{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T20:28:57Z","timestamp":1771014537460,"version":"3.50.1"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T00:00:00Z","timestamp":1648512000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Alzheimer's Society UK","award":["S-JF-19a-004-517"],"award-info":[{"award-number":["S-JF-19a-004-517"]}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["EXC 2145 SyNergy \u2013 ID 390857198"],"award-info":[{"award-number":["EXC 2145 SyNergy \u2013 ID 390857198"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002283","name":"Alzheimer\u2019s Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002283","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Leonard Wolfson Experimental Neurology Centre (LWENC) Clinical Research Facility"},{"name":"Miriam Marks Brain Research UK","award":["MR\/M008525\/1"],"award-info":[{"award-number":["MR\/M008525\/1"]}]},{"name":"NIHR Rare Disease Translational Research Collaboration","award":["BRC149\/NS\/MH"],"award-info":[{"award-number":["BRC149\/NS\/MH"]}]},{"name":"MRC UK GENFI","award":["MR\/M023664\/1"],"award-info":[{"award-number":["MR\/M023664\/1"]}]},{"name":"Bluefield Project"},{"name":"JPND GENFI-PROX","award":["2019-02248"],"award-info":[{"award-number":["2019-02248"]}]},{"name":"NIHR Cambridge Biomedical Research Centre","award":["BRC-1215-20014"],"award-info":[{"award-number":["BRC-1215-20014"]}]},{"DOI":"10.13039\/100015873","name":"The National Brain Appeal","doi-asserted-by":"crossref","award":["RCN 290173"],"award-info":[{"award-number":["RCN 290173"]}],"id":[{"id":"10.13039\/100015873","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100015873","name":"National Brain Appeal","doi-asserted-by":"crossref","award":["RCN 290173"],"award-info":[{"award-number":["RCN 290173"]}],"id":[{"id":"10.13039\/100015873","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Introduction<\/jats:title>\n                <jats:p>A third of frontotemporal dementia (FTD) is caused by an autosomal-dominant genetic mutation in one of three genes: microtubule-associated protein tau (<jats:italic>MAPT<\/jats:italic>), chromosome 9 open reading frame 72 (<jats:italic>C9orf72<\/jats:italic>) and progranulin (<jats:italic>GRN<\/jats:italic>). Prior studies of prodromal FTD have identified impaired executive function and social cognition early in the disease but few have studied naming in detail.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We investigated performance on the Boston Naming Test (BNT) in the GENetic Frontotemporal dementia Initiative cohort of 499 mutation carriers and 248 mutation-negative controls divided across three genetic groups: <jats:italic>C9orf72<\/jats:italic>, <jats:italic>MAPT<\/jats:italic> and <jats:italic>GRN<\/jats:italic>. Mutation carriers were further divided into 3 groups according to their global CDR plus NACC FTLD score: 0 (asymptomatic), 0.5 (prodromal) and 1\u2009+\u2009(fully symptomatic). Groups were compared using a bootstrapped linear regression model, adjusting for age, sex,\u00a0language and education. Finally, we identified neural correlates of anomia within carriers of each genetic group using a\u00a0voxel-based morphometry analysis.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>All symptomatic groups performed worse on the BNT than controls with the <jats:italic>MAPT<\/jats:italic> symptomatic group scoring the worst. Furthermore, <jats:italic>MAPT<\/jats:italic> asymptomatic and prodromal groups performed significantly worse than controls. Correlates of anomia in <jats:italic>MAPT<\/jats:italic> mutation carriers included bilateral anterior temporal lobe regions and the anterior insula. Similar bilateral anterior temporal lobe involvement was seen in <jats:italic>C9orf72<\/jats:italic> mutation carriers as well as more widespread left frontal atrophy. In <jats:italic>GRN<\/jats:italic> mutation carriers, neural correlates were limited to the left hemisphere, and involved frontal, temporal, insula and striatal regions.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>This study suggests the development of early anomia in <jats:italic>MAPT<\/jats:italic> mutation carriers, likely to be associated with impaired semantic knowledge. Clinical trials focused on the prodromal period within individuals with <jats:italic>MAPT<\/jats:italic> mutations should use language tasks, such as the BNT for patient stratification and as outcome measures.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-022-11068-0","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T08:07:07Z","timestamp":1648541227000},"page":"4322-4332","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Anomia is present pre-symptomatically in frontotemporal dementia due to MAPT mutations"],"prefix":"10.1007","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-8590","authenticated-orcid":false,"given":"Arabella","family":"Bouzigues","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5023-5893","authenticated-orcid":false,"given":"Lucy L.","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3319-138X","authenticated-orcid":false,"given":"Georgia","family":"Peakman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1814-5024","authenticated-orcid":false,"given":"Martina","family":"Bocchetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6446-1960","authenticated-orcid":false,"given":"Caroline V.","family":"Greaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9477-1812","authenticated-orcid":false,"given":"Rhian S.","family":"Convery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Todd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7216-8679","authenticated-orcid":false,"given":"James B.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Borroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Galimberti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Tiraboschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Masellis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Carmela","family":"Tartaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4461-7427","authenticated-orcid":false,"given":"Elizabeth","family":"Finger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6278-6844","authenticated-orcid":false,"given":"John C.","family":"van Swieten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harro","family":"Seelaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lize","family":"Jiskoot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Sorbi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris R.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Graff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Gerhard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Langheinrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Laforce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Sanchez-Valle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"de Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fermin","family":"Moreno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthis","family":"Synofzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rik","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Ducharme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Le Ber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5092-4306","authenticated-orcid":false,"given":"Johannes","family":"Levin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian","family":"Danek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6647-5944","authenticated-orcid":false,"given":"Markus","family":"Otto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Pasquier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonathan D.","family":"Rohrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Genetic FTD Initiative, GENFI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aitana Sogorb","family":"Esteve","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annabel","family":"Nelson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0267-8590","authenticated-orcid":false,"given":"Arabella","family":"Bouzigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"Heller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline V","family":"Greaves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Cash","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Todd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanya","family":"Benotmane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imogen J","family":"Swift","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Nicholas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiran","family":"Samra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucy L","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1814-5024","authenticated-orcid":false,"given":"Martina","family":"Bocchetta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rachelle","family":"Shafei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhian S","family":"Convery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Timberlake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Cope","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy","family":"Rittman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Benussi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Premi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Gasparotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Archetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Gazzina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Cantoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Arighi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Fenoglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elio","family":"Scarpini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Fumagalli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittoria","family":"Borracci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giacomina","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Giaccone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Caroppo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Tiraboschi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Prioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Redaelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Tang-Wai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterina","family":"Rogaeva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Castelo-Branco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ron","family":"Keren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Black","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Mitchell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christen","family":"Shoesmith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robart","family":"Bartha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"Rademakers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jackie","family":"Poos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janne M","family":"Papma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Giannini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rick","family":"Minkelen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yolande","family":"Pijnenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedetta","family":"Nacmias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Ferrari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Polito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Bessi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Veldsman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christin","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hakan","family":"Thonberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linn","family":"\u00d6ijerstedt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vesna","family":"Jelic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Langheinrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Llad\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Antonell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaume","family":"Olives","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mircea","family":"Balasa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuria","family":"Bargall\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergi","family":"Borrego-Ecija","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Verdelho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina","family":"Maruta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catarina B","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Miltenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederico Sim\u00f5es","family":"do Couto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alazne","family":"Gabilondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Gorostidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Villanua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Ca\u00f1ada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikel","family":"Tainta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miren","family":"Zulaica","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myriam","family":"Barandiaran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia","family":"Alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Bender","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Wilke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Graf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annick","family":"Vogels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathieu","family":"Vandenbulcke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Van Damme","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose","family":"Bruffaerts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koen","family":"Poesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Rosa-Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Camuzat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexis","family":"Brice","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lie","family":"Funkiewiez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisy","family":"Rinaldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Saracino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Colliot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Sayah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catharina","family":"Prix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Wlasich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Wagemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Loosli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Sch\u00f6necker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Hoegen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jolina","family":"Lombardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Anderl-Straub","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeline","family":"Rollin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory","family":"Kuchcinski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maxime","family":"Bertoux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thibaud","family":"Lebouvier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Deramecourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Santiago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Duro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Jo\u00e3o","family":"Leit\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Rosario","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"T\u00e1buas-Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f3nia","family":"Afonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annerose","family":"Engel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryna","family":"Polyakova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,3,29]]},"reference":[{"issue":"3","key":"11068_CR1","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1136\/jnnp.70.3.323","volume":"70","author":"JS Snowden","year":"2001","unstructured":"Snowden JS (2001) Distinct behavioural profiles in frontotemporal dementia and semantic dementia. J Neurol Neurosurg Psychiatry 70(3):323\u2013332. https:\/\/doi.org\/10.1136\/jnnp.70.3.323","journal-title":"J Neurol Neurosurg Psychiatry"},{"issue":"18","key":"11068_CR2","doi-asserted-by":"publisher","first-page":"1451","DOI":"10.1212\/WNL.0b013e3181bf997a","volume":"73","author":"JD Rohrer","year":"2009","unstructured":"Rohrer JD et al (2009) The heritability and genetics of frontotemporal lobar degeneration. Neurology 73(18):1451\u20131456. https:\/\/doi.org\/10.1212\/WNL.0b013e3181bf997a","journal-title":"Neurology"},{"issue":"2","key":"11068_CR3","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3233\/JAD-150806","volume":"50","author":"CJD Hardy","year":"2016","unstructured":"Hardy CJD et al (2016) The language profile of behavioral variant frontotemporal dementia. J Alzheimers Dis 50(2):359\u2013371. https:\/\/doi.org\/10.3233\/JAD-150806","journal-title":"J Alzheimers Dis"},{"issue":"3","key":"11068_CR4","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/S1474-4422(14)70233-9","volume":"14","author":"JD Rohrer","year":"2015","unstructured":"Rohrer JD et al (2015) C9orf72 expansions in frontotemporal dementia and amyotrophic lateral sclerosis. Lancet Neurol 14(3):291\u2013301. https:\/\/doi.org\/10.1016\/S1474-4422(14)70233-9","journal-title":"Lancet Neurol"},{"issue":"7\u20138","key":"11068_CR5","doi-asserted-by":"publisher","first-page":"497","DOI":"10.3109\/21678421.2015.1074700","volume":"16","author":"JS Snowden","year":"2015","unstructured":"Snowden JS et al (2015) Distinct clinical and pathological phenotypes in frontotemporal dementia associated with MAPT, PGRN and C9orf72 mutations. Amyotroph Lateral Scler Front Degener 16(7\u20138):497\u2013505. https:\/\/doi.org\/10.3109\/21678421.2015.1074700","journal-title":"Amyotroph Lateral Scler Front Degener"},{"issue":"4","key":"11068_CR6","doi-asserted-by":"publisher","first-page":"331","DOI":"10.2174\/156720509788929264","volume":"6","author":"EJ Rogalski","year":"2009","unstructured":"Rogalski EJ, Mesulam MM (2009) Clinical trajectories and biological features of primary progressive aphasia (PPA). Curr Alzheimer Res 6(4):331\u2013336. https:\/\/doi.org\/10.2174\/156720509788929264","journal-title":"Curr Alzheimer Res"},{"issue":"9","key":"11068_CR7","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1001\/jamaneurol.2016.2016","volume":"73","author":"KG Ranasinghe","year":"2016","unstructured":"Ranasinghe KG et al (2016) Distinct subtypes of behavioral variant frontotemporal dementia based on patterns of network degeneration. JAMA Neurol 73(9):1078\u20131088. https:\/\/doi.org\/10.1001\/jamaneurol.2016.2016","journal-title":"JAMA Neurol"},{"issue":"8","key":"11068_CR8","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1136\/jnnp-2017-315667","volume":"88","author":"JA Saxon","year":"2017","unstructured":"Saxon JA et al (2017) Examining the language and behavioural profile in FTD and ALS-FTD. J Neurol Neurosurg Psychiatry 88(8):675\u2013680. https:\/\/doi.org\/10.1136\/jnnp-2017-315667","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"11068_CR9","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.cortex.2019.04.027","volume":"120","author":"JS Snowden","year":"2019","unstructured":"Snowden JS et al (2019) Naming and conceptual understanding in frontotemporal dementia. Cortex 120:22\u201335. https:\/\/doi.org\/10.1016\/j.cortex.2019.04.027","journal-title":"Cortex"},{"issue":"4","key":"11068_CR10","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1159\/000077163","volume":"17","author":"C McMillan","year":"2004","unstructured":"McMillan C, Gee J, Moore P, Dennis K, DeVita C, Grossman M (2004) Confrontation naming and morphometric analyses of structural mri in frontotemporal dementia. Dement Geriatr Cogn Disord 17(4):320\u2013323. https:\/\/doi.org\/10.1159\/000077163","journal-title":"Dement Geriatr Cogn Disord"},{"issue":"3","key":"11068_CR11","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1093\/brain\/awh075","volume":"127","author":"M Grossman","year":"2004","unstructured":"Grossman M et al (2004) What\u2019s in a name: voxel-based morphometric analyses of MRI and naming difficulty in Alzheimer\u2019s disease, frontotemporal dementia and corticobasal degeneration. Brain 127(3):628\u2013649. https:\/\/doi.org\/10.1093\/brain\/awh075","journal-title":"Brain"},{"key":"11068_CR12","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neurobiolaging.2017.10.008","volume":"62","author":"DM Cash","year":"2018","unstructured":"Cash DM et al (2018) Patterns of gray matter atrophy in genetic frontotemporal dementia: results from the GENFI study. Neurobiol Aging 62:191\u2013196. https:\/\/doi.org\/10.1016\/j.neurobiolaging.2017.10.008","journal-title":"Neurobiol Aging"},{"key":"11068_CR13","unstructured":"Kaplan E, Goodglass H, Weintraub S (2001) The Boston Naming Test: Pro- Ed"},{"issue":"2","key":"11068_CR14","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1097\/WAD.0b013e318191c7dd","volume":"23","author":"S Weintraub","year":"2009","unstructured":"Weintraub S et al (2009) The Alzheimer\u2019s disease centers\u2019 uniform data set (UDS): the neuropsychological test battery. Alzheimer Dis Assoc Disord 23(2):91\u2013101. https:\/\/doi.org\/10.1097\/WAD.0b013e318191c7dd","journal-title":"Alzheimer Dis Assoc Disord"},{"issue":"1","key":"11068_CR15","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/alz.12033","volume":"16","author":"T Miyagawa","year":"2020","unstructured":"Miyagawa T et al (2020) Utility of the global CDR\u00ae plus NACC FTLD rating and development of scoring rules: data from the ARTFL\/LEFFTDS Consortium. Alzheimers Dement J Alzheimers Assoc 16(1):106\u2013117. https:\/\/doi.org\/10.1002\/alz.12033","journal-title":"Alzheimers Dement J Alzheimers Assoc"},{"issue":"1","key":"11068_CR16","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.neuroimage.2007.07.007","volume":"38","author":"J Ashburner","year":"2007","unstructured":"Ashburner J (2007) A fast diffeomorphic image registration algorithm. Neuroimage 38(1):95\u2013113. https:\/\/doi.org\/10.1016\/j.neuroimage.2007.07.007","journal-title":"Neuroimage"},{"issue":"1","key":"11068_CR17","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.neuroimage.2008.08.045","volume":"44","author":"GR Ridgway","year":"2009","unstructured":"Ridgway GR, Omar R, Ourselin S, Hill DLG, Warren JD, Fox NC (2009) Issues with threshold masking in voxel-based morphometry of atrophied brains. Neuroimage 44(1):99\u2013111. https:\/\/doi.org\/10.1016\/j.neuroimage.2008.08.045","journal-title":"Neuroimage"},{"key":"11068_CR18","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.neuroimage.2014.09.034","volume":"104","author":"IB Malone","year":"2015","unstructured":"Malone IB et al (2015) Accurate automatic estimation of total intracranial volume: a nuisance variable with less nuisance. Neuroimage 104:366\u2013372. https:\/\/doi.org\/10.1016\/j.neuroimage.2014.09.034","journal-title":"Neuroimage"},{"issue":"6","key":"11068_CR19","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1007\/s00415-018-8850-7","volume":"265","author":"LC Jiskoot","year":"2018","unstructured":"Jiskoot LC et al (2018) Longitudinal cognitive biomarkers predicting symptom onset in presymptomatic frontotemporal dementia. J Neurol 265(6):1381\u20131392. https:\/\/doi.org\/10.1007\/s00415-018-8850-7","journal-title":"J Neurol"},{"issue":"2","key":"11068_CR20","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1017\/S1355617718001005","volume":"25","author":"G Cheran","year":"2019","unstructured":"Cheran G et al (2019) Cognitive indicators of preclinical behavioral variant frontotemporal dementia in MAPT carriers. J Int Neuropsychol Soc 25(2):184\u2013194. https:\/\/doi.org\/10.1017\/S1355617718001005","journal-title":"J Int Neuropsychol Soc"},{"issue":"3","key":"11068_CR21","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1016\/j.neuroimage.2005.10.008","volume":"30","author":"PJ Nestor","year":"2006","unstructured":"Nestor PJ, Fryer TD, Hodges JR (2006) Declarative memory impairments in Alzheimer\u2019s disease and semantic dementia. Neuroimage 30(3):1010\u20131020. https:\/\/doi.org\/10.1016\/j.neuroimage.2005.10.008","journal-title":"Neuroimage"},{"key":"11068_CR22","doi-asserted-by":"publisher","DOI":"10.1080\/23279095.2020.1716357","author":"K Moore","year":"2020","unstructured":"Moore K et al (2020) A modified Camel and Cactus Test detects presymptomatic semantic impairment in genetic frontotemporal dementia within the GENFI cohort. Appl Neuropsychol Adult. https:\/\/doi.org\/10.1080\/23279095.2020.1716357","journal-title":"Appl Neuropsychol Adult"},{"issue":"11","key":"11068_CR23","doi-asserted-by":"publisher","first-page":"3256","DOI":"10.1093\/brain\/awq272","volume":"133","author":"M Mion","year":"2010","unstructured":"Mion M et al (2010) What the left and right anterior fusiform gyri tell us about semantic memory. Brain 133(11):3256\u20133268. https:\/\/doi.org\/10.1093\/brain\/awq272","journal-title":"Brain"},{"issue":"3","key":"11068_CR24","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1002\/ana.10825","volume":"55","author":"ML Gorno-Tempini","year":"2004","unstructured":"Gorno-Tempini ML et al (2004) Cognition and anatomy in three variants of primary progressive aphasia. Ann Neurol 55(3):335\u2013346. https:\/\/doi.org\/10.1002\/ana.10825","journal-title":"Ann Neurol"},{"issue":"18","key":"11068_CR25","doi-asserted-by":"publisher","first-page":"1562","DOI":"10.1212\/WNL.0b013e3181a4124e","volume":"72","author":"JD Rohrer","year":"2009","unstructured":"Rohrer JD et al (2009) Patterns of cortical thinning in the language variants of frontotemporal lobar degeneration. Neurology 72(18):1562\u20131569. https:\/\/doi.org\/10.1212\/WNL.0b013e3181a4124e","journal-title":"Neurology"},{"issue":"9","key":"11068_CR26","doi-asserted-by":"publisher","first-page":"3344","DOI":"10.1523\/JNEUROSCI.5544-10.2011","volume":"31","author":"E Rogalski","year":"2011","unstructured":"Rogalski E et al (2011) Anatomy of language impairments in primary progressive aphasia. J Neurosci 31(9):3344\u20133350. https:\/\/doi.org\/10.1523\/JNEUROSCI.5544-10.2011","journal-title":"J Neurosci"},{"key":"11068_CR27","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.neuroimage.2017.12.068","volume":"171","author":"SM Wilson","year":"2018","unstructured":"Wilson SM, Bautista A, McCarron A (2018) Convergence of spoken and written language processing in the superior temporal sulcus. Neuroimage 171:62\u201374. https:\/\/doi.org\/10.1016\/j.neuroimage.2017.12.068","journal-title":"Neuroimage"},{"issue":"1","key":"11068_CR28","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1177\/1073858412440596","volume":"19","author":"ML Seghier","year":"2013","unstructured":"Seghier ML (2013) The angular gyrus: multiple functions and multiple subdivisions. Neuroscientist 19(1):43\u201361. https:\/\/doi.org\/10.1177\/1073858412440596","journal-title":"Neuroscientist"},{"issue":"11","key":"11068_CR29","doi-asserted-by":"publisher","first-page":"1004","DOI":"10.1016\/S1474-4422(07)70266-1","volume":"6","author":"JR Hodges","year":"2007","unstructured":"Hodges JR, Patterson K (2007) Semantic dementia: a unique clinicopathological syndrome. Lancet Neurol 6(11):1004\u20131014. https:\/\/doi.org\/10.1016\/S1474-4422(07)70266-1","journal-title":"Lancet Neurol"},{"issue":"7","key":"11068_CR30","doi-asserted-by":"publisher","first-page":"1823","DOI":"10.1016\/j.cortex.2012.09.014","volume":"49","author":"SA Savage","year":"2013","unstructured":"Savage SA, Ballard KJ, Piguet O, Hodges JR (2013) Bringing words back to mind\u2014improving word production in semantic dementia. Cortex 49(7):1823\u20131832. https:\/\/doi.org\/10.1016\/j.cortex.2012.09.014","journal-title":"Cortex"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-022-11068-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-022-11068-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-022-11068-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,18]],"date-time":"2022-07-18T16:32:21Z","timestamp":1658161941000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-022-11068-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,29]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2022,8]]}},"alternative-id":["11068"],"URL":"https:\/\/doi.org\/10.1007\/s00415-022-11068-0","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,29]]},"assertion":[{"value":"22 November 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 March 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 March 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 March 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare that they have no conflict of interest. Johannes Levin reports speaker fees from Bayer Vital, Biogen and Roche, consulting fees from Axon Neuroscience and Biogen, author fees from Thieme medical publishers and W. Kohlhammer GmbH medical publishers, non-financial support from Abbvie and compensation for duty as part-time CMO from MODAG, outside the submitted work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Local ethics committees at each site provided ethical approval in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}},{"value":"All participants provided informed written consent prior to their inclusion.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"Not required.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}