{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T04:00:38Z","timestamp":1784174438401,"version":"3.55.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T00:00:00Z","timestamp":1656115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["J Neurol"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1007\/s00415-022-11223-7","type":"journal-article","created":{"date-parts":[[2022,6,25]],"date-time":"2022-06-25T15:02:54Z","timestamp":1656169374000},"page":"5582-5595","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Investigating the use of plasma pTau181 in retired contact sports athletes"],"prefix":"10.1007","volume":"269","author":[{"given":"Anna","family":"Vasilevskaya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foad","family":"Taghdiri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namita","family":"Multani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miracle","family":"Ozzoude","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apameh","family":"Tarazi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mozhgan","family":"Khodadadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Wennberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Rusjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Houle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Green","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Colella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Karikari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Mikulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili-Naz","family":"Hazrati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor G.","family":"Kovacs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Deborah","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Tator","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5944-8497","authenticated-orcid":false,"given":"Maria Carmela","family":"Tartaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,6,25]]},"reference":[{"key":"11223_CR1","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1136\/bjsports-2017-097791","volume":"51","author":"G Manley","year":"2017","unstructured":"Manley G, Gardner AJ, Schneider KJ, Guskiewicz KM, Bailes J, Cantu RC et al (2017) A systematic review of potential long-term effects of sport-related concussion. Br J Sports Med 51:969\u2013977","journal-title":"Br J Sports Med"},{"key":"11223_CR2","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1001\/jama.2017.8334","volume":"318","author":"J Mez","year":"2017","unstructured":"Mez J, Daneshvar DH, Kiernan PT, Abdolmohammadi B, Alvarez VE, Huber BR et al (2017) Clinicopathological evaluation of chronic traumatic encephalopathy in players of american football. JAMA 318:360\u2013370","journal-title":"JAMA"},{"key":"11223_CR3","doi-asserted-by":"crossref","unstructured":"Schwab N, Wennberg R, Grenier K, Tartaglia C, Tator C, Hazrati L-N (2021) Association of position played and career duration and chronic traumatic encephalopathy at autopsy in elite football and hockey players. Neurology. Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology. https:\/\/n.neurology.org\/content\/early\/2021\/02\/24\/WNL.0000000000011668","DOI":"10.1212\/WNL.0000000000011668"},{"key":"11223_CR4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jocn.2018.07.002","volume":"56","author":"DM Costello","year":"2018","unstructured":"Costello DM, Kaye AH, O\u2019Brien TJ, Shultz SR (2018) Sport related concussion\u2014potential for biomarkers to improve acute management. J Clin Neurosci 56:1\u20136","journal-title":"J Clin Neurosci"},{"key":"11223_CR5","doi-asserted-by":"publisher","first-page":"1784","DOI":"10.1089\/neu.2015.4295","volume":"33","author":"JM Oliver","year":"2016","unstructured":"Oliver JM, Jones MT, Kirk KM, Gable DA, Repshas JT, Johnson TA et al (2016) Serum neurofilament light in American football athletes over the course of a season. J Neurotrauma 33:1784\u20131789 (Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA)","journal-title":"J Neurotrauma"},{"key":"11223_CR6","doi-asserted-by":"publisher","first-page":"1788","DOI":"10.1212\/WNL.0000000000003912","volume":"88","author":"P Shahim","year":"2017","unstructured":"Shahim P, Zetterberg H, Tegner Y, Blennow K (2017) Serum neurofilament light as a biomarker for mild traumatic brain injury in contact sports. Neurology 88:1788\u20131794","journal-title":"Neurology"},{"key":"11223_CR7","doi-asserted-by":"publisher","first-page":"e1780","DOI":"10.1212\/WNL.0000000000005518","volume":"90","author":"P Shahim","year":"2018","unstructured":"Shahim P, Tegner Y, Marklund N, Blennow K, Zetterberg H (2018) Neurofilament light and tau as blood biomarkers for sports-related concussion. Neurology 90:e1780\u2013e1788","journal-title":"Neurology"},{"key":"11223_CR8","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1111\/ene.14251","volume":"27","author":"F Taghdiri","year":"2020","unstructured":"Taghdiri F, Multani N, Ozzoude M, Tarazi A, Khodadadi M, Wennberg R et al (2020) Neurofilament-light in former athletes: a potential biomarker of neurodegeneration and progression. Eur J Neurol 27:1170\u20131177","journal-title":"Eur J Neurol"},{"key":"11223_CR9","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.jalz.2018.02.013","volume":"14","author":"MM Mielke","year":"2018","unstructured":"Mielke MM, Hagen CE, Xu J, Chai X, Vemuri P, Lowe VJ et al (2018) Plasma phospho-tau181 increases with Alzheimer\u2019s disease clinical severity and is associated with tau-and amyloid-positron emission tomography. Alzheimer\u2019s Dementia 14:989\u2013997","journal-title":"Alzheimer\u2019s Dementia"},{"key":"11223_CR10","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/S1474-4422(20)30071-5","volume":"19","author":"TK Karikari","year":"2020","unstructured":"Karikari TK, Pascoal TA, Ashton NJ, Janelidze S, Benedet AL, Rodriguez JL et al (2020) Blood phosphorylated tau 181 as a biomarker for Alzheimer\u2019s disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts. Lancet Neurol 19:422\u2013433","journal-title":"Lancet Neurol"},{"key":"11223_CR11","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1038\/s41591-020-0762-2","volume":"26","author":"EH Thijssen","year":"2020","unstructured":"Thijssen EH, La Joie R, Wolf A, Strom A, Wang P, Iaccarino L et al (2020) Diagnostic value of plasma phosphorylated tau181 in Alzheimer\u2019s disease and frontotemporal lobar degeneration. Nat Med 26:387\u2013397","journal-title":"Nat Med"},{"key":"11223_CR12","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1038\/s41380-020-00923-z","volume":"26","author":"TK Karikari","year":"2021","unstructured":"Karikari TK, Benedet AL, Ashton NJ, Lantero Rodriguez J, Snellman A, Su\u00e1rez-Calvet M et al (2021) Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer\u2019s Disease Neuroimaging Initiative. Mol Psychiatry 26:429\u2013442","journal-title":"Mol Psychiatry"},{"key":"11223_CR13","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1093\/brain\/awaa399","volume":"144","author":"A Moscoso","year":"2021","unstructured":"Moscoso A, Grothe MJ, Ashton NJ, Karikari TK, Rodriguez JL, Snellman A et al (2021) Time course of phosphorylated-tau181 in blood across the Alzheimer\u2019s disease spectrum. Brain 144:325\u2013339","journal-title":"Brain"},{"key":"11223_CR14","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1038\/s41591-020-0755-1","volume":"26","author":"S Janelidze","year":"2020","unstructured":"Janelidze S, Mattsson N, Palmqvist S, Smith R, Beach TG, Serrano GE et al (2020) Plasma P-tau181 in Alzheimer\u2019s disease: relationship to other biomarkers, differential diagnosis, neuropathology and longitudinal progression to Alzheimer\u2019s dementia. Nat Med 26:379\u2013386","journal-title":"Nat Med"},{"key":"11223_CR15","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1007\/s00401-020-02195-x","volume":"140","author":"J Lantero Rodriguez","year":"2020","unstructured":"Lantero Rodriguez J, Karikari TK, Su\u00e1rez-Calvet M, Troakes C, King A, Emersic A et al (2020) Plasma p-tau181 accurately predicts Alzheimer\u2019s disease pathology at least 8 years prior to post-mortem and improves the clinical characterisation of cognitive decline. Acta Neuropathol 140:267\u2013278","journal-title":"Acta Neuropathol"},{"key":"11223_CR16","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s00401-021-02275-6","volume":"141","author":"NJ Ashton","year":"2021","unstructured":"Ashton NJ, Pascoal TA, Karikari TK, Benedet AL, Lantero-Rodriguez J, Brinkmalm G et al (2021) Plasma p-tau231: a new biomarker for incipient Alzheimer\u2019s disease pathology. Acta Neuropathol 141:709\u2013724","journal-title":"Acta Neuropathol"},{"key":"11223_CR17","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1001\/jamaneurol.2020.4986","volume":"78","author":"A Moscoso","year":"2021","unstructured":"Moscoso A, Grothe MJ, Ashton NJ, Karikari TK, Lantero Rodr\u00edguez J, Snellman A et al (2021) Longitudinal associations of blood phosphorylated Tau181 and neurofilament light chain with neurodegeneration in Alzheimer disease. JAMA Neurol 78:396\u2013406","journal-title":"JAMA Neurol"},{"issue":"7","key":"11223_CR18","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1002\/alz.12283","volume":"17","author":"J Simr\u00e9n","year":"2021","unstructured":"Simr\u00e9n J, Leuzy A, Karikari TK, Hye A, Benedet AL, Lantero-Rodriguez J et al (2021) The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer\u2019s disease. Alzheimers Dement 17(7):1145\u20131156","journal-title":"Alzheimers Dement"},{"key":"11223_CR19","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1186\/s13195-021-00805-8","volume":"13","author":"C Clark","year":"2021","unstructured":"Clark C, Lewczuk P, Kornhuber J, Richiardi J, Mar\u00e9chal B, Karikari TK et al (2021) Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer\u2019s disease pathology and clinical disease progression. Alzheimers Res Ther 13:65","journal-title":"Alzheimers Res Ther"},{"key":"11223_CR20","doi-asserted-by":"publisher","first-page":"1572","DOI":"10.1093\/brain\/awaa071","volume":"143","author":"JD Arena","year":"2020","unstructured":"Arena JD, Smith DH, Lee EB, Gibbons GS, Irwin DJ, Robinson JL et al (2020) Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer\u2019s disease. Brain 143:1572\u20131587","journal-title":"Brain"},{"key":"11223_CR21","unstructured":"Schmidt M. Rey auditory verbal learning test: A handbook. Western Psychological Services Los Angeles, CA; 1996."},{"key":"11223_CR22","volume-title":"Neuropsychological assessment","author":"MD Lezak","year":"2004","unstructured":"Lezak MD, Howieson DB, Loring DW, Fischer JS (2004) Neuropsychological assessment. Oxford University Press"},{"key":"11223_CR23","unstructured":"Strauss E, Sherman EM, Spreen O (2006) A compendium of neuropsychological tests: administration, norms, and commentary. American Psychological Association"},{"key":"11223_CR24","unstructured":"Wechsler D. WMS-III (1997) Wechsler memory scale administration and scoring manual. Psychological Corporation"},{"key":"11223_CR25","doi-asserted-by":"publisher","first-page":"907","DOI":"10.1016\/0028-3932(93)90147-R","volume":"31","author":"C Bench","year":"1993","unstructured":"Bench C, Frith C, Grasby P, Friston K, Paulesu E, Frackowiak R et al (1993) Investigations of the functional anatomy of attention using the Stroop test. Neuropsychologia 31:907\u2013922","journal-title":"Neuropsychologia"},{"key":"11223_CR26","volume-title":"Symbol digit modalities test","author":"A Smith","year":"1982","unstructured":"Smith A (1982) Symbol digit modalities test. Western Psychological Services Los Angeles"},{"key":"11223_CR27","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.bandc.2009.03.005","volume":"71","author":"E Nyhus","year":"2009","unstructured":"Nyhus E, Barcel\u00f3 F (2009) The Wisconsin Card Sorting Test and the cognitive assessment of prefrontal executive functions: a critical update. Brain Cogn 71:437\u2013451","journal-title":"Brain Cogn"},{"key":"11223_CR28","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1207\/S15324826AN0902_5","volume":"9","author":"KB Kortte","year":"2002","unstructured":"Kortte KB, Horner MD, Windham WK (2002) The trail making test, part B: cognitive flexibility or ability to maintain set? Appl Neuropsychol 9:106\u2013109","journal-title":"Appl Neuropsychol"},{"key":"11223_CR29","volume-title":"Personality assessment inventory","author":"LC Morey","year":"1991","unstructured":"Morey LC (1991) Personality assessment inventory. Psychological Assessment Resources Odessa"},{"key":"11223_CR30","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1080\/13854049008401496","volume":"4","author":"G Geffen","year":"1990","unstructured":"Geffen G, Moar K, O\u2019hanlon A, Clark C, Geffen L (1990) Performance measures of 16\u2013to 86-year-old males and females on the auditory verbal learning test. Clin Neuropsychol 4:45\u201363","journal-title":"Clin Neuropsychol"},{"key":"11223_CR31","volume-title":"Comprehensive norms for an expanded Halstead-Reitan battery: a supplement for the Wechsler Adult Intelligence Scale-Revised","author":"R Heaton","year":"1992","unstructured":"Heaton R (1992) Comprehensive norms for an expanded Halstead-Reitan battery: a supplement for the Wechsler Adult Intelligence Scale-Revised. Psychological Assessment Resources, Odessa"},{"key":"11223_CR32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13195-017-0329-8","volume":"10","author":"P Lewczuk","year":"2018","unstructured":"Lewczuk P, Ermann N, Andreasson U, Schultheis C, Podhorna J, Spitzer P et al (2018) Plasma neurofilament light as a potential biomarker of neurodegeneration in Alzheimer\u2019s disease. Alzheimer\u2019s Res Ther Sprin 10:1\u201310","journal-title":"Alzheimer\u2019s Res Ther Sprin"},{"key":"11223_CR33","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","volume":"33","author":"B Fischl","year":"2002","unstructured":"Fischl B, Salat DH, Busa E, Albert M, Dieterich M, Haselgrove C et al (2002) Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain. Neuron 33:341\u2013355","journal-title":"Neuron"},{"key":"11223_CR34","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1089\/neu.2017.5274","volume":"35","author":"F Taghdiri","year":"2017","unstructured":"Taghdiri F, Chung J, Irwin S, Multani N, Tarazi A, Ebraheem A et al (2017) Decreased number of self-paced saccades in post-concussion syndrome associated with higher symptom burden and reduced white matter integrity. J Neurotrauma 35:719\u2013729","journal-title":"J Neurotrauma"},{"key":"11223_CR35","doi-asserted-by":"crossref","unstructured":"Vasilevskaya A, Taghdiri F, Multani N, Anor C, Misquitta K, Houle S et al (2020) PET tau imaging and motor impairments differ between corticobasal syndrome and progressive supranuclear palsy with and without Alzheimer\u2019s disease biomarkers. Front Neurol https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7366127\/","DOI":"10.3389\/fneur.2020.00574"},{"key":"11223_CR36","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.pscychresns.2006.01.011","volume":"147","author":"P Rusjan","year":"2006","unstructured":"Rusjan P, Mamo D, Ginovart N, Hussey D, Vitcu I, Yasuno F et al (2006) An automated method for the extraction of regional data from PET images. Psychiatry Res 147:79\u201389","journal-title":"Psychiatry Res"},{"key":"11223_CR37","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1038\/jcbfm.1992.81","volume":"12","author":"HW M\u00fcller-G\u00e4rtner","year":"1992","unstructured":"M\u00fcller-G\u00e4rtner HW, Links JM, Prince JL, Bryan RN, McVeigh E, Leal JP et al (1992) Measurement of radiotracer concentration in brain gray matter using positron emission tomography: MRI-based correction for partial volume effects. J Cereb Blood Flow Metab 12:571\u2013583","journal-title":"J Cereb Blood Flow Metab"},{"key":"11223_CR38","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1001\/jama.2018.12917","volume":"320","author":"R Ossenkoppele","year":"2018","unstructured":"Ossenkoppele R, Rabinovici GD, Smith R, Cho H, Sch\u00f6ll M, Strandberg O et al (2018) Discriminative accuracy of [18F] flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders. J Am Med Assoc 320:1151\u20131162","journal-title":"J Am Med Assoc"},{"key":"11223_CR39","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1001\/jamaneurol.2020.0528","volume":"77","author":"AS Fleisher","year":"2020","unstructured":"Fleisher AS, Pontecorvo MJ, Devous MD, Lu M, Arora AK, Truocchio SP et al (2020) Positron emission tomography imaging with [18F] flortaucipir and postmortem assessment of Alzheimer disease neuropathologic changes. JAMA Neurol Am Med Assoc 77:829\u2013839","journal-title":"JAMA Neurol Am Med Assoc"},{"key":"11223_CR40","doi-asserted-by":"publisher","first-page":"1911","DOI":"10.1007\/s00429-015-1012-0","volume":"221","author":"R Goswami","year":"2016","unstructured":"Goswami R, Dufort P, Tartaglia M, Green R, Crawley A, Tator C et al (2016) Frontotemporal correlates of impulsivity and machine learning in retired professional athletes with a history of multiple concussions. Brain Struct Function Spring 221:1911\u20131925","journal-title":"Brain Struct Function Spring"},{"key":"11223_CR41","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.3109\/02699052.2015.1035334","volume":"29","author":"PJ Dean","year":"2015","unstructured":"Dean PJ, Sato JR, Vieira G, McNamara A, Sterr A (2015) Long-term structural changes after mTBI and their relation to post-concussion symptoms. Brain Inj 29:1211\u20131218","journal-title":"Brain Inj"},{"key":"11223_CR42","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1007\/s11682-018-0018-7","volume":"14","author":"AL Ware","year":"2020","unstructured":"Ware AL, Wilde EA, Newsome MR, Moretti P, Abildskov T, Vogt GS et al (2020) A preliminary investigation of corpus callosum subregion white matter vulnerability and relation to chronic outcome in boxers. Brain Imaging Behav 14:772\u2013786","journal-title":"Brain Imaging Behav"},{"key":"11223_CR43","doi-asserted-by":"publisher","first-page":"e781","DOI":"10.1212\/WNL.0000000000009930","volume":"95","author":"Y-C Wu","year":"2020","unstructured":"Wu Y-C, Harezlak J, Elsaid NMH, Lin Z, Wen Q, Mustafi SM et al (2020) Longitudinal white-matter abnormalities in sports-related concussion: a diffusion MRI study. Neurology 95:e781\u2013e792 (Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology)","journal-title":"Neurology"},{"key":"11223_CR44","doi-asserted-by":"crossref","unstructured":"Asken BM, Tanner JA, VandeVrede L, Mantyh WG, Casaletto KB, Staffaroni AM, et al (2022) Plasma P-tau181 and P-tau217 in patients with traumatic encephalopathy syndrome with and without evidence of Alzheimer disease pathology. Neurology (AAN Enterprises)","DOI":"10.1212\/WNL.0000000000200678"},{"key":"11223_CR45","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1038\/s41586-019-1026-5","volume":"568","author":"B Falcon","year":"2019","unstructured":"Falcon B, Zivanov J, Zhang W, Murzin AG, Garringer HJ, Vidal R et al (2019) Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules. Nature 568:420","journal-title":"Nature"},{"key":"11223_CR46","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1136\/jnnp-2020-323487","volume":"91","author":"A Benussi","year":"2020","unstructured":"Benussi A, Karikari TK, Ashton N, Gazzina S, Premi E, Benussi L et al (2020) Diagnostic and prognostic value of serum NfL and p-Tau181 in frontotemporal lobar degeneration. J Neurol Neurosurg Psychiatry 91:960\u2013967 (BMJ Publishing Group Ltd)","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"11223_CR47","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1038\/s41582-020-0348-0","volume":"16","author":"NJ Ashton","year":"2020","unstructured":"Ashton NJ, Hye A, Rajkumar AP, Leuzy A, Snowden S, Su\u00e1rez-Calvet M et al (2020) An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders. Nat Rev Neurol 16:265\u2013284","journal-title":"Nat Rev Neurol"},{"key":"11223_CR48","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1212\/WNL.0000000000003587","volume":"88","author":"J Gill","year":"2017","unstructured":"Gill J, Merchant-Borna K, Jeromin A, Livingston W, Bazarian J (2017) Acute plasma tau relates to prolonged return to play after concussion. Neurology 88:595\u2013602 (Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology)","journal-title":"Neurology"}],"container-title":["Journal of Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-022-11223-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00415-022-11223-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00415-022-11223-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T23:57:53Z","timestamp":1668470273000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00415-022-11223-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,25]]},"references-count":48,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["11223"],"URL":"https:\/\/doi.org\/10.1007\/s00415-022-11223-7","relation":{},"ISSN":["0340-5354","1432-1459"],"issn-type":[{"value":"0340-5354","type":"print"},{"value":"1432-1459","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,25]]},"assertion":[{"value":"5 February 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 May 2022","order":2,"name":"revised","label":"Revised","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2022","order":3,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2022","order":4,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"HZ has served at scientific advisory boards for Eisai, Denali, Roche Diagnostics, Wave, Samumed, Siemens Healthineers, Pinteon Therapeutics, Nervgen, AZTherapies, and CogRx, has given lectures in symposia sponsored by Cellectricon, Fujirebio, Alzecure, and Biogen, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program (outside submitted work). KB has served as a consultant, at advisory boards, or at data monitoring committees for Abcam, Axon, Biogen, JOMDD\/Shimadzu. Julius Clinical, Lilly, MagQu, Novartis, Roche Diagnostics, and Siemens Healthineers, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB (BBS), which is a part of the GU Ventures Incubator Program. GGK has served at advisory board for Biogen.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study was approved by the Research Ethics Board of the University Health Network and written informed consent was obtained from all participants.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}