenticated-orcid":false,"given":"Klaus","family":"Jahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,2,25]]},"reference":[{"key":"11033_CR1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jcma.2012.09.003","volume":"76","author":"AH Alghadir","year":"2013","unstructured":"Alghadir AH, Iqbal ZA, Whitney SL (2013) An update on vestibular physical therapy. 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KJ and MW received funding from NeuroConn (DC-stimulator). On behalf of all authors, the corresponding author states that there is no other conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This double-blinded clinical explorative study aimed to evaluate the impact of imperceptible amounts of nGVS on the efficacy of vestibular rehabilitation in patients with BVP. The study protocol was approved by the ethics committee of the University of Munich and was conducted in accordance with the Declaration of Helsinki.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants gave their written informed consent.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Informed consent"}}]}}