{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T14:23:57Z","timestamp":1761402237404,"version":"3.37.3"},"reference-count":32,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 - Universit\u00e4tsmedizin Berlin","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Background<\/jats:title>\n                <jats:p>Epilepsy surgery cases are becoming more complex and increasingly require invasive video-EEG monitoring (VEM) with intracranial subdural or intracerebral electrodes, exposing patients to substantial risks. We assessed the utility and safety of using foramen ovale (FO) and epidural peg electrodes (FOP) as a next step diagnostic approach following scalp VEM.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>We analyzed clinical, electrophysiological, and imaging characteristics of 180 consecutive patients that underwent FOP VEM between 1996 and 2021. Multivariate logistic regression was used to assess predictors of clinical and electrophysiological outcomes.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>FOP VEM allowed for immediate resection recommendation in 36 patients (20.0%) and excluded this option in 85 (47.2%). Fifty-nine (32.8%) patients required additional invasive EEG investigations; however, only eight with bilateral recordings. FOP VEM identified the ictal onset in 137 patients, compared to 96 during prior scalp VEM, <jats:italic>p<\/jats:italic>\u2009=\u2009.004. Predictors for determination of ictal onset were temporal lobe epilepsy (OR 2.9, <jats:italic>p<\/jats:italic>\u2009=\u2009.03) and lesional imaging (OR 3.1, <jats:italic>p<\/jats:italic>\u2009=\u2009.01). Predictors for surgery recommendation were temporal lobe epilepsy (OR 6.8, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), FO seizure onset (OR 6.1, <jats:italic>p<\/jats:italic>\u2009=\u2009.002), and unilateral interictal epileptic activity (OR 3.8, <jats:italic>p<\/jats:italic>\u2009=\u2009.02). One-year postsurgical seizure freedom (53.3% of patients) was predicted by FO ictal onset (OR 5.8, <jats:italic>p<\/jats:italic>\u2009=\u2009.01). Two patients experienced intracerebral bleeding without persisting neurologic sequelae.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>FOP VEM adds clinically significant electrophysiological information leading to treatment decisions in two-thirds of cases with a good benefit\u2013risk profile. Predictors identified for electrophysiological and clinical outcome can assist in optimally selecting patients for this safe diagnostic approach.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-022-11208-6","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T19:39:16Z","timestamp":1655321956000},"page":"5474-5486","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Presurgical video-EEG monitoring with foramen ovale and epidural peg electrodes: a 25-year perspective"],"prefix":"10.1007","volume":"269","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0842-1806","authenticated-orcid":false,"given":"Gadi","family":"Miron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Dehnicke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz-Joachim","family":"Meencke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Onken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Holtkamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"11208_CR1","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1111\/epi.12544","volume":"55","author":"P Jayakar","year":"2014","unstructured":"Jayakar P, Gaillard WD, Tripathi M et al (2014) Diagnostic test utilization in evaluation for resective epilepsy surgery in children. 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MH reports personal fees as speaker and consultant within the last 3\u00a0years from Angelini\/Arvelle, Bial, Desitin, Eisai, GW Pharma, UCB and Zogenix outside the submitted work. The remaining authors have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"This study was approved by the Institutional Review Board of Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin. Due to the retrospective nature of the study and due to the fact that all procedures were part of routine care, informed consent of patients was waived.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical approval"}}]}}