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Group subtraction analyses, e.g., for responders and non-responders, comparisons with healthy controls and correlation analyses of regional cerebral glucose metabolism (rCGM) with symptom duration, ataxia (SARA) and quality of life (QoL) scores were calculated.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>Prior to treatment rCGM was consistently downregulated at the cerebellar level and increased in multisensory cortical areas, e.g., somatosensory, primary and secondary visual (including V5, precuneus), secondary vestibular (temporal gyrus, anterior insula), and premotor\/supplementary motor areas. With AL (PET B vs. A) cerebellar hypometabolism was deepened and sensorimotor hypermetabolism increased only in responders with clinical benefit, but not for the non-responders and the whole CA group. A positive correlation of ataxia improvement with rCGM was found in visual and vestibular cortices, a negative correlation in cerebellar and brainstem areas. QoL showed a positive correlation with rCGM in the cerebellum and symptom duration in premotor and somatosensory areas.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusions<\/jats:title>\n                <jats:p>Central compensatory processes in CA mainly involve multisensory visual, vestibular, and somatosensory networks as well as premotor\/primary motor areas at the cortical level. The enhanced divergence of cortical sensorimotor up- and cerebellar downregulation with AL in responders could reflect amplification of inhibitory cerebellar mechanisms.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00415-022-11252-2","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T13:03:21Z","timestamp":1658754201000},"page":"44-56","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Acetyl-dl-leucine in cerebellar ataxia ([18F]-FDG-PET study): how does a cerebellar disorder influence cortical sensorimotor networks?"],"prefix":"10.1007","volume":"270","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9214-3583","authenticated-orcid":false,"given":"Sandra","family":"Becker-Bense","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Becker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Feil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolin","family":"Muth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie L.","family":"Albert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Unterrainer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bartenstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Strupp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Dieterich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2022,7,25]]},"reference":[{"issue":"5","key":"11252_CR1","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1007\/s12311-018-0937-2","volume":"17","author":"W Ilg","year":"2018","unstructured":"Ilg W, Branscheidt M, Butala A, Celnik P, de Paola L, Horak FB, Sch\u00f6ls L, Teive HAG, Vogel AP, Zee DS, Timmann D (2018) Consensus paper: neurophysiological assessments of ataxias in daily practice. 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Prof. Strupp reported being the joint chief editor of the Journal of Neurology, editor in chief of Frontiers of Neuro-otology, and section editor of F1000. He also reported receiving speaker\u2019s honoraria from Abbott, Actelion, Auris Medical, Biogen, Eisai GmbH, Gr\u00fcnenthal, GlaxoSmithKline, Hennig Pharma, Interacoustics, MSD Sharp & Dohme, Mylan, Otometrics, Pierre Fabre, TEVA GmbH, and UCB SA Belgium; and being a paid consultant for Abbott, Actelion, AurisMedical, Heel, IntraBio, and Sensorion. He is an investor and shareholder in IntraBio as well as the distributor of Mglasses and the Positional Vertigo App. He has reported receiving grants for research for Decibel, Heel Pharma, and Hennig Pharma.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"The study protocol was approved by the Ethics Committee of the University of Munich (21-0166) and was conducted in accordance with the regulations of the Helsinki Declaration.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical standards"}}]}}